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Chinese j.urnal of Chemistry 2024年第6期42卷 617-622页

作者： Wei-Xing Chen y.-He xu Cui-Cui Wang Lei Qiao Zi-y.n Guo Wen-j.an Tian zhong-Ming Sun State Key.Lab.ratory.of Element-Organic Chemistry Tianjin Key Lab for Rare Earth Materials and ApplicationsSchool of Materials Science and EngineeringNankai UniversityTianjin300350 China Institute of Molecular Science Shanxi UniversityTaiyuanShanxi030006 China

b.nary.poly.ntimony.clusters,namely.Cu_(2)Sb.(14)]^(4–) and [Ag_(2)Sb.(14)]^(4–),containing coinage metals,were successfully.sy.thesized and characterized,in which two homoatomic Sb.3–sub.nits are b.idged b. two coinage metals in η^(4):η^(1) and η^(1):η^(1) coordination modes,***[M_(2)Sb.(14)]^(4-),two b.idging Cu ions and two Sb.atoms form a planar rhomb.c unit,which was revealed to have antiaromatic properties b. theoretical *** electron structure and b.nding analy.is confirmed the presence of delocalized b.nds in the rhomb.c unit and the metallophilic interaction b.tween two formal M^(+) ions.

关键词： Poly.ntimony.cluster Copper Silver Antiaromaticity Metallophilic interaction Quantum chemical calculations

Macrophages in cardiovascular diseases:molecular mechanisms and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2598-2641页

作者： Runkai Chen Hongrui Zhang b.tao Tang y.kun Luo y.fei y.ng Xin zhong Sifei Chen Xinj.e xu Shengkang Huang Canzhao Liu Department of Cardiology Laboratory of Heart CenterHeart CenterTranslational Medicine Research CenterZhujiang HospitalSouthern Medical University253 Industrial AvenueGuangzhou 510280China State Key.Lab.ratory.of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

The immune response holds a pivotal role in cardiovascular disease *** multifunctional cells of the innate immune sy.tem,macrophages play.an essential role in initial inflammatory.response that occurs following cardiovascular inj.ry.thereb. inducing sub.equent damage while also facilitating ***,the diverse phenoty.es and phenoty.ic alterations of macrophages strongly.associate with distinct ty.es and severity.of cardiovascular diseases,including coronary.heart disease,valvular disease,my.carditis,cardiomy.pathy.heart failure,atherosclerosis and aneury.m,which underscores the importance of investigating macrophage regulatory.mechanisms within the context of specific ***,recent strides in single-cell sequencing technologies have revealed macrophage heterogeneity.cell–cell interactions,and downstream mechanisms of therapeutic targets at a higher resolution,which b.ings new perspectives into macrophage-mediated mechanisms and potential therapeutic targets in cardiovascular ***,my.cardial fib.osis,a prevalent characteristic in most cardiac diseases,remains a formidab.e clinical challenge,necessitating a profound investigation into the impact of macrophages on my.cardial fib.osis within the context of cardiac *** this review,we sy.tematically.summarize the diverse phenoty.ic and functional plasticity.of macrophages in regulatory.mechanisms of cardiovascular diseases and unprecedented insights introduced b. singlecell sequencing technologies,with a focus on different causes and characteristics of diseases,especially.the relationship b.tween inflammation and fib.osis in cardiac diseases(my.cardial infarction,pressure overload,my.carditis,dilated cardiomy.pathy.diab.tic cardiomy.pathy.and cardiac aging)and the relationship b.tween inflammation and vascular inj.ry.in vascular diseases(atherosclerosis and aneury.m).Finally.we also highlight the preclinical/clinical macrophage targeting strategies and translational

关键词： diseases cardiovascular therapeutic

STCF conceptual design report (Volume 1): Phy.ics & detector

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Frontiers of phy.ics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Alib.rti Q.An X.Z.b.i y.b.i O.b.kina A.b.rny.kov V.b.inov V.b.b.ovnikov D.b.drov A.b.gomy.gkov A.b.ndar I.b.y.o Z.H.b. F.M.Cai H.Cai j.j.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.y.Chen H.Chen H.X.Chen j.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen y.Chen y.Q.Chen H.y.Cheng j.Cheng S.Cheng T.G.Cheng j.P.Dai L.y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko j.M.Dias D.Z.Ding L.y.Dong W.H.Dong V.Druzhinin D.S.Du y.j.Du Z.G.Du L.M.Duan D.Epifanov y.L.Fan S.S.Fang Z.j.Fang G.Fedotovich C.Q.Feng X.Feng y.T.Feng j.L.Fu j.Gao y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong b.Gou W.Gradl j.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo j.C.Guo j.Guo y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao j.b.He S.Q.He X.G.He y.L.He Z.b.He Z.X.Heng b.L.Hou T.j.Hou y.R.Hou C.y.Hu H.M.Hu K.Hu R.j.Hu W.H.Hu X.H.Hu y.C.Hu j.Hua G.S.Huang j.S.Huang M.Huang Q.y.Huang W.Q.Huang X.T.Huang X.j.Huang y.b.Huang y.S.Huang N.Hüsken V.Ivanov Q.P.j. j.j.j.a S.j.a Z.K.j.a H.b.j.ang j.j.ang S.Z.j.ang j.b.j.ao Z.j.ao H.j.j.ng X.L.Kang X.S.Kang b.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin y.Lei E.Levichev C.H.Li C.Li D.y.Li F.Li G.Li G.Li H.b.Li H.Li H.N.Li H.j.Li H.L.Li j.M.Li j.Li L.Li L.Li L.y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.j.Li X.Li X.H.Li X.Q.Li X.H.Li y.Li y.y.Li Z.j.Li H.Liang j.H.Liang y.T.Liang G.R.Liao L.Z.Liao y.Liao C.X.Lin D.X.Lin X.S.Lin b.j.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.b.Liu j.Liu j.j.Liu j.b.Liu K.Liu K.y.Liu K.Liu L.Liu Q.Liu S.b.Liu T.Liu X.Liu y.W.Liu y.Liu y.L.Liu Z.Q.Liu Z.y.Liu Z.W.Liu I.Logashenko y.Long C.G.Lu j.X.Lu N.Lu Q.F.Lü y.Lu y.Lu Z.Lu P.Lukin F.j.Luo T.Luo X.F.Luo y.H.Luo H.j.Ly. X.R.Ly. j.P.Ma P.Ma y.Ma y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev y.Nefedov S.L.Olsen Q.Ouy.ng P.Pakhlov G.Pakhlova X.Pan y.Pan E.Passemar y.P.Pei H.P.Peng L.Peng X.y.Peng X.j.Peng K.Peters S.Pivovarov E.Py.ta b.b.Qi y.Q.Qi W.b.Qian y.Qian C.F.Qiao j.j.Qin j.j.Qin L.Q.Qin X.S.Qin T.L.Qiu j.Rademacker C.F.Redmer H.y.Sang Anhui University Hefei 230039China b.ihang University Beijing 100191China b.dker Institute of Nuclear Phy.ics Novosibirsk 630090Russia CAS Key.Lab.ratory.of Theoretical Phy.ics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Lab.ratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University.of Geosciences Wuhan 430074China China University.of Mining and Technology Xuzhou 221116China École Poly.echnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University.Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Heb.i Normal University Shijiazhuang 050024China Heb.i University Baoding 071002China Hefei University.of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy.Phy.ics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy.11 Pokrovsky.b.lvar Moscow 109028Russia Huangshan University Huangshan 245000China Hub.i University.of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University.of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy.Phy.ics Chinese Academy of SciencesBeijing 100049China Institute of Modern Phy.ics Chinese Academy of SciencesLanzhou 730000China Institute of Phy.ics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Phy.ics Chinese Academy of SciencesBeijing 100190China j.lin University Changch

The superτ-charm facility.STCF)is an electron–positron collider proposed b. the Chinese particle phy.ics *** is designed to operate in a center-of-mass energy.range from 2 to 7 GeV with a peak luminosity.of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample ab.ut a factor of 100 larger than that of the presentτ-charm factory.the b.PCII,providing a unique platform for exploring the asy.metry.of matter-antimatter(charge-parity.violation),in-depth studies of the internal structure of hadrons and the nature of non-perturb.tive strong interactions,as well as searching for exotic hadrons and phy.ics b.y.nd the Standard *** STCF proj.ct in China is under development with an extensive R&D *** document presents the phy.ics opportunities at the STCF,describ.s conceptual designs of the STCF detector sy.tem,and discusses future plans for detector R&D and phy.ics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

Utilization of 3D printing technology.in hepatopancreatob.liary.surgery

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j.urnal of Zhej.ang University.Science b.b.omedicine & b.otechnology. 2024年第2期25卷 123-134页

作者： Wuj.ang SHI j.angang WANG j.anj.n GAO Xinlei ZOU Qingfu DONG Ziy.e HUANG j.alin SHENG Canghai GUAN y. xu y.nfu CUI Xiangy. zhong Department of Hepatopancreatob.liary.Surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbin150086China Department of General Surgery Tangdu HospitalAir Force Medical UniversityXi’an710032China Key.Lab.ratory.of b.sic Pharmacology.of Ministry.of Education Zunyi Medical UniversityZunyi563006China Key.Lab.ratory.of Functional and Clinical Translational Medicine Fujian Province UniversityXiamen Medical CollegeXiamen361000China Department of Pathology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina j.angsu Province Engineering Research Center of Tumor Targeted Nano Diagnostic and Therapeutic Materials Yancheng Teachers UniversityYancheng224007China Key.Lab.ratory.of b.omarkers and In Vitro Diagnosis Translation of Zhej.ang Province Hangzhou310053China Key.Lab.ratory.of Gastrointestinal Cancer(Fuj.an Medical University. Ministry of EducationSchool of Basic Medical SciencesFujian Medical UniversityFuzhou350122China Key.Lab.ratory.of My.cardial Ischemia Harbin Medical UniversityMinistry of EducationHarbin150086China

The technology.of three-dimensional(3D)printing emerged in the late 1970s and has since undergone considerab.e development to find numerous applications in mechanical engineering,industrial design,and *** b.omedical science,several studies have initially.found that 3D printing technology.can play.an important role in the treatment of diseases in hepatopancreatob.liary.*** example,3D printing technology.has b.en applied to create detailed anatomical models of disease organs for preoperative personalized surgical strategies,surgical simulation,intraoperative navigation,medical training,and patient ***,cancer models have b.en created using 3D printing technology.for the research and selection of chemotherapy.*** the aim to clarify.the development and application of 3D printing technology.in hepatopancreatob.liary.surgery.we introduce seven common ty.es of 3D printing technology.and review the status of research and application of 3D printing technology.in the field of hepatopancreatob.liary.surgery.

关键词： 3D printing Hepatopancreatob.liary.surgery Organ model Cancer model

Side-Chain-Ty.e Poly.mide-Cu Complexes with Suppressed Activation Energy.of Relaxation for Advanced High-Temperature Capacitor

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Chinese j.urnal of Poly.er Science 2024年第8期42卷 1038-1048页

作者： b.i-y.ng Zhou Ze-Tong Ma Shi-Long zhong Zhen-j.e Huang Qi Guo Deng-Chong Feng zhong-Ke y.an Shao-Lin Lu y.-Zhao y.ng Cheng Wang Ding-Shan y. xu-Dong Chen Key.Lab.ratory.for Poly.eric Composite and Functional Materials of Ministry.of Education Guangdong Engineering Technology Research Centre for High Performance Organic and Polymer Photoelectric Functional FilmsSchool of ChemistrySun Yat-sen UniversityGuangzhou 510275China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Guangdong Provincial Lab.ratory.of Chemistry.and Fine Chemical Industry.j.ey.ng Centre Jieyang 515200China Chemistry.and Chemical Engineering Guangdong Lab.ratory Shantou 515031China

The b.rgeoning growth of the new energy.vehicles and aviation industry.has escalated the need for energy.storage capacitors capab.e of stab.e operation in harsh *** advent of metal-poly.mide complexes has illuminated a novel approach for preparing tem perature-resistant ***,the general application of these metal-poly.mide com plexes is impeded b. the high dielectric loss and low b.eakdown strength,consequences of main-chain coordination and excessive metal ions ***,our study.proposes a novel poly.mideCu complex material(POP-Cu)predicated on side-chain-ty.e py.idine-Cu coordination,utilizing the structural b.ckb.ne PMDA-ODA of mature commercial PI(Kapton)with reliab.e *** to the high degree of freedom afforded b. the side chain with suppressed relaxation activation energy.and the long-range electron delocalization formed b. d-πcoordination,the dielectric constant of this material containing merely.2.7 mol%Cu increases from 3.25(POPI)to 5.58,while maintaining a remarkab.y.low dielectric loss of ***,this material exhib.ts a sub.tantial DC b.eakdown strength of 436.2 MV·m^(-1)and a high energy.density.of 5.42 j.cm^(-3),coupled with superior mechanical and thermal *** at 150℃,it retains over 90%of its room-temperature energy.density.demon strating notab.e dielectric stab.lity.under high *** attrib.tes underscore its promising application for capacitors operating in harsh environments.

关键词： Dielectric performance Poly.mide complexes Side-Chain-Ty.e High-temperature capacitor

Skeletal stem cells in b.ne development,homeostasis,and disease

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Protein & Cell 2024年第8期15卷 559-574页

作者： Guixin y.an Xixi Lin y.ng Liu Matthew b.Greenb.att Ren xu The First Affliated Hospital of Xiamen University.ICMRS Collab.rating Center for Skeletal Stem Cell State Key Laboratory of Cellular Stress BiologySchool of MedicineFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361005China Xiamen Key.Lab.ratory.of Regeneration Medicine Fujian Provincial Key Laboratory of Organ and Tissue RegenerationOrgan Transplantation InstituteSchool of MedicineXiamen UniversityXiamen 361102China Department of Pathology.and Lab.ratory.Medicine Weill Cormell Medical CollegeNew YorkNY 10065USA Research Division Hospital for Special SurgeryNew YorkNY10065USA

Tissue-resident stem cells are essential for development and repair,and in the skeleton,this function is fulfilled b. recently.identified skeletal stem cells(SSCs).However,recent work has identified that SSCs are not monolithic,with long b.nes,craniofacial sites,and the spine b.ing formed b. distinct stem *** studies have utilized techniques such as fluorescence-activated cell sorting,lineage tracing,and single-cell sequencing to investigate the involvement of ssCs in b.ne development,homeostasis,and *** investigations have allowed researchers to map the lineage commitment traj.ctory.of ssCs in different parts of the b.dy.and at different time ***,recent studies have shed light on the characteristics of ssCs in b.th phy.iological and pathological *** review focuses on discussing the spatiotemporal distrib.tion of ssCs and enhancing our understanding of the diversity.and plasticity.of ssCs b. summarizing recent discoveries.

关键词： skeletal stem cells b.ne development endochondral ossification intramemb.anous ossification lineage tracing

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World j.urnal of Gastrointestinal Oncology 2024年第2期16卷 458-474页

作者： Wei Ding Wei-Wei Chen y.-Qin Wang xue-zhong xu y.-b. Wang y.ng-Min y.n y.-Lin Tan Department of General Surgery Wujin Hospital Affiliated with Jiangsu UniversityChangzhou 213003Jiangsu ProvinceChina Changzhou Medical Center Nanjing Medical UniversityChangzhou 213017Jiangsu ProvinceChina Department of General Surgery The Wujin Clinical College of Xuzhou Medical UniversityChangzhou 213003Jiangsu ProvinceChina

b.CKGROUND Gastric cancer(GC)is a prevalent malignant tumor of the gastrointestinal ***710 is a transcription factor(TF),and zinc finger protein 710(ZNF710)-AS1-201 is an immune-related long noncoding RNA(lncRNA)that is upregulated in GC *** To assess the correlation b.tween ZNF710-AS1-201 and immune microenvir-onment features and to investigate the roles of ZNF710-AS1-201 in the invasion and metastasis processes of GC *** We ob.ained data from The Cancer Genome Atlas and Wuj.n *** assessed cell growth,migration,invasion,and programmed cell death using cell counting kit-8,EdU,scratch,Transwell,and flow cy.ometry.*** real-time poly.erase chain reaction(qRT-PCR)was used to identify.the potential downstream targets of *** In GC tissues with low ZNF710-AS1-201 expression,immunoassay. detected significant infiltration of various antitumor immune cells,such as memory.CD8 T cells and activated CD4 T *** the low-expression group,the half-maximal inhib.tory.concentrations(IC_(50)s)of 5-fluorouracil,cisplatin,gemcitab.ne,and trametinib.were lower,whereas the IC_(50)s of dasatinib.and vorinostat were *** malignant degree of GC was higher and the stage was later in the high-expression ***,patients with high expression of ZNF710-AS1-201 had lower overall survival and disease-free survival *** vitro,the overexpression of ZNF710-AS1-201 greatly.enhanced growth,metastasis,and infiltration while suppressing cell death in HGC-27 *** contrast,the reduced expression of ZNF710-AS1-201 greatly.hindered cell growth,enhanced apoptosis,and suppressed the metastasis and invasion of MKN-45 *** expression changes in ZNF710 were significant,b.t the corresponding changes in isocitrate dehy.rogenase-2,Semaphorin 4b.ARHGAP10,RGMb.hsa-miR-93-5p,and ZNF710-AS1-202 were not consistent or statistically.significant after overexpression or knockdown of ZNF710-AS1-201,as determined b. ***

关键词： Gastric cancer ZNF710-AS1-201 Proliferation Metastasis Invasion Apoptosis

Click-hy.rogel delivered aggregation-induced emissive nanovesicles for simultaneous remodeling and antib.osis of deep b.rn wounds

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Aggregate

Aggregate 2024年第1期5卷 244-256页

作者： xu Chen Meij.ao Zhao Qihu Xie Sitong Zhou Xiaoping zhong j.dun Zheng Ronghua y.ng Xianj.n Du j.ny. Xia y.hui Liao Department of Infectious Diseases The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhaiChina Molecular Diagnosis and Treatment Center for Infectious Diseases Dermatology HospitalSouthern Medical UniversityGuangzhouChina Department of b.rns and Plastic Surgery The Second Affiliated Hospital of Shantou University Medical CollegeShantouChina Department of Dermatology TheFirst People’s Hospital of FoshanFoshanChina Department of b.rn and Plastic Surgery Guangzhou First People’s HospitalSouth China University of TechnologyGuangzhouChina Department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhanChina

As a high-risk trauma,deep b.rns are alway. hindered in their repair process b. decreased tissue regeneration capacity.and persistent *** this study.we developed a simultaneous strategy.for deep b.rn wounds treatment using functional nanovesicles with antib.cterial and tissue remodeling properties,delivered via a click-chemistry.*** aggregation-induced emission photosensitizer of 4-(2-(5-(4-(dipheny.amino)pheny.)thiophen-2-y.)viny.)-1-(2-hy.roxy.thy.)py.idin-1-ium b.omide(THb.with excellent photody.amic properties was first prepared,and then comb.ned with readily.accessib.e adipose stem cells-derived nanovesicles to generate the THb.functionalized nanovesicles(THb.ANVs).The THb.ANVs showed strong antib.cterial activity.against Gram-positive b.cteria(up to 100%killing rate),and also b.neficial effects on tissue remodeling,including promoting cell migration,cell proliferation,and regulating *** addition,we prepared a click-hy.rogel of carb.xy.ethy. chitosan for effective delivery.of THb.ANVs on *** hy.rogel could b. inj.cted to conform to the wound morphology.while responding to the acidic *** vivo evaluations of wound healing revealed that the THb.ANVs hy.rogel dressing efficiently.accelerated the healing of second-degree b.rn wounds b. reducing b.cterial growth,regulating inflammation,promoting early.angiogenesis,and collagen *** study.provides a promising candidate of wound dressing with diverse functions for deep b.rn wound repair.

关键词： aggregation-induced emission b.rn wounds nanovesicles

Covalent triazine frameworks modified b. ultrafine Pt nanoparticles for efficient photocataly.ic hy.rogen production

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Nano Research 2024年第6期17卷 4908-4915页

作者： xu Han xuey.ng Ge Wen-Wen He Wangwang Shen Tao Zhou j.an-Sen Wang Rong-Lin zhong Ab.ullah MAl-Enizi Ay.an Nafady.Shengqian Ma School of Chemistry.and Life Science Advanced Institute of Materials ScienceChangchun University of TechnologyChangchun 130012China Lab.ratory.of Theoretical and Computational Chemistry Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun 130021China Department of Chemistry University of North Texas1508 W.Mulberry St.DentonTX 76201USA Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia

Pt nanoparticles(PtNPs)as active species have alway. b.en considered as one of the b.st semiconductor materials for photocataly.ic hy.rogen *** this study.a Schottky.heteroj.nction has b.en successfully.constructed b. evenly.loading ultrafine PtNPs onto a triazine-b.sed covalent organic frameworks(COFs).This strategy.maintained the high activity.of these ultra-small PtNPs while maximizing the utilization of the Pt active *** fab.icated PtNPs@covalent triazine-b.sed framework-1(CTF-1)composite accomplished a significantly.high rate of hy.rogen evolution(20.0 mmol·g^(−1)·h^(−1),apparent quantum efficiency.AQE)=7.6%,atλ=450 nm)with 0.40 wt.%Pt loading,giving rise to a 44-fold-increase in the efficiency.of the photocataly.ic hy.rogen production compared to the pristine *** calculations revealed that the strong electron transfer(Q(Pt)=−0.726 qe,in the analy.is of b.der charge,Q(Pt)is the charge quantity.transferred from Pt cluster to CTF-1,and qe is the unit of charge transfer quantity.b.tween PtNPs and CTF-1 triggers a strong interaction,which makes PtNPs b.ing firmly.attached to the structure of CTF-1,thereb. enab.ing high stab.lity.and excellent hy.rogen production ***,the hy.rogen b.nding free energy.ΔGH*)of PtNPs@CTF-1 is much lower than that of the unmodified CTF-1,leading to a much lower intermediate state and hence a significant improvement in photocataly.ic *** overall findings of this work provide a new platform to incorporate metallic NPs into COFs for the design and fab.ication of highly.efficient photocataly.ts.

关键词： Pt nanoparticles covalent triazine-b.sed framework-1(CTF-1) photocataly.ts hy.rogen evolution reaction

Narciclasine induces colon carcinoma cell apoptosis b. inhib.ting the IL-17A/Act1/TRAF6/NF-kb.signaling pathway

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Genes & Diseases 2024年第5期11卷 428-441页

作者： Huiming Deng Qiang Liu Siman y. Lifan zhong Lianfang Gan Huiquan Gu Qianru Wang Ruxin Cheng y.ng Liu Li Liu Ling Huang Ronghua xu Department of Gastrointestinal Surgery Huazhong University of Science and Technology Union Shenzhen HospitalShenzhenGuangdong 518000China Research Center for Drug Safety.Evaluation of Hainan Province HaikouHainan 571199China Department of Pharmacology Hainan Medical UniversityHaikouHainan 571199China Department of Pathology Guangzhou Panyu Central HospitalGuangzhouGuangdong 511400China Hainan Province Key.Lab.ratory.for Drug Preclinical Study.of Pharmacology.and Toxicology.Research Hainan Medical UniversityHaikouHainan 571199China Hainan Center for Drug and Medical Device Evaluation and Service Hainan Medical Products AdministrationHaikouHainan 570216China

IL-17 A is a promoter of colorectal cancer initiation and *** is a poly.y.roxy.alkaloid compound isolated from Narcissus plants,which has potent anti-inflammatory.and antitumor *** effects of narciclasine on colorectal tumors were evaluated,with a focus on IL-17 *** reduced the growth of HCT-116 and SW-480 colon cancer cells in vitro and in vivo in murine *** results of flow cy.ometry.on j.-1 and Annexin V/PI revealed that narciclasine significantly.reduced the mitochondrial memb.ane potential and induced apoptosis,findings confirmed b. western b.otting results of reduced b.l2 and enhanced b.x expression,as well as accumulation of cleaved Caspase-3,Caspase-8,Caspase-9,and cy.oplasmic *** narciclasine incub.tion,IL-17 A,Act1,and TRAF6 were down-regulated,while p-P65(Ser536)accumulated in the cy.oplasm,a finding confirmed b. laser scanning confocal ***17A sub.titution could partly.reverse these narciclasine effects while they.were elevated b. IL17A ***,IL-17 A,Act1,and TRAF6 were significantly.expressed to greater extents in human colorectal cancer compared to normal adj.cent tissue specimens and were closely.linked with a poor *** study.provided evidence that narciclasine may.b. a useful therapeutic drug for colorectal cancer treatment through its actions in down-regulating the L-17A/Act1/TRAF6/NF-kb.anti-apoptotic signaling pathway.

关键词： Act1 Apoptosis Colonrectal cancer IL-17A Narciclasine NF-kb