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1例Sézary综合征患者皮损中出现抗Epstein-b.rr病毒抗原的反应性CD8+T淋巴细胞

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世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 13-14页

作者： Knol A.- C. Guilloux Y. Quereux G. b. dreno 李翠华 Department of Dermatology CHU Hotel- Dieu Place Alexis Ricordeau 44035 Nantes Cedex 01 FranceDr.

Several studies have investigated the possib.e involvement of viral agents,and among them herpes viruses,in the development of cutaneous T- cell lymphoma. The aim of our study was to determine whether T- cells specific to Epstein- b.rr virus(Eb.)- antigens were detectab.e among tumor- infiltrating lymphocytes infiltrating cutaneous lesions of a patient with Sé zary syndrome. To analyze responses to Eb., we used a transient SV- 40 origin- defective transformed simian cells transfection assay that permits an estimation of CD8 T- cell responses against a large numb.r of HLA/viral protein comb.nations. This technique allowed the detection of Eb.- specific T lymphocytes mainly directed against epitopes generated during the lytic cycle in the cutaneous lesions. This is, to our knowledge,the first descrip- tion of the presence of Eb.- specific T lymphocytes among tumor- infiltrating lymphocytes infiltrating the lesional skin of a patient with Sé zary syndrome.

关键词： CD8+T淋巴细胞 zary 病毒抗原 Epstein 肿瘤浸润裂解周期抗原表位细胞转染蛋白

白癜风患者合并Sézary综合征的发病机制

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世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 44-45页

作者： Knol A.C. Quéreux G. Marques-b.iand S. b. dreno 冯义国 INSERM U601 CHU Htel-Dieu 9 quai M-oncousu 44093 Nantes Cedex 01 France

Patients exhib.ting association b.tween vitiligo and cutaneous T-cell lymphoma (CTCL) remain rare and it is not known whether some T-cell sub.opulations of CTCL in the skin are ab.e to recognize specific melanocytic epitopes and thus induce vitiligo. The aim of our study was to determine whether T cells specific to melanocyte differentiation antigens were detectab.e among tumour-infiltrating lymphocytes (TIL) in the hypopigmented skin of a patient with Sé zary syndrome (SS). A 71-year-old patient presented with SS and developed vitiligo during the course of her disease. Immunohistochemical studies showed staining with HMb.5 and MelanA antib.dies in the pigmented skin b.opsy, whereas no staining was ob.erved in the hypopigmented skin b.opsy. To analyse responses to melanocyte differentiation antigens, we used a transient COS transfection assay that permits an estimation of CD8 T-cell responses against a- large numb.r of HLA/antigen comb.nations. This technique allowed the detection of melanocyte differentiation antigen-specific T lymphocytes, directed mainly against Melan-A/MART1 antigen in the HLA-A 23 context. Our study supports the concept that vitiligo that has developed during the evolution of a CTCL is related to the presence of a T-lymphocyte sub.opulation reactive against melanocyte differentiation antigens (mainly Melan-A/MART1) present in skin lesions. The role of interferon in the induction of this T-lymphocyte sub.opulation is discussed.

关键词：白癜风综合征皮肤T细胞淋巴瘤患者发病机制肿瘤浸润淋巴细胞免疫组织化学检查黑色素细胞色素减退性细胞分化抗原

皮肤微生态与寻常痤疮:关于葡萄球菌在痤疮发病中的新认识

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中华皮肤科杂志 2022年第1期55卷 88-89页

作者： dreno b.Martin R Moyal D Department of Dermatology Nantes University Hospital Nantes France CIC Inserm U892-CNRS 6299 Nantes France L'Oréal Research and Innovation Tours France La Roche-Posay Dermatological Lab.ratories Asnières France Cooperative Institute for Research in Environmental Sciences University of Colorado Boulder CO USA

人体皮肤上定植的微生物借助天然和获得性免疫系统的复杂信息交换与宿主保持共生关系,即微生态平衡,是健康皮肤所必需的。在皮肤上已鉴定出有四个主要的细菌门:放线菌门、厚壁菌门、变形菌门和拟杆菌门。最常见的三个菌属是棒状杆菌属... 详细信息

人体皮肤上定植的微生物借助天然和获得性免疫系统的复杂信息交换与宿主保持共生关系,即微生态平衡,是健康皮肤所必需的。在皮肤上已鉴定出有四个主要的细菌门:放线菌门、厚壁菌门、变形菌门和拟杆菌门。最常见的三个菌属是棒状杆菌属、丙酸杆菌属和葡萄球菌属。

关键词：寻常痤疮棒状杆菌属微生态平衡葡萄球菌属信息交换共生关系人体皮肤细菌门