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International Journal of Mining Science and Technology 2017年第2期27卷 379-386页

作者： b.k.sahoo S.De b.C.Meikap Department of Chemical Engineering Indian Institute of Technology Research and Development Centre for Iron and Steel Steel Authority of India Limited Chemical Engineering School of Engineering Howard College University of Kwazulu-Natal

Detailed experimental investigations were carried out for microwave pre-treatment of high ash Indian coal at high power level(900 W) in microwave oven. The microwave exposure times were fixed at60 s and 120 s. A rheology characteristic for microwave pre-treatment of coal-water slurry(CWS) was performed in an online bohlin viscometer. The non-Newtonian character of the slurry follows the rheological model of Ostwald de Waele. The values of n and k vary from 0.31 to 0.64 and 0.19 to 0.81 Pa·sn,respectively. This paper presents an artificial neural network(ANN) model to predict the effects of operational parameters on apparent viscosity of CWS. A 4-2-1 topology with Levenberg-Marquardt training algorithm(trainlm) was selected as the controlled ANN. Mean squared error(MSE) of 0.002 and coefficient of multiple determinations(R^2) of 0.99 were obtained for the outperforming model. The promising values of correlation coefficient further confirm the robustness and satisfactory performance of the proposed ANN model.

关键词： Microwave pre-treatment Coal-water slurry Apparent viscosity Artificial neural network back propagation algorithm

Influence of coke structure on coke quality using image analysis method

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International Journal of Coal Science & Technology 2018年第4期5卷 473-485页

作者： b.Ghosh b.k.sahoo b.Chakrabortv k.k.Manjhi S.k.Das J.N.Sahu Atul k.Varma Research & Development Centre for Iron and Steel Steel Authority of India Limited (SAIL)RanchiJharkhand 834002India Institute of Chenlical Technology Faculty of ChemistryUniversity of Stuttgart70550 StuttgartGermany Coal Geology and Organic Petrology Laboratory Department of Applied GeologyIITIndian School of Mines (ISM)Dhanbad 826004India South Ural State University 76Lenin Aven.ChelyabinskRussia 454080

The quality of coke affects the performance of the blast furnace, factors affecting coke quality include coal properties, coal charge granulometry and carbonization conditions. The coke properties in elude the size analysis, cold strength (Micum Indices-M4(). MI0) and hot strength (Coke Reactivity Index-CRI, Coke Strength after Reaction-CSR) properties and structural properties such as coke structure and texture. Structural properties comprise the porosity, pore-cell wall thickness and pore sizes, while textures consist of the carbon forms in the coke. In present work, advanced method such as image analysis method was used to interpret coke microstructure. Conventional methods such as determination of coke porosity by measurement of real and apparent density and mercury porosimetry have a number of limitations. Coke size, magnification, number of image frames captured, process of pellet preparations and coke properties such as M4(), M|0, CRI and CSR (low, medium and high values) were taken as variables for experimental purposes. The coke structure parameters such as porosity, length, perimeter, breadth, roundness, pore-wall thickness and pore size distribution of the pores were determined by image analysis method. This method provided average porosity in addition to pore-wall thickness and pore-size distribution. The pore wall thickness measuremenl by image analysis method provided significant correlations with M40, CRI and CSR values. This explained the usability of image analysis for coke structure measurement.

关键词： Image analysis Coke structure Porosity Micro structure Roundness Pore wall thickness

Influence of tool rotational speed on mechanical and corrosion behaviour of friction stir processed AZ31/Al_(2)O_(3)nanocomposite

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镁合金学报(英文) 2023年第7期11卷 2585-2599页

作者： Ashish kumar V.P.Singh Akhileshwar Nirala R.C.Singh Rajiv Chaudhary Abdel-Hamid I.Mourad b.k.sahoo Deepak kumar Department of Mechanical Engineering Delhi Technological UniversityDelhi 110042India Department of Mechanical Engineering Galgotias College of Engineering and Technology Greater Noida 201310India Department of Mechanical Engineering National Institute of Technology MizoramAizawl 796012India Department of Mechanical Engineering IES College of Technology Bhopal462044India Mechanical and Aerospace Engineering Department College of EngineeringUnited Arab Emirates UniversityAl-Ain 15551United Arab Emirates Materials Engineering Division CSIR-National Metallurgical Laboratory(NML)Jamshedpur831007India Department of Mechanical Engineering Carnegie Mellon UniversityPittsburghPA 15213USA

Nano-sized reinforcements improved the mechanical characteristics efficiently by promoting more implicit particle hardening mechanisms compared to micron-sized ***-sized particles lessen the critical particle solidification velocity for swamp and thus offers better *** the present investigation,the friction stir processing(FSP)is utilized to produce AZ31/Al_(2)O_(3)nanocomposites at various tool rotation speeds(i.e.,900,1200,and 1500 rpm)with an optimized 1.5%volume alumina(Al_(2)O_(3))reinforcement *** mechanical and corrosion behavior of AZ31/Al_(2)O_(3)-developed nanocomposites was investigated and compared with that of the AZ31 base *** AZ31 alloy experienced a comprehensive dynamic recrystallization during FSP,causing substantial grain ***-size strengthening is the primary factor contributed to the enhancement in the strength of the fabricated *** strength and yield strength values were lower than those for the base metal matrix,although an upward trend in both values has been observed with an increase in tool rotation *** 19.72%increase in hardness along with superior corrosion resistance was achieved compared to the base alloy at a tool rotational speed of 1500 *** corrosion currents(Jcorr)of all samples dropped with increase in the rotational speed,in contrast to the corrosion potentials(Ecorr),which *** values of Jcorr of AZ31/Al_(2)O_(3)were 42.3%,56.8%,and 65.5%lower than those of AZ31 alloy at the chosen rotating speeds of 900,1200,and 1500 rpm,*** corrosion behavior of friction stir processed nanocomposites have been addressed in this manuscript which has not been given sufficient attention in the existing ***,this work offers an effective choice for the quality assurance of the FSP process of AZ31/Al_(2)O_(3)*** obtained results are relevant to the development of lightweight automobile and aerospace structures and components

关键词： Friction stir processing AZ31 alloy Al_(2)O_(3) Nanocomposite Mechanical properties Corrosion resistance

Analysis and Optimization of Operational and Pollutant Attributes of Diesel Engine with CNT-Infused Orange Peel biodiesel-Diesel blend Fuel

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Journal of Thermal Science 2024年第2期33卷 761-778页

作者： Ranjeet RAI R.R.sahoo Mechanical Engineering Department GLA UniversityMathura281406India Mechanical Engineering Department IIT(BHU)Varanasi221005India

The current study is performed to find sustainable solutions for the future of transportation and environmental *** conventional methods and experimental design table(L16 Orthogonal Array)techniques have been employed to examine and optimize a diesel-powered engine's operational and pollutant *** L16 Orthogonal Array is obtained through Taguchi's experimental design approach using Minitab 16 *** experimental design incorporated three control variables,namely engine speed,fuel type,and engine load,each with four *** operational parameters,namely brake thermal efficiency(bTE)and brake specific fuel consumption(bSFC),as well as the emission characteristics,including hydrocarbon(HC),carbon monoxide(CO),nitrogen oxide(NO),and smoke emissions,were acquired using the L16 orthogonal array(OA) and subsequently *** utilization of methodologies such as signal-to-noise(S/N) ratio and grey analysis was employed to determine the optimal operational state of the engine to achieve maximum performance while minimizing *** engine's ideal state of operation,in terms of bTE and bSFC,was determined to be at 75% engine load,1000 r/min engine speed,and using 10^(-4)(in vol) carbon nanotube incorporated 20% orange peel biodiesel(OPb20CNT100) blended fuel(A3-b1-C4).The study indicated that engine load significantly influenced bTE and bSFC,with 84.05% and 87.79% contribution factors,*** 25% engine load,1000 r/min,and OPb20CNT100 fuel(A1-b1-C4) CO,smoke,NO,and HC emissions were the *** load affects emissions the *** bSFC increased 3.10% and NO emissions 1.77%.bTE,CO,smoke,and HC emissions decreased by 1.9%,12.29%,47.05%,and 47.22%,respectively,at optimal operating conditions concerning diesel *** study shows that Taguchi-Grey's experimental design optimizes diesel engine operational and pollutant *** outcomes revealed that orange peel biodiesel infused with CNT can replace diesel fuel in a

关键词： Taguchi-Grey method OPb20CNT100 transesterification S/N ratio GRG HC CO and NO

Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

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Acta Pharmaceutica Sinica b 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana Martinez bulnes Anupam Dhasmana Swathi Holla Nivesh k.Mittal Nirakar sahoo Tripti Saini Francesco Giorgianni Mohammad Sikander Andrew E.Massey bilal b.Hafeez Manish k.Tripathi Vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.behrman Sheema khan Subhash C.Chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of Excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of biomedical Imaging and bioengineering(NIbIb) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

Investigation into machining performance of microstructurally engineered in-situ particle reinforced magnesium matrix composite

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Journal of Magnesium and Alloys 2023年第3期11卷 916-935页

作者： S.k.sahoo b.N.sahoo S.k.Panigrahi Department of Mechanical Engineering Indian Institute of Technology MadrasChennai 600036India Applied Magnesium Research Group Center of Excellence in Materials and Manufacturing for Futuristic MobilityIndian Institute of Technology MadrasChennai 600036India Department of Mechanical Engineering Sardar Vallabhbhai National Institute of TechnologySurat 395007India

Magnesium and magnesium in-situ composites have significant potential in the application of design and manufacturing for automotive and aerospace industries because of their high specific strength and reduced fuel *** there are many challenges for machining of Mg based alloys and composites because of the high tendency of fire and *** challenges can be minimized through microstructural *** this present study,the machining performances of AZ91 Mg alloy and in-situ hybrid TiC+Tib_(2)reinforced AZ91 metal matrix composite was *** effectβ-Mg_(17)Al_(12)phases and grain refinement with and without in-situ particles on machinability were studied through microstructural engineering via aging and friction stir *** end milling operation was carried out at different cutting speeds ranging from 25 mm/min to 90 mm/min under dry environment by using an AlTiN-coated tungsten carbide *** optimum cutting speed for machining was found to be 75 mm/min based on the surface roughness values of all conditioned *** base material with dendritic microstructure was found to have poor machinability in terms of inadequate surface finish and edge-burrs *** combined effect of in-situ TiC+Tib_(2)particles addition and grain refinement enhanced the machining performance of the material with superior surface finish,negligible edge-burr formation and better tool wear *** influence of in-situ TiC+Tib_(2)particles,β-Mg_(17)Al_(12)phases and grain refinement on machining characteristics are explained based on the tool wear mechanisms,chip behavior and machining induced affected zone.

关键词： Magnesium In-situ composite End-milling Tool wear Chip morphology

Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis

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Acta Pharmaceutica Sinica b 2024年第8期14卷 3661-3679页

作者： baolong Liu Phuong Linh Nguyen Han Yu Xingzhi Li Huiren Wang Tram Gia bao Nguyen Prakash kumar sahoo Meghna Sur Jay Reddy Sarah Sillman Stephen D.kachman bara Altartouri Guoqing Lu Sathish kumar Natarajan Mahesh Pattabiraman Jiujiu Yu Department of Nutrition and Health Sciences University of Nebraska-LincolnLincolnNE 68583USA Shaanxi key Laboratory of Molecular biology for Agriculture College of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA School of Veterinary Medicine and biomedical Sciences University of Nebraska-LincolnLincolnNE 68583USA Department of Statistics University of Nebraska-LincolnLincolnNE 68583USA Center for biotechnology University of Nebraska-LincolnLincolnNE 68588USA Department of biology University of Nebraska OmahaOmahaNE 68182USA Department of Chemistry University of Nebraska-KearneyKearneyNE 68849USA

Non-alcoholic steatohepatitis(NASH),an advanced form of non-alcoholic fatty liver disease(NAFLD),has emerged as the leading cause of liver failure and related ***,no medication is specifically approved to treat NAFLD or *** we report that oral administration of honey vesiclelike nanoparticles(H-VLNs)to naturally aged mice protects the liver from NASH development.H-VLNs are dominantly taken up by kupffer cells in the liver and suppress hepatic chronic inflammation and further development of fibrosis and nodule formation in aged *** their reported antiinflammasome function,H-VLNs are found to inhibit the transcriptional activities of C-JUN and nuclear factor-kappa b(NF-κb).MicroRNAs miR5119 and miR5108 and phenolic compound luteolin in H-VLNs are identified in suppressing both the C-JUN and NF-kb ***,oral intake of H-VLNs represents a promising new user-friendly modality to prevent the development of NASH.

关键词： Honey Extracellular vesicles Exosomes Nanoparticles microRNAs Aging Inflammation Non-alcoholic steatohepatitis

An optimized ion trap geometry to measure quadrupole shifts of ^(171)Yb~＋ clocks

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Chinese Physics b 2016年第11期25卷 230-237页

作者： N batra b.k.sahoo S De Academy of Scientific and Innovative Research CSIR-NPL Campus New Delhi India CSIR-National Physical Laboratory Dr. K. S. Krishnan Marg New Delhi 110012 India Theoretical Physics Division Physical Research Laboratory Navrangpura Ahmedabad 380009 India

We propose a new ion-trap geometry to carry out accurate measurements of the quadrupole shifts in the （171）Yb *** trap will minimize the quadrupole shift due to the harmonic component of the confining potential by an order of *** will be useful to reduce the uncertainties in the clock frequency measurements of the 6s 2S（1/2）→4f（13）6s2 2F（7/2）and 6s 2S（1/2）→5d2D（3/2） transitions,from which we can deduce the precise values of the quadrupole moments（0s） of the 4f（13）6s2 2F（7/2） and 5d2D（3/2） ***,it may be able to affirm the validity of the measured 0 value of the4f（13）6s22F（7/2） state,for which three independent theoretical studies defer almost by one order of magnitude from the *** also calculate 0s using the relativistic coupled-cluster（RCC） *** use these 0 values to estimate the quadrupole shift that can be measured in our proposed ion trap experiment.

关键词： validity minimize carry clock relativistic precise deduce magnitude expectation spatially

Comparative study on high temperature deformation behavior and processing maps of Mg-4Zn-1RE-0.5Zr alloy with and without in-situ sub-micron sized Tib2 reinforcement

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Journal of Magnesium and Alloys 2022年第12期10卷 3520-3541页

作者： S.k.sahoo S.k.Panigrahi Department of Mechanical Engineering Indian Institute of Technology MadrasChennai-600036India Applied Magnesium Research Group Center of Excellence in Materials and Manufacturing for Futuristic Mobility Indian Institute of Technology MadrasChennai-600036India

Mg-4Zn-1RE-0.5Zr (ZE41) Mg alloy is extensively used in the aerospace and automobile *** order to improve the applicability and performance,this alloy was engineered with in-situ Ti b2reinforcement to form Ti b2/ZE41 *** high temperature deformation behavior and manufacturability of the newly developed Ti b2/ZE41 composite and the parent ZE41 Mg alloy were studied via establishing constitutive modeling of flow stress,deformation activation energy and processing map over a temperature range of 250℃-450℃ and strain rate range of 0.001 s-1-10 *** predicted flow stress behavior of both materials were found to be well consistent with the experimental values.A significant improvement in activation energy was found in Ti b2/ZE41 composite (171.54 k J/mol) as compared to the ZE41 alloy (148.15 k J/mol) due to the dispersed strengthening of in-situ Ti *** processing maps were developed via dynamic material modeling.A wider workability domain and higher peak efficiency (45%) were observed in Ti b2/ZE41 composite as compared to ZE41 alloy (41%).The Dynamic recrystallization is found to be the dominating deformation mechanism for both materials;however,particle stimulated nucleation was found to be an additional mode of deformation in Ti b2/ZE41 *** twinning and stress induced cracks were observed in both the materials at low temperature and high strain rate.A narrow range of instability zone is found in the present Ti b2/ZE41 composite among the existing published literature on Mg based *** detailed microstructural characterization was carried out in both workability and instability domains to establish the governing deformation mechanisms.

关键词： ZE41 Mg composite In-situ Tib2 particles ZE41 Mg alloy Constitutive equations Processing map Dynamic recrystallization

Synthesis and Characterization of bio-based Epoxy blends from Renewable Resource based Epoxidized Soybean Oil as Reactive Diluent

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Chinese Journal of Polymer Science 2015年第1期33卷 137-152页

作者： Sushanta k sahoo Smita Mohanty Sanjay k Nayak Laboratory for Advanced Research in Polymeric Materials (LARPM) Central Institute of Plastics Engineering & Technology (CIPET)B/25 CNI complex Patia Bhubaneswar 751024 Odisha India

A novel bioresin, epoxidized soybean oil was synthesized by in situ method and was characterized employing FTIR and NMR. The bioresin was blended with epoxy（DGEbA） at different ratios as reactive diluents for improved processibility and toughened nature. The composition with 20 wt% bioresin exhibited improved impact strength to the tune of 60% as compared to virgin epoxy. Fracture toughness parameters critical stress intensity factor（kIC） and critical strain energy release rate（GIC） were evaluated using single edge notch bending test and demonstrated superior enhancement in toughness. Dynamic mechanical, thermal, thermo mechanical and fracture morphological analyses have been studied for bio-based epoxy blends. Curing kinetics has been evaluated through DSC analysis to investigate the effect of bioresin on cross-linking reaction of neat epoxy with triethylenetetramine as curing agent.

关键词： bio-based epoxy Soybean oil Fracture toughness Curing kinetics TMA.