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International Journal of Modeling, Simulation, and Scientific Computing 2020年第6期11卷 1-22页

作者： Suresh R.Halhalli b.n.jagdale Shounak Rushikesh Sugave Electronics Engineering M.S.Bidve Engineering College LaturIndia School of CET Dr.Vishwanath Karad MIT World Peace University PuneIndia

Mobile ad hoc network(MAnET)consists of a group of self-operated mobile nodes that form a network without considering predefined *** the network,each node poses less energy due to battery-operated sensor *** methods are devised for routing,but each method suffered from the energy *** paper proposes an energy-efficient multipath routing protocol for exploiting different routes between source and destination to mitigate energy *** key idea is to determine the optimal path from a set of paths available between the source and the target *** improve the security in routing protocol,the factors,like energy,trust,and mobility are considered as major ***,the trust is modeled by considering trust factors,like average encounter rate(AER),successful cooperation frequency(SCF),direct trust,integrity factor,and forwarding rate ***,secure routing is performed between the nodes using the proposed Adaptive-Atom Whale Optimization algorithm(AdaptiveAWOA).The proposed (Adaptive-AWOA)is designed by incorporating the Adaptive concept in the Atom Whale Optimization algorithm(AWOA).The fitness function is newly modeled considering mobility,energy,and trust *** proposed AdaptiveAWOA outperformed the other methods with a minimal end-to-end delay of 0.009,maximal throughput of 85.802%and maximal packet delivery ratio(PDR)of 97.391%,respectively.

关键词： MAnET energy multipath routing trust mobility

Green ionic metal-organic frameworks as nanocatalysts for CO_(2)fixation

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nano Research 2025年第1期18卷 260-269页

作者： nuria Martín Miguel Maireles-Porcar Julián Sánchez Velandia belén Altava Francisco G.Cirujano Eduardo García-Verdugo Departamento de Química Inorgánica y Orgánica Universidad Jaume IAv.Sos Baynats/nCastellóde la PlanaCastellón 12071Spain

Co,ni,and Zn iso-reticular coordination polymers of 2,5-dihydroxyterphthalic acid(H_(2)dot)can be rapidly obtained under room temperature and aqueous conditions using either sodium or ammonium hydroxide as the bases to deprotonate the *** use of metal bromides and tetrabutylammonium hydroxide(TbAOH)as the base allows the green synthesis of ionic metal-organic frameworks(MOFs),characterized by X-ray diffraction(XRD),Fourier transform infrared(FTIR),scanning electron microscopy(SEM),thermo gravimetric analysis(TGA),H-nuclear magnetic resonance(nMR),elemental analysis,and X-ray photoelectron spectroscopy(XPS),and employed in the pressure,solvent,and additive-free CO_(2)fixation to epoxides by its cycloaddition to epichlorohydrin,exhibiting a cooperative behavior between the MOF and the ionic liquid formed within the framework,achieving TOns of the confined tetrabutylammonium bromide(TbAbr)up to 700.

关键词： metal-organic frameworks(MOFs) ionic liquids heterogeneous catalysis CO_(2)conversion

Impacts of PI3K/protein kinase b pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase b(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κb serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GAbA_b-GIRK assembly

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

Magnetically propelled Carreau fluid flow over penetrable sensor surface influenced by thermal radiation,Joule heating and heat generation

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Communications in Theoretical Physics 2022年第2期74卷 9-18页

作者： b J Gireesha b nagaraja n Srikantha n G Rudraswamy A Felicita Department of Studies and Research in Mathematics Kuvempu UniversityShankaraghattaShivamoggaKarnatakaIndia Department of Mathematics MS Ramaiah Institute of TechnologyBangaloreIndia Department of Mathematics P.C.Jabin Science College(Autonomous)HubballiIndia

This examination emphasizes the analysis of thermal transmission of Carreau fluid flow on a permeable sensor surface equipped with radiation,Joule heating,an internal heat source,and a magnetic *** the above effects and assumptions,the equations that administer the flow are formulated.A configured system of equations is productively reduced to a system of ordinary differential *** reduced system is then dealt with using the Runge–Kutta-Fehlberg fourth–fifth order tool equipped by the shooting *** numerical solutions are utilized to plot graphs and *** conclusion of the study outlines some important findings such as the power law index,the thermal radiation parameter and the heat source parameter enhance the thermal panel whereas the Weissenberg number deescalates the *** power law index and permeable velocity decrease the velocity panel *** representation of streamlines of the flow has been given to strengthen the study.A detailed description has been produced about the results obtained in the study.

关键词： sensor surface Carreau fluid squeezed flow thermal radiation heat generation

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia nürnberger barbara Schaedl James Ferguson nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal nógrádi Andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tnGCs). However, the use of tnGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tnGCs and compared the various features of these improved silk^(+) tnGCs with the tubes without holes(silk^(–) tnGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tnGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tnGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tnGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tnGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Hydroclimatological data and analyses from a headwaters region of Mongolia as boundary objects in interdisciplinary climate change research

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Frontiers of Earth Science 2017年第3期11卷 457-468页

作者： n.b.H. VEnAbLE ESS-Watershed Science Colorado State University Fort Collins CO 80523-1476 USA

Collaborative work on increasingly complex hydroclimatic investigations often crosses disciplinary boundaries. Elements of scientific inquiry, such as data or the results of analyses can become objectified, or capable of being adopted and/or adapted by users from multiple disciplinary realms. These objects often provide a bridge for collaborative endeavors, or are used as tools by individuals pursuing multi-disciplinary work. boundary object terminology was first formalized and applied by social scientists. However, few examples of the application of this useful framework are found in the hydrologic literature. The construct is applied here to identify and discuss how common researcb products and processes are used both internally and externally through providing examples from a project examining the historical and paleo proxy-based hydroclimatology of a headwaters region of Mongolia. The boundary object concept is valuable to consider when conducting and critiquing basic research, collaborating across multiple disciplinary teams as when studying climate change issues, as an individual researcher working in a cross boundary sense using methods from differing disciplines to answer questions, and/or when one group adapts the work of another to their own research problems or interpretive needs, as occurred with selected products of this project.

关键词： Mongolia boundary objects climate change,hydroclimate

Critical Exponents for the Re-entrant Phase Transitions in the Three-Dimensional blume-Emery-Grifilths Model on the Cellular Automaton

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Chinese Physics Letters 2007年第7期24卷 2040-2043页

作者： n. Seferoglu b. Kutlu GaziUfniversitesi Fen Bilimleri Enstitfisfi Fizik Anabilim Dah Ankara Turkey GaziUniversitesi Fen-Edebiyat Fakiiltesi Fizik Boliumfi 06500 Teknikokullar Ankara Turkey

The critical behaviour of the three-dimensional blume-Emery-Griffiths （bEG） model ＆ investigated at D/ J = O, -0.25 and -1 in the range of-1 ≤ K/J ≤ 0 for J -- 100. The simulations are carried out on a simple cubic lattice using the heating algorithm improved from the Creutz cellular automaton （CCA ） under periodic boundary conditions. The universality of the model are obtained for re-entrant and double re-entrant phase transitions which occur at certain D/J and K/J parameters, with J and K representing the nearest-neighbour bilinear and biquadratic interactions, and D being the single-ion anisotropy parameter. The values of static critical exponents β, γ and v are estimated within the framework of the finite-size scaling theory. The results are compatible with the universal Ising critical behaviour for all continuous phase transitions in these ranges.

关键词： Three-Dimensional blume-Emery-Griffiths bEG CCA

Evaluation of groundwater quality using pollution index of groundwater(PIG) and non-carcinogenic health risk assessment in part of the Gangetic basin

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Acta Geochimica 2021年第3期40卷 419-440页

作者： Apoorv Verma n.b.Singh Environmental Science and Engineering Civil Engineering DepartmentInstitute of Engineering and TechnologyDr.A.P.J.Abdul Kalam Technical UniversityLucknow 226021India Harcourt butler Technical University Kanpur 208002India

The aim of this study was to evaluate groundwater fitness for domestic and irrigational use in Unnao district of Uttar Pradesh,*** this study,block wise(n=16)groundwater samples were collected,and measured parameters were analyzed using the pollution index of groundwater(PIG),various irrigational indices,and graphical *** results of this study suggested that most of the parameters were within the prescribed limits of WHO and bIS,excluding F-(0.4 to 2.6 mg L^(-1))and Fe^(2+)(0.1 to 1.7 mg L^(-1)).Concentrations of total dissolved solids(TDS)were exceeded the desirable limit(>500 mg L^(-1))in 43.75%of samples at some *** Gibbs plot revealed that groundwater chemistry was governed by rock-water interaction in the region,especially silicate *** Piper plot suggested that Ca^(2+)-HCO3-is dominant hydrochemical facies in the area followed by mixed Ca^(2+)-na^(+)-HCO_(3)^(-)type,na^(+)-Cl^(-)type,and na^(+)-HCO_(3)^(-)*** evaluation revealed that the contribution of F-and Fe2+in groundwater degradation is high in comparison to other elements in the region,about 18.75%samples showed low pollution,while about 6.25%samples shows moderate pollution,and 6.25%samples reflected high *** human health risk(HHR)assessment finding suggested that children(mean:1.36)are more vulnerable than adults(mean:1.01).Sodium absorption ration(SAR),Residual sodium carbonate(RSC),and Permeability index(PI)indicated that most of the groundwater was suitable for irrigation,whereas,Magnesium hazard ration(MHR)and Potential salinity(PS)indices suggested that only 37.5%and 56.25%of the samples were suitable for irrigational use,*** regional study would help in decision making for stakeholders and relevant authorities in the execution of groundwater management and remediation plans in the area.

关键词： Groundwater Pollution index of groundwater Irrigational indices Silicate weathering Human health risk

Fano profile in a novel double cavity optomechanical system with harmonically bound mirrors

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Communications in Theoretical Physics 2020年第9期72卷 96-103页

作者： Vaibhav n Prakash Aranya b bhattacherjee School of Physical Sciences Jawaharlal Nehru UniversityNew Delhi-110067India Department of Physics Birla Institute of Technology and SciencePilaniHyderabad CampusHyderabad一50007&India

We investigate a double cavity optomechanical system generating single and double Fano resonance(multi-Fano). by altering a single parameter, the tunnelling rate g of the middle mirror, we are able to switch between single and double Fano line shapes. The first spectral line shape is stronger in the case of multi-Fano than in the case of single Fano. Also the behaviour of the steady state value of the displacement of the middle mirror, with respect to g, heavily influences the behaviour of double Fano lines in our scheme. This tunability along with using a single pump and signal/probe laser has an added advantage in situations where only low power consumption is available.

关键词： optomechanics double Fano resonance optical switch single Fano resonance