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A dynamic peripheral immune landscape during human pregnancy

Fundamental Research 2025年第1期5卷 391-406页

作者： Xiuxing Liu Lei Zhu Zhaohao Huang Zhaohuai Li Runping Duan He Li Lihui Xie Xiaozhen Chen Wen ding binyao Chen Yuehan Gao Juan Su Xianggui Wang Wenru Su State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceSun Yat-Sen UniversityGuangzhou 510060China Eye Center of Xiangya Hospital Central South UniversityChangsha 410078China Hunan Key Laboratory of Skin Cancer and Psoriasis Xiangya HospitalCentral South UniversityChangsha 410008China Guangzhou Women and Children's Medical Center Guangzhou Medical UniversityGuangzhou 510623China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Engineering Research Center of Skin Health and Disease Central South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Ophthalmology Changsha 410078China

Extensive immune adaptations occur during pregnancy to ensure successful ***,these changes can increase the risk of disease in the ***,we conducted single-cell RNA sequencing on peripheral blood mononuclear cells from pregnant women at different stages of pregnancy to elucidate the dynamic transcriptional changes in the maternal immune *** reduced cytotoxicity phenotype in highly variable cytotoxic T and natural killer cell types were observed during *** T-and b-cell response-related MHC-II and CD40 signaling as well as enhanced protolerance inducible costimulator and activin signaling may underlie the pregnancy-related weakening of adaptive ***,pro-inflammatory genes and pathways were upregulated in monocytes,possibly to compensate for the reduced T-cell ***,the transition from adaptive immune reduction to activation in late pregnancy in dendritic cells and CD4^(+)T cells was also ***,we proposed a novel view of the pro-aging effect of pregnancy from the perspective of immunity,and this effect may be restored *** work expands our knowledge of pregnancy immunity and may provide insights into the altered disease risks during pregnancy.

关键词： Single-cell RNA sequencing Pregnancy Maternal immune system Aging Immune tolerance Dampened adaptive immunity

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Pentaploidization allows introgression of Aegilops tauschii into tetraploid wheat

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The Crop Journal 2025年第1期13卷 227-232页

作者： Fan Yang Zehou Liu Hongshen Wan Sujie Yang Ning Yang Hongxia ding Yun Jiang Junyan Feng Jie Zhang Ying Wang Xing Fan Yonghong Zhou Jun Li Wuyun Yang Crop Research Institute Sichuan Academy of Agricultural SciencesChengdu 610066SichuanChina biotechnology and Nuclear Technology Research Institute Sichuan Academy of Agricultural SciencesChengdu 610066SichuanChina Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina College of Agronomy Sichuan Agricultural UniversityChengdu 611130SichuanChina

Pentaploid hybrids produced from crosses between hexaploid and tetraploid wheats combine the genetic variation of both *** a synthetic hexaploid wheat LM/AT23 with its Ab-genome donor,the durum wheat LM,and selfing the pentaploid hybrids to the F7 generation yielded mostly euploid tetraploids and a few *** special derivatives of tetraploid were isolated,including a 4D(4b)substitution line with large panicles and high resistance to stripe rust and a 2DS.2AL translocation line with non-waxy *** discovery of small D-genome introgressions in the A and b genomes suggested that pentaploidization can be used to induce homoeologous *** introgression of D genome from Aegilops tauschii to the Ab genomes might promote the development of super tetraploid wheat with hexaploid biological characteristics(especially stress resistance)and quality functions and the functional study of the introduced chromosomes or fragments.

关键词： Pentaploid hybridization Interspecific hybridization Alien introgression Homoeologous recombination Aegilops tauschii

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A facile data-driven battery capacity estimation framework for on-road plug-in hybrid electric vehicle

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Progress in Natural Science:Materials International 2025年第01期 166-176页

作者： Jianlu Li Yanming Chen Tongxing Lei Jianguo Liu Guizheng Liu Zhaoyang Deng Xuebiao Wu Zhiyu ding Yinghe Zhang Junwei Wu Yanan Chen Guangzhou Automobile Group Co. Ltd. School of Materials Science and Engineering Harbin Institute of Technology School of Materials and Environmental Engineering Shenzhen Polytechnic University School of Science Shenzhen Key Laboratory of Flexible Printed Electronics Technology Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application Harbin Institute of Technology School of Materials Science and Engineering Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education Tianjin Key Laboratory of Composite and Functional Materials Tianjin University

A data-driven framework with strong generalization capabilities is proposed to effectively extract features and easily access battery capacity. This framework can make highly accurate predictions for the battery capacities of plug-in electric vehicles. The feature extraction process is entirely based on statistics, which are always available and can be generalized to various types of battery data. An improved ampere-hour integral method can easily access battery capacity with just short-charging segments lasting 500 s. Several machine-learning models are trained to verify the framework's effectiveness, with the best model achieving a test error of 0.84 % based on leave-one-out validation. SHAP values are used to provide a reasonable interpretation of the relationships between the constructed features and model outputs. The proposed framework offers advantages such as reduced computational resources, wide generalization, and high prediction accuracy, showing great potential for battery management.

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Integrated analysis of single-cell and bulk transcriptomes uncovers clinically relevant molecular subtypes in human prostate cancer

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Chinese Journal of Cancer Research 2025年第01期 90-126页

作者： Tao ding Lina He Guowen Lin Lei Xu Yanjun Zhu Xinan Wang Xuefei Liu Jianming Guo Fanghong Lei Zhixiang Zuo Jianghua Zheng Department of Urology Yuebei People's Hospital Shantou University Medical College Department of Urology Southern Medical University Affifiliated Fengxian Hospital School of Life Sciences State Key Laboratory of Oncology in South China Cancer Center Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Department of Urology Fudan University Shanghai Cancer Center Department of Urology Zhongshan HospitalFudan University Department of Urology Tongji Hospital School of Medicine Tongji University Department of biochemistry School of Medicine Southern University of Science and Technology Department of Pathology Yuebei People's Hospital Shantou University Medical College Central Laboratory Tongji HospitalSchool of Medicine Tongji University Department of Laboratory Medicine Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital

Objective: Prostate cancer(PCa) is a complex disease characterized by diverse cellular ecosystems within the tumor microenvironment(TME) and high tumor heterogeneity, which challenges clinically stratified management and reinforces the need for novel strategies to fight against castration-resistant PCa(CRPC).Methods: We performed single-cell RNA sequencing(scRNA-seq) on 10 untreated primary PCa tissues and integrated public scRNA-seq resources from three normal prostate tissues, two untreated primary PCa tissues, and six CRPC tumors to portray a comprehensive cellular and molecular interaction atlas of PCa. We further integrated the single-cell and bulk transcriptomes of PCa to establish a molecular classification ***: scRNA-seq profiles revealed substantial inter-and intra-tumoral heterogeneity across different cell subpopulations in untreated PCa and CRPC tumors. In the malignant epithelial reservoir, cells evolved along decoupled paths in treatment-naive PCa and CRPC tumors, and distinct transcriptional reprogramming processes were activated, highlighting anti-androgen therapy-induced lineage plasticity. based on the specifically expressed markers of the epithelial subpopulations, we conducted unsupervised clustering analysis in The Cancer Genome Atlas prostate adenocarcinoma(TCGA-PRAD) cohort and identified three molecularly and clinically distinct subtypes. The C1 subtype, characterized by high enrichment of CRPC-enriched epithelial cells, had a high risk of rapid development of anti-androgen resistance and might require active surveillance and additional promising intervention treatments, such as integrin A3(ITGA3) + integrin b1(ITGb1) inhibition. The C2 subtype resembled the immune-modulated subtype that was most likely to benefit from anti-LAG3 immunotherapy. The C3 subtype had a favorable ***: Our study provides a comprehensive and high-resolution landscape of the intricate architecture of the PCa TME, and our trichotomic molecu

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Physarum polycephalum-inspired adaptive optimization design of artificial microtubular networks

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Science China Chemistry 2025年

作者： Si-Min Zeng Di-Wei Zheng Ting Pan Xing-Lan ding Yun Zhang Chi-Hui Yang Si-Xue Cheng Xian-Zheng Zhang Key Laboratory of biomedical Polymers of Ministry of Education&Department of Chemistry Wuhan University

Natural biological microtubular networks have undergone adaptive evolutionary selection and may offer viable solutions to design challenges in artificial microtubular networks. The plasmodium of the slime mold Physarum polycephalum(P. polycephalum) extends continuously to form a protoplasmic microtubular network structure, directly connecting food *** simulations revealed that the formation of this adaptive P. polycephalum microtubular network could be captured by a mathematical algorithm. Inspired by the P. polycephalum microtubular networks, we propose an adaptive optimization design method for artificial microtubular networks. Specifically, we utilized hydrogels with biodegradable and tissue-adhesive properties to replicate the P. polycephalum microtubular networks via photomask. In Rhodamine b diffusion and glucosecatalyzed reaction experiments, we found that the P. polycephalum microtubular networks exhibited significantly enhanced efficiency compared to vascular and artificial networks. Furthermore, we demonstrated the potential for uric acid(UA) degradation of the hydrogels with a real P. polycephalum microtubular network loaded with urate oxidase(UOx) in a rodent model of hyperuricemia. And this network achieved more than double the effect of the artificial network. This underscores the potential of natural microtubular networks to replace artificial microtubular networks.

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Rotation-induced plasmonic chiral quasi-bound states in the continuum

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Photonics Research 2025年第01期13卷 69-79页

作者： CHUNHUA QIN YADONG DENG TIANSHUO LYU CHAO MENG S?REN IM SANDE SERGEY I.bOZHEVOLNYI JINHUI SHI FEI ding Key Laboratory of In-Fiber Integrated Optics of Ministry of Education and Key Laboratory of Photonic Materials and Devices Physics for Oceanic Applications of Ministry of Industry and Information Technology College of Physics and Optoelectronic EngineeringHarbin Engineering University Centre for Nano Optics University of Southern Denmark

Nanoscale light manipulation using plasmonic metasurfaces has emerged as a frontier in photonic research,offering strongly enhanced light-matter interactions with potential applications in sensing,communications,and quantum ***,we unveil the realization and control of chiral quasi-bound states in the continuum(quasi-bICs) by judiciously rotating one of the paired plasmonic bricks and thereby influencing structural *** precisely controlling the rotation angle,we enable continuous modulation of the radiation loss in quasibICs and transition from a perfect half-wave plate to a good absorber for the left-handed circularly polarized *** transformation leverages the intrinsic chirality with moderately high circular dichroism of ～0.35 in both simulation and experimental observations,manifesting unprecedented control over the chiral light within subwavelength *** modeling and numerical simulations complement our experimental findings,offering deep insights into underlying mechanisms and the role of symmetry breaking in realizing chiral *** observed phenomena open new pathways for developing ultra-compact chiral photonic devices with tailored optical properties,including highly sensitive chiral biosensors,circular dichroism spectroscopy,and chiral flat optical components for information processing.

关键词： Dichroism

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Improving performance of screening MM/PbSA in protein–ligand interactions via machine learning

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Chinese Physics b 2025年第1期34卷 486-496页

作者： Yuan-Qiang Chen Yao Xu Yu-Qiang Ma Hong-Ming ding Center for Soft Condensed Matter Physics and Interdisciplinary Research School of Physical Science and TechnologySoochow UniversitySuzhou 215006China National Laboratory of Solid State Microstructures and Department of Physics Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

Accurately estimating protein–ligand binding free energy is crucial for drug design and biophysics, yet remains a challenging task. In this study, we applied the screening molecular mechanics/Poisson–boltzmann surface area(MM/PbSA)method in combination with various machine learning techniques to compute the binding free energies of protein–ligand interactions. Our results demonstrate that machine learning outperforms direct screening MM/PbSA calculations in predicting protein–ligand binding free energies. Notably, the random forest(RF) method exhibited the best predictive performance,with a Pearson correlation coefficient(rp) of 0.702 and a mean absolute error(MAE) of 1.379 kcal/mol. Furthermore, we analyzed feature importance rankings in the gradient boosting(Gb), adaptive boosting(Ada boost), and RF methods, and found that feature selection significantly impacted predictive performance. In particular, molecular weight(MW) and van der Waals(VDW) energies played a decisive role in the prediction. Overall, this study highlights the potential of combining machine learning methods with screening MM/PbSA for accurately predicting binding free energies in biosystems.

关键词： molecular mechanics/Poisson-boltzmann surface area(MM/PbSA) binding free energy machine learning protein-ligand interaction

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蜗舌尺寸结构对离心风机性能及运行噪声影响研究

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噪声与振动控制 2025年第1期45卷 84-88页

作者：李保航丁问司华南理工大学机械与汽车工程学院广州510641

为探究蜗舌与叶轮间隙t、蜗舌圆角r等结构尺寸对离心风机性能和运行噪声的影响,以某一叶轮出口直径D_(2)=630 mm的后向离心风机为研究对象,通过实验验证了数值模拟的可行性、正确性,通过实验分析发现,对于t/D_(2)在0.016~0.05,以及r/D_... 详细信息

为探究蜗舌与叶轮间隙t、蜗舌圆角r等结构尺寸对离心风机性能和运行噪声的影响,以某一叶轮出口直径D_(2)=630 mm的后向离心风机为研究对象,通过实验验证了数值模拟的可行性、正确性,通过实验分析发现,对于t/D_(2)在0.016~0.05,以及r/D_(2)在0.008~0.04的区间内的25种组合,风机效率变化均在2%以内,r/D_(2)=0.024比r/D_(2)=0.008时的噪声低1.1 d b,t/D_(2)=0.042比t/D_(2)=0.016时的噪声低3.7 d b。可以发现在实验取值变化范围内风机性能并不发生大的变化,而噪声受到的影响显著。分析发现,在t/D_(2)=0.016时风机噪声大幅提升,在其余参数范围内风机噪声随着蜗舌圆角和间隙的增大而降低,此可为风机降噪优化提供指导。

关键词：声学蜗舌离心风机气动噪声 CFD 降噪

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A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang ding Zixun Geng Chencheng Hu Long Yang Zitong Kan biao Dong Miae Won Hongwei Song Lin Xu Jong Seung Kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines(Chinese Academy of Sciences) Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical OncogenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055China Shenzhen bay Laboratory Shenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Microbial Metabolism School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China Molecular biology Experimental Center Germplasm Bank of Wild Species in Southwest ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201China Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Research Unit of Chemical biology of Natural Anti-Virus Products Chinese Academy of Medical SciencesBeijing 100730China

In the intricate process of natural product biosynthesis,a metabolon can enhance metabolic flux by associating sequential enzymes.A fungal metabolon,comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G,is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide b and its diastereomer(+)-versicolamide *** notoamide E as a substance,Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation,followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium ***,(+)-notoamide b and(+)-versicolamide b are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol *** provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

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