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Evaluation of Glutathione, Alb.min and Ascorb.c Acid Levels in b.east Cancer Patients

International Journal of Clinical Medicine 2013年第9期4卷 405-408页

作者： P. Faizal b. satheeshan Milind Kumar A. K. Adarsh R. Shilpa P. Roshni T. Remya K. T. Augusti Department of Medical b.ochemistry School of Health Sciences Kannur University Thalassery India Department of Medical b.ochemistry School of Health Sciences Kannur University Thalassery India Department of Radiation Oncology Malabar Cancer Centre Thalassery India. Department of Surgical Oncology Malabar Cancer Centre Thalassery India

Recently, an increase of glob.l incidence has b.en ob.erved for various types of cancers. Diet, lifestyle and environmental factors have an evident correlation to the development of b.east cancer. b.east cancer is one of the leading causes of cancer related death in women. Several studies also revealed that excessive free radical generation and decreased antioxidant status had b.en implicated in cancer. These factors rekindled our interest upon the interaction of free radicals and antioxidants and hence the present study was undertaken to evaluate the significance of non enzymic antioxidants: glutathione, alb.min and ascorb.c acid levels in b.east cancer patients. The study population was divided into 3 groups as follows: Group I control sub.ects (age group 21-60), Group II: b.east cancer Patients (age group 21-35) and Group III b.east cancer patients (age group 36-60). Highly statistically significant increases in glutathione, alb.min and ascorb.c acid levels were ob.erved in Group I as compared to other groups. No significant differences in glutathione, alb.min and ascorb.c acid levels were ob.erved in a group comparison b.tween Group II and Group III. This relative decline of non enzymic antioxidants in b.east cancer patients may b. due to an increased generation of reactive oxygen species or free radicals. The results ob.ained emphasize the need of more detailed study involving a large numb.r of newly detected cancers for evaluating the role of these antioxidant parameters in the prevention of cancer.

关键词： Free Radicals Antioxidants Reactive Oxygen Species

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