检索结果-南通市图书馆

Journal of b.onic Engineering 2024年第1期21卷 192-208页

作者： ang Chen b.feng Song ZhiheWang kang Liu Dong Xue Xiaojun Yang School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China Harb.n Institute of Technology Shenzhen 518055China

This paper is b.sed on a previously developed b.o-inspired Flapping Wing Aerial Vehicle(FWAV),Rob.Falcon,which can fly with a morphing-coupled flapping *** this paper,a simple flapping stroke control system b.sed on Hall effect sensors is designed and applied,which is capab.e of assigning different up-and down-stroke speeds for the Rob.Falcon platform to achieve an adjustab.e downstroke *** aerodynamic and power characteristics of the morphing-coupled flapping pattern and the conventional flapping pattern with varying downstroke ratios are measured through a wind tunnel experiment,and the corresponding aerodynamic models are developed and analyzed b. the nonlinear least squares *** relatively low power consumption of the slow-downstroke mode of this vehicle is verified through outdoor flight *** results of wind tunnel experiments and flight tests indicate that increased downstroke duration can improve aerodynamic and power performance for the Rob.Falcon platform.

关键词： Flapping wing aerial vehicle(FWAV) Downstroke ratio b.o-inspired design Morphing-coupled flapping

Effects of dynamical spanwise retraction and stretch on flapping-wing forward flights

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第4期37卷 181-202页

作者： kang LIU b.feng SONG ang CHEN Zhihe Wang Dong XUE Wenqing Yang School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Intelligent Aircraft Research Center Chengdu Technological UniversityChengdu 610031China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China Harb.n Institute of Technology Shenzhen 518055China

b.rds and b.ts retract and stretch their wings dynamically during each flap in level flights, implying intriguing mechanisms for the aerodynamic performance improvement of flapping wings. A numerical investigation into the aerodynamic effects of such b.o-inspired concept in forward flights has b.en performed b.sed on a three-dimensional wing in plunging motion and a twosection wing in flapping motion. The currently considered Reynolds numb.r and Strouhal numb.r are Re=1.5×10^(5) and St=0.3, respectively. During the research, the mean angle of attack is varied in relatively wide ranges to achieve lift-thrust interconversion for the wings. The conclusive results show that dynamical spanwise retraction and stretch has induced three ab.olutely desirab.e scenarios for the oscillating wings in forward flights, namely producing more lift and consuming less power for a given thrust generation, producing more thrust and consuming less power for a given lift generation, and producing more lift and more thrust while consuming less power. Furthermore,the morphing wings have alleviated periodical aerodynamic load fluctuations compared with the non-morphing b.seline. The mechanism of the aerodynamic effects of the b.onic morphing mode is analyzed with the aid of field visualization. The current article is the first to reveal the ab.olute advantages of the b.onic spanwise morphing. Hopefully, it may help comprehend the b.haviors of natural fliers and provide inspirations for performance enhancement of micro artificial flappingwing vehicles.

关键词： Flapping wing Morphing wing b.onic Aerodynamics Vortex Flight

A transfer learning enhanced physics-informed neural network for parameter identification in soft materials

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2024年第10期45卷 1685-1704页

作者： Jing'ang ZHU Yiheng XUE Zishun LIU International Center for Applied Mechanics State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi'an Jiaotong University

Soft materials, with the sensitivity to various external stimuli, exhib.t high flexib.lity and stretchab.lity. Accurate prediction of their mechanical b.haviors requires advanced hyperelastic constitutive models incorporating multiple parameters. However,identifying multiple parameters under complex deformations remains a challenge, especially with limited ob.erved data. In this study, we develop a physics-informed neural network(PINN) framework to identify material parameters and predict mechanical fields,focusing on compressib.e Neo-Hookean materials and hydrogels. To improve accuracy, we utilize scaling techniques to normalize network outputs and material parameters. This framework effectively solves forward and inverse prob.ems, extrapolating continuous mechanical fields from sparse b.undary data and identifying unknown mechanical *** explore different approaches for imposing b.undary conditions(b.s) to assess their impacts on accuracy. To enhance efficiency and generalization, we propose a transfer learning enhanced PINN(TL-PINN), allowing pre-trained networks to quickly adapt to new scenarios. The TL-PINN significantly reduces computational costs while maintaining accuracy. This work holds promise in addressing practical challenges in soft material science, and provides insights into soft material mechanics with state-of-the-art experimental methods.

关键词： 35Q74 74A20 74b.0 74G75 inverse prob.em O242 O343 parameter identification physics-informed neural network (PINN) soft material transfer learning

A neural m^(6)A pathway regulates b.havioral aggregation in migratory locusts

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第6期67卷 1242-1254页

作者： Xianliang Huang Qing Li Yanan Xu ang Li Shanzheng Wang Yusheng Chen Chunrui Zhang Xia Zhang Hailin Wang Cong Lv b.ofa Sun Shaoqin Li Le kang b.ng Chen School of Life Science Institutes of Life Science and Green DevelopmentHebei UniversityBaoding 071002China College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070China State Key Lab.ratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute of Health Sciences Anhui UniversityHefei 230601China b.ijing Institute of Genomics Chinese Academy of SciencesBeijing 100101China State Key Lab.ratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100101China

RNA N6-methyladenosine(m^(6)A),as the most ab.ndant modification of messenger RNA,can modulate insect b.haviors,b.t its specific roles in aggregation b.haviors remain ***,we conducted a comprehensive molecular and physiological characterization of the individual components of the methyltransferase and demethylase in the migratory locust Locusta *** results demonstrated that METTL3,METTL14 and ALKb.5 were dominantly expressed in the b.ain and exhib.ted remarkab.e responses to crowding or *** individual knockdown of methyltransferases(i.e.,METTL3 and METTL14)promoted locust movement and conspecific attraction,whereas ALKb.5 knockdown induced a b.havioral shift toward the solitary ***,glob.l transcriptome profiles revealed that m^(6)A modification could regulate the orchestration of gene expression to fine tune the b.havioral aggregation of *** summary,our in vivo characterization of the m^(6)A functions in migratory locusts clearly demonstrated the crucial roles of the m^(6)A pathway in effectively modulating aggregation b.haviors.

关键词： RNA methylation N^(6)-methyladenosine transcriptional orchestration aggregation b.havior Locusta migratoria

High-density lipoprotein regulates angiogenesis b. affecting autophagy via miRNA-181a-5p

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第2期67卷 286-300页

作者： b.-ang kang Hua-Ming Li Ya-Ting Chen Meng-Jie Deng Yan Li Yue-Ming Peng Jian-Jun Gao Zhi-Wei Mo Jia-Guo Zhou Zhi-Jun Ou Jing-Song Ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-Guangdong Joint Engineering Lab.ratory for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China NHC key Lab.ratory of Assisted Circulation(Sun Yat-sen University) Guangzhou 510080China Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Division of Hypertension and Vascular Diseases Department of CardiologyCardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key Lab.ratory of b.ain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

We previously demonstrated that normal high-density lipoprotein(nHDL)can promote angiogenesis,whereas HDL from patients with coronary artery disease(d HDL)is dysfunctional and impairs *** plays a critical role in angiogenesis,and HDL regulates ***,it is unclear whether n HDL and d HDL regulate angiogenesis b. affecting *** cells(ECs)were treated with n HDL and d HDL with or without an autophagy ***,endothelial nitric oxide synthase(e NOS)expression,miRNA expression,nitric oxide(NO)production,superoxide anion(O2^(·-))generation,EC migration,and tub. formation were evaluated.n HDL suppressed the expression of miR-181a-5p,which promotes autophagy and the expression of e NOS,resulting in NO production and the inhib.tion of O2^(·-)generation,and ultimately increasing in EC migration and tub. formation.d HDL showed opposite effects compared to n HDL and ultimately inhib.ted EC migration and tub. *** found that autophagy-related protein 5(ATG5)was a direct target of ***5 silencing or miR-181a-5p mimic inhib.ted n HDL-induced autophagy,e NOS expression,NO production,EC migration,tub. formation,and enhanced O2^(·-)generation,whereas overexpression of ATG5 or miR-181a-5p inhib.tor reversed the ab.ve effects of d ***5 expression and angiogenesis were decreased in the ischemic lower limb. of hypercholesterolemic low-density lipoprotein receptor null(LDLr^(-/-))mice when compared to C57b./6 ***5 overexpression improved angiogenesis in ischemic hypercholesterolemic LDLr^(-/-)*** together,nHDL was ab.e to stimulate autophagy b. suppressing miR-181a-5p,sub.equently increasing e NOS expression,which generated NO and promoted *** contrast,d HDL inhib.ted angiogenesis,at least partially,b. increasing miR-181a-5p expression,which decreased autophagy and e NOS expression,resulting in a decrease in NO production and an increase in O2^(·-)*** findings reveal a nov

关键词： high-density lipoprotein angiogenesis autophagy ATG5 miRNA endothelial nitric oxide synthase

Thermodynamic model for deoxidation of liquid steel considering strong metal-oxygen interaction in the quasichemical model framework

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 988-1002页

作者： Yong-Min Cho Youn-b.e kang Graduate Institute of Ferrous and Eco Materials Technology Pohang University of Science and TechnologyPohangKyungbuk37673Rep.of Korea N.EX.T Hub POSCO HoldingsPohangKyungbuk37673Rep.of Korea Department of Materials Science and Engineering Pohang University of Science and TechnologyPohangKyungbuk37673Rep.of Korea

Herein,a thermodynamic model aimed at describ.ng deoxidation equilib.ia in liquid steel was *** model provides explicit forms of the activity coefficient of solutes in liquid steel,eliminating the need for the minimization of internal Gib.s energy preliminarily when solving deoxidation *** elimination of internal Gib.s energy minimization is particularly advantageous during the coupling of deoxidation equilib.ium calculations with computationally intensive approaches,such as computational fluid *** model enab.es efficient calculations through direct emb.dment of the explicit forms of activity coefficient in the computing *** proposed thermodynamic model was developed using a quasichemical approach with two key approximations:random mixing of metallic elements(Fe and oxidizing metal) and strong nonrandom pairing of metal and oxygen as nearest *** these approximations,the quasichemical approach yielded the activity coefficients of solutes as explicit functions of composition and temperature without requiring the minimization of internal Gib.s energy or the coupling of separate *** model was successfully applied in the calculation of deoxidation equilib.ia of various elements(Al,b.C,Ca,Ce,Cr,La,Mg,Mn,Nb.Si,Ti,V,and Zr).The limitations of the model arising from these assumptions were also discussed.

关键词： deoxidation equilib.ia thermodynamics quasichemical approach computational fluid dynamics

Role of inflammatory lipid and fatty acid metab.lic ab.ormalities induced b. plastic additives exposure in childhood asthma

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第3期137卷 172-180页

作者： Zhiyu Chen Fang Li Lei Fu Yu Xia Ying Luo ang Guo Xiaona Zhu Huifang Zhong Qian Luo Institute of b.omedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Rheumatology&Immunology Department of Shenzhen Children’s Hospital Shenzhen 518038China Hub.i Key Lab.ratory of Environmental and Health Effects of Persistent Toxic Sub.tances Institute of Environment and HealthJianghan UniversityWuhan 430056China

Lipid metab.lism play an essential role in occurrence and development of asthma,and it can b. disturb.d b. phthalate esters(PAEs)and organophosphate fame retardants(OPFRs).As a chronic infammatory respiratory disease,the occurrence risk of childhood asthma is increased b. PAEs and OPFRs exposure,b.t it remains not entirely clear how PAEs and OPFRs contrib.te the onset and progress of the *** have profiled the serum levels of PAEs and OPFRs congeners b. liquid chromatography coupled with mass spectrometry,and its relationships with the dysregulation of lipid metab.lism in asthmatic,b.onchitic(acute infammation)and healthy(non-infammation)*** PAEs and nine OPFRs congeners were found in the serum of children(1–5 years old)from Shenzhen,and their total median levels were 615.16 ng/m L and 17.06 ng/m L,***,the serum levels of mono-methyl phthalate(MMP),tri-propyl phosphate(TPP)and tri-n-b.tyl phosphate(TNb.)were significant higher in asthmatic children than in healthy and b.onchitic children as ***-one characteristic lipids and fatty acids of asthma were screened b. machine-learning random forest model b.sed on serum lipidome data,and the alterations of infammatory characteristic lipids and fatty acids including palmitic acids,12,13-Di HODE,14,21-Di HDHA,prostaglandin D2 and Lyso PA(18:2)showed significant correlated with high serum levels of MMP,TPP and *** results imply PAEs and OPFRs promote the occurrence of childhood asthma via disrupting infammatory lipid and fatty acid metab.lism,and provide a novel sight for b.tter understanding the effects of plastic additives on childhood asthma.

关键词： Phthalate esters Organophosphate fame retardants Childhood asthma Lipid and fatty acid metab.lism Machine-learning random forest model Chronic airway infammation

Genotypes and Phenotypes of Uygur Children with Xeroderma Pigmentosum: A Case Study in Xinjiang, China

在线全文

学校读者我要写书评

暂无评论

International Journal of Dermatology and Venereology 2024年第3期7卷 144-149页

作者： Qiu Y. Wang W.-J. Liang J.-Q. Yakeya b. Wang P. Zhang J.-Z. kang X.-J. Department of Dermatology and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang Clinical Research Center for Dermatologic Diseases Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang Key Lab.ratory of Dermatology Research (XJYS1707) Xinjiang Uygur Autonomous Region Urumqi 830001 China

Ob.ective: Xeroderma pigmentosum (XP) is a rare autosomal recessive dermatosis caused b. genetic defects of DNA repair. This study was performed to detect and analyze the genes of 2 Uygur patients with XP and their families and assess the patients' phenotypes, which may enrich the understanding of the genetic skin disorder spectrum in Xinjiang area. Methods: We collected the clinical data from 2 patients with XP and peripheral b.ood samples from the patients and their family memb.rs. The patients' DNA was sequenced and detected b. Sanger sequencing, and gene mutations were screened. Results: The prob.nd in family 1 presented with b.own maculae at the exposure site and squamous cell carcinoma secondary to a facial rash. The prob.nd had a homozygous nucleotide variation of XPC c.2251-2A> G (A change from A to G in the penultimate position of the intron b.fore the 2251 position in the coding region), which was a shear mutation. In this family, b.th parents were heterozygous, and no similar mutation detected in the sister. In family 2, the prob.nd had scattered b.ack b.own spots and papules on the trunk and limb.. and his younger sister was also a patient. The prob.nd and his younger sister had homonucleotide variation of XPA c.631C> T, which was nonsense mutation, resulting in the codon for Arg No.211 b.ing changed into termination codon (***211X), thus terminating the peptide chain synthesis prematurely. All the normal individuals in the two families were heterozygotes, and homozygous mutations occurred in all the patients, which was consistent with the autosomal recessive inheritance. Conclusion: XP is rare in Uygur population. This study expanded the mutation spectrum of XP and provided a b.sis for early diagnosis, treatment, prognostic prediction, and prenatal genetic consultation. © 2022 Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences, and Chinese Medical Association, pub.ished b. Wolters Kluwer, Inc.

关键词： gene mutation xeroderma pigmentosum XPA gene XPC gene

The comb.ned effects of quantum and strong coupling on the nonlinear collective excitation in quantum dusty plasmas

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2024年第10期76卷 137-142页

作者： Chengkai Li Youyou kang Yunliang Wang Department of Physics School of Mathematics and Physics University of Science and Technology Beijing

The quantum hydrodynamic model for electrons and ions and the generalized hydrodynamic model for the strongly coupled dust particles are proposed in the strongly coupled quantum dusty plasma, where the comb.ned quantum effects of quantum diffraction, quantum statistic pressure,as well as electron exchange and correlation effects are all considered in the quantum hydrodynamic model. The shear and b.lk viscosity effects are included in the viscoelastic relaxation, which leads to the decay of the dust-ion-acoustic waves. The approximate time-dependent solitary solution is ob.ained b. the momentum conservation law in the presence of viscosity.

关键词： dusty plasma quantum plasma strongly coupled plasma

microRNA-2184 orchestrates Mauthner-cell axon regeneration in zeb.afish via syt3 modulation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第9期51卷 911-921页

作者： Xinghan Chen Yueru Shen Zheng Song Xinliang Wang Huaitong Yao Yuan Cai Zi-ang Zhao b.ng Hu Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefeiAnhui 230026China The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China Center for Advanced Interdisciplinary Science and b.omedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China

MicroRNAs(miRNAs)play a significant role in axon regeneration following spinal cord ***,the functions of numerous miRNAs in axon regeneration within the central nervous system(CNS)remain largely ***,we elucidate the positive role of microRNA-2184(miR-2184)in axon regeneration within zeb.afish Mauthner cells(M-cells).The upregulation of miR-2184 in a single M-cell can facilitate axon regeneration,while the specific sponge-induced silencing of miR-2184 leads to impeded *** show that syt3,a downstream target of miR-2184,negatively regulates axon regeneration,and the regeneration suppression modulated b. syt3 depends on its b.nding to Ca2+.Furthermore,pharmacological stimulation of the cAMP/PKA pathway suggests that changes in the readily releasab.e pool may affect axon *** data indicate that miR-2184 promotes axon regeneration of M-cells within the CNS b. modulating the downstream target syt3,providing valuab.e insights into potential therapeutic strategies.

关键词： Axon regeneration Axon ab.ation miR-2184 syt3 Readily releasab.e pool