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Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João b.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell biology(IbMC) University of PortoPortoPortugal Department of biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

Machine learning in solid organ transplantation:Charting the evolving landscape

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World Journal of Transplantation 2025年第1期15卷 165-177页

作者： badi Rawashdeh Haneen Al-abdallat Emre Arpali beje Thomas Ty b Dunn Matthew Cooper Division of Transplant Surgery Medical College of WisconsinMilwaukeeWI 53202United States Department of Medicine Jordan University HospitalAmman 11263Jordan Department of Nephrology Medical College of WisconsinMilwaukeeWI 53226United States

bACKGROUND Machine learning(ML),a major branch of artificial intelligence,has not only demonstrated the potential to significantly improve numerous sectors of healthcare but has also made significant contributions to the field of solid organ *** provides revolutionary opportunities in areas such as donorrecipient matching,post-transplant monitoring,and patient care by automatically analyzing large amounts of data,identifying patterns,and forecasting *** To conduct a comprehensive bibliometric analysis of publications on the use of ML in transplantation to understand current research trends and their *** On July 18,a thorough search strategy was used with the Web of Science *** and transplantation-related keywords were *** the aid of the VOS viewer application,the identified articles were subjected to bibliometric variable analysis in order to determine publication counts,citation counts,contributing countries,and institutions,among other *** Of the 529 articles that were first identified,427 were deemed relevant for bibliometric analysis.A surge in publications was observed over the last four years,especially after 2018,signifying growing interest in this *** 209 publications,the United States emerged as the top ***,the"Journal of Heart and Lung Transplantation"and the"American Journal of Transplantation"emerged as the leading journals,publishing the highest number of relevant *** keyword searches revealed that patient survival,mortality,outcomes,allocation,and risk assessment were significant themes of *** The growing body of pertinent publications highlights ML's growing presence in the field of solid organ *** bibliometric analysis highlights the growing importance of ML in transplant research and highlights its exciting potential to change medical practices and enhance patient *** collaboration between signific

关键词： Machine learning Artificial Intelligence Solid organ transplantation bibliometric analysis

Compact embedding in besov spaces and b-separable elleptic operators

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Science China Mathematics 2010年第4期53卷 1067-1084页

作者： SHAKHMUROV Veli b. Department of Electronics Engineering and Communication Okan University

Necessary and sufficient conditions for compactness of sets in banach space valued besov class bp,q s(Ω;E) is *** embedding theorems in besov-Lions type spaces b l,s p,q(Ω;E0,E) are studied,where E0,E are two banach spaces and E 0  *** most regular class of interpolation space E α,between E 0 and E are found such that the mixed differential operator D α is bounded and compact from b p,q l,s (Ω;E 0,E) to b p,q s (Ω;E α) and Ehrling-Nirenberg-Gagliardo type sharp estimates *** using these results the separability of differential operators with variable coefficients and the maximal b-regularity of parabolic Cauchy problem are *** applications,the infinite systems of the elliptic partial differential equations and parabolic Cauchy problems are studied.

关键词： embedding theorems banach-valued function spaces differential-operator equations maximal b-regularity operator-valued Fourier multipliers interpolation of banach spaces abstract parabolic Cauchy problem

Estimation of radiative capture^(13)b(n,γ0+1)^(14)b reaction rate in the modified potential cluster model

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Chinese Physics C 2023年第10期47卷 130-142页

作者： A.S.Tkachenko N.A.burkova b.M.Yeleusheva S.b.Dubovichenko Fesenkov Astrophysical Institute 050020AlmatyKazakhstan al-Farabi Kazakh National University 050040AlmatyKazakhstan

We discuss current attempts to employ the modified potential cluster model to describe the available experimental data on the^(13)b(n,γ0+1)^(14)b total *** estimated results of the M1 and E1 transitions from the n^(13)b scattering states to the ground and first excited states of^(14)b are *** 1st resonance at Ex=1.275 MeV(1+)is revealed in both the cross-section and reaction *** the variation in the asymptotic constant,a thermal cross-section interval of 5.1-8.9 mb is *** on the theoretical total cross-sections at energies of 0.01 eV to 5 MeV,we calculate the reaction rate in the temperature range of 0.01 to *** ignition T9 values of the^(13)b(n,γ0+1)^(14)b reaction depending on a neutron number density n_(n)of~10^(22)cm^(−3)are *** radiative neutron capture reaction rates on the boron^(10-13)b and carbon^(12-14)Сisotopes are compared.

关键词： radiative neutron capture ^(14)b nucleus total cross-sections reaction rate potential cluster model r-process

Microstructural characteristics of Nd_2Fe_(14)b/α-Fe nanocomposite ribbons bearing Nb element

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Rare Metals 2008年第3期27卷 299-302页

作者： WANG Zhanyong LIU Wenqing ZHOU bangxin NI Jiansen XU Hui LI Qiang Department of Materials Engineering Shanghai Institute of Technology Shanghai 200235 China Institute of Materials Shanghai University Shanghai 200072 China

The effects of Nb on the microstructure and magnetic properties of （Nd0.9Dy0.1）9.5Fe79_xCo5Nbxb6.5 （x = 0, 1） nanocomposite magnets were investigated. A fine and uniform microstructure was achieved for the ribbons annealed at 710℃ for 4 min, enhancing the interaction coupling between grains and improving the magnetic properties. The results of three-dimensional atom probe （3DAP） indicated that Fe-Nb-b inter- granular phase existed at the grain boundaries, suppressing the grain growth during the crystallization process. The coercivity was improved from 224 to 643 kA/m for the modification of the microstructure.

关键词： Nd2Fe14b/α-Fe nanocomposite magnet 3DAP magnetic properties

The fat and the furious:fatty acids fuel hyperproliferative germinal center b cells

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Cellular & Molecular Immunology 2020年第8期17卷 794-796页

作者： Rens Peeters Annemiek b.van Spriel Department of Tumor Immunology Radboud Institute for Molecular Life SciencesRadboudumcNijmegenThe Netherlands

The germinal center(GC)reaction is considered the cornerstone of our humoral immune *** in specialized follicles inside secondary lymphoid organs,germinal center b cells(GCbCs)execute a pivotal *** an infection,the number of GCbCs is rapidly expanded,and subsequently GCbCs differentiate into specialized antibody-secreting *** intricate process is driven by the positive selection of GCbCs via the b-cell receptor with the highest affinity for the respective *** this period of extensive proliferation,GCbCs are among the fastest dividing cells in our *** has been established that cell proliferation requires tremendous amounts of energy and building ***,there remains a paucity of evidence to explain how proliferating GCbCs meet these metabolic *** their latest publication in Nature Immunology,Weisel et *** new insights that may have a far-reaching impact on the evolution of the immunometabolism field.

关键词： metabolism organs specialized

Distribution and geochemical significance of dibenzofurans,phenyldibenzofurans and benzo[b]naphthofurans in source rock extracts from Niger Delta basin,Nigeria

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Acta Geochimica 2020年第6期39卷 973-987页

作者： Abiodun b.Ogbesejana Oluwasesan M.bello Department of Applied Chemistry Federal University Dutsin-MaP.M.B.5001Dutsin-MaKatsina StateNigeria

The distribution and geochemical significance of dibenzofurans,phenyldibenzofurans and benzo[b]naptho-furans in source rocks from Niger Delta basin,Nigeria,were investigated by Rock-Eval pyrolysis and gas chro-matography--mass spectrometry(GC--MS).The data obtained from the source rocks evaluation showed that the rock samples contained type 1/III kerogen capable of generating oil and gas and were within immature to early mature *** relative abundance of the Cor,C1-and C2-dibenzofurans range from 1.75%to 29.82%,27.60%to 40.52%and 29.66%to 6889%,*** diben-zofurans were dominated by *** the C1-dibenzofurans,2-+3-methyldibenzofuran was the most abundant in the rock samples while 1-methy ldibenzofuran appeared to be the *** relative abundance of benzo[b]naphtho[1,2-d]furan(1,2]bNF),benzo[b]naph-tha[2,1-d]furan(2.1]bNF)and benzo[b]naphtha[2,3-d]fu-ran([2.3]bNF)in the rock extracts range from 12.01%to 52.58%,32.61%to 75.219%and 10.27%to 52.43%.The wide range of values recorded for the three isomers of benzo[b lnapthofurans in the samples suggest source rocks formed from mixed organic *** the pheny ldibenzofuran isomers,4-pheny ldibenzofuran was the most abundant while 1-phenyldibenzofuran was the *** ratio-1(PhFR-1)and pheny ldibenzofuran ratio-2(PhFR-2)values range from 0.13 to 1.20 and 0.11 to 2.11,*** resuls showed that the relative abundance of PhFR-1 and PhFR-2 increase gradually with increasing burial depth and maturity(VRo≤0.77%,MPI-1≤*** s 443℃),and have a good correlations with calculated vitrinite ***-I and maximum Temperature(Tmax)-This range of values suggested immature to early mature source *** source rocks were found to have shale and coul lithologics and deposited in a lacustrine/fuvial deltaic settings within immature to early mature stages based on the distribution of dibenzofurans,pheny ldiben-zofurans and benzo[b]naphthofurans in the source rock

关键词： Dibenzofurans benzo[b]napthofurans Source rocks Niger delta Gas chromatography-mass spectrometry

Chyle leak following root of mesentery dissection in pancreaticoduodenectomy with inferior infracolic superior mesenteric artery first approach

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World Journal of Clinical Cases 2025年第8期13卷 8-14页

作者： Prabir Maharjan Sujan Regmee Spandan D Adhikari Rabin Pahari Roshan Ghimire Dhiresh K Maharjan Suman K Shrestha Prabin b Thapa Department of Gastrointestinal and General Surgery Kathmandu Medical College and Teaching HospitalKathmandu 44600Nepal

bACKGROUND The root of mesentery dissection is one of the critical maneuvers,especially in borderline resectable pancreatic head ***-abdominal chyle leak(CL)including chylous ascites may ensue in up to 10%of patients after pancreatic *** recognized superior mesenteric artery(SMA)first approaches are invariably *** mesenteric dissection through the inferior infracolic approach has been discussed in this study emphasizing its post-operative impact on CL which is the cornerstone of this *** To assess incidence,risk factors,clinical impact of CL following root of mesentery dissection,and the different treatment *** This is a retrospective study incorporating the patients who underwent dissection of the root of mesentery with inferior infracolic SMA first approach pancreat-oduodenectomy for the ventral body and uncinate mass of pancreas in the Department of Gastrointestinal and General Surgery of Kathmandu Medical College and Teaching Hospital from January 1,2021 to February 28,***-erative findings and postoperative outcomes were *** In three years,ten patients underwent root of mesentery dissection with inferior infracolic SMA first approach *** mean age was 67.6 years with a male-to-female ratio of 4:*** was seen in four *** virtue of CL,Clavien-Dindo grade Ⅱ or higher morbidity was observed in four *** patients had a hospital stay of more than 20 days with the former having a delayed gastric emptying and the latter with long-term total parenteral nutrition *** mean operative time was 330 *** resection was achieved in 100%of the *** mean duration of the intensive care unit and hospital stay were 2.55±1.45 days and 15.7±5.32 days,*** Root of mesentery dissection with lymphadenectomy and vascular resection correlated with occurrence of *** complete curative resection,these were managed with tota

关键词： Chyle leak Chylous ascites Clavien-Dindo Pancreatoduodenectomy Root of mesentery dissection Superior mesenteric artery first approach Total parenteral nutrition Uncinate mass Vascular resection Ventral body mass

Nonlinear three-dimensional stretched flow of an Oldroyd-b fluid with convective condition, thermal radiation, and mixed convection

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Applied Mathematics and Mechanics(English Edition) 2017年第7期38卷 969-980页

作者： b. MAHANTHESH b. J. GIREESHA S.A. SHEHZAD F.M. AbbASI R. S. R. GORLA Department of Mathematics Christ University Bangalore 560029 Karnataka India Department of Studies and Research in Mathematics Kuvempu University Shankarghatta 577451 Karnataka India Department of Mathematics COMSATS Institute of Information Technology Sahiwal 57000 Pakistan Department of Mathematics COMSATS Institute of Information Technology Islamabad 44000 Pakistan Department of Mechanical and Civil Engineering Purdue University Northwest Indiana 46391 U. S. A

The effect of non-linear convection in a laminar three-dimensional Oldroyd-b fluid flow is addressed. The heat transfer phenomenon is explored by considering the non-linear thermal radiation and heat generation/absorption. The boundary layer as- sumptions are taken into account to govern the mathematical model of the flow analy- sis. Some suitable similarity variables are introduced to transform the partial differen- tial equations into ordinary differential systems. fifth-order techniques with the shooting method The Runge-Kutta-Fehlberg fourth- and are used to obtain the solutions of the dimensionless velocities and temperature. The effects of various physical parameters on the fluid velocities and temperature are plotted and examined. A comparison with the exact and homotopy perturbation solutions is made for the viscous fluid case, and an excellent match is noted. The numerical values of the wall shear stresses and the heat transfer rate at the wall are tabulated and investigated. The enhancement in the values of the Deborah number shows a reverse behavior on the liquid velocities. The results show that the temperature and the thermal boundary layer are reduced when the non- linear convection parameter increases. The values of the Nusselt number are higher in the non-linear radiation situation than those in the linear radiation situation.

关键词： nonlinear thermal convection nonlinear thermal radiation Oldroyd-b fluid,convective boundary condition heat source/sink