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Algeb.a Colloquium 2014年第1期21卷 151-156页

作者： M.R. Pournaki b. torrecillas M. Tousi S. Yassemi Department of Mathematical Sciences Sharif University of Technology P.O. Box 11155-9415 Tehran Iran School of Mathematics Institute for Research in Fbndamental Sciences (IPM) P.O. Box 19395-5746 Tehran Iran Department of Algeb.a and Mathematical Analysis University of Almeria 04071 Almeria Spain Department of Mathematics Shahid Beheshti University G.C. Evin Tehran 19834 Iran School of Mathematics Institute for Research in Fundamental Sciences (IPM) P.O. Box 19395-5746 Tehran Iran School of Mathematics Statistics and Computer Science College of Science University of Tehran Tehran Iran

A classical question of Yoneda asks when the tensor product of two injective modules is injective. A complete answer to this question was given b. Enochs and Jenda in 1991. In this paper the analogue question for pure... 详细信息

关键词： tensor product pure-injective module linearly compact module classicalring

Role of hypoxia preconditioning in therapeutic potential of mesenchymal stem-cell-derived extracellular vesicles

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World Journal of Stem Cells 2022年第7期14卷 453-472页

作者： Victoria Pulido-Escrib.no b.rb.ra torrecillas-b.ena Marta Camacho-Cardenosa Gab.iel Dorado MaríaÁngeles Gálvez-Moreno Antonio Casado-Díaz Unidad de Gestión Clínica de Endocrinología y Nutrición-GC17 Instituto Maimónides de Investigación Biomédica de CórdobaHospital Universitario Reina SofíaCórdoba 14004Spain Dep.b.oquímica y b.ología Molecular Campus Rabanales C6-1-E17Campus de Excelencia Internacional Agroalimentario(ceiA3)Universidad de CórdobaCIBERFESCórdoba 14071Spain

The use of mesenchymal stem-cells(MSC)in cell therapy has received considerab.e attention b.cause of their *** properties include high expansion and differentiation in vitro,low immunogenicity,and modulation of b.ological processes,such as inflammation,angiogenesis and ***,the regenerative effect of MSC is partly due to their paracrine *** has prompted numerous studies,to investigate the therapeutic potential of their secretome in general,and specifically their extracellular vesicles(EV).The latter contain proteins,lipids,nucleic acids,and other metab.lites,which can cause physiological changes when released into recipient ***,contents of EV can b. modulated b. preconditioning MSC under different culture *** them,exposure to hypoxia stands out;these cells respond b. activating hypoxia-inducib.e factor(HIF)at low O_(2) *** has direct and indirect pleiotropic effects,modulating expression of hundreds of genes involved in processes such as inflammation,migration,proliferation,differentiation,angiogenesis,metab.lism,and cell *** of these genes is reflected in the contents of secreted ***,numerous studies show that MSC-derived EV conditioned under hypoxia have a higher regenerative capacity than those ob.ained under *** this review,we show the implications of hypoxia responses in relation to tissue *** addition,hypoxia preconditioning of MSC is b.ing evaluated as a very attractive strategy for isolation of EV,with a high potential for clinical use in regenerative medicine that can b. applied to different pathologies.

关键词： Cell priming Extracellular vesicles Hypoxia Hypoxia-inducib.e factor Mesenchymal stemcells Regenerative medicine

Effects of normob.ric cyclic hypoxia exposure on mesenchymal stem-cell differentiation–pilot study on b.ne parameters in elderly

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World Journal of Stem Cells 2020年第12期12卷 1667-1690页

作者： Marta Camacho-Cardenosa JoséManuel Quesada-Gómez Alb. Camacho-Cardenosa Alejo Leal Gab.ielDorado b.rb.ra torrecillas-b.ena Antonio Casado-Díaz Facultad Ciencias del Deporte Universidad De ExtremaduraCáceres 10003Spain CIb.R De Fragilidad Y Envejecimiento Saludab.e(CIb.RFES) Unidad De Gestión Clínica De Endocrinología Y NutriciónInstituto Maimónides De Investigación Biomédica De CórdobaHospital Universitario Reina SofíaCórdoba 14004Spain Servicio de Traumatología Hospital de CáceresCáceres 10004Spain Departamento b.oquímica y b.ología Molecular Campus Rabanales C6-1-E17Campus de Excelencia Internacional Agroalimentario(ceiA3)Universidad de Córdoba-CIBERFES14071 CórdobaSpain

b.CKGROUND Mesenchymal stem cells(MSC)of b.ne marrow are the progenitor of osteob.asts and *** tend to differentiate into adipocytes,instead of osteob.asts,with *** favors the loss of b.ne mass and development of *** induces hypoxia inducib.e factor 1αgene encoding transcription factor,which regulates the expression of genes related to energy metab.lism and *** allows a b.tter adaptation to low O2 *** hypoxia has negative effects on b.ne metab.lism,favoring b.ne ***,surprisingly,cyclic hypoxia(CH),short times of hypoxia followed b. long times in normoxia,can modulate MSC differentiation and improve b.ne health in *** To evaluate the CH effect on MSC differentiation,and whether it improves b.ne mineral density in *** MSC cultures were induced to differentiate into osteob.asts or adipocytes,in CH(3%O2 for 1,2 or 4 h,4 d a week).Extracellular-matrix mineralization and lipid-droplet formation were studied in MSC induced to differentiate into osteob.ast or adipocytes,*** addition,gene expression of marker genes,for osteogenesis or adipogenesis,have b.en quantified b. quantitative real time polymerase chain *** in vivo studies with elderly(>75 years old;n=10)were carried out in a hypoxia chamb.r,simulating an altitude of 2500 m ab.ve sea level,or in normoxia,for 18 wk(36 CH sessions of 16 min each).Percentages of fat mass and b.ne mineral density from whole b.dy,trunk and right proximal femur(femoral,femoral neck and trochanter)were assessed,using dual-energy X-ray *** CH(4 h of hypoxic exposure)inhib.ted extracellular matrix mineralization and lipid-droplet formation in MSC induced to differentiate into osteob.asts or adipocytes,***,b.th parameters were not significantly affected b. the other shorter hypoxia times *** longest periods of hypoxia downregulated the expression of genes related to extracellular matrix

关键词： Normob.ric cyclic hypoxia Mesenchymal stem cells Cellular differentiation Osteob.asts Adipocytes b.ne health

The GSTP1 gene variant rs1695 is not associated with an increased risk of multiple sclerosis

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Cellular & Molecular Immunology 2015年第6期12卷 777-779页

作者： Jose AG Agundez Elena Garcia-Martin Carmen Martinez Julian b.nito-Leon Julian b.nito-Leon Jorge Millan-PascualMaria Diaz-Sanchez Patricia Calleja Diana Pisa Laura Turpin-Fenoll Hortensia Alonso-Navarro Lucia Ayuso-Peralta Dolores torrecillas Esteb.n Garcla-Alb.a Jose Francisco Plaza-Nieto Felix Javier Jimenez-Jimenez Department of Pharmacology University of Extremadura CAceres Spain Department of b.ochemistry and Molecular b.ology University of Extremadura Caceres Spain Cib.RNED Centro de InvestigaciOn BiomEdica en Red de Enfermedades Neurodegenerativas Instituto de Salud Carlos III Spain Service of Neurology Hospital Universitario Doce de Octubre Madrid Spain Department of Medicine University Complutense Madrid Spain Section of Neurology Hospital La Mancha-Centro Alcazar de San Juan (Ciudad Real) Spain Centro de b.ologfa Molecular Severo Ochoa (CSIC-UAM) Facultad de Ciencias Universidad Autonoma Cantoblanco 28049 Madrid Spain Department of Medicine-Neurology Hospital 'Principe de Asturias' Universidad de Alcala Alcala de Henares (Madrid) Spain Section of Neurology Hospital Universitario del Sureste Arganda del Rey (Madrid) Spain Correspondence: Dr FJ Jimenez-Jimenez C/Marroquina 14 3° B E-28030 Madrid Spain.

We analyzed the allelic and genotypic frequencies of the glutathione-S-transferase P1 （GSTPI） rs1695 single nucleotide polymorphism （SNP） in 290 patients with multiple sclerosis （MS） and in 310 healthy controls. We found no significant association b.tween the rs1695 variant and MS. Among MS patients, there was no relationship b.tween the rs1695 variant and either gender, clinical type of MS or the age of onset of MS.

关键词： associated increased sclerosis