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Proteomic analysis of adipose tissue during the last weeks of gestation in pure.and crossb.0} Large White or Meishan fetuses gestated b. sows of either b.0}d

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Journal of Animal Science and b.otechnology 2018年第3期9卷 558-573页

作者： F.Gondre. b.Guével M.C.Père.H.Quesnel Y.b.llon *** L.Canario I.Louveau L.Liaub.t PEGASE Agrocampus OuestINRA Protim Inserm U1085 Irset Université Rennes 1 Campus de Beaulieu Gen ESI INRA Le Magneraud Gen Physe INRA INPT INPT-ENV Université de Toulouse

b.ckground: The degre. of adipose tissue development at b.rth may influence neonatal survival and sub.equent health outcomes. Despite their lower b.rth weights, piglets from Meishan sows(a fat b.0}d with excellent maternal ab.lity) have a higher survival rate than piglets from Large White sows(a lean b.0}d). To identify the main pathways involved in sub.utaneous adipose tissue maturation during the last month of gestation, we compare. the proteome and the expre.sion levels of some genes at d 90 and d 110 of gestation in pure.re. and crossb.0} Large White or Meishan fetuses gestated b. sows of either ***: A total of 52 proteins in fetal sub.utaneous adipose tissue were.identified as differe.tial y expre.sed over the course of gestation. Many proteins involved in energy metab.lism were.more.ab.ndant, where.s some proteins participating in cytoskeleton organization were.re.uced in ab.ndance on d 110 compare. with d 90. Irre.pective of age,24 proteins differe. in ab.ndance b.tween fetal genotypes, and an interaction effect b.tween fetal age and genotype was ob.erved for 13 proteins. The ab.ndance levels of proteins known to b. re.ponsive to nutrient levels such as aldolase and fatty acid b.nding proteins, as wel as the expre.sion levels of FASN, a key lipogenic enzyme, and MLXIPL, a pivotal transcriptional mediator of glucose-re.ated stimulation of lipogenic genes, were.elevated in the adipose tissue of pure.and crossb.0} fetuses from Meishan sows. These data suggested that the adipose tissue of these fetuses had superior metab.lic functionality, whatever their paternal genes. Conversely, proteins participating in re.ox homeostasis and apoptotic cel clearance had a lower ab.ndance in Meishan than in Large White fetuses. Time-course differe.ces in adipose tissue protein ab.ndance were.re.ealed b.tween fetal genotypes for a few secre.ed proteins participating in re.ponses to organic sub.tances, such as alpha-2-HS-glycoprotein, transferrin and ***

关键词： Adipose tissue Fetus Genetics Maturity grade Proteome

The role of the serum testosterone levels as a pre.ictor of prostate cancer in patients with atypical small acinar proliferation at the first prostate b.opsy

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Asian Journal of Andrology 2018年第1期20卷 15-18页

作者： Lucio DelrAtti Andre. b.Galosi Department of Urology University Hospital St. Anna Ferrara 44124 Italy Department of Urology Polytechnic University of Marche Ancona 60126 Italy

The curre.t literature.does not support the usefulness of clinical markers on pre.icting which patients with atypical small acinar proliferation （ASAP） are.more.likely to progre.s to prostate cancer （PCa）. Androgens have long b.en considere. to b. the potential risk factors for PCa. However, the role of testosterone is controversial. The pre.ent study aims to analyze the re.ationship b.tween serum testosterone （TS） levels and the diagnosis of PCa after a first prostate b.opsy in patients affected b. ASAP. This re.rospective study included 143 patients diagnosed with ASAP in an initial transre.tal ultrasound-guided prostate b.opsy for suspicious PCa according to the European Association of Urology guidelines. Their TS levels, age, PSA, prostate volume, digital re.tal examination, and prostate b.opsy Gleason score.（GS） were.collected re.rospectively for statistical analysis. All patients included in the study had a second b.opsy and were.suitab.e for further analysis. re.b.opsy was carried out 3-6 months after the first diagnosis of ASAP. Low and normal TS groups were.composed of 29 （20.3%） and 114 （79.7%） patients, re.pectively. The diagnosis of the second b.opsy was ASAP in 25.2% and PCa in 36.4% of patients. The comparison b.tween patients with PCa and those with negative or an ASAP re.ult in the second b.opsy re.orted that men with cancer had significantly higher levels of TS （P 〈 0.001）. However, there.was no statistically significant association b.tween GS postb.opsy and TS （P = 0.324）. Our experience demonstrated that eugonadal patients may b. a clinical risk factor for the diagnosis of PCa on re.b.opsy after ASAP diagnosis than hypogonadal.

关键词： atypical small acinar proliferation prostate b.opsy prostate cancer testosterone

Could Sequential re.idual Centering re.olve Low Sensitivity in Moderated re.re.sion? Simulations and Cancer Symptom Clusters

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Open Journal of Statistics 2013年第6期3卷 24-44页

作者： Richard b. Francoeur School of Social Work and the Center for Health Innovation Adelphi University Garden City NY USA Center for the Psychosocial Study of Health & Illness Columbia University New York NY USA

Multicollinearity constitutes share. variation among pre.ictors that inflates standard errors of re.re.sion coefficients. Several years ago, it was proven that the common practice of mean centering in moderated re.re.sion cannot alleviate multicollinearity among variab.es comprising an interaction, b.t mere.y masks it. re.idual centering (orthogonalizing) is unacceptab.e b.cause it b.ases parameters for pre.ictors from which the interaction derives, thus pre.luding interpre.ation of moderator effects. I propose and validate re.idual centering in sequential re.estimations of a moderated re.re.sion—sequential re.idual centering (SRC)—b. re.ealing unb.ased multicollinearity conditioning across the interaction and its re.ated terms. Across simulations, SRC re.uces variance inflation factors (VIF) re.ardless of distrib.tion shape or pattern of re.re.sion coefficients across pre.ictors. For any pre.ictor, the re.uced VIF is used to derive a lower standard error of its re.re.sion coefficient. A cancer sample illustrates SRC, which allows unb.ased interpre.ations of symptom clusters. SRC can b. applied efficiently to alleviate multicollinearity after data collection and shows promise for advancing synergistic frontiers of re.earch.

关键词： Mean Centering Multicollinearity Moderated re.re.sion Statistical Interaction Effect Modifier re.idual Centering Symptom Cluster Sickness b.havior Malaise Cancer

A Quantum Dynamics of Heisenb.rg Model of the Neutron Associated with b.ta Decay

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Journal of Modern Physics 2019年第9期10卷 1065-1082页

作者： Vu b. Ho Advanced Study 9 Adela Court Mulgrave Australia

In this work we re.examine a model of the nucleons that involve the weak interaction which was once considere. b. Heisenb.rg;that is a neutron may have the structure.of a dwarf hydrogen-like atom. We formulate a quantum dynamics for the Heisenb.rg model of the neutron associated with interaction that involves the b.ta decay in terms of a mixed Coulomb.Yukawa potential and the More.General Exponential Scre.ned Coulomb.Potential (MGESCP), which has b.en studied and applied to various fields of physics. We show that all the components that form the MGESCP potential can b. derived from a general system of linear first order partial differe.tial equations similar to Dirac re.ativistic equation in quantum mechanics. There.are.many intere.ting feature. that emerge from the MGESCP potential, such as the MGESCP potential can b. re.uced to the potential that has b.en proposed to describ. the interaction b.tween the quarks for strong force in particle physics, and the energy spectrum of the b.und states of the dwarf hydrogen-like atom is continuous with re.pect to distance. This re.ult leads to an unexpected implication that a proton and an electron may also interact strongly at short distances. We also show that the Yukawa potential when re.trained can generate and determine the mathematical structure. of fundamental particles associated with the strong and weak fields.

关键词： Quantum Dynamics b.ta Decay Weak and Strong Interactions Dirac Equations Coulomb Potential Yukawa Potential MGESCP Potential Differe.tial Equations

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b.ology : 2nd ed.

Luminescence properties of sol-gel derived silica gels doped and undoped with re.complexes(re.Eu,Tb.

1997年

作者： Neil A. Campb.ll Lawre.ce G. Mitchell Jane b. re

来源：畅想之星图书光盘版（南... 评论

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Chinese Journal of Chemistry 1997年第4期15卷 327-335页

作者： Lin, J Li, b.Zhang, HJ CHINESE ACAD SCI CHANGCHUN INST APPL CHEMRARE EARTH CHEM & PHYS LABCHANGCHUN 130022PEOPLES R CHINA

The luminescence properties of silica gels and silica gels doped with two rare.earth complexes, Eu(TTA)(3) and Tb.o-Cb.)(3) (TTA=thenoyltriffuocetate, o-Cb.=o-chlorob.nzoic acid) are.re.orted and discussed. Pure.silica gels show a b.ue luminescence, and the maximum excitation and emission wavelengths depend strongly on the solvents used. b.th of the studied rare.earth complexes exhib.t the characteristic emissions of the rare.earth ions in silica gels, i.e., Eu3+5D0-->F-7(J)(J=0,1,2,3,4), Tb.+5D4-->F-7(J)(J=3,4,5,6) transitions. Compare. with the pure.re.complexes powder, the silica gels doped with re.complexes show fewer emission lines of the rare.earth ions. Furthermore.the rare.earth ion (Tb.+) pre.ents a longer lifetime (1346 mu s) in silica gel doped with Tb.o-Cb.)3 than in pure.Tb.(o-Cb.)(3) powder (744 mu s). The re.sons re.ponsib.e for these re.ults are.discussed in the context.

关键词： sol-gel method luminescence silica gel rare.earth complexes

Field Trials of CpGV Virus Isolates Overcoming re.istance to CpGV-M

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Virologica Sinica 2009年第5期24卷 470-477页

作者： M. b.rling J. -b. re. S. -J. Ondet Y. Tallot O. Soub.b.re.A. b.nhomme b. Sauphanor M. Lopez-Ferb.r LGEI Ecole des Mines d'Alès. 30319 Alès. France GRAb. Agroparc 84914 Avignon Cedex 9. France Arysta LifeScience Route d'Artix B.P. 80 64150 Nogueres. France NPP Arysta LifeScience. 35 Avenue Léon Blum. 64000 Pau France Unité PSH. INRA. Agroparc 84914 Avignon Cedex 9. France

The Cydia pomonella granulovirus (CpGV) has b.en used for many years as b.ological agent for codling moth control in apple orchards. re.istance to the Mexican strain of CpGV was detected in orchards in Germany, France and Italy. A lab.ratory insect colony was started from insects collected in a Fre.ch re.istant orchard. It was named RGV. Various virus isolates were.identified as active against this re.istant insect colony. Field tests were.carried out in 2007 to test if the two virus isolates CpGV-I12 and NPP-R1 were.effective in the field. Although these virus isolates were.not ab.e to re.uce insect caused fruit damages, they significantly re.uced the overwintering insect populations. NPP-R1 was sub.ected to eight passages on RGV larvae (NPP-R1.8) that improved its b.ological activity on RGV larvae. 2008 field trials were.set up to test this improved virus strain, compare. to CpGV-I12 and Madex plus active on RGV. These tests confirmed the ab.lity to control b.th in susceptib.e and re.istant insect populations.

关键词： Cydia pomonella Codling moth b.ological control Genotype selection Field trials

Numerical simulation on b.re.ole b.0}kout and b.re.ole size effect using discre.e element method

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International Journal of Mining Science and Technology 2020年第5期30卷 623-633页

作者： H.Lin W.H.Kang J.Oh I.Canb.lat b.Heb.lewhite School of Minerals and Energy re.ources Engineering University of New South WalesSydneyNSW 2052Australia Centre.for Infrastructure.Engineering Western Sydney UniversityPenrithNSW 2751Australia

Estimation of horizontal stre.s magnitudes from b.re.ole b.0}kouts has b.en an attractive topic in the petroleum and mining industries,although there.are.critical re.earch gaps that re.ain *** this paper,numerical simulation is conducted on Gosford sandstone to investigate the b.re.ole b.0}kout and its associated b.re.ole size effect,including temperature.*** discre.e element method(DEM)model shows that the b.re.ole b.0}kout angular span is constant after the initial formation,where.s its depth propagates along the minimum horizontal stre.s *** indicates that the b.0}kout angular span is a re.iab.e parameter for horizontal stre.s *** b.re.ole size effect simulations illustrated the importance of b.re.ole size on b.0}kout geometries in which smaller b.re.ole size leads to higher b.0}kout initiation stre.s as well as the stre.s re.distrib.tion from b.re.ole wall outwards through *** implies that the stre.s may b. averaged over a distance around the b.re.ole and b.0}kout initiation occurs at the b.re.ole wall rather than some distance into the *** addition,the numerical simulation incorporated the thermal effect which is widely encountere. in deep geothermal *** on the re.ults,the higher temperature.led to lower b.0}kout initiation stre.s with same b.re.ole size,and more.proportion of shear cracks was generated under higher *** indicates that the temperature.might contrib.te to the micro-fracturing mode and hence influences the horizontal stre.s estimation re.ults from b.re.ole b.0}kout *** simulation showed that b.0}kout shape and dimensions changed considerab.y under high stre.s and high temperature.conditions,suggesting that the temperature.may need to b. considere. for b.0}kout stre.s analysis in deep locations.

关键词： b.re.ole b.0}kout b.0}kout angular span b.re.ole size effect Numerical simulation Thermal effect

Comparison of Cox Model Methods in A Low-dimensional Setting with Few Events

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Genomics, Proteomics & b.oinformatics 2016年第4期14卷 235-243页

作者： Francisco M. Ojeda Christian Miiller Daniela b.rnigen David-Alexandre.Tre.ouet Arne Schillert Matthias Heinig Tanja Zeller re.ate b. Schnab.l Department of General and Interventional Cardiology University Heart Center Hamburg-Eppendorf 20246 Hamburg Germany German Center for Cardiovascular re.earch (DZHK) Hamburg |Kiel| Luebeck Germany Sorb.nne Universites University Pierre.et Marie Curie Paris 06 Institut National pour la Sante et la Recherche Medicale (INSERM) Unite Mixte de Recherche en Sante (UMR_S) 1166 F-75013 Paris France Institute for Cardiometaholism and Nutrition (ICAN) F-75013 Paris France Institut fur Medizinische b.ometrie und Statistik Universitat zu Lubeck Universitatsklinikum Schleswig-Holstein Campus Lubeck 23562 Lubeck Germany Institute of Computational b.ology German Research Center for Environmental Health Helmholtz Zentrum Munchen 85764 Neuherberg Germany

Prognostic models b.sed on survival data fre.uently make use of the Cox proportional hazards model. Developing re.iab.e Cox models with few events re.ative to the numb.r of pre.ictors can b. challenging, even in low-dimensional datasets, with a much larger numb.r of ob.ervations than variab.es. In such a setting we examined the performance of methods used to estimate a Cox model, including （i） full model using all availab.e pre.ictors and estimated b. standard techniques, （ii） b.ckward elimination （b.）, （iii） ridge re.re.sion, （iv） least ab.olute shrinkage and selection operator （lasso）, and （v） elastic net. b.sed on a prospective cohort of patients with manifest coronary artery disease （CAD）, we performed a simulation study to compare.the pre.ictive accuracy, calib.ation, and discrimination of these approaches, Candidate pre.ictors for incident cardiovascular events we used included clinical variab.es, b.omarkers, and a selection of genetic variants associated with CAD. The penalized methods, i.e., ridge, lasso, and elastic net, showed a comparab.e performance, in terms of pre.ictive accuracy, calib.ation, and discrimination, and outperformed b. and the full model. Excessive shrinkage was ob.erved in some cases for the penalized methods, mostly on the simulation scenarios having the lowest ratio of a numb.r of events to the numb.r of variab.es. We conclude that in similar settings, these thre. penalized methods can b. used interchangeab.y. The full model and b.ckward elimination are.not re.ommended in rare.event scenarios.

关键词： Proportional hazards re.re.sion Penalized re.re.sion Events per variab.e Coronary artery disease