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A Matrix-Vector Operation-based Numerical Solution Method for Linear m-th Order Ordinary Differential Equations:Application to Engineering Problems

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Advances in Applied Mathematics and Mechanics 2013年第3期5卷 269-308页

作者： M.Aminbaghai M.Dorn J.Eberhardsteiner b.pichler Institute for Mechanics of Materials and Structures Vienna University of Technology(TU Wien)Karlsplatz 13/202A-1040 ViennaAustria Linnaeus University Department of Building and Energy TechnologyL¨uckligs Plats 1S-35195 V¨axj¨oSweden

Many problems in engineering sciences can be described by linear,inhomogeneous,m-th order ordinary differential equations(ODEs)with variable *** this wide class of problems,we here present a new,simple,flexible,and robust solution method,based on piecewise exact integration of local approximation polynomials as well as on averaging local *** method is designed for modern mathematical software providing efficient environments for numerical matrix-vector operation-based *** on cubic approximation polynomials,the presented method can be expected to perform(i)similar to the Runge-Kutta method,when applied to stiff initial value problems,and(ii)significantly better than the finite difference method,when applied to boundary value ***,we use the presented method for the analysis of engineering problems including the oscillation of a modulated torsional spring pendulum,steady-state heat transfer through a cooling web,and the structural analysis of a slender tower based on second-order beam *** convergence studies provide insight into the satisfying characteristics of the proposed solution scheme.

关键词： Numerical integration polynomial approximation ODE variable coefficients initial conditions boundary conditions stiff equation

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MicroRNAs as novel predictive biomarkers and therapeutic targets in colorectal cancer

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World Journal of Gastroenterology 2014年第33期20卷 11727-11735页

作者： Verena Stiegelbauer Samantha Perakis Alexander Deutsch Hui Ling Armin Gerger Martin pichler Division of Clinical Oncology Department of Internal Medicine Medical University of Graz 8036 Graz Austria Division of Hematology Department of Internal Medicine Medical University of Graz 8036 Graz Austria Department of Experimental Therapeutics University of Texas MD Anderson Cancer Center Houston TX 77030 United States

Colorectal cancer(CRC) is the third most common cancer in western countries. Despite significant improvement in available treatment options, CRC still remains the second leading cause of cancer-related death. Traditionally, 5-fluorouracil has been used as the main chemotherapy drug for treatment of metastatic CRC(mCRC). However, during the last two decades more effective chemotherapeutic agents such as oxaliplatin, irinotecan and the monoclonal antibodies cetuximab, panitumumab and bevacizumab have been used in clinical practice. More recently, the therapeutic armamentarium has been supplemented by the monoclonal antibodies bevacizumab, cetuximab and panitumumab as well as the protein-trap aflibercept and the smallmolecule multi-kinase inhibitor regorafenib. One of the major problems for the management of CRC is the inherent or acquired resistance to therapeutic approaches. The discovery of microRNAs(miRNAs), a class of small, endogenous, non-coding, single-stranded RNAs that play a role as post-transcriptional regulators, has added new dimensions to the diagnosis and treatment of cancer. because miRNAs are important regulators of carcinogenesis, progression, invasion, angiogenesis and metastases in CRC, they might serve as potential predictive and prognostic factors and even as therapeutic targets themselves. Several miRNAs are already known to be dysregulated in CRCs and have been linked to biological processes involved in tumor progression and response to anti-cancer therapies. This review summarizes current therapeutic approaches for treating CRC and highlights the role of miRNAs as novel predictive biomarkers and potential drug targets in CRC patients.

关键词： Colorectal cancer MicroRNAs 5-fluorouracil Epidermal growth factor receptor Targeted therapy

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Carbon nanotube-dependent synthesis of armchair graphene nanoribbons

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Nano Research 2022年第3期15卷 1709-1714页

作者： Yifan Zhang Kecheng Cao Takeshi Saito Hiromichi Kataura Hans Kuzmany Thomas pichler Ute Kaiser Guowei Yang Lei Shi State Key Laboratory of Optoelectronic Materials and Technologies Nanotechnology Research CenterGuangzhou Key Laboratory of Flexible Electronic Materials and Wearable DevicesSchool of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275China Central Facility for Electron Microscopy Electron Microscopy Group of Materials ScienceUlm UniversityUlm 89081Germany School of Physical Science and Technology Shanghai Tech UniversityShanghai 201210China Nanomaterials Research Institute National Institute of Advanced Industrial Science and TechnologyTsukuba 305-8565Japan Faculty of Physics University of ViennaVienna 1090-AAustria

Sub-nanometer armchair graphene nanoribbons(GNRs)with moderate band gap have great potential towards novel *** can be synthesized in the confined tubular space of single-walled carbon nanotubes(SWCNTs),in which precursor molecules have been specifically designed to form the GNRs with certain width and ***,it is still unexplored how the diameter and metallicity of SWCNTs influence the synthesis of the ***,we applied a series of SWCNTs with different average diameters to study the diameter-dependent synthesis of *** using Raman spectroscopy and transmission electron microscopy,we found that the width of the GNRs can be tailored by the diameter of the ***,the SWCNTs with average diameter of 1.3 nm produced 6 and 7 armchair GNRs with the highest yield,which can be well explained by considering the width of the GNRs and van der Waals radius of hydrogen and carbon *** addition,semiconducting and metallic SWCNTs produced GNRs with different yields,which could attribute to different diameter distributions and density of *** results enable the possibility of a high-yield production of certain armchair graphene nanoribbons in large scale,which would benefit future applications as semiconductor with sub-nanometer in width.

关键词： armchair graphene nanoribbons single-walled carbon nanotubes Raman spectroscopy diameter dependence metallicity dependence

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临界低温时的心房纤颤和明显J(Osborn)波

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世界核心医学期刊文摘（心脏病学分册） 2005年第1期1卷 34-34页

作者： Strohmer b. pichler M. 任付先 Department of Cardiology Muellner Haupts trasse 48 Landeskliniken A-5020 Salzburg Salzburg Austria

The J wave is a deflection that appears on the surface ECG as a late de lta wav e following the QRS complex. Also known as an Osborn wave, the J wave has been o bserved in various conditions and diseases. Our case highlights the typical elec trocardiographic manifestations of hypothermia including the J deflection and ST segment elevation during atrial fibrillation. Thorough knowledge of these findi ngs is important for prompt diagnosis and treatment of hypothermic states.

关键词：心房纤颤 Osborn 临界低温体表心电图心电图改变

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光学成像示踪细胞

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国际医学放射学杂志 2008年第A6期31卷 517-517页

作者： E.J.Sutton T.D.Henning b.J.pichler C.bremer H.E.Daldrup-Link 段小慧 Department of Radiology University of CaliforniaSan Francisco CA 94143-0628 USA.

因光具适应性、灵敏性、分辨率和无创性,其作为科学研究工具由来已久,也是光学成像(optical imaging,OI的基础。光学成像包括多种成像技术及方法。

关键词：光学成像细胞示踪荧光染料近红外光活体内分子成像

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人脑MR/PET同步显像可行性的研究

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国际医学放射学杂志 2008年第A6期31卷 493-493页

作者： H.P.Schlemmer b.J.pichler M.Schmand Z.burbar C.Michel R.Ladebeck 李芳 Department of Diagnostic Radiology University Hospital Tbingen Hoppe-Seyler-Strasse 3 D-72076 Tbingen Germany.

本研究目的是应用MR兼容正电子发射体层显像术(PET)探测技术对脑部和颅底进行MR/PET同步显像。PET探测器环是由LOS(lutetium oxyorthosilicate)

关键词：发射体 MR/PET 探测技术分子成像头线圈闪烁晶体影像融合功能信息体模 fluorin

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