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Ne. and Ne.e. Vaccine. for SARS-CoV-2 Variants. Are.the.Major Vaccine.De.e.ope.s on the.Right Track, Or Is De.ipidation the.Answe.?

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Advance. in Infe.tious Dise.se. 2021年第2期11卷 165-170页

作者： b. e. cham Australasian Institute.of Me.ical Re.e.rch Port Vila Republic of Vanuatu

b.ckground: Glob.l Covid-19 pande.ic has le. to re.arkab.e.scie.tific achie.e.e.ts re.ulting in the.de.e.opme.t and rapid imple.e.tation of vaccine. towards the.original wild-type.SARS-CoV-2 virus. Most Covid-19 vaccine. are.targe.e. to only one.prote.n (the.Spike.prote.n) on the.virus. SARS-CoV-2 that cause. Covid-19 naturally unde.goe. multiple.mutations ove. time. Such mutations can b. inconse.ue.tial or have.dire.conse.ue.ce.. The.lack of e.fe.tive.e.s of curre.t vaccine. towards mutate. variants of Covid-19 is of major conce.n. The.ob.e.tive.of this study is to de.crib. an optimal solve.t syste. that cre.te., via de.ipidation, a non-synthe.ic, host-de.ive. or nonhost-de.ive. modifie. viral particle.that has its lipid e.ve.ope.re.ove., e.posing hidde. unde.ature. prote.ns from within the.virus, that ge.e.ate.a positive.immunologic re.ponse.whe. administe.e. into a host, the.e.0} providing a vaccine.that offe.s strong and b.oad prote.tion against the.virus. Me.hods: Lipid re.oval from viruse. b. spe.ific proce.ure. re.de.s the.e.posure.of hidde. prote.ns. Prote.tion b. antib.die. to all of the.virus’ prote.n type. has shown to b. far supe.ior to prote.tion b. antib.die. that are.cre.te. b. a single.prote.n type. Re.ults: Pub.ishe. studie. with the.He.atitis virus, Pe.tivirus and HIV virus have.re.orte. the.wide.range.of applications with this de.ipidation approach re.ulting in e.fe.tive.y long-te.m and b.oad prote.tion vaccine.. Conclusion: Mutations are.re.de.ing e.isting vaccine. le.s e.fe.tive. Ne. approache. to ob.ain a more.pe.mane.t vaccine.that minimize. the.e.fe.ts of mutation are.ob.ainab.e.b. de.ipidation of the.viral particle.and the.e.0} cre.ting vaccine. that are.more.pe.mane.t with b.oad prote.tion.

关键词： SARS-CoV-2 Covid-19 Spike.Prote.n Variant Mutation Vaccine Virus b.tanol Diisopropyle.he. De.ipidation Total Prote.n

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Comb.nation Tre.tme.t with b.C and Cisplatin Syne.gistically Augme.ts Anticance. Activity and Re.ults in Incre.se. Ab.olute.Survival

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Journal of Cance. The.apy 2020年第8期11卷 470-482页

作者： b. e. cham Australasian Me.ical Re.e.rch Port Vila Republic of Vanuatu

Plant-de.ive. b.C with its main compone.t solamargine.posse.se. anticance. activitie. via its e.fe.t on a varie.y of b.ological pathways in a wide.range.of human cance. ce.ls. High cure.rate. with b.C the.apy have.b.e. ob.aine. in animals with de.dly cance.s, and, in humans with te.minal cance.s promising re.ults have.b.e. re.orte.. At a clinical le.e., optimal conce.trations of b.C have.b.e. e.tab.ishe. in a topical cre.m formulation Curade.m, for e.fe.tive.re.oval of skin cance.s, b.t optimal conce.trations of b.C have.not b.e. re.orte. for othe. cance.s. The.ob.e.tive.of this study was to de.e.mine.whe.he. comb.nation the.apy of Cisplatin with b.C would re.ult in syne.gism using cure.rate. as e.d points. b.C on its own cure. Sarcoma 180 in mice. whe.e.s, Cisplatin on its own has no e.fe.t on Sarcoma 180 activity. A comb.nation of b.C and Cisplatin shows syne.gism, re.ulting in highe. cure.rate. than b.C and Cisplatin at comparab.e.individual conce.trations.

关键词： b.C Solamargine Cisplatin Curade.m Anti-Cance.

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First in Man Topical Tre.tme.t of Me.anoma with Solasodine.Glycoside. in a Formulation Curade.m: A Case.Re.ort

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Journal of Cance. The.apy 2020年第10期11卷 617-630页

作者： b. e. cham Australasian Me.ical Re.e.rch Port Vila Republic of Vanuatu

b.ckground: The.e.is ample.e.ide.ce.to support the.safe.y and e.ficacy of the.topical anticance. cre.m Curade.m in the.tre.tme.t of non-me.anoma skin cance.s. Curade.m contains the.natural glycoalkaloid solamargine.in... 详细信息

b.ckground: There is ample evidence to support the safety and efficacy of the topical anticancer cream Curaderm in the treatment of non-melanoma skin cancers. Curaderm contains the natural glycoalkaloid solamargine in the form of BEC, which has been established as a novel antineoplastic agent. BEC is the initials of the inventor of the described technology. It is known that BEC expresses anti-melanoma properties in cell culture and animals. Because of potential metastasis, clinical work with BEC on melanoma was stalled. However, recent studies show that BEC has anti-metastatic properties and this, together with currently better understanding of the mode of anti-cancer actions of BEC, has led to the treatment of a patient who refused to have surgery for her clinically diagnosed stage II melanoma. b.Treatment: b.A 67-year woman had a birthmark that developed into a clinically diagnosed stage II melanoma and was treated with topical application of Curaderm twice daily for 7 weeks. b.Results:b. The pattern of response of the melanoma to Curaderm therapy was similar to that observed when basal cell carcinoma is treated with Curaderm. The melanoma responded rapidly to the treatment and in 7 weeks the lesion was removed with no demonstrable side effects. The cosmetic end result was very acceptable. b.Conclusion:b.e."font-family:Ve.dana;"> The.clinical re.olution of the.me.anoma with Curade.m pharmacothe.

关键词： Me.anoma Curade.m b.C Solamargine Non-Me.anoma Skin Cance. Me.astasis

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Curade.m, the.Long-Awaite. b.e.kthrough for b.sal Ce.l Carcinoma

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Inte.national Journal of Clinical Me.icine 2020年第10期11卷 579-604页

作者： T. Chase.K. e. cham b. e. cham Australasian Me.ical Re.e.rch Port Vila Republic of Vanuatu

b.ckground: b.sal ce.ls form a continuous ce.l laye. at the.b.ttom of the.e.ide.mis, which is the.oute.most laye. of the.skin. b.sal ce.l carcinoma occurs whe. a mutation occurs in the.DNA of a b.sal ce.l. The.mutation inhib.ts apoptosis—the.programme. ce.l de.th me.hanism. The.ce.l continue. to multiply b.t doe. not die. re.ulting in a change.in the.skin, such as a growth or sore.that will not he.l. b.sal ce.l carcinoma is the.most common form of skin cance. and the.most fre.ue.tly occurring form of all cance.s. Ke. words se.rche. for the.datab.se.of this communication we.e. Curade.m, b.C 5, cance., skin cance., b.sal ce.l carcinoma, nonme.anoma skin cance., solamargine. solasonine.and solasodine.glycoside.. Tre.tme.ts: Se.e.al type. of tre.tme.ts are.availab.e.to re.ove.or de.troy b.sal ce.l carcinoma. All curre.tly use. tre.tme.ts are.indiscriminate.and also re.ove.or de.troy normal skin ce.ls re.ulting in compromise. cosme.ic outcome.. De.e.opme.t of Curade.m Pharmacothe.apy: Curade.m pharmacothe.apy discriminate. and spe.ifically activate. apoptosis at the.mole.ular le.e. in cance. ce.ls b.t not in normal ce.ls. Accordingly, Curade.m pharmacothe.apy for b.sal ce.l carcinoma e.fe.tive.y and safe.y tre.ts virtually all type., size. and le.ion locations. This re.ie. de.crib.s studie. from the.ince.tion of Curade.m pharmacothe.apy and cove.s the.discove.y of the.anti-cance. e.fe.ts, mode.of action, pre.linical, clinical and fie.d applications with e.phasis on e.ficacy, safe.y, compliance. tole.ance. cost e.fe.tive.e.s and e.pe.ially cosme.ic outcome. In 2018 Curade.m was approve. b. the.e.rope.n He.lth Authoritie. as a Me.ical De.ice.Class 1 for the.indication “Topical Tre.tme.t with Ke.atolytic Action, and Antine.plastic Activity in the.Tre.tme.t and He.ling of Localize. b.sal Ce.l Carcinoma of the.Skin”.

关键词： b.sal Ce.l Carcinoma Skin Cance. b.C Solamargine Curade.m Topical Pharmacothe.apy

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e.aluation of De.mal Irritation and Skin Se.sitization b. Curade.m

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Inte.national Journal of Clinical Me.icine 2020年第9期11卷 548-558页

作者： T. Chase.K. e. cham b. e. cham Australasian Me.ical Re.e.rch Port Vila Republic of Vanuatu

Purpose. To e.tab.ish whe.he. Curade.m, a topical pharmacothe.apy for skin cance., irritate. or se.sitize. normal skin. Me.hods: The.de.mal irritation and skin se.sitization toxicity of Curade.m we.e.inve.tigate. in rab.its and guine. pigs in compliance.with the.Organization for e.onomic Coope.ation and De.e.opme.t guide.ine. To asse.s de.mal irritation, rab.its we.e.de.mally e.pose. to Curade.m for varying pe.iods of time. To asse.s hype.se.sitivity, the.guine.-pig maximisation te.t was applie.. Re.ults: Curade.m was only ne.ligib.y irritating using the.crite.ia of e.ythe.a and oe.e.a. Curade.m did not produce.any se.sitization toxicity of the.skin. Conclusion: The.e.studie. confirm the.non-toxic ob.e.vations on normal skin e.pe.ie.ce. in the.clinical se.ting whe. tre.ting skin cance. and re.nforce.the.spe.ificity of Curade.m towards cance. ce.ls.

关键词： Curade.m b.C Solamargine Skin Cance. De.mal Irritation Skin Se.sitization Psoriasis

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A simple.me.hod for automatic re.re.tion of railway horizontal alignme.ts

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RAILWAY e.GINe.RING SCIe.Ce 2025年第1期33卷 62-78页

作者： Castro, Alb.rte.Casal, Ge.ardo Santamarina, Duarte.Vazque.-Me.de., Migue. e. Univ Santiago De.Composte.a Transportat & Infrastruct Engn EPSE Rua Benigno Ledo Lugo 27002 Spain Univ Santiago De.Composte.a Dept Appl Math EPSE Rua Benigno Ledo Lugo 27002 Spain CITMAga Rua Constantino Candeira Santiago De Compostela 15782 Spain

This pape. de.ls with the.prob.e. of re.re.ting horizontal alignme.ts of e.isting railway line.. The.main ob.e.tive.is to propose.a simple.me.hod for automatically ob.aining optimize. re.re.te. alignme.ts locate. as close.as possib.e.to an e.isting one. b.se. on a pre.iously de.ine. ge.me.ric mode., two diffe.e.t constraine. optimization prob.e.s are.formulate.. The.first prob.e. use. only the.information provide. b. a se. of points re.re.e.ting the.track ce.te.line.while.the.se.ond one.also conside.s additional data ab.ut the.e.isting alignme.t. The.propose. me.hodology consists of a two-stage.proce.s in which b.th prob.e.s are.solve. conse.utive.y using nume.ical te.hnique.. The.main re.ults ob.aine. applying this me.hodology are.pre.e.te. to show its pe.formance.and to prove.its practical use.ulne.s: an acade.ic e.ample.use. to compare.with othe. me.hods, and a case.study of a railway se.tion locate. in Parga (Spain) in which the.ge.me.ry of its horizontal alignme.t is succe.sfully re.ove.e..

关键词： Railway horizontal alignme.t Ge.me.rical mode. Constraine. optimization prob.e. Nume.ical re.olution

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Plant-sub.trate.b.ochar prope.tie. critical for me.iating re.uctive.de.0}omination of 1,2-dib.omoe.hane

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Journal of e.vironme.tal Scie.ce. 2025年第1期147卷 1-10页

作者： Jonathan H.Lindhardt Pe.e. e.Holm Yong-Guan Zhu Changyong Lu Hans Christian b.Hanse. De.artme.t of Plant and e.vironme.tal Scie.ce. Faculty of ScienceUniversity of CopenhagenThorvaldsensvej 401871 Frederiksberg CDenmark Ke. lab.of Urb.n e.vironme.t and He.lth Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Sino-Danish Ce.te. for e.ucation and re.e.rch China and DenmarkDalgas Avenue 4DK-8000 Aarhus C.Denmark

Dib.omoe.hane.is a wide.pre.d,pe.siste.t organic *** are.known me.iators of re.uctive.de.aloge.ation b. laye.e. Fe.(Ⅱ)-Fe.(Ⅲ)hydroxide.(gre.n rust),which can re.uce.1,2-dib.omoe.hane.to innocuous b.omide.and ***,the.critical characte.istics that de.e.mine.me.iator functionality are.le.se. *** b.ochar sub.trate. we.e.pyrolyze. at 600℃and 800℃,characte.ize. b. e.e.e.tal analysis,X-ray photo spe.trome.ry C and N surface.spe.iation,X-ray powde. diffraction,spe.ific surface.are. analysis,and te.te. for me.iation of re.uctive.de.0}omination of 1,2-dib.omoe.hane.b. a gre.n rust re.uctant unde. anoxic conditions.A statistical analysis was pe.forme. to de.e.mine.the.b.ochar prope.tie.,critical for de.0}omination kine.ics and total de.0}omination *** was shown that se.e.te. plant b.se. b.ochars can me.iate.de.0}omination of 1,2-dib.omoe.hane.that the.highe.t first orde. rate.constant was 0.082/hr,and the.highe.t de.0}omination e.te.t was 27%in re.ctivity e.pe.ime.ts with 0.1μmol(20μmol/L)1,2-dib.omoe.hane.≈22 mmol/L Fe.(Ⅱ)GR,and 0.12 g/L soyb.an me.l b.ochar(7 days).Conte.ts of Ni,Zn,N,and P,and the.re.ative.contrib.tion of quinone.surface.functional groups we.e.significantly(pe.y corre.ate. with 1,2-dib.omoe.hane.de.0}omination,while.adsorption,spe.ific surface.are.,and the.re.ative.contrib.tion of pyridinic N oxide.surface.groups we.e.significantly ne.ative.y corre.ate. with de.0}omination.

关键词： e.vironme.tal re.e.iation b.ochar Pe.siste.t organic pollutants(POPs) e.vironme.tal catalysis Gre.n rust

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Se.ime.t Quality Asse.sme.t on b.rtle.t Pond in Lare.o, Southe.n Te.as, USA

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Ope. Journal of Soil Scie.ce 2025年第1期15卷 43-69页

作者： Maya P. b.att Gane.h b. Malla Ame.e.Rub.o Alfre. Addo-Me.sah De.artme.t of b.ology and Che.istry Texas A&M International University University Boulevard Laredo Texas USA De.artjme.t of Mathe.atics Computer Geology and Physics University of Cincinnati-Clermont College Clermont Drive Batavia OH USA

This study e.aluate. the.dynamics of trace.me.als impacts on the.e.osyste.s of the.b.rtle.t Pond, a small shallow we.land pond locate. in Lare.o, Te.as b. analyzing se.ime.t sample. take. from four quadrants of the.pond. The.conce.trations of trace.e.e.e.ts in se.ime.t sample. are.highe.t for iron (Fe., followe. b. chromium (Cr), the. le.d (Pb., with lowe. conce.tration of antimony (Sb., cob.lt (Co), arse.ic (As), cadmium (Cd), and the.lowe.t conce.tration b.ing thallium (Tl) within b.rtle.t Pond. The.se.ime.t quality of the.pond is acce.tab.e.for organisms and the.e.vironme.t as trace.e.e.e.t conce.trations (e.g. As, Cd, Cr, and Pb. are.within the.prob.b.e.e.fe.t conce.tration (Pe.) of National Oce.n and Atmosphe.ic Administration (NOAA) guide.ine. although the.Pe. value. for Co, Fe. Sb.and Tl are.not give.. b.variate.and multivariate.corre.ation analysis shows that most trace.e.e.e.ts e.hib.t a strong positive.corre.ation among the. indicating the.same.anthropoge.ic source. and b.oge.che.ical proce.se. control the.e.trace.e.e.e.ts conce.trations within the.pond. We.provide. a compre.e.sive.snapshot of trace.e.e.e.t conce.trations in se.ime.ts through de.criptive.analysis, laying the.foundation for future.e.vironme.tal risk asse.sme.ts. Corre.ation analysis of e.ght trace.e.e.e.ts he.pe. ide.tify re.ationships, offe.ing insights into pollution source. and pote.tial he.lth impacts. Additionally, univariate.and multivariate.pre.ictive.analyse. ge.e.ate. nume.ous mode.s, e.te.ding b.yond the.inte.pre.ation of partial and full re.re.sion coe.ficie.ts. We.also include. graphical analyse. of trace.e.e.e.t variations, which are.critical for unde.standing e.vironme.tal proce.se. and ge.che.ical patte.ns. The.e.findings advance.our unde.standing ab.ut trace.me.als dynamics in se.ime.ts and may b. a valuab.e.re.e.e.ce.for e.osyste.s and e.vironme.tal manage.e.t of diffe.e.t landscape..

关键词： Trace.e.e.e.ts Se.ime.t We.lands b.rtle.t Pond e.osyste. e.ology

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Ne.roinflammation re.isite. through the.microglial le.s

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Ne.ral Re.e.e.ation Re.e.rch 2025年第7期20卷 1989-1990页

作者： Re.ato Socodato João b.Re.vas Institute.of Re.e.rch and Innovation in He.lth(i3S)and Institute.for Mole.ular and Ce.l b.ology(Ib.C) University of PortoPortoPortugal De.artme.t of b.ome.icine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Ne.roimmunology is e.e.ging as a pivotal fie.d,she.ding light on the.intricate.dialogue. b.twe.n the.ce.tral ne.vous syste.(CNS)and the.immune.*** e.ploration is particularly significant in unde.standing microglia,the.CNS’s innate.immune.ce.ls,b.yond the.conve.tional conflation of“ne.roinflammation”and“microglial activation.”This conflation has cloude. the.true.comple.ity of the.e.proce.se.,pote.tially stalling scie.tific progre.s and the.de.e.opme.t of ne. *** challe.ge.the.long-standing pe.spe.tive. that have.ove.simplifie. the.e.inte.actions,advocating for a de.pe. e.ploration of the.dynamic re.ationship b.twe.n ne.roinflammation and microglial *** disse.ting spe.ific mole.ular pathways,we.aim to illuminate.the.r e.ab.rate.role. in ne.roinflammatory re.ponse.,e.pe.ially in the.conte.t of Alzhe.me.’s dise.se.AD).He.e.ne.roinflammation is not me.e.y a passive.ob.e.ve. or a dire.t antagonist b.t a comple. age.t in the.dise.se.s *** article.calls for a significant paradigm shift towards an inte.rative.multi-omics approach to *** such a compre.e.sive.frame.ork is crucial for advancing our unde.standing of ne.roinflammatory conditions and paving the.way for targe.e. the.ape.tic strate.ie. for b.ain dise.se..

关键词： inflammation simplifie. activation

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基于神经网络ODe.非线性MPC的De.建模与控制

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自动化学报 2025年第1期51卷 186-196页

作者：黄鹏王亚午吴俊东苏春翌福岛 e.文彦中国地质大学(武汉)自动化学院武汉430074 复杂系统先进控制与智能自动化湖北省重点实验室武汉430074 地球探测智能化技术教育部工程研究中心武汉430074 东京工科大学工学部日本东京192-0982 康考迪亚大学Gina Cody工程与计算机科学学院加拿大蒙特利尔QC H3G 1M8

针对介电弹性体驱动器(Die.e.tric e.astome. actuator,De.)建模与控制的挑战性问题,提出基于神经网络常微分方程(Ordinary diffe.e.tial e.uation,ODe.和非线性模型预测控制(Mode. pre.ictive.control,MPC)的De.动力学建模与跟踪控制方法.首先,基于神经网络ODe.立De.的动力学模型以描述其复杂的动态行为.然后,基于所建立的De.动力学模型,设计非线性模型预测控制器实现其跟踪控制目标.最后,在所搭建的实验平台上进行一系列跟踪控制实验.在所有实验结果中,De.的运动均能很好地跟踪目标轨迹,且相对均方根误差均不超过3.30%,说明了所提动力学建模与跟踪控制方法的有效性.

关键词：介电弹性体驱动器神经网络常微分方程动力学建模非线性模型预测控制

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