检索结果-南通市图书馆

High-density lipoprotein regulates angiogenesis by affecting autophagy via miRNA-181a-5p

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第2期67卷 286-300页

作者： bi-Ang Kang Hua-Ming Li Ya-Ting Chen Meng-Jie Deng Yan Li Yue-Ming Peng Jian-Jun Gao Zhi-Wei Mo Jia-Guo Zhou Zhi-Jun Ou Jing-Song Ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China NHC key Laboratory of Assisted Circulation(Sun Yat-sen University) Guangzhou 510080China Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Division of Hypertension and Vascular Diseases Department of CardiologyCardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key Laboratory of brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

We previously demonstrated that normal high-density lipoprotein(nHDL)can promote angiogenesis,whereas HDL from patients with coronary artery disease(d HDL)is dysfunctional and impairs *** plays a critical role in angiogenesis,and HDL regulates ***,it is unclear whether n HDL and d HDL regulate angiogenesis by affecting *** cells(ECs)were treated with n HDL and d HDL with or without an autophagy ***,endothelial nitric oxide synthase(e NOS)expression,miRNA expression,nitric oxide(NO)production,superoxide anion(O2^(·-))generation,EC migration,and tube formation were evaluated.n HDL suppressed the expression of miR-181a-5p,which promotes autophagy and the expression of e NOS,resulting in NO production and the inhibition of O2^(·-)generation,and ultimately increasing in EC migration and tube formation.d HDL showed opposite effects compared to n HDL and ultimately inhibited EC migration and tube *** found that autophagy-related protein 5(ATG5)was a direct target of ***5 silencing or miR-181a-5p mimic inhibited n HDL-induced autophagy,e NOS expression,NO production,EC migration,tube formation,and enhanced O2^(·-)generation,whereas overexpression of ATG5 or miR-181a-5p inhibitor reversed the above effects of d ***5 expression and angiogenesis were decreased in the ischemic lower limbs of hypercholesterolemic low-density lipoprotein receptor null(LDLr^(-/-))mice when compared to C57bL/6 ***5 overexpression improved angiogenesis in ischemic hypercholesterolemic LDLr^(-/-)*** together,nHDL was able to stimulate autophagy by suppressing miR-181a-5p,subsequently increasing e NOS expression,which generated NO and promoted *** contrast,d HDL inhibited angiogenesis,at least partially,by increasing miR-181a-5p expression,which decreased autophagy and e NOS expression,resulting in a decrease in NO production and an increase in O2^(·-)*** findings reveal a nov

关键词： high-density lipoprotein angiogenesis autophagy ATG5 miRNA endothelial nitric oxide synthase

在线全文

学校读者我要写书评

暂无评论

论电商平台知识产权的公私协同治理模式

上海交通大学学报（哲学社会科学版） 2024年第8期32卷 68-81,107页

作者：毕文轩东南大学法学院南京211189 东南大学民事检察研究中心南京211189 东南大学最高人民法院司法大数据(东南大学)研究基地

平台经济快速发展的同时也呈现出诸多问题,面对电商领域知识产权治理的复杂性,亟待探索契合平台现实需要的公私协同治理模式。政府行政规制模式存在运动式执法导致效果不稳定以及相关知识产权维权援助机构属性不明的不足,而企业自我规... 详细信息

平台经济快速发展的同时也呈现出诸多问题,面对电商领域知识产权治理的复杂性,亟待探索契合平台现实需要的公私协同治理模式。政府行政规制模式存在运动式执法导致效果不稳定以及相关知识产权维权援助机构属性不明的不足,而企业自我规制模式则可能因平台作为治理者的正当性和中立性受质疑而存在缺陷,这使得传统治理模式陷入失衡。为克服这种缺陷,有必要借鉴公私合作模式,将主体包容性与价值多元化的理念融入电商平台知识产权治理的各个环节,并以包容审慎作为基本原则。公私协同模式能缓解公私部门在应对电商知识产权治理中的紧张关系,通过强化开放型共治组织架构、加强交互型共治规范建设以及落实制衡型共治权责配置等举措,提升知识产权综合治理的实际效益,实现多元共赢的治理目标。

关键词：电商平台知识产权公私协同治理模式转型

Fast mode decomposition for few-mode fiber based on lightweight neural network

在线全文

学校读者我要写书评

暂无评论

Chinese Optics Letters 2024年第2期22卷 88-95页

作者：赵佳佳陈国辉毕轩蔡汪洋岳磊唐明 School of Computer and Communication Engineering Changsha University of Science and TechnologyChangsha 410114China Wuhan National Laboratory for Optoelectronics(WNLO)and National Engineering Laboratory for Next Generation Internet Access System School of Optical and Electronic InformationHuazhong University of Science and TechnologyWuhan 430074China

In this paper,we present a fast mode decomposition method for few-mode fibers,utilizing a lightweight neural network called *** method can quickly and accurately predict the amplitude and phase information of different modes,enabling us to fully characterize the optical field without the need for expensive experimental *** train the MobileNetV3-Light using simulated near-field optical field maps,and evaluate its performance using both simulated and reconstructed near-field optical field *** validate the effectiveness of this method,we conduct mode decomposition experiments on a few-mode fiber supporting six linear polarization(LP)modes(LP01,LP11e,LP11o,LP21e,LP21o,LP02).The results demonstrate a remarkable average correlation of 0.9995 between our simulated and reconstructed near-field lightfield *** the mode decomposition speed is about 6 ms per frame,indicating its powerful real-time processing *** addition,the proposed network model is compact,with a size of only 6.5 Mb,making it well suited for deployment on portable mobile devices.

关键词： deep learning lightweight neural network few-mode fiber mode decomposition

bursting oscillations as well as the bifurcation mechanism in a non-smooth chaotic geomagnetic field model

在线全文

学校读者我要写书评

暂无评论

Chinese Physics b 2018年第11期27卷 412-418页

作者： ran Zhang Miao Peng Zhengdi Zhang Qinsheng bi Faculty of Science Jiangsu University Zhenjiang 212013 China Faculty of Civil Engineering and Mechanics Jiangsu University Zhenjiang 212013 China

based on the chaotic geomagnetic field model, a non-smooth factor is introduced to explore complex dynamical behaviors of a system with multiple time scales. by regarding the whole excitation term as a parameter, bifurcation sets are derived, which divide the generalized parameter space into several regions corresponding to different kinds of dynamic behaviors. Due to the existence of non-smooth factors, different types of bifurcations are presented in spiking states, such as grazing-sliding bifurcation and across-sliding bifurcation. In addition, the non-smooth fold bifurcation may lead to the appearance of a special quiescent state in the interface as well as a non-smooth homoclinic bifurcation phenomenon. Due to these bifurcation behaviors, a special transition between spiking and quiescent state can also occur.

关键词： multiple time scales grazing bifurcation across-sliding bifurcation non-smooth homoclinic bi- furcation

Quantum dynamics within curved thin layers with deviation

在线全文

学校读者我要写书评

暂无评论

Chinese Physics b 2024年第7期33卷 502-507页

作者：程润赵浩罗翠柏周璇王必利李延标王骏 Physics Department of basic Department Army Engineering University of PLANanjing 211101China National Laboratory of Solid State Microstructure Collaborative Innovation Center of Advanced Microstructuresand School of PhysicsNanjing UniversityNanjing 210093China School of Physics and Electronics Hunan UniversityChangsha 410082China Department of Physics Anhui Normal UniversityWuhu 241002China

Combining the deviation between thin layers' adjacent surfaces with the confining potential method applied to the quantum curved systems,we derive the effective Schr?dinger equation describing the particle constrained within a curved layer,accompanied by a general geometric potential V_(gq) composed of a compression-corrected geometric potential V_(gq)~*and a novel potential V_(gq)~(**) brought by the *** this analysis to the cylindrical layer emerges two types of deviation-induced geometric potential,resulting from the the cases of slant deviation and tangent deviation,respectively,which strongly renormalizes the purely geometric potential and contribute to the energy spectrum based on a very substantial deepening of bound states they offer.

关键词： confining potential method quantum mechanics curved thin layer

在线全文

学校读者我要写书评

暂无评论

集成非互易光学器件(特邀)

光学学报 2024年第15期44卷 341-358页

作者：张子健严巍秦俊毕磊国家电磁辐射控制材料工程技术研究中心四川成都611731 多频谱吸波材料与结构教育部重点实验室(b类) 四川成都611731

光隔离器、光环行器等非互易光学器件广泛应用于信息光子系统,在光纤通信、光纤传感等技术中发挥了不可替代的作用。面向集成光学系统,研制平面化、可集成的非互易光学器件是该领域的关键难题之一,被称为“缺失的一环”。介绍了在集成... 详细信息

光隔离器、光环行器等非互易光学器件广泛应用于信息光子系统,在光纤通信、光纤传感等技术中发挥了不可替代的作用。面向集成光学系统,研制平面化、可集成的非互易光学器件是该领域的关键难题之一,被称为“缺失的一环”。介绍了在集成光波导器件中实现光学非互易性的主要原理,总结了近年来基于磁光效应、非线性光学效应和时空调制机理研制集成非互易光学器件的部分代表性工作。最后分析了该领域面临的挑战,并对未来发展趋势进行了展望。

关键词：非互易光学磁光效应非线性光学时空调制硅基光电子

老年人口腔健康与营养不良肌少症以及衰弱的相关关系

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华老年医学杂志 2024年第9期43卷 1096-1100页

作者：毕江涵康琳中国医学科学院北京协和医院老年医学科北京100730

老年人营养不良、肌少症、衰弱是常见的老年综合征,严重影响老年人的功能状态和生活质量,口腔健康状况不佳可能是这些常见老年综合征的危险因素之一。本文介绍了口腔衰弱及口腔相关生活质量的定义,阐述了口腔衰弱或口腔相关生活质量不... 详细信息

老年人营养不良、肌少症、衰弱是常见的老年综合征,严重影响老年人的功能状态和生活质量,口腔健康状况不佳可能是这些常见老年综合征的危险因素之一。本文介绍了口腔衰弱及口腔相关生活质量的定义,阐述了口腔衰弱或口腔相关生活质量不佳与营养不良、肌少症、衰弱相关关系的临床证据,以期为未来通过早期干预口腔问题改善老年人整体健康状况提供依据。

关键词：营养不良肌少症衰弱口腔健康

Prediction of collapse process and tipping points for mutualistic and competitive networks with k-core method

在线全文

学校读者我要写书评

暂无评论

Chinese Physics b 2024年第5期33卷 173-180页

作者：段东立毕菲菲李思凡吴成星吕长春蔡志强 School of Information and Control Engineering Xi'an University of Architecture and TechnologyXi'an 710311China School of Mechanical Engineering Northwestern Polytechnical UniversityXi'an 710072China

Ecosystems generally have the self-adapting ability to resist various external pressures or disturbances,which is always called ***,once the external disturbances exceed the tipping points of the system resilience,the consequences would be catastrophic,and eventually lead the ecosystem to complete *** capture the collapse process of ecosystems represented by plant-pollinator networks with the k-core nested structural method,and find that a sufficiently weak interaction strength or a sufficiently large competition weight can cause the structure of the ecosystem to collapse from its smallest k-core towards its largest *** we give the tipping points of structure and dynamic collapse of the entire system from the one-dimensional dynamic function of the *** work provides an intuitive and precise description of the dynamic process of ecosystem collapse under multiple interactions,and provides theoretical insights into further avoiding the occurrence of ecosystem collapse.

关键词： complex networks tipping points dimension reduction k-core

Pien Tze Huang Inhibits Migration and Invasion of Hepatocellular Carcinoma Cells by Repressing PDGFRb/YAP/CCN2 Axis Activity

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第2期30卷 115-124页

作者： LUO Zhi-yi TIAN Qi CHENG Niang-mei LIU Wen-han YANG Ye CHEN Wei ZHANG Xiang-zhi ZHENG Xiao-yuan CHEN Ming-sheng ZHUANG Qiu-yu ZHAO bi-xing LIU Cong-sheng LIU Xiao-long LI Qin WANG Ying-chao The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development Zhangzhou Pien Tze Huang Pharmaceutical Co.Ltd.ZhangzhouFujian Province(363099)China College of biological Science and Engineering and Mengchao Med-X Center Fuzhou UniversityFuzhou(350116)China Department of Internal Medicine Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China

Objective:To investigate the effects of Pien Tze Huang(PZH) on the migration and invasion of HCC cells and underlying molecular ***:Cell counting kit-8(CCK-8) was applied to evaluate the cell viabilities of SMMC-7721,SK-Hep-1,C3A and HL-7702(6 × 10^(3)cells/well) co-incubated with different concentrations of PZH(0,0.2,0.4,0.6,0.8 mg/mL) for 24 ***,wound healing assay,CCK-8and Annexin V-FITC/PI staining were conducted to investigate the effects of PZH on the migration,invasion,proliferation and apoptosis of SK-Hep-1 and SMMC-7721 cells(650 μg/mL for SK-Hep-1 cells and 330 μg/mL for SMMC-7721 cells),*** vivo,lung metastasis mouse model constructed by tail vein injection of HCC cells was used for evaluating the anti-metastasis function of ***-Hep-1 cells(10^(6)cells/200 μL per mice) were injected into b-NDG mice via tail *** 8 mice were randomly divided into PZH and control groups,4 mice in each *** 2-d inoculation,mice in the PZH group were administered with PZH(250 mg/kg,daily) and mice in the control group received only vehicle(PbS) from the 2nd day after xenograft to day *** analysis based on RNA-seq was subsequently used for deciphering anti-tumor mechanism of *** real-time polymerase chain reaction(qRT-PCR) and Western blot were applied to verify RNA-seq *** reporter assay was performed to examine the transcriptional activity of yes-associated protein(YAP).Results:PZH treatment significantly inhibited the migration,invasion,proliferation and promoted the apoptosis of HCC cells in vitro and in vivo(Pranscriptome analysis indicated that Hippo signaling pathway was associated with anti-metastasis function of *** study showed PZH significantly inhibited the expressions of platelet derived growth factor receptor beta(PDGFRb),YAP,connective tissue growth factor(CCN2),N-cadherin,vimentin and matrix metallopeptidase 2(MMP2,P<0.01).Meanwhile,the phosphorylatio

关键词： PienTzeHuang hepatocellular carcinoma RNA-seq Hippo yes-associated protein