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A rabbit model of pediatric nonalcoholic steatohepatitis: The role of adiponectin

world Journal of Gastroenterology 2009年第8期15卷 912-918页

作者： Jun-Fen Fu yan-Lan fang Li Liang Chun-Lin wang fang Hong Guan-Ping Dong Department of Endocrinology The Children's Hospital of Zhejiang University School of Medicine Hangzhou 310003 Zhejiang Province China

AIM： To create a rabbit model of pediatric nonalcoholic steatohepatitis （NAsH） and to evaluate the role of adiponectin in the process. METHODs： Thirty-two specific pathogen-free male New Zealand rabbits were divided randomly into three groups：（1） the normal control group （n = 10） was fed with standard diet for 12 wk; （2） the model group A （n = 11）; and （3） model group b （n = 11） were fed with a highfat diet （standard diet ＋ 10% lard ＋ 2% cholesterol） for 8 and 12 wk, respectively. Hepatic histological changes were observed and biochemical parameters as well as serum levels of adiponectin, interleukin （IL）-6, IL-10 and tumor necrosis factor （TNF）-α were measured. rEsULTs： Typical histological hepatic lesions of NAsH were observed in both model groups described as liver steatosis, liver inflammatory infiltration, cytologic ballooning, perisinusoidal fibrosis and overall fibrosis. Compared with the normal control group, there were significant increases in model groups A and b in weight gain （1097.2 ± 72.3, 1360.5± 107.6 vs 928.0 ±58.1, P 〈 0.05, P 〈 0.01）, liver weight （93.81±6.64, 104.6±4.42 vs 54.4±1.71, P 〈 0.01）, Lg （ALT）（1.9±0.29, 1.84± 0.28 vs 1.60±0.17, P 〈 0.01）, and Lg （TG）（1.03 ±0.24, 1.16 ±0.33 vs 0.00 ±0.16, P 〈 0.01）. weight gain was much more in model group b than in model group A （1360.5± 107.6 vs 1097.2 ±72.3, P 〈 0.05）. but, there was no significant difference between the two groups concerning the other indexes. Pro-inflammatory cytokines （IL-6 and TNF-α） increased in model group b compared with that of control and model group A （IL-6：1.86±0.21 vs 1.41 ±0.33, 1.38± 0.42, P 〈 0.01; TNF-α： 1.18±0.07 vs 0.66 ±0.08, 0.86 ±0.43, P 〈 0.01, P 〈 0.05）, whereas serum adiponectin and IL-10 decreased in model groups compared with that in the control （adiponectin： A： 21.87±4.84 and b： 21.48 ±4.60 vs 27.36 ±7.29, P 〈 0.05. IL-10： A： 1.72± 0.38 and b： 1.83 ±0.39 vs 2.26±0.24, P 〈 0.01）. Lg （TC） and the degree of liver fatty infiltration was an independent determi

关键词： Nonalcoholic steatohepatitis Pediatricanimal model Adiponectin Interleukin 6 Tumornecrosis factor

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利用三级质谱与二级质谱匹配策略鉴定丹参中酚酸类成分

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分析化学 2024年第2期52卷 267-285页

作者：李菡张珂李婷陈蔚李军屠鹏飞赵云芳宋月林北京中医药大学北京中医药研究院北京中医药大学中药学院

多级质谱信息(Ms/Ms information)可提供鉴定化合物结构的关键线索，多级质谱(Ms/Ms)图谱到结构的转换(Ms/Ms spectrum to structure)是精准鉴定化合物结构的重要过程。本研究提出了化合物的三级质谱(Ms3)图谱与其结构单元的二级质谱(M... 详细信息

多级质谱信息(Ms/Ms information)可提供鉴定化合物结构的关键线索，多级质谱(Ms/Ms)图谱到结构的转换(Ms/Ms spectrum to structure)是精准鉴定化合物结构的重要过程。本研究提出了化合物的三级质谱(Ms3)图谱与其结构单元的二级质谱(Ms2)图谱匹配策略，实现了化合物结构的精准鉴定。首先，利用三重四极杆复合线性离子阱质谱仪(qtrap-Ms)的双碰撞池，采集酯类化合物酯基质谱裂解产生的特征碎片离子(c~–和y~–)在线性离子阱(LIT)内经第二次碰撞诱导解离(Collision-induced dissociation, CID)后的Ms3图谱，并同步采集其结构单元化合物([M–H]~–)在LIT中经碰撞诱导解离后的Ms2图谱，结果表明，酯类化合物特征碎片离子的Ms3图谱与结构单元化合物的Ms2图谱匹配。最后，采用Hr-Ms/Ms对丹参总酚酸(Total salvianolic acid derivatives, TsA)进行定性分析，结合文献报道及数据库信息，初步鉴定了36种化合物。进一步利用Ms3与Ms2图谱匹配策略实现了对迷迭香酸和丹酚酸b的精准鉴定，证明了本方法的可行性。本方法为化合物的精准定性分析提供了新的思路和参考。

关键词：多级质谱信息三级质谱与二级质谱图谱匹配酯类化合物丹参总酚酸结构鉴定

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全膝置换围手术期三种抗凝方法比较

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中国矫形外科杂志 2024年第15期32卷 1424-1427,1431页

作者：邓立庆万伦黄继何芳黄奇西藏自治区人民政府驻成都办事处医院骨科四川成都610041

[目的]比较全膝关节置换术(total knee arthroplasty,TKA)围手术期三种抗凝治疗在西藏患者的效果。[方法]2021年1月—2021年7月,60例行TKA的西藏患者纳入本研究,采用随机数字表法随机分为三组,A组20例使用阿司匹林25mg/d;b组20例使用阿... 详细信息

[目的]比较全膝关节置换术(total knee arthroplasty,TKA)围手术期三种抗凝治疗在西藏患者的效果。[方法]2021年1月—2021年7月,60例行TKA的西藏患者纳入本研究,采用随机数字表法随机分为三组,A组20例使用阿司匹林25mg/d;b组20例使用阿司匹林100 mg/d;C组20例使用低分子肝素钙0.4 ml/d抗凝。评价三组临床和彩超检查结果。[结果]三组手术时间、术中出血量、总失血量的差异均无统计学意义(P>0.05)。与1 d相比,术后3、7 d三组的VAs评分均显著减少(PrOM均显著增加(P0.05)。相应时间点,三组间VAs评分、rOM、髌上周径的差异均无统计学意义(P>0.05)。超声检查方面,术后三组血栓发生率的差异无统计学意义(5%vs 5%vs 10%,P>0.05)。[结论]本研究中TKA术后使用25 mg、100 mg阿司匹林和低分子肝素钙的术后早期血栓发生率无明显差异。

关键词：全膝关节置换阿司匹林低分子肝素深静脉血栓

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基于社会支持理论缓解南充市医务人员职业倦怠的策略研究

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卫生软科学 2024年第7期38卷 80-84页

作者：朱陶方登富张树山川北医学院公共卫生学院四川南充637000 遂宁市第一人民医院四川遂宁629000 川北医学院附属医院四川南充637000

[目的]探索分析基于社会支持理论缓解南充市医务人员职业倦怠的策略。[方法]采用分层抽样的方法抽取南充市10家医院514名医务人员作为研究对象,利用《中国职业倦怠量表》《社会支持评定量表》及自制的一般情况调查表进行问卷调查,采用χ... 详细信息

[目的]探索分析基于社会支持理论缓解南充市医务人员职业倦怠的策略。[方法]采用分层抽样的方法抽取南充市10家医院514名医务人员作为研究对象,利用《中国职业倦怠量表》《社会支持评定量表》及自制的一般情况调查表进行问卷调查,采用χ^(2)检验、偏相关分析、协方差分析及Logistic回归分析等探究缓解职业倦怠的策略。[结果]参与调查的514名南充市医务人员职业倦怠总均分为(41.2±12.45)分,检出率为49.8%。χ^(2)检验分析发现,职业倦怠检出率男性高于女性、大专及以下学历者高于本科及以上者、二级医院工作者高于三级医院工作者、日均睡眠时间≤6h者高于≥7h者、对薪酬体系不满意者高于满意者,且差异均有统计学意义(Pstic回归显示,低社会支持(Or=0.530)、男性(Or=0.529)、大专及以下学历(Or=0.623)、二级医院上班(Or=0.468)、对薪酬体系不满意(Or=0.476)是医务人员职业倦怠的独立危险因素(P<0.05)。[结论]南充市医务人员职业倦怠水平较高,社会支持具有负向预测作用,性别、学历、医院等级、薪酬体系满意度是影响医务人员职业倦怠的主要影响因素。

关键词：医务人员社会支持职业倦怠策略

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A numerical study on the influence of grain boundary oxides on dwell fatigue crack growth of a nickel-based superalloy

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Journal of Materials science & Technology 2022年第9期104卷 224-235页

作者： C.Z.fang H.C.basoalto M.J.Anderson H.y.Li s.J.williams P.bowen Department of Materials science and Engineering University of SheffieldMappin StSheffield S13JDUK school of Metallurgy and Materials University of BirminghamEdgbastonBirmingham B152TTUK Institute of structural Materials Swansea UniversitySwansea SA18ENUK

A theoretical treatment on the oxide-controlled dwell fatigue crack growth of aγ'strengthened nickelbased superalloys is *** particular,this study investigates the influence of an externally applied load and variations in theγ'dispersion on the grain boundary oxide growth kinetics.A dislocation-based viscoplastic constitutive description for high temperature deformation is used to simulate the stress state evolution in the vicinity of a crack at elevated *** viscoplastic model explicitly accounts for multimodalγ'particle size distributions.A multicomponent mass transport formulation is used to simulate the formation/evolution of an oxide wedge ahead of the crack tip,where stress-assisted vacancy diffusion is assumed to *** resulting set of constitutive and mass transport equations have been implemented within a finite element *** of predicted compositional fields across the matrix/oxide interface are compared with experiments and shown to be in good *** indicate that the presence of a fineγ'size distribution has a strong influence on the predicted ow stress of the material and consequently on the relaxation in the vicinity of the crack-tip/oxide *** is shown that a unimodal dispersion leads to reduced oxide growth rates(parabolic behavior)when compared to a bimodal *** conditions for oxide formation are investigated and is associated with the prediction of compressive stresses within the oxide layer just ahead of the crack tip,which become progressively negative as the oxide wedge ***,mechanical equilibrium requirements induce tensile stresses at the tip of the oxide wedge,where failure of the oxide is *** time taken to reach this critical stress for oxide failure has been calculated,from which dwell crack growth rates are computationally *** predicted rates are shown to be in good agreement with available experimental data.

关键词： Nickel based superalloy Dwell crack growth Gamma prime Creep Oxidation Dislocation-based modeling Multicomponent diffusion Finite element method

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Urban heat mitigation by green and blue infrastructure:Drivers,effectiveness,and future needs

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The Innovation 2024年第2期5卷 145-166页

作者： Prashant Kumar sisay E.Debele soheila Khalili Christos H.Halios Jeetendra sahani Nasrin Aghamohammadi Maria de Fatima Andrade Maria Athanassiadou Kamaldeep bhui Nerea Calvillo shi-Jie Cao Frederic Coulon Jill L.Edmondson David Fletcher Edmilson Dias de Freitas Hai Guo Matthew C.Hort Madhusudan Katti Thomas rodding Kjeldsen steffen Lehmann Giuliano Maselli Locosselli shelagh K.Malham Lidia Morawska rajan Parajuli Christopher D.F.rogers runming yao fang wang Jannis wenk Laurence Jones Global Centre for Clean Air research(GCArE) School of SustainabilityCivil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Institute for sustainability University of SurreyGuildford GU27XHSurreyUK school of built Environment University of ReadingWhiteknightsReading RG66BUUK school Design and the built Environment Curtin University Sustainability Policy InstituteKent StBentley 6102Western Australia Harry butler Institute Murdoch UniversityMurdoch 6150Western Australia Atmospheric sciences Department Institute of AstronomyGeophysics and Atmospheric SciencesUniversity of Sao PauloSao Paulo 05508-090Brazil Met Office FitzRoy RoadExeter EX13PBUK Department of Psychiatry and Nuffield Department of Primary Care Health sciences Wadham CollegeUniversity of OxfordOxfordUK Centre for Interdisciplinary Methodologies University of WarwickWarwickUK school of Architecture Southeast University2 SipailouNanjing 210096China Cranfield University School of WaterEnvironment and EnergyCranfield MK430ALUK Plants PhotosynthesisSoil ClusterSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK UK Centre for Ecology&Hydrology Environment Centre WalesDeiniol RoadBangor LL572UWUK Air quality studies Department of Civil and Environmental EngineeringThe Hong Kong Polytechnic UniversityHong KongChina Department of Forestry and Environmental resources Faculty Excellence Program for Leadership in Public ScienceNorth Carolina State UniversityChancellorRaleighNC 27695USA Departments of Architecture&Civil Engineering and Chemical EngineeringUniversity of BathBath BA27AYUK school of Architecture University of NevadaLas VegasNV 89154USA Department of Tropical Ecosystems Functioning Center of Nuclear Energy in AgricultureUniversity of São PauloPiracicaba 13416-000Sao PauloBrazil school of Ocean sciences Bangor UniversityMenai BridgeAnglesey LL595 ABUK International Laboratory for Air quality and Health Science and Engine

The combination of urbanization and global warming leads to urban overheating and compounds the frequency and intensity of extreme heat events due to climate ***,the risk of urban overheating can be mitigated by urban green-blue-grey infrastructure(GbGI),such as parks,wetlands,and engineered greening,which have the potential to effectively reduce summer air *** many reviews,the evidence bases on quantified GbGI cooling benefits remains partial and the practical recommendations for implementation are *** systematic literature review synthesizes the evidence base for heat mitigation and related co-benefits,identifies knowledge gaps,and proposes recommendations for their implementation to maximize their *** screening 27,486 papers,202 were reviewed,based on 51 GbGI types categorized under 10 main *** GbGI(green walls,parks,street trees)have been well researched for their urban cooling ***,several other GbGI have received negligible(zoological garden,golf course,estuary)or minimal(private garden,allotment)*** most efficient air cooling was observed in botanical gardens(5.0±3.5℃),wetlands(4.9±3.2℃),green walls(4.1±4.2℃),street trees(3.8±3.1℃),and vegetated balconies(3.8±2.7℃).Under changing climate conditions(2070–2100)with consideration of rCP8.5,there is a shift in climate subtypes,either within the same climate zone(e.g.,Dfa to Dfb and Cfb to Cfa)or across other climate zones(e.g.,Dfb[continental warm-summer humid]to bsk[dry,cold semi-arid]and Cwa[temperate]to Am[tropical]).These shifts may result in lower efficiency for the current GbGI in the *** the importance of multiple services,it is crucial to balance their functionality,cooling performance,and other related co-benefits when planning for the future *** global GbGI heat mitigation inventory can assist policymakers and urban planners in prioritizing effective interventions to reduce the risk of urban overheating,fi

关键词： estuary walls extreme

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Coarse woody debris features of a warm temperate deciduous broad-leaved forest,northern China

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Journal of Forestry research 2021年第3期32卷 1105-1114页

作者： fang Ma Liwen Zhuang shunzhong wang weiguo sang Minzu University of China No.27Zhongguancun NandajieHaidian DistrictBeijing 100081People’s Republic of China Heilongjiang Academy of Forestry science No 134 Haping RoadNangang DistrictHarbin 150081People’s Republic of China Key Lab of Environment and Vegetation Change Institute of BotanyChinese Academy of SciencesNo.20 Xiangshan NanxincunHaidian DistrictBeijing 100093People’s Republic of China

stocking and structural composition of a deciduous broad-leaved forest were determined to predict coarse woody debris quantity by quantifying the empirical relationships between these two *** most ecologically significant families by stem density were salicaceae,betulaceae,Fagaceae,and Aceraceae.P opulus davidiana was the most dominant species followed by b etula dahurica,quercus mongolica,and Acer *** four species accounted for 69.5%of total *** small-diameter species characterized the coarse woody debris showing a reversed J-shaped *** coarse debris of ***,***,and *** mainly comprised the 10–20 cm size class,whereas *** debris was mainly in the 5–10 cm size *** spatial patterns of different size classes of coarse woody debris were analyzed using the g-function to determine the size of the tree at its *** results indicate that the spatial patterns at the 0–50 m scale shifted gradually from an aggregated to a random *** some species,the larger coarse debris might change from an aggregated to a random distribution more *** the importance of coarse woody debris in forest ecosystems,its composition and patterns can improve understanding of community structure and *** aggregation pattern might be due to density dependence and self-thinning effects,as well as by succession and *** four dominant species across the different size classes showed distinct aggregated distribution features at different spatial *** suggests a correlation between the dominant species population,size class,and aggregated distribution of coarse woody debris.

关键词： Tree mortality Diversity size class Forest dynamic plot

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Practice and Challenge of International Peer review: A Case study of research Evaluation of CAs Centers for Excellence

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Journal of Data and Information science 2019年第3期4卷 22-34页

作者： fang xu xiaoxuan Li Institutes of science and Development Chinese Academy of Sciences Beijing 100090 China school of Public Policy and Management University of Chinese Academy of Sciences Beijing 100049 China

Purpose: The main goal of this paper is to show that international peer review can work in China’s context with satisfactory outcomes. Moreover, this paper also provides a reference for the practice of science and technology ***/methodology/approach: This paper starts with a discussion of two critical questions about the significance and design of international peer review. A case study of international peer review of CAs Centers for Excellence is further analyzed. Findings: International peer review may provide a solution to address the problem of quantitative oriented research evaluation in China. The case study of research evaluation of CAs Centers for Excellence shows that it is possible and feasible to conduct an international peer review in China’s context. when applying this approach to other scenarios, there are still many issues to consider including individualized design of international peer review combined with practical demands, and further improvement of theories and methods of international peer review. research limitation: 1) Only the case of international peer review of CAs Centers for Excellence is analyzed;2) A relatively small number of respondents were surveyed in the questionnaire. Practical implications: The work presented in this study can be used as a reference for future ***/value: Currently, there are no similarly detailed studies exploring the significance and methodology of international peer review in China.

关键词： Chinese Academy of sciences CAs Centers for Excellence International peer review research evaluation

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Endoscopic retrograde cholangiopancreatography in evaluation of choledochal dilatation in patients with obstructive jaundice

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Hepatobiliary & Pancreatic Diseases International 2002年第1期1卷 111-113页

作者： Chen w.-x. Zhang y. Li y.-M. xu G.-q. fang y. Cai s.-P. Department of Gastroenterology First Affiliated Hospital Zhejiang University School Medicine Hangzhou 310003 China

Objective: To determine the causes of choledochal di-latation in patients with obstructive ***: One hundred and sixty-four patients withobstructive jaundice were investigated by endoscopicretrograde cholangiopancreatography(ErCP), and pa-tients with choledochal dilatation (group Ⅰ, n=110)were compared with those without choledochal dilata-tion(group Ⅱ, n=54).results: The causes of common bile duct dilatationwere choledocholith, juxtapapillary duodenal divertic-ula and congenital dilatation of the common bile *** distal common bile duct and its surroundings wereabnormal in 104(94.55%) of the 110 patients and in 13(24.08%) of the 54 patients (Pxtapapil-lary duodenal diverticulum accounted for 24.55% ingroup Ⅰ, and only in 9.26% in group Ⅱ (Pst-cholecystectomy patients were 13.64% in groupⅠ, and only 5.56% in group Ⅱ.Conclusions: The abnormalities of the distal commonbile duct and its surroundings can usually be detectedas underlying causes of common bile duct *** is necessary before cholecystectomy, since it isconsidered the "gold standard" for the diagnosis ofdistal common bile duct abnormalities.

关键词： ErCP choledochal dilatation choledcholith juxtapapillary duodenal diverticula

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Molecular beam epitaxy growth of monolayer hexagonal MnTe_(2)on si(111)substrate

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Chinese Physics b 2021年第12期30卷 142-147页

作者： s Lu K Peng P D wang A x Chen w ren x w fang y wu Z y Li H F Li F y Cheng K L xiong J y yang J Z wang s A Ding y P Jiang) L wang q Li F s Li L F Chi Institute of Functional Nano&soft Materials(FUNsOM) Soochow UniversitySuzhou 215123China Vacuum Interconnected Nanotech workstation(Nano-x) Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)Suzhou 215123China Key Laboratory of Polar Materials and Devices(MOE) Department of ElectronicSchool of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China school of Physical science and Technology Southwest UniversityChongqing 400715China school of Nano-Tech and Nano-bionics University of Science and Technology of ChinaHefei 230026China

Monolayer MnTe_(2)stabilized as 1 T structure has been theoretically predicted to be a two-dimensional(2 D)ferromagnetic metal and can be tuned via strain *** is no naturally van der waals(vdw)layered MnTe_(2)bulk,leaving mechanical exfoliation impossible to prepare monolayer MnTe_(2).Herein,by means of molecular beam epitaxy(MbE),we successfully prepared monolayer hexagonal MnTe_(2)on si(111)under Te rich *** reflection high-energy electron diffraction(rHEED)and low-energy electron diffraction(LEED)patterns suggest the monolayer is atomically flat without surface *** valence state of Mn^(4+)and the atom ratio of([Te]:[Mn])further confirm the MnTe_(2)*** tunneling spectroscopy(sTs)shows the hexagonal MnTe_(2)monolayer is a semiconductor with a large bandgap of~2.78 *** valence-band maximum(VbM)locates at theΓpoint,as illustrated by angle-resolved photoemission spectroscopy(ArPEs),below which three hole-type bands with parabolic dispersion can be *** successful synthesis of monolayer MnTe_(2)film provides a new platform to investigate the 2D magnetism.

关键词： molecular beam epitaxy hexagonal MnTe_(2) band structure

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