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Significant association between AbO blood group and pancreatic cancer

World Journal of Gastroenterology 2010年第44期16卷 5588-5591页

作者： Julia b Greer Mark H Yazer Jay S Raval M Michael barmada Randall E brand David C Whitcomb Department of Medicine Division of GastroenterologyHepatology and NutritionUniversity of Pittsburgh School of Medicine Department of Pathology University of Pittsburgh School of Medicine The Institute for Transfusion Medicine Department of Human Genetics Graduate School of Public HealthUniversity of Pittsburgh University of Pittsburgh Cancer Institute

AIM:To evaluate whether the AbO blood group is related to pancreatic cancer risk in the general population of the United ***:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central blood bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion Service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological AbO blood group *** AbO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central blood bank between 1979 and ***:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group b (n=38) and Ab (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was ***:The AbO blood group is associated with pancreatic cancer *** studies should examine the mechanism linking pancreatic cancer risk to AbO blood group.

关键词： AbO blood group Pancreatic adenocarcinoma Surveillance Risk reduction Epidemiology

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Experimental and numerical investigations of bonding interface behavior in stationary shoulder friction stir lap welding

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Journal of Materials Science & Technology 2019年第1期35卷 192-200页

作者： Q.Wen W.Y.Li W.b.Wang F.F.Wang Y.J.Gao V.Patel State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of Friction Welding Technologies Northwestern Polytechnical University China FSW Center China Academy of Launch Vehicle Technology Beijing Institute of Astronautical Systems Engineering Capital Aerospace Machinery Company Pandit Deendayal Petroleum University

Stationary shoulder friction stir lap welding(SSFSLW) was employed to weld 2024 aluminum alloy. A coupled Eulerian-Lagrangian(CEL) model was developed to investigate the lap interface behavior during SSFSLW. Numerical results of material movement and equivalent plastic strain were in good agreement with the experimental work. With increasing welding speed, the distances from the hook tip to the top surface of the upper workpiece on the retreating side(RS) and the advancing side(AS) increase, while the distance between two wave-shaped alclads decreases. A symmetric interface bending is observed on the AS and the RS during plunging, while the interface bending on the AS is bigger than that on the RS during welding. The peak temperature of the interface on the AS is higher than that on the RS. The equivalent plastic strain gradually increases as the distance to the weld center decreases, and its peak value is obtained near the bottom of the weld.

关键词： Stationary shoulder friction stir lap welding Coupled Eulerian-Lagrangian Temperature field Material distribution Equivalent plastic strain

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Science Letters:Quantification of Helicobacter pylori levels in soil samples from public playgrounds in Spain

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Journal of Zhejiang University-Science b(biomedicine & biotechnology) 2010年第1期11卷 27-29页

作者： Leonardo Martín PéREZ Francesc CODONY Daniela LóPEZ LEYTON Mariana FITTIPALDI bárbara ADRADOS Jordi MORATó Health and Environmental Laboratory (MSM-Lab)-Aquasost UNESCO Chair in SustainabilityUiversitat Politècnica de Catalunya Environmental Science Center EULA-Chile University of Concepcion

Helicobacter pylori are ubiquitous Gram-negative bacteria with a high estimated level of infection in the world populations, but a majority of the infected persons are asymptomatic. This pathogen has been classified by the World Health Organization as a class I carcinogen and recognized as the causal agent of most peptic ulcers and chronic gastritis that might lead to stomach cancer. Although not all the transmission pathways of these bacteria into humans have been propedy identified, enough data have suggested that the oral-oral or fecal-oral ones are the main infection routes. Helicobacterpylori have been detected in non-treated water and in drinking water, which suggested that water might be an important infection source. As childhood is the critical period of infection, the aim of the present work was to examine the presence of Helicobacterpylori in soil samples from public playing areas of Spanish parks.

关键词： Heficobacterpylori Real time polymerase chain reaction (qPCR) Environmental soil samples

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Prediction of plane-strain specimen geometry to efficiently obtain a forming limit diagram by Marciniak test

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Journal of Iron and Steel Research International 2018年第5期25卷 539-545页

作者： Qing-bao Yang Jun-ying Min John E. Carsley Yuan-yuan Wen bernd Kuhlenkotter Thomas b. Stoughton Jian-ping Lin School of Mechanical Engineering Tongji UniversityShanghai 201804 China General Motors Research & Development WarrenMI 48095-9055 USA Chair of Production Systems Ruhr-University BochumBochum 44780 Germany

Plane-strain forming limit strain （also known as FLD0） is an important data point on a forming limit diagram （FLD）. The effects of friction coefficients and material parameters on the specimen width associated with the FLDo （W FLD0） in Marciniak test were studied by finite element simulation. WFLD0 was expressed as a function of the Lankford coefficients, n-value, k-value and sheet thickness and validated with various sheet materials. The determination of W FLD0 is of significance not only to reduce iterative attempts to accurately obtain FLDo, but also to obtain a full valid FLD with the least number of test specimens, which largely increases the efficiency and reduces cost to experimentally measure valid FLDs.

关键词： Forming limit test ·Sheet metal· Plane-strain state· Marciniak test

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Effect of Ca addition on the as-cast microstructure and creep properties of Mg-5Zn-5Sn magnesium alloy

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Rare Metals 2009年第6期28卷 576-581页

作者： YANG Mingbo CHENG Liang SHEN Jia PAN Fusheng Materials Science and Engineering College Chongqing University of Technology Chongqing 400050 China Materials Science and Engineering College Chongqing University Chongqing 400030 China

The effect of Ca addition on the as-cast micmstructure and creep properties of Mg-5Zn-5Sn magnesium alloy was investigated. The results indicate that adding 1.0 wt.% Ca to Mg-5Zn-5Sn alloy can effectively refine the as-cast microstructure of the alloy, and the CaMgSn phase with high thermal stability is formed in the alloy. In addition, adding 1.0 wt.% Ca to Mg-5Zn-5Sn alloy can also improve the creep properties of the alloy. After adding 1.0 wt.% Ca to Mg-5Zn-5Sn alloy, the second creep rate of the alloy at 150℃ and 50 MPa for 100 h decreases from 4.67 ×10^-8 to 1.43 × 10^-8 s^-1. The strengthening mechanism is mainly attributed to the microstructural refinement and the formation of CaMgSn phase.

关键词： magnesium alloys Ca addition creep properties microstructure

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Hepatitis C eradication with sofosbuvir leads to significant metabolic changes

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World Journal of Hepatology 2016年第35期8卷 1557-1563页

作者： Amilcar L Morales Zachary Junga Manish b Singla Maria Sjogren Dawn Torres Hepatology Service San Antonio Military Medical Center Gastroenterology Service Walter Reed National Military Medical Center Department of Internal Medicine Walter Reed National Military Medical Center

AIMTo assess the effect of sofosbuvir (SOF) based regimens on glycemic and lipid control. METHODSThis is a retrospective analysis of hepatitis C virus (HCV)-infected patients treated and cured with a SOF regimen [SOF/ribavirin/interferon, SOF/simeprevir, or SOF/ledipasvir (LDV) ± ribavirin] from January 2014 to March 2015. Patients with hemoglobin A1C (HbA1C) and lipid panels within six months before and six months after therapy were identified and included in our study. Due to the known hemolytic effect of ribavirin, HbA1C was obtained a minimum of three months post-treatment for the patients treated with a ribavirin regimen. Medical history, demographics, HCV genotype, pre-therapy RNA, and liver biopsies were included in our analysis. The patients who started a new medication or had an adjustment of baseline medical management for hyperlipidemia or diabetes mellitus (DM) were excluded from our analysis. RESULTSTwo hundred and thirty-four patients were reviewed, of which 60 patients met inclusion criteria. Sixty-three point three percent were male, 26.7% were Caucasian, 41.7% were African American and 91.7% were infected with hepatitis C genotype 1. Mean age was 60.6 ± 6.7 years. Thirty-nine patients had HbA1C checked before and after treatment, of which 22 had the diagnosis of DM type 2. HbA1C significantly decreased with treatment of HCV (pretreatment 6.66% ± 0.95% vs post-treatment 6.14% ± 0.65%, P vs 0.71% ± 0.83%, P = 0.070). Fifty-two patients had pre- and post-treatment lipid panels; there was a significant increase in low-density lipoprotein (LDL) and total cholesterol (TC) after treatment (LDL: 99.5 ± 28.9 mg/dL vs 128.3 ± 34.9 mg/dL, P vs 199.7 ± 40.0 mg/dL, P P = 0.684). CONCLUSIONEradication of HCV with a SOF regimen resulted in a significant drop in HbA1C and an increase in LDL and TC post therapy.

关键词： Hepatitis C Sofosbuvir Hyperlipidemia Hemoglobin A1c Low-density lipoprotein

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Synthesis and Crystal Structure of an Ion- pair Compound: [HL]2[Ni（CN）4]·4H2O (L = 4-（2- Hydroxyphenyl）-1,5, 9-triazacyclododecan-2-one)

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Chinese Journal of Structural Chemistry 2004年第4期23卷 361-365+352页

作者： LI Jian-Ronga, b XIE Ya-bob CAI Li-Zhena GUO Guo-Conga② bU Xian-Heb② HUANG Jin-Shuna a (State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, The Chinese Academy of Sciences, Fuzhou, Fujian 350002, China) b (Department of Chemistry, Nankai University, Tianjin 300071, China) 中科院福建物质结构所 State Key Laboratory of Structural ChemistryCAS 福建 Fuzhou 350002 Department of Chemistry Nankai University 天津 300071

An ion-pair compound, [HL]2[Ni(CN)4]4H2O 1 has been obtained as an unexpected product when we attempt to prepare a heterometallic cyano-bridged complex by the reaction of GdCl3nH2O, K2Ni(CN)4 and L (L=4-(2-hydroxyphenyl)-1,5,9-triazacyclododecan-2-one) in aqueous solution, and characterized by single-crystal X-ray diffraction. It crystallizes in monoclinic, space group P21/n with a = 12.380(1), b = 9.9637(8), c = 17.087(1) ? ?= 105.947(2)? V = 2026.6(3) ?, Rint = 0.0509, Z = 2, Dc = 1.297 g/cm3, C34H56O8N10Ni, Mr = 791.60, F(000) = 844, m(MoKa) = 0.538 mm1, S = 1.030, the final R = 0.0644 and wR = 0.1299 for 2023 observed reflections with I ≥ 2(I). The title compound 1 contains one anion of [Ni(CN)4]2, two cations of [HL]+ and four packing water molecules, which are held together by the NH···O and OH···O hydrogen bonds to form a three- dimensional framework.

关键词： tetracyanonickelate anion macrocyclic triamine cation crystal structure

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铭鉴经典财富吸引力法则

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2018年

作者： b库

本书内容包括:追求财富,首先要有积极的心态、我思考,我致富、追求财富,要制订合理切实的目标、富人是这样炼成的、敢于创新才能赢得未来、不仅富有,而且拥有魅力等。

ISBN: (纸本)9787513919135

关键词：成功心理通俗读物

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REMAINING LIFE ASSESSMENT OF A 1Cr5Mo STEEL bY USING Z-PARAMETER METHOD

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Acta Metallurgica Sinica(English Letters) 2004年第4期17卷 601-605页

作者： J.Zhao S.Q.Han S.M.Xie H.b.Gao L.Wang Department of Materials Engineering Dalian University of Technology Dalian 116024 ChinaDepartment of Materials Engineering Dalian University of Technology Dalian 116024 ChinaDepartment of Materials Engineering Dalian University of Technology Dalian 116024 ChinaDepartment of Materials Engineering Dalian University of Technology Dalian 116024 ChinaDepartment of Materials Engineering Dalian University of Technology Dalian 116024 China

Z-parameter method based on the Larson-Miller relationship is proposed to assess remaining life of a 1Cr5Mo steel. The non-linear master curve of stress a vs. Larson-Miller parameter P of the steel can be expressed as: P=29.608-5. 085logσ. A family of curves parallel to the master curve can be expressed as: P=29.608-Z-5.085logσ, where the value of Z represents the magnitude deviated from the master curve. A relationship between the value of Z-parameter and the level of spheroidization E (mi-crostructural degradation) can be expressed as: Z=0.203(E-1).

关键词： life assessment spheroidization carbides creep rupture

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AI powered, automated discovery of polymer membranes for carbon capture

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npj Computational Materials 2023年第1期9卷 966-976页

作者： Ronaldo Giro Hsianghan Hsu Akihiro Kishimoto Toshiyuki Hama Rodrigo F.Neumann binquan Luan Seiji Takeda Lisa Hamada Mathias b.Steiner IbM Research Av.República do Chile330CEP 20031-170 Rio de JaneiroRJBrazil IbM Research 7-7Shin-KawasakiSaiwai-KuKawasakiKanagawa 212-0032Japan IbM Research 1101 Kitchawan Road PO Box 218Yorktown HeightsNY 10598-0218USA

The generation of molecules with artificial intelligence(AI)or,more specifically,machine learning(ML),is poised to revolutionize materials *** applications range from development of potent drugs to efficient carbon capture and separation ***,existing computational discovery frameworks for polymer membranes lack automated training data creation,generative design,and physical performance validation at meso-scale where complex properties of amorphous materials *** methodological gaps are less relevant to the ML design of individual molecules such as the monomers which constitute the building blocks of ***,we report automated discovery of complex materials through inverse molecular design which is informed by meso-scale target features and process *** have explored the multi-scale discovery regime by computationally generating and validating hundreds of polymer candidates designed for application in post-combustion carbon dioxide ***,we have validated each discovery step,from training dataset creation,via graph-based generative design of optimized monomer units,to molecular dynamics simulation of gas permeation through the polymer *** the latter,we have devised a representative elementary volume(REV)enabling permeability simulations at about 1000×the volume of an individual,ML-generated monomer,obtaining quantitative *** discovery-to-validation time per polymer candidate is on the order of 100 h using one CPU and one GPU,offering a computational screening alternative prior to lab validation.

关键词： monomer latter elementary

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