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Intrumer:A Multi Module Distributed Explainable IDs/IPs for securing Cloud Environment

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Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen banu A s.K.b.sangeetha Department of Computer science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDs,have been developed to tackle these ***,most conventional Intrusion Detection system(IDs)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDsmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDs datasets CICIDs 2017,Honeypots,and NsL-KDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

采用320层螺旋CT冠状动脉CTA联合腺苷心肌灌注负荷成像的诊断准确性的初步研究

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国际医学放射学杂志 2013年第5期 490-490页

作者： A.Nasis b.s.ko M.C.Leung P.R.Antonis D.Nandurkar D.T.Wong 高明 Monash Cardiovascular Research Centre Monash HeartDepartment of Medicine Monash Medical Centre (MMC)Southern Health and Monash University

摘要目的探讨联合320层螺旋CT冠状动脉血管成像(CTA)和腺苷心肌灌注负荷成像(CTP)诊断冠状动脉闭塞(CAD)所致异常灌注的准确性。方法 20例单光子发射计算机体层心肌灌注成像(sPECT-MPI)疑为CAD的病人,同时行320层CTA/CTP和血管造影。2... 详细信息

摘要目的探讨联合320层螺旋CT冠状动脉血管成像(CTA)和腺苷心肌灌注负荷成像(CTP)诊断冠状动脉闭塞(CAD)所致异常灌注的准确性。方法 20例单光子发射计算机体层心肌灌注成像(sPECT-MPI)疑为CAD的病人,同时行320层CTA/CTP和血管造影。2位心血管专家独立评估血管造影影像质量(QCA),1位核医学专家独立分析sPECTMPI影像中固定及可逆转的灌注缺损。另2位心血管医生单独评估CTA/CTP影像。量化冠状动脉造影结果中,管腔狭窄/

关键词： CTA CTP CT 心肌灌注螺旋 sPECT 腺苷冠状动脉

320层CT冠状动脉成像预期稳定性冠状动脉疾病是否需要血管重建并作为行有创性血管造影的决定指标:储备血流分数的相关性研究

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国际医学放射学杂志 2014年第3期 298-298页

作者： b.s.ko D.T.L.Wong J.D.Cameron D.P.Leong M.Leung I.T.Meredith 唐光健 Monash Heart 246 Clayton RoadClayton 3168VICAustralia

摘要目的明确以储备血流分数(FFR)作为参考标准,320层多层CT冠状动脉血管成像(M320-CCTA)检出稳定性冠状动脉疾病功能性狭窄与预期血管重建的准确性。方法

关键词：冠状动脉疾病血管重建分数 CCTA 有创血流储备 CT

Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato socodato João b.Relvas Institute of Research and Innovation in Health(i3s)and Institute for Molecular and Cell biology(IbMC) University of PortoPortoPortugal Department of biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNs)and the immune *** exploration is particularly significant in understanding microglia,the CNs’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

Federated Learning’s Role in Next-Gen TV Ad Optimization

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Computers, Materials & Continua 2025年第1期82卷 675-712页

作者： Gabriela Dobrita simona-Vasilica Oprea Adela bâra Department of Economic Informatics and Cybernetics Bucharest University of Economic StudiesBucharest010374Romania

In the rapidly evolving landscape of television advertising,optimizing ad schedules to maximize viewer engagement and revenue has become *** methods often operate in silos,limiting the potential insights gained from broader data analysis due to concerns over privacy and data *** article introduces a novel approach that leverages Federated Learning(FL)to enhance TV ad schedule optimization,combining the strengths of local optimization techniques with the power of global Machine Learning(ML)models to uncover actionable insights without compromising data *** combines linear programming for initial ads scheduling optimization with ML—specifically,a K-Nearest Neighbors(KNN)model—for predicting ad spot *** into account the diversity and the difficulty of the ad-scheduling problem,we propose a prescriptivepredictive approach in which first the position of the ads is optimized(using Google’s OR-Tools CP-sAT)and then the scheduled position of all ads will be the result of the optimization ***,this output becomes the target of a predictive task that predicts the position of new entries based on their characteristics ensuring the implementation of the scheduling at large scale(using KNN,Light Gradient boosting Machine and Random Forest).Furthermore,we explore the integration of FL to enhance predictive accuracy and strategic insight across different broadcasting networks while preserving data *** FL approach resulted in 8750 ads being precisely matched to their optimal category placements,showcasing an alignment with the intended diversity ***,there was a minimal deviation observed,with 1133 ads positioned within a one-category variance from their ideal placement in the original dataset.

关键词： Ad scheduling prescriptive-predictive approach federated learning KNN

secure Probabilistic Prediction of Dynamic Thermal Line Rating

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Journal of Modern Power systems and Clean Energy 2022年第2期10卷 378-387页

作者： N.safari s.M.Mazhari C.Y.Chung s.b.ko Grid Operations support SaskPower.ReginaSKS4P 0S1Canada the Department of Electrical and Computer Engineering University of SaskatchewanSaskatoonSKS7N 5A9Canada

Accurate short-term prediction of overhead line(OHL)transmission ampacity can directly affect the efficiency of power system operation and *** overcstiniation of the dynamic thermal line rating(DTLR)can lead to the lifetime degradation and failure of OHLs,safety hazards,*** paper presents a secure yet sharp probabilistic model for the hour-ahead prediction of the *** security of the proposed DTLR limits the frequency of DTLR prediction exceeding the actual *** model is based on an augmented deep learning architecture that makes use of a wide range of predictors,including historical climatology data and latent variables obtained during DTLR ***,by introducing a customized cost function,the deep neural network is trained to consider the DTLR security based on the required probability of exceedance while minimizing the deviations of the predicted DTLRs from the actual *** proposed probabilistic DTLR is developed and verified using recorded experimental *** simulation results validate the superiority of the proposed DTLR compared with the state-of-the-art prediction models using well-known evaluation metrics.

关键词： Deep neural network dynamic thermal line rating overhead line prediction recurrent neural network

brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-borràs Marta balanyà-segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina silvera-simón Manel M.santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase b receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated Trkb/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorb

Influences of Pr and Ta doping concentration on the characteristic features of FTO thin film deposited by spray pyrolysis

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Chinese Physics b 2015年第10期24卷 414-422页

作者： Güven Turgut Adem koqyigit Erdal snmez Erzurum Technical University Science FacultyDepartment of Basic Sciences Igdir University Engineering FacultyDepartment of Electrical Electronic Engineering Ataturk University Kazim Karabekir Education FacultyDepartment of Physics

The Pr and Ta separately doped FTO（10 at.% F incorporated sn O2） films are fabricated via spray pyrolysis. The microstructural, topographic, optical, and electrical features of fluorine-doped TO（FTO） films are investigated as functions of Pr and Ta dopant concentrations. The x-ray diffraction（XRD） measurements reveal that all deposited films show polycrystalline tin oxide crystal property. FTO film has（200） preferential orientation, but this orientation changes to（211） direction with Pr and Ta doping ratio increasing. Atomic force microscopy（AFM） and scanning electron microscopy（sEM） analyses show that all films have uniform and homogenous nanoparticle distributions. Furthermore, morphologies of the films depend on the ratio between Pr and Ta dopants. From ultraviolet-visible（UV-Vis） spectrophotometer measurements, it is shown that the transmittance value of FTO film decreases with Pr and Ta doping elements increasing. The band gap value of FTO film increases only at 1 at.% Ta doping level, it drops off with Pr and Ta doping ratio increasing at other doped FTO films. The electrical measurements indicate that the sheet resistance value of FTO film initially decreases with Pr and Ta doping ratio decreasing and then it increases with Pr and Ta doping ratio increasing. The highest value of figure of merit is obtained for 1 at.% Ta- and Pr-doped FTO film. These results suggest that Pr- and Ta-doped FTO films may be appealing candidates for TCO applications.

关键词： Pr-doped FTO Ta-doped FTO spray pyrolysis tin oxide thin films double doping

Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia Monteiro António J.salgado Nuno A.silva Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3b’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury