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Apolipoprotein A-i binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-Ho choi Keun-Young Kim Yury i.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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胰腺局灶性病变体素内非相干性运动扩散加权MR成像特征

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国际医学放射学杂志 2014年第2期 173-174页

作者： K.M.Kang J.M.Lee J.H.Yoon b.Kiefer J.K.Han b.i.choi 滕泽 Department of Radiology Division of Abdominal Imaging Seoul National University College of Medicine 28 Yeongon -dongJongno-gu Seoul 110-744Korea

目的评价MR表观扩散系数(ADC)及体素内非相干性运动(iViM)扩散衍生系数在区分常见胰腺肿瘤、慢性胰腺炎及正常胰腺组织,以及显示恶性导管内乳头状黏液性

关键词：扩散加权体素胰腺肿瘤消化系肿瘤非相干性 MR

体素内非相干性运动扩散加权MRi在非酒精性脂肪肝兔模型诊断中的实验研究

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国际医学放射学杂志 2014年第2期 162-163页

作者： i.Joo J.M.Lee J.H.Yoon J.J.Jang J.K.Han b.i.choi 肖雅雯 Department of Radiology Institute of Radiation Medicine Seoul National University Hospital

目的本研究旨在探讨应用无创性多b值体素内非相干性运动(iViM)扩散加权成像诊断非酒精性脂肪性肝病(NAFLD)的可行性。材料与方法本研究经动物管理委员

关键词： NAFLD 正常组程度扩散加权非相干性 MRi 体素

MDCT在胰腺神经内分泌肿瘤的应用——探讨临床分期的准确性以及与不典型胰腺癌的鉴别诊断

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国际医学放射学杂志 2016年第4期 449-450页

作者： J.H.Kim H.W.Eun Y.J.Kim J.M.Lee J.K.Han b.i.choi 卢宝兰 Department of Radiology Seoul National University Hospital

摘要目的探讨MDCT对胰腺神经内分泌肿瘤分期的准确性,以及与胰腺癌的鉴别诊断。方法回顾性分析109例经手术病理证实为胰腺内分泌肿瘤(NET)病人的术前CT资料[NETG1 66例,NETG2 31例,胰腺内分泌癌(NEC)12例]。

关键词：胰腺神经内分泌肿瘤胰腺癌 MDCT 临床分期鉴别诊断

自旋回波-回波平面成像(SE-EPi)MR弹性成像在慢性肝病或肝硬化病人中的检查成功率和可靠性

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国际医学放射学杂志 2020年第3期 372-372页

作者： S.L.choi E.S.Lee A.Ko H.J.Park S.b.Park b.i.choi 柴一桐 Department of Radiology Chung-Ang University Hospital Chung -Ang University College of Medicine

摘要目的确定建立的梯度回波(GRE)和自旋回波-回波平面成像(SE-EPi)序列MR弹性成像(MRE)检查的成功率,并比较2种序列慢性肝病和肝硬化病人呼气期和吸气期

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Machine Learning for QoS Optimization and Energy-Efficient in Routing Clustering Wireless Sensors

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Computers, Materials & Continua 2025年第1期82卷 327-343页

作者： Rahma Gantassi Zaki Masood Yonghoon choi Department of Electrical Engineering Chonnam National University Gwangju61186Republic of Korea

Wireless sensor network(WSN)technologies have advanced significantly in recent *** in WSNs,machine learning algorithms are crucial in selecting cluster heads(CHs)based on various quality of service(QoS)*** paper proposes a new clustering routing protocol employing the Traveling Salesman Problem(TSP)to locate the optimal path traversed by the Mobile Data Collector(MDC),in terms of energy and QoS *** bemore specific,to minimize energy consumption in the CH election stage,we have developed the M-T protocol using the K-Means and the grid clustering *** addition,to improve the transmission phase of the Low Energy Adaptive Clustering-Grid-KMeans(LEACH-G-K)protocol,the MDC is employed as an intermediary between the CH and the sink to improve the wireless sensor network(WSN)*** results of the experiment demonstrate that the M-T protocol enhances various Low Energy Adaptive Clustering protocol(LEACH)improvements such as the LEACH-G-K,LEACH-C,Threshold sensitive Energy Efficient Sensor Networks(TEEN),MDC maximum residual energy leach protocol.

关键词： LEACH-G-K MDC TSP QoS K-Means

Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee Kim Rudolph ETanzi Se Hoon choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for brain Health Massachusetts General HospitalBostonMAUSA

irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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体素内不相干运动扩散加权MR成像对于监测血管破坏试剂CKD-516在兔VX2肝肿瘤疗效中的应用

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国际医学放射学杂志 2014年第5期 482-482页

作者： i.Joo J.M.Lee J.K.Han b.i.choi 林园凯 Department of Radiology Seoul National University Hospital

摘要目的评估体素内不相干运动(iViM)扩散加权(DW)MR成像定量评估血管破坏试剂(VDA)(CKD-516)在兔VX2肝肿瘤治疗中的诊断价值。材料与方法这项研究经

关键词：肝肿瘤 VX2 CKD-516 体素内不相干运动血管破坏扩散加权试剂 MR