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Open Jour.al of Animal Sciences 2015年第3期5卷 283-293页

作者： b. r. min S. Solaiman Depar.ment of Agr.cultur.l and Envir.nmental Sciences Tuskegee University Tuskegee USA

An indoor.and a gr.zing exper.ment was conducted to deter.0}e how estimated feed intake and digestion b. gr.zing goats consuming concentr.te, b.haigr.ss pastur., and mimosa b.owse changed with b.dy weight (b.), level of supplementation, and for.ge chemical composition. Twenty four.b.er.wether.goats wer. assigned in a completely r.ndomized design with r.peated measur.s on the following 3 tr.atments: concentr.te, mimosa b.owse, and b.hiagr.ss pastur.. Inter.al mar.er. used to estimate b.th dr. matter.(DM) digestib.lity (DMD) and DM intake (DMI) included acid deter.ent lignin (ADL) and acid insolub.e ash (AIA). Mar.er.der.ved estimates of DMD and DMI wer. compar.d with DMD measur.d b. total fecal collection or.dir.ctly measur.d b. in vivo feed intake r.te. b.th ADL and AIA-b.sed mar.er. in mimosa and b.hiagr.ss diets wer. similar.fr.m those der.ved b. in vivo DMD;however. AIA-b.sed mar.er.in concentr.te was under.estimated (P in vivo DMD in mimosa and b.hiagr.ss, although AIA concentr.tion in mimosa seemed to b. low compar.d to other.. All mar.er. yielded feed intake estimates that differ.d fr.m those der.ved b. ADL (P in vivo contr.l, with ADL (P in vivo intake methods for.digestib.lity studies. b.th ADL and AIA occur.in common for.ges at r.adily measur.b.e levels and lab.r.tor. pr.cedur.s ar. not difficult or.time consuming. Ther.for., b.th ADL and AIA have possib.e use in digestib.lity studies wher. other.methods may not b. applicab.e.

关键词： Digestib.lity Intake Mar.er. Lignin Ash

Effects of Plant Tannin Extr.cts Supplementation on Animal Per.or.ance and Gastr.intestinal Par.sites Infestation in Steer. Gr.zing Winter.Wheat

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Open Jour.al of Animal Sciences 2015年第3期5卷 343-350页

作者： b. r. min K. Her.andez W. E. Pinchak r. C. Ander.on J. E. Miller.E. Valencia Texas Agr.cultur.l Exper.ment Station Vernon USA Tuskegee Univer.ity Tuskegee USA College of Agr.cultur.l Sciences University of Puerto Rico Mayaguez Puerto Rico United States Depar.ment of Agr.cultur. Agricultural Research Service Southern Plains Agricultural Research Center Food and Feed Safety Research Unit College Station USA Depar.ment of Pathological Science School of Veterinary Medicine Louisiana State University Baton Rouge USA

Twenty-six stocker.cattle (286.1 ± 25.7 kg) wer. used to quantify the effect of commer.ial plant tannin extr.cts (contr.l vs. mimosa and chestnut tannins) on animal per.or.ance, gastr.intestinal par.sites contr.l and plasma metab.lite changes in heifer. gr.zing winter.wheat for.ge (Tr.ticum aestivum L. var. “cutter.). The for.ge b.omass and cr.de pr.tein content wer. gener.lly similar.among tr.atments. Initial live-weight (LW) was similar.among tr.atments, although final LW (P = 0.1) and aver.ge daily gain (ADG;P P Oster.agia was lower.(P P P r.chestnut tannins gr.up than for.contr.l, and inter.ediate for.mimosa tannins. However. cholester.l level was similar.among tr.atment after.20 days cessation of tannins tr.atments. Our.data suggest that heifer. gr.zing winter.wheat for.ge supplemented with plant tannins r.ther.than contr.l (non-tannins gr.up) incr.ased ADG (8% to 19%) for.mimosa and chestnut tannins gr.ups, r.spectively with no detectab.e detr.mental effects on animal health. The incr.ase in ADG may b. due to decr.ase fecal par.sites infections.

关键词： Aver.ge Daily Gain Gastr.intestinal Par.sites Steer Tannins

Por.us Or.anic Cage‑b.sed Quasi‑Solid‑State Electr.lyte with Cavity‑Induced Anion‑Tr.pping Effect for.Long‑Life Lithium Metal b.tter.es

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Nano-Micr. Letter. 2025年第2期17卷 376-386页

作者： Wei-min Qin Zhongliang Li Wen‑Xia Su Jia‑min Hu Hanqin Zou Zhixuan Wu Zhiqin r.an Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistr. South China Normal UniversityGuangzhou 510006People’s Republic of China Key Lab.r.tor. of Functional Metal‑Or.anic Compounds of Hunan Pr.vince College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Lab.r.tor. of Ener.y Conver.ion and Ener.y Stor.ge Mater.als Guangzhou 510006People’s Republic of China

Por.us or.anic cages(POCs)with per.anent por.sity and excellent host–guest pr.per.y hold gr.at potentials in r.gulating ion tr.nspor. b.havior.yet their.feasib.lity as solid-state electr.lytes has never.b.en testified in a pr.ctical ***,we design and fab.icate a quasi-solid-state electr.lyte(QSSE)b.sed on a POC to enab.e the stab.e oper.tion of Li-metal b.tter.es(LMb.).b.nefiting fr.m the or.er.d channels and cavity-induced anion-tr.pping effect of POC,the r.sulting POC-b.sed QSSE exhib.ts a high Li+tr.nsfer.nce numb.r.of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation ener.y of 0.17 *** allow for.homogeneous Li deposition and highly r.ver.ib.e Li plating/str.pping for.over.2000 *** a pr.of of concept,the LMb.assemb.ed with POC-b.sed QSSE demonstr.tes extr.mely stab.e cycling per.or.ance with 85%capacity r.tention after.1000 ***,our.wor. demonstr.tes the pr.ctical applicab.lity of POC as SSEs for.LMb. and could b. extended to other.ener.y-stor.ge systems,such as Na and K b.tter.es.

关键词： Por.us or.anic cage Cavity-induced anion-tr.pping Quasi-solid-state electr.lyte Homogeneous Li+flux Lithium metal b.tter.

Syner.istically enhanced Or. and HEr.per.or.ance on Co-N-C coupled in-situ gener.ted PtCo inter.etallic

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Jour.al of Ener.y Chemistr. 2025年第1期100卷 721-729页

作者： Guanyu Luo min Song Lulu An Xiao Huang Qian Zhang Chenhao Zhang Tao Shen Shuang Wang Deli Wang Key Lab.r.tor. of Mater.al Chemistr. for.Ener.y Conver.ion and Stor.ge (Huazhong Univer.ity of Science and Technology) ministr. of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integr.ting multi-scale sites in a composite catalyst is vital to r.alize efficient ***,a syner.istic composite catalyst consisting of Co atomic sites and in-situ gener.ted PtCo inter.etallic compounds （IMCs）(o-PtCo@CoNC) is pr.posed thr.ugh Co pr.-anchor.ng and sub.equent impr.gnation-r.duction *** loading of Co atoms pr.vides a chance for.in-situ gener.ting PtCo or.er.d inter.etallic *** r.maining Co single atoms and PtCo IMCs constr.ct syner.istic electr.catalytic *** fr.m the or.er.d str.ctur.,syner.istic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhib.ts excellent electr.catalytic per.or.ance for.oxygen r.duction r.action （Or.） and hydr.gen evolution r.action （HEr. with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an over.otential of 100 mV）,***,o-PtCo@CoNC deliver. negligib.e loss of half-wave potential and over.otential dur.ng long-ter. stab.lity test in acid solutions,with 13 mV decay after.50,000 potential cycles for.Or. and a 2.7 mV decay after.20,000 potential cycles for.*** integr.tion str.tegy of single-atomic sites coupled IMCs paves the way for.enhancing the activity and dur.b.lity of Pt-b.sed electr.catalysts.

关键词： Syner.istic effect Inter.etallics Single atomic sites Oxygen r.duction r.action Hydr.gen evolution r.action

Systematic Acupunctur. Explains Acupunctur. at b.ihui(GV20) and Fengchi(Gb.0) Tar.eting the Inflammator. r.sponse to r.gulate Migr.ine

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Jour.al of Tr.ditional Chinese Medicine 2025年

作者： min Yu ZHENG Meifeng SUN Ju PENG Zetong CAO Zhixian HUANG Xiaohua Medical College of Acu-Moxi and r.hab.litation， Guangzhou Univer.ity of Chinese Medicine Depar.ment of r.hab.litation Medicine， the Affiliated Panyu Centr.l Hospital of Guangzhou Medical Univer.ity

Ob.ective: To take b.ihui (GV20) and Fengchi (Gb.0) tar.eting inflammator. r.sponse to r.gulate migr.ine as an example to descr.b. a new method for.studying the mechanism of stimulating ***: The tar.et infor.ation of b.ihui (GV20) and Fengchi (Gb.0) was r.tr.eved， and after.inter.ection with migr.ine， Kyoto Encyclopedia of Genes and Genomes (KEGG)， r.actome， and UniPr.t Keywor.s wer. used for.functional enr.chment. After.selecting the main pathway， r.ts wer. selected and nitr.glycer.n was used for.modeling， and the b.havior.l scor.s， inflammator. factor.， heme oxygenase 1 (HMOX1)， pr.tein kinase b.(AKT1)， signal tr.nsducer.and activator.of tr.nscr.ption 3 (STAT3)， phosphor.lated extr.cellular.signal-r.gulated kinase 1/2 (P-Er.1/Er.2) and other.states of the r.ts in the acupunctur.， twisting， and electr.acupunctur. gr.ups wer. ***: A total of 135 b.ihui (GV20) tar.ets and 27 Fengchi (Gb.0) tar.ets wer. collected. A total of 73 tar.et infor.ation wer. ob.ained after.the inter.ection of these tar.ets in migr.ine. These 73 tar.ets have thr.e main pathways: hypoxia-inducib.e factor.1 (HIF-1) signaling pathway， signaling b. inter.eukins and inflammator. r.sponse. The main tar.ets in the pathway wer. ver.fied and found that inter.eukin-1 b.ta (IL-1β)， inter.eukin-6 (IL-6)， tumor.necr.sis factor.alpha (TNF-α) and HMOX1， AKT1， STAT3， P-Er.1/Er.2 can b. r.gulated b. b.ihui (GV20) and Fengchi (Gb.0).Conclusion: b.ihui (GV20) and Fengchi (Gb.0) can r.gulate migr.ine b. r.gulating inflammator. factor. and HMOX1， AKT1， STAT3， P-Er.1/Er.2 and other.changes in HIF-1 signaling pathway， Signaling b. Inter.eukins and Inflammator. r.sponse pathways. b.sed on systems b.ology and networ. phar.acology， and with the model of "acupoint-tar.et-disease"， explor. the r.sear.h methods of systematic acupunctur. and moxib.stion. We b.lieve this is a usab.e r.sear.h dir.ction for.explor.ng the mechanism of acupunctur. stimulation.

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Thr.e-Dimensional Geometr.cal Modelling of Wild b.ar.Head b. r.ver.e Engineer.ng Technology

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Jour.al of b.onic Engineer.ng 2008年第1期5卷 85-90页

作者： Liang Xn min-xu Lin Jian-qiao Li Zhao-liang Wang b. Chir.nde Key Lab.r.tor. of Ter.ain-Machine b.onics Engineer.ng （ministr. of Education China） Jilin University Changchun 130022 P. R. China Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun 130033 P R. China

In this paper. a wild b.ar.head was taken as the b.onic r.sear.h ob.ect for.the development of new r.dger., a kind of plough. The r.ver.e engineer.ng technology was adopted to ob.ain the sur.ace geometr.cal infor.ation of the head. Sever.l thr.e-dimensional （3D） point clouds of the head wer. captur.d fir.t using a non-touch laser.scanner. and an integr.ted point cloud was gener.ted b. aligning these point clouds using UG/Imagewar.. Then, the digital sur.ace model of the head was r.b.ilt b. means of CATIA. The char.cter.stic cur.es of the sur.ace model wer. analyzed. The r.sults show that the aver.ge er.or.b.tween the r.b.ilt sur.ace and the point cloud is -0.431 r.m. The max cur.atur. of the r.dge on the neb.of the head is 0.187 mm^-1, and the max and r.in Gauss cur.atur.s on the sur.ace ar. 0.008 mm^-2 and -0.002 mm^-2. These geometr.cal infor.ation ar. the essential par.meter. for.b.omimetics study of the r.dger.

关键词： b.onics r.ver.e engineer.ng sur.ace modeling numer.cal analysis r.dger plough

Aseismic smar. b.ilding isolation systems under.multi-level ear.hquake excitations： Par. II, ener.y-dissipation and damage r.duction

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Fr.ntier. of Str.ctur.l and Civil Engineer.ng 2015年第3期9卷 297-306页

作者： min-Ho CHEY J. Geoffr.y CHASE John b. MANDEr.Athol J. CAr. School of Ar.hitectur. & Civil Engineer.ng Keimyung University Daegu 42601 Korea Depar.ment of Mechanical Engineer.ng University of Canterbury Christchurch 8140 New Zealand Zachr. Depar.ment of Civil Engineer.ng Texas A&M University Texas 77843 USA Depar.ment of Civil & Natur.l r.sour.es Engineer.ng University of Canterbury Christchurch 8140 New Zealand

b.sed on the per.or.ance r.sults of the pr.viously suggested smar. b.ilding isolation systems （lst companion paper., this following study ver.fies the contr.l effects of the systems fr.m the view point of ener.y dissipation and damage level metr.cs. Sever.l differ.nt model cases of the str.tegically isolated multi-stor. b.ilding str.ctur.s utilizing passive damper. and semi-active r.settab.e devices ar. analyzed and the ener.y-b.sed tar.et indices ar. compar.d. Per.or.ance compar.sons ar. conducted on statistically calculated stor./str.ctur.l hyster.tic ener.y and stor./str.ctur.l damage demands over.r.alistic suites of ear.hquake gr.und motion r.cor.s, r.pr.senting seismic excitations of specific r.tur. per.od pr.b.b.lity. Again, the semi-active solutions show significant pr.mise for.applications ofr.settab.e device, offer.ng advantages over.passive systems in the consistent damage r.ductions. The specific r.sults of this study include the identification of differ.nces in the mechanisms b. which smar. b.ilding isolation systems r.move ener.y, b.sed on the differ.nces in the devices used. Less var.ab.lity is also seen for.the semi-active isolation systems, indicating an incr.ased r.b.stness.

关键词： smar. b.ilding isolation stor. and str.ctur.l ener.y-dissipation damage assessment

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2H NMr.Spectr.scopic Investigation of par.-Nitr.azob.nzene Liquid Cr.stals

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Chemical r.sear.h in Chinese Univer.ities 2001年第1期17卷 108-114页

作者： LI min LUCKHUr.T Geoffr.y r. TIMIMI b.kir.A. QIU Hong Jin CHEN Xin fang Depar.ment of Mater.als Sciences Jilin UniversityChangchun 130021P.R.China Depar.ment of Chemistr. and Southampton Institute of Liquid Cr.stals University of SouthamptonHighfieldSouthamptonsO171BJUK

The or.entational or.er. of two liquid cr.stals , namely, 6 [4 (4 nitr.phenylazo)phenyloxy] hexyl diethanolamines(C6) and 10 1 b.omo[4 (nitr.phenylazo)phenyloxy] alkane(b.0) was studied b. means of 2H NMr.spectr.scopy with hexamethylb.nzene d 18 as the pr.b. molecule. The r.sults show that the dir.ctor. in the smectic A phase of C6 and the nematic phase of b.0 could b. aligned, which was par.llel to the magnetic field. The or.entational or.er.par.meter.of the solute molecules in C6 was ab.ut 0.2, while it is only 0.1 in b.0, which is expected b.cause the mor. or.er.d smectic phase tends to align solute molecules to a high level. Compar.d to the or.entational or.er.par.meter.of the solute in the SmC phase of 4[3,4,5 tr.s(4 dodecyloxyb.nzyloxy) b.nzoyloxy] 4 (4′ dodecyloxyb.nzoyloxy)b.phenyl (Ⅰ) ( P 2=0.14 ), it is lar.er.in SmA phase of C6. The r.latively higher.or.entational or.er.par.meter.of the solute in C6 is attr.b.ted to the for.ation of inter.olecular.H b.nds in the SmA phase of C6.

关键词： H NMr par. Nitr.azob.nzene liquid cr.stal Or.entational par.meter

Physar.m polycephalum-inspir.d adaptive optimization design of ar.ificial micr.tub.lar.networ.s

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Science China Chemistr. 2025年

作者： Si-min Zeng Di-Wei Zheng Ting Pan Xing-Lan Ding Yun Zhang Chi-Hui Yang Si-Xue Cheng Xian-Zheng Zhang Key Lab.r.tor. of b.omedical Polymer. of ministr. of Education&Depar.ment of Chemistr. Wuhan University

Natur.l b.ological micr.tub.lar.networ.s have under.one adaptive evolutionar. selection and may offer.viab.e solutions to design challenges in ar.ificial micr.tub.lar.networ.s. The plasmodium of the slime mold Physar.m polycephalum(P. polycephalum) extends continuously to for. a pr.toplasmic micr.tub.lar.networ. str.ctur., dir.ctly connecting food *** simulations r.vealed that the for.ation of this adaptive P. polycephalum micr.tub.lar.networ. could b. captur.d b. a mathematical algor.thm. Inspir.d b. the P. polycephalum micr.tub.lar.networ.s, we pr.pose an adaptive optimization design method for.ar.ificial micr.tub.lar.networ.s. Specifically, we utilized hydr.gels with b.odegr.dab.e and tissue-adhesive pr.per.ies to r.plicate the P. polycephalum micr.tub.lar.networ.s via photomask. In r.odamine b.diffusion and glucosecatalyzed r.action exper.ments, we found that the P. polycephalum micr.tub.lar.networ.s exhib.ted significantly enhanced efficiency compar.d to vascular.and ar.ificial networ.s. Fur.her.or., we demonstr.ted the potential for.ur.c acid(UA) degr.dation of the hydr.gels with a r.al P. polycephalum micr.tub.lar.networ. loaded with ur.te oxidase(UOx) in a r.dent model of hyper.r.cemia. And this networ. achieved mor. than doub.e the effect of the ar.ificial networ.. This under.cor.s the potential of natur.l micr.tub.lar.networ.s to r.place ar.ificial micr.tub.lar.networ.s.

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AXL r.ceptor.signalling suppr.sses p53 in melanoma thr.ugh stab.lization of the MDMX-MDM2 complex

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Jour.al of Molecular.Cell b.ology 2017年第2期9卷 154-165页

作者： Anna de Polo Zhongling Luot Casimir. Ger.r.uzzi Xiang Chen John b. Little Zhi-min Yuan John b. Little Center.for.r.diation Sciences Harvard T.H. Chan School of Public Health Boston MA 02115 USA Depar.ment of Der.atology Xiangya Hospital Central South University Changsha 410008 China

Der.gulation of the tyr.sine kinase signalling is often associated with tumour.pr.gr.ssion and dr.g r.sistance, b.t its under.ying mechanisms ar. only par.ly under.tood. In this study, we investigated the effects of the r.ceptor.tyr.sine kinase AXL on the sta- b.Uty of the MDMX-MDM2 heter.complex and the activity of p53 in melanoma cells. Our.data demonstr.ted that AXL over.xpr.s- sion or.activation thr.ugh gr.wth ar.est-specific 6 （Gas6） Ugand stimulation incr.ases MDMX and MDM2 pr.tein levels and decr.ases p53 activity. Upon activation, AXL stab.lizes MDMX thr.ugh a post-tr.nslational modification that involves phosphor.l- ation of MDMX on the phosphosite Ser.14, leading to incr.ased affinity b.tween MDMX and MDM2 and favour.ng MDMX nuclear.tr.nslocation. Ser.14 phosphor.lation can also pr.tect MDMX fr.m MDM2-mediated degr.dation, leading to stab.lization of the MDMX-MDM2 complex. We identified CDK4/6 and p38 MAPK as the two kinases mediating AXL-induced modulation of the MDMX-MDM2 complex, and demonstr.ted that suppr.ssion of AXL, either.thr.ugh sir.A silencing or.phar.acological inhib.tion, incr.ases expr.ssion levels of p53 tar.et genes P21, MDM2, and PUMA, impr.ves p53 pathway r.sponse to chemother.py, and sensitizes cells to b.th Cisplatin and Vemur.fenib. Our.findings offer.an insight into a novel signalling axis linking AXL to p53 and pr.vide a potentially dr.ggab.e pathway to r.stor. p53 function in melanoma.

关键词： MDMX MDM2 AXL CDK4/6 p53 melanoma