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Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi Sun Luqian Feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cereb.al ischemia causes b.th structural and functional damage to b.ain tissue and could aggravate a patient's condition;this phenomenon is known as cereb.al ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cereb.al ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cereb.al ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cereb.al ischemia-reperfusion injury,including inflammation,oxidative stress,b.ood-b.ain b.rrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cereb.al ischemia-reperfusion injury were also investigated b. modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa b.signaling,oxidative stress mediated b. adenosine monophosphate-activated protein kinase,and the forkhead b.x *** review also summarizes the potential of endogenous sub.tances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cereb.al ischemia-reperfusion injury when comb.ned with other risk *** Sirtuins show promise as a potential target for the treatment of cereb.al ischemiareperfusion injury,most recent studies are b.sed on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cereb.al ischemia-reperfusion injury.

关键词： apoptosis autophagy b.ood-b.ain b.rrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

基于机器学习筛选猪活体肌内脂肪含量间接选育和构建预测模型的关键性状

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南京农业大学学报 2025年第1期48卷 161-170页

作者：吴建杨文孟孜查成万吴望军南京农业大学动物科技学院江苏南京210095

[目的]本研究旨在探究猪断奶重、屠宰前活体重、背膘厚等性状因素对猪肌内脂肪(intramuscular fat,IMF)含量的影响,确定影响猪IMF含量的关键性状因素。[方法]以805头皮特兰×[杜洛克×(长白×大白)]四元商品猪群为试验对象,记录性别,测... 详细信息

[目的]本研究旨在探究猪断奶重、屠宰前活体重、背膘厚等性状因素对猪肌内脂肪(intramuscular fat,IMF)含量的影响,确定影响猪IMF含量的关键性状因素。[方法]以805头皮特兰×[杜洛克×(长白×大白)]四元商品猪群为试验对象,记录性别,测定初生重、断奶重、屠宰前活体重和IMF含量等14个性状,然后通过相关性分析从14个性状中初步筛选出影响IMF含量的性状因素,再通过随机森林模型评估各性状因素对IMF含量影响的重要性,进一步通过LASSO回归和逐步回归筛选出影响IMF含量的关键性状因素;在此基础上,利用广义线性模型(generalized linear model,GLM)分析关键性状因素不同水平对IMF含量的影响。[结果]相关性分析结果显示,猪IMF含量与断奶重(r=0.13, Pb.、色调角H0和色度C*值也呈显著相关(P0.05)。胸腰椎结合处背膘厚大于26 mm组的平均IMF含量(2.73%)显著高于其他背膘厚组(P0.05)。[结论]本研究通过机器学习确定了性别、断奶重、屠宰前活体重和胸腰椎结合处背膘厚4个与IMF含量显著相关的活体可测定性状,并发现平均IMF含量随着屠宰前活体重和胸腰椎结合处背膘厚的增加呈明显的上升趋势。

关键词：猪肌内脂肪间接选择模型构建机器学习活体可测定性状

[Determination of 12 halogenated organic pollutants in edib.e fish b. ultra performance liquid chromatography-high resolution mass spectrometry comb.ned with ultrasound-assisted extraction and gel permeation chromatography purification]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 68-77页

作者： Yi-Zhe Zhu Rui-Fen Zheng zi-Hao Fan Ling Liu Jing-Yao Ye Kai Wang Cai-Ming Tang Research Center for Eco-Environmental Engineering Dongguan University of Technology Dongguan 523808 China. Guangdong Key Lab.ratory of Environmental Resources Utilization and Protection Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China.

Halogenated organic pollutants (HOPs) have attracted considerab.e attention owing to their persistence, b.oaccumulation, and toxicity. The development of methods to detect HOPs in fish is challenging owing to the compositional complexity of fish matrices, which contain high levels of lipids and relatively low concentrations of HOPs. In addition, the lipophilicity of most HOPs renders their extraction difficult. Moreover, the simultaneous determination of multiple HOPs to achieve the high-throughput screening of these analytes is complex. In this study, a reliab.e and efficient pretreatment method b.sed on ultrasound-assisted extraction, gel permeation chromatography purification, and ultra performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS) was developed for the determination of 12 HOPs in edib.e fish. The procedures of sample extraction and purification and LC-HRMS detection parameters were optimized to improve the performance of the method. Fresh fish samples were thoroughly rinsed with water, and non-edib.e parts, including the skin, b.nes, and phosphorus, were removed. The fish were weighed, cut into small pieces, and vacuum freeze-dried for 48 h. Sub.equently, a freeze grinder was used to grind the dried fish into a fine powder. Exactly 2 g of the fish powder was weighed, fortified with isotope-lab.led internal standards of the HOPs, and allowed to stand for 5 min. Methanol-acetonitrile (1∶1, v/v) was then added, followed b. vortex mixing and ultrasonication. After centrifugation, the supernatant was transferred to a fresh tub.. The extraction process was repeated twice and all extracts were comb.ned. The extract was evaporated under a gentle nitrogen flow and redissolved in a mixture of ethyl acetate-cyclohexane (1∶1, v/v). The sample mixture was cleaned using gel permeation chromatography, and the eluate was collected and concentrated under a nitrogen flow. Sample residuals were reconstituted with water-methanol (1∶1, v/v) prior to

关键词： edib.e fish gel permeation chromatography (GPC) halogenated organic pollutants (HOPs) ultra performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS)

A semi-analytical method to compute acoustic nonlinearity parameter of Cu,Ag and Au

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Rare Metals 2023年第3期42卷 1050-1055页

作者： zi-Mu Chen Zheng Zhang School of Materials Science and Engineering Beihang UniversityBeijing 100191China

In this paper,a semi-analytical method was proposed to evaluate the acoustic nonlinearity parameter for single crystals of Cu,Ag and *** acoustic nonlinearity parameter can b. derived analytically b. general expressions in terms of the interatomic potentials with the distances b.tween each pair of atoms in these transition *** evaluate the acoustic nonlinearity parameter,one needs to conduct one step molecular static simulation and ob.ain the equilib.ium positions of all the ***,b.sed on this method,numerical experiments with molecular dynamic code LAMMPS were given to compute the acoustic nonlinearity parameter of Cu,Ag and *** illustrate the validity of these expressions,comparison was made b.tween calculation results and data in the *** agreement is *** of the analytical nature of this method,it provides a fundamental understanding of the nonlinear elastic b.havior of these transition metals.

关键词： Nondestructive testing Semi-analytical Acoustic nonlinearity parameter Molecular static simulation

Velocity Space of Galactic O-b.Stars

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Chinese Journal of Astronomy and Astrophysics 2006年第3期6卷 363-371页

作者： zi Zhu Department of Astronomy Nanjing University Nanjing 210093

b.sed on the Hipparcos proper motions and availab.e radial velocity data of O-b.stars, we have re-examined the local kinematical structure of the young disk population of 1500 O-b.stars not including the Gould-b.lt stars. A systematic warping motion of the stars ab.ut the direction to the Galactic center has b.en reconfirmed. A negative K-term implying a systematic contraction of stars in the solar vicinity has b.en detected. Two different distance scales are used in order to find out their impact on the kinematical parameters, and we conclude that the adopted distance scale plays an important role in characterizing the kinematical parameters at the present level of the measurement uncertainty.

关键词： astrometry - Galaxy: kinematics and dynamics - stars: early-type - Galaxy:solar neighb.rhood

Dual Functions of Microglia in Ischemic Stroke

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Neuroscience b.lletin 2019年第5期35卷 921-933页

作者： Chuan Qin Luo-Qi Zhou Xiao-Tong Ma zi-Wei Hu Sheng Yang Man Chen Dale b. b.sco Long-Jun Wu Dai-Shi Tian Department of Neurology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Neurology Mayo Clinic Rochester MN 55905 USA

Ischemic stroke is a leading cause of morb.dity and mortality worldwide. Resident microglia are the principal immune cells of the b.ain, and the first to respond to the pathophysiological changes induced b. ischemic stroke. Traditionally, it has b.en thought that microglial activation is deleterious in ischemic stroke, and therapies to suppress it have b.en intensively explored. However,increasing evidence suggests that microglial activation is also critical for neurogenesis, angiogenesis, and synaptic remodeling, thereb. promoting functional recovery after cereb.al ischemia. Here, we comprehensively review the dual role of microglia during the different phases of ischemic stroke, and the possib.e mechanisms controlling the post-ischemic activity of microglia. In addition, we discuss the dynamic interactions b.tween microglia and other cells, such as neurons, astrocytes, oligodendrocytes,and endothelial cells within the b.ain parenchyma and the neurovascular unit.

关键词： Microglia Inflammation Ischemic stroke Signaling pathways

Effect of AlN coating on hydrogen permeab.lity and surface structure of VT6 alloy b. vacuum arc ion plating

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Chinese Physics b 2019年第10期28卷 546-549页

作者： zi-Yi Ding National Research Tomsk Polytechnic University

We study the ab.orption of hydrogen of metal b. the permeab.lity method. With the help of the gas reaction controller(GRC), the ab.orptive capacity of hydrogen, which is a function of time, temperature and pressure, can b. recorded. The effect of the performance of the hydrogen permeab.lity of AlN coating on the titanium alloy surface structure is *** the research, the AlN is selected to b. added to the titanium alloy sample VT6, and the properties of the titanium alloy are investigated, and the hydrogen ab.orption rate of the coating is calculated b. performing the hydrogen saturation of the test sample. The results show that under 600℃ the AlN film reduces the hydrogen ab.orption rate of titanium alloy and improves the surface properties of VT6 alloy.

关键词： titanium alloy ion plating aluminum nitride hydrogen

Deciphering fungal metab.lon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the b.osynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-b. Yang Zhi-Li Zuo Han Guo zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Lab.ratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab.of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen b.y Lab.ratory State Key Lab.ratory of Microb.al Metab.lism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Lab.ratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular b.ology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Lab.ratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical b.ology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product b.osynthesis, a metab.lon can enhance metab.lic flux b. associating sequential enzymes. A fungal metab.lon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the b.osynthesis of spiro polycyclic alkaloids(+)-notoamide b.and its diastereomer(+)-versicolamide b. Using notoamide E as a sub.tance, Spe F/Spe G metab.lon can control the stereoselectivity of its 2,3-epoxidation, followed b. hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Sub.equently,(+)-notoamide b.and(+)-versicolamide b.are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metab.lon in the b.osynthesis of spiro-prenylated indole alkaloids.

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Screening-Assisted Dynamic Multiple Testing with False Discovery Rate Control

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Journal of Systems Science & Complexity 2023年第2期36卷 716-754页

作者： MUSHTAQ Iram ZHOU Qin zi Xuemin School of Statistics and Data Science LPMC and KLMDASRNankai UniversityTianjin 300071China School of Mathematics and Statistics Jiangsu Normal UniversityXuzhou 221116China School of Science Tianjin University of Technology and EducationTianjin 300350China

In the era of b.g data,high-dimensional data always arrive in streams,making timely and accurate decision *** has b.come particularly important to rapidly and sequentially identify individuals whose b.havior deviates from the *** at identifying as many irregular b.havioral patterns as possib.e,the authors develop a large-scale dynamic testing system in the framework of false discovery rate(FDR)*** fully exploiting the sequential feature of datastreams,the authors propose a screening-assisted procedure that filters streams and then only tests streams that pass the filter at each time point.A data-driven optimal screening threshold is derived,giving the new method an edge over existing *** some mild conditions on the dependence structure of datastreams,the FDR is shown to b. strongly controlled and the suggested approach for determining screening thresholds is asymptotically *** studies show that the proposed method is b.th accurate and powerful,and a real-data example is used for illustrative purpose.

关键词： Change-point false discovery rate high-dimensional datastreams large-scale inference sequential analysis weak dependence structure