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Long-term outcomes after endoscopic removal of malignant colorectal polyps:Results from a 10-year cohort

World Journal of Gastrointestinal Endoscopy 2024年第4期16卷 193-205页

作者： Anna Fábián Renáta bor béla Vasas Mónika Szűcs tibor tóth Zsófia bősze Kata Judit Szántó Péter bacsur Anita bálint bernadett Farkas Klaudia Farkas Ágnes Milassin Mariann Rutka tamás Resál tamás Molnár Zoltán Szepes Department of Internal Medicine University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6725Hungary Department of Pathology University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6725Hungary Department of Medical Physics and Medical Informatics University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6720Hungary USZ translational Colorectal Research Group Hungarian Centre of Excellence for Molecular MedicineSzeged 6725Hungary

bACKGROUND Choosing an optimal post-polypectomy management strategy of malignant colorectal polyps is challenging,and evidence regarding a surveillance-only strategy is *** to evaluate long-term outcomes after endoscopic removal of malignant colorectal *** A single-center retrospective cohort study was conducted to evaluate outcomes after endoscopic removal of malignant colorectal polyps between 2010 and *** disease rate and nodal metastases after secondary surgery and local and distant recurrence rate for those with at least 1 year of follow-up were *** rates for categorical variables and means for continuous variables with 95%confidence intervals were calculated,and Fisher’s exact test and Mann-Whitney test were *** risk factors of adverse outcomes were RESULtS In total,135 lesions(mean size:22.1 mm;location:42%rectal)from 129 patients(mean age:67.7 years;56%male)were *** proportion of pedunculated and non-pedunculated lesions was similar,with en bloc resection in 82%and 47%of lesions,*** differentiation,distance from resection margins,depth of submucosal invasion,lymphovascular invasion,and budding were reported at 89.6%,45.2%,58.5%,31.9%,and 25.2%,*** tumor was found in 10 patients,and nodal metastasis was found in 4 of 41 patients who underwent secondary surgical *** analysis identified piecemeal resection as a risk factor for residual malignancy(odds ratio:1.74;P=0.042).At least 1 year of follow-up was available for 117 lesions from 111 patients(mean follow-up period:5.59 years).Overall,54%,30%,30%,11%,and 16%of patients presented at the 1-year,3-year,5-year,7-year,and 9-10-year surveillance *** outcomes occurred in 9.0%(local recurrence and dissemination in 4 patients and 9 patients,respectively),with no difference between patients undergoing secondary surgery and surveillance *** Reporting of histological featur

关键词： Malignant colorectal polyps t1 tumor Endoscopic removal Outcomes Long-term Surveillance

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An Easy Access to Oxime Ethers by Pd-Catalyzed C—O Cross-Coupling of Activated Aryl bromides with Ketoximes and Chalcone Oximes

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Chinese Journal of Chemistry 2020年第8期38卷 830-836页

作者： Reeta t.M.Rangarajan raj Pal Singh R.P.Singh Manjula Singh Centre for Fire Explosive and Environment SafetyDRDODelhiIndia Department of Chemistry University of DelhiDelhiIndia Department of Chemistry Sri Venkateswara CollegeUniversity of DelhiNew DelhiIndia Department of Chemistry Shivaji CollegeUniversity of DelhiNew DelhiIndia

An efficient Pd-catalyzed method for C—O cross-coupling of ketoximes and chalcone oximes with activated aryl bromides and bromo-chalcones has been *** oxime ethers were obtained in good to excellent yields by[(π-allyl)PdCl]2/tbuXPhos(L7)catalyst ***(L11)was also found to be effective for the oxime *** method offers an easy and smooth coupling of chalcone oximes with activated aryl bromides and bromo-chalcones,which has not been previously explored.

关键词： coupling coupling bromide

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Laser material processing optimization using bayesian optimization: a generic tool

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Light(Advanced Manufacturing) 2024年第3期5卷 75-85页

作者： tobias Menold Volkher Onuseit Matthias buser Michael Haas Nico bär Andreas Michalowski Institut fuer Strahlwerkzeuge(IFSW) University of Stuttgart70569 StuttgartGermany Graduate School of Excellence advanced Manufacturing Engineering(GSaME) University of Stuttgart70569 StuttgartGermany

Optimizing laser processes is historically challenging,requiring extensive and costly *** solve this issue,we apply bayesian optimization for process parameter optimization to laser cutting,welding,and *** demonstrate how readily available bayesian optimization frameworks enable efficient optimization of laser processes with only modest expert *** studies on laser cutting,welding,and polishing highlight its adaptability to real-world manufacturing ***,the examples emphasize that with suitable cost functions and boundaries an acceptable optimization result can be achieved after a reasonable number of experiments.

关键词： bayesian optimization Design of experiments Laser cutting Laser welding Laser polishing

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Adaptive-optical 3D microscopy for microfluidic multiphase flows

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Light(Advanced Manufacturing) 2024年第3期5卷 105-119页

作者： Clemens bilsing Erik Nützenadel Sebastian burgmann Jürgen Czarske Lars büttner Laboratory of Measurement and Sensor System techniques TUD Dresden University of Technology01069 DresdenGermany Chair of Fluid Mechanics Bergische Universitát Wuppertal42119 WuppertalGermany bIOLAS Laboratory of Measurement and Sensor System Techniques01069 DresdenGermany

Measurements based on optical microscopy can be severely impaired if the access exhibits variations of the refractive *** the case of fluctuating liquid-gas boundaries,refraction introduces dynamical aberrations that increase the measurement *** is prevalent at multiphase flows(***,film flows)that occur in many technical applications as for example in coating and cleaning processes and the water management in fuel *** this paper,we present a novel approach based on adaptive optics for correcting the dynamical aberrations in real time and thus reducing the measurement *** shape of the fluctuating water-air interface is sampled with a reflecting light beam(Fresnel Guide Star)and a Hartmann-Shack sensor which makes it possible to correct its influence with a deformable mirror in a closed ***-dimensional flow measurements are achieved by using a double-helix point spread *** measure the flow inside a sessile,oscillating 50-μl droplet on an opaque gas diffusion layer for fuel cells and show that the temporally varying refraction at the droplet surface causes a systematic underestimation of the flow field magnitude corresponding to the first droplet eigenmode which plays a major role in their detachment *** demonstrate that the adaptive optics correction is able to reduce this systematic ***,the adaptive optics system can pave the way to a deeper understanding of water droplet formation and detachment which can help to improve the efficiency of fuels cells.

关键词： Double-Helix point spread function Adaptive optics Particle tracking velocimetry Aberration correction Depth-resolving microscopy Closed-loop control

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Chromomagnetic dipole moments of light quarks in the bestest little Higgs model

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Chinese Physics C 2024年第10期48卷 125-136页

作者： t.Cisneros-Pérez E.Cruz-Albaro A.Y.Ojeda-Castañeda S.E.Solís-Núñez Unidad Académica de Ciencias Químicas Universidad Autónoma de ZacatecasApartado Postal C-58598060 ZacatecasMexico Facultad de Física Universidad Autónoma de ZacatecasApartado Postal C-58098060 ZacatecasMexico

In this study,we investigated the anomalous Chromomagnetic Dipole Moment(CMDM),denoted as μ_(q)^(bLHM),of light quarks q=(u,c,d,s,b) within the framework of the bestest Little Higgs Model(bLHM)as an extension of the Standard Model(SM).Our investigation encompassed novel interactions among the light quarks,heavy quark b,and heavy bosons (W'^(±),H^(±),φ^(±),η^(±))incorporating the extended Cabibbo-Kobayashi-Maskawa(CKM)matrix characteristic of the *** thoroughly explored the permissible parameter space,yielding a spectrum of CMDM values ranging from 10^(-10) to 10^(-3).

关键词： beyond standard model flavor physics chromomagnetic dipole light quarks

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Molecular mechanisms of enzalutamide resistance in prostate cancer

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Cancer Drug Resistance 2019年第2期2卷 189-197页

作者： Eliot b.blatt Ganesh V.raj Department of Urology University of Texas Southwestern Medical CenterDallasTX 75390USA Department of Pharmacology University of Texas Southwestern Medical CenterDallasTX 75390USA.

An estimated 30,000 men in the United States will die of metastatic prostate cancer(PCa)each year due to the development of therapy resistance,most notably resistance to second-generation antiandrogen *** vast majority of PCa is driven by the androgen receptor(AR).Enzalutamide is an AR antagonist,which extends patient survival and is widely used in the clinic for the treatment of castration-resistant prostate cancer(CRPC);however,many patients will have primary or develop acquired resistance and continue to *** of the molecular mechanisms of enzalutamide resistance provides insight into potentially efficacious therapies for enzalutamide-resistant CRPC(ER-CRPC).Understanding these mechanisms is critical for the identification of biomarkers predictive of therapy resistance and the development of therapeutic strategies to target ER-CRPC.

关键词： Drug resistant cancers resistance modulation biomarkers of drug responsiveness targeted therapy resistance

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Genetic Algorithm based 7-Level Step-Up Inverter with Reduced Harmonics and Switching Devices

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Intelligent Automation & Soft Computing 2023年第3期35卷 3081-3097页

作者： t.Anand Kumar M.Kaliamoorthy I.Gerald Christopher raj Department of EEE Dr.Mahalingam College of Engineering and TechnologyPollachiTamilnaduIndia Department of EEE PSNA College of Engineering and TechnologyDindigulTamilnaduIndia

this paper presents a unique voltage-raising topology for a single-phase seven-level inverter with triple output voltage gain using single input source and two switched *** output voltage has been boosted up to three times the value of input voltage by conﬁguring the switched capacitors in series and parallel combinations which eliminates the use of additional step-up converters and *** selective harmonic elimination(SHE)approach is used to remove the lower-order *** optimal switching angles for SHE is determined using the genetic *** switching angles are com-bined with a level-shifted pulse width modulation(PWM)technique for pulse generation,resulting in reduced total harmonic distortion(tHD).A detailed com-parison has been made against other relevant seven-level inverter topologies in terms of the number of switches,drivers,diodes,capacitors,and boosting facil-ities to emphasize the beneﬁts of the proposed *** proposed topology is simulated using MAtLAb/SIMULINK and an experimental prototype has been developed to validate the *** Digital Signal Processing(DSP)tMS320F2812 board is used to generate the switching pulses for the proposed technique and the experimental results concur with the simulated model outputs.

关键词： Genetic algorithm multilevel inverter pulse width modulation selective harmonic elimination switched capacitor

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StCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.bai Y.bai O.bakina A.barnyakov V.blinov V.bobrovnikov D.bodrov A.bogomyagkov A.bondar I.boyko Z.H.bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.t.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng t.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.t.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong t.Gong b.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.b.He S.Q.He X.G.He Y.L.He Z.b.He Z.X.Heng b.L.Hou t.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.t.Huang X.J.Huang Y.b.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.b.Jiang J.Jiang S.Z.Jiang J.b.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang b.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li F.Li G.Li G.Li H.b.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li t.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.t.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin b.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.b.Liu J.Liu J.J.Liu J.b.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.b.Liu t.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo t.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata b.b.Qi Y.Q.Qi W.b.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin t.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China beihang University Beijing 100191China budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

the superτ-charm facility(StCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** StCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the bEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** StCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the StCF,describes conceptual designs of the StCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity StCF detector conceptual design

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Interaction of photons with silver and indium nuclei at energies up to 20 MeV

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Chinese Physics C 2024年第2期48卷 135-140页

作者： J.H.Khushvaktov M.A.Demichev D.L.Demin S.A.Evseev M.I.Gostkin V.V.Kobets F.A.Rasu-lova S.V.Rozov E.t.Ruziev A.A.Solnyshkin t.N.tran E.A.Yakushev b.S.Yuldashev Joint Institute for Nuclear Research(JINR) DubnaRussia Institute of Nuclear Physics of the Academy of Sciences of the Republic of Uzbekistan(INP ASRU) TashkentUzbekistan Institute of Physics of the Vietnam Academy of Science and technology(IP VASt) HanoiVietnam

the yields of photonuclear reactions in the 107Ag,113In,and 115In nuclei were *** Carlo simulations were performed using the Geant4 code,and the results were compared with the experimental *** isomeric ratios of the yields in the reactions 107Ag(γ,n)106m,gAg and 113In(γ,m)112m,gIn were determined,and the cross sections for the reactions 107Ag(γ,n)106gAg and 107Ag(γ,2n)105Ag at an energy of 20 MeV were calculated based on the experimental data.

关键词： 107Ag(γ,n)10mgAg and I13In(γ,n)12m-2In reactions cross section yield isomeric ratio simula-tion Geant4 tALYS

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Neutrophils in Atlantic salmon(Salmo salar L.)are MHC class II^(+)and secret IL-12p40 upon bacterial exposure

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Aquaculture and Fisheries 2024年第2期9卷 144-153页

作者： Gyri teien Haugland Anita Rønneseth Lene Gundersen Harald SæbøLunde Kaja Nordland Heidrun Inger Wergeland Department of biological Sciences Bergen High-Technology CentreUniversity of BergenBergen5020Norway

Antigen-presentation via major histocompatibility complex(MHC)to t cells is the key event to initiate adaptive immune *** teleosts,as in mammals,the main types of professional antigen-presenting cells(APCs)are dendritic cells(DCs),monocytes/macrophages,and b *** the current study,flow cytometry,immunostaining and qPCR have been used to show that neutrophils in the teleost fish Atlantic salmon(Salmo salar L.)have antigen-presenting *** neutrophils were positive for MHC class II,CD83 and CD80/86,and upon in vitro bacterial exposure,gene expression analysis of purified neutrophils showed that IL-12p40,which is essential for proliferation of naïve t cells,was highly upregulated at both 6 and 24 h post bacterial *** on presence of MHC class II and upregulation of molecules involved in antigen presentation and t cell activation,we suggest that neutrophils in Atlantic salmon have potential to function as professional *** work makes an important basis for further exploring the potential of using neutrophils to develop new,targeted immunoprophylactic measures.

关键词： Granulocytes Antigen presenting cells Major histocompatibility complex t cell activation b cells CD83 CD80/86 MHC classⅡ

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