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Passively Q-switched femtosecond-laser-written thulium waveguide laser based on evanescent field interaction with carbon nanotubes

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Photonics Research 2018年第10期6卷 971-980页

作者： ESROM KIFLE PAVEL LOIKO JAVIER RODRíGUEZ VáZQUEZ DE ALDANA CAROLINA ROMERO AIRáN RóDENAS SUN YUNG CHOI JI EUN bAE FAbIAN ROTERMUND VIKTOR ZAKHAROV ANDREY VENIAMINOV MAGDALENA AGUILó FRANCESC DíAZ UWE GRIEbNER valentin PETROV XAVIER MATEOS Universitat Rovira i Virgili Departament Quimica Fisica i Inorgànica Fisica i Cristal·lografia de Materials i Nanomaterials (FiCMA-FiCNA)-EMaS Campus Sescelades E-43007 Tarragona Spain ITMO University 49 Kronverkskiy pr. 197101 St. Petersburg Russia Aplicaciones del Láser y Fotónica University of Salamanca 37008 Salamanca Spain Istituto di Fotonica e Nanotecnologie Consiglio Nazionale delle Ricerche (IFN-CNR) Piazza Leonardo da Vinci 32 20133 Milano Italy Department of Physics KAIST 291 Daehak-ro Yuseong-gu 34141 Daejeon South Korea Max born Institute for Nonlinear Optics and Short Pulse Spectroscopy Max-Bom-Str. 2a D-12489 Berlin Germany

Surface channel waveguides(WGs) were fabricated in a monoclinic Tm^(3+):KLu(WO_4)_2 crystal by femtosecond direct laser writing(fs-DLW). The WGs consisted of a half-ring cladding with diameters of 50 and 60 μm located just beneath the crystal surface. They were characterized by confocal laser microscopy and μ-Raman spectroscopy,indicating a reduced crystallinity and stress-induced birefringence of the WG cladding. In continuous-wave(CW)mode, under Ti:sapphire laser pumping at 802 nm, the maximum output power reached 171.1 mW at 1847.4 nm,corresponding to a slope efficiency η of 37.8% for the 60 μm diameter WG. The WG propagation loss was0.7 0.3 d b∕cm. The top surface of the WGs was spin-coated by a polymethyl methacrylate film containing randomly oriented(spaghetti-like) arc-discharge single-walled carbon nanotubes serving as a saturable absorber based on evanescent field coupling. Stable passively Q-switched(PQS) operation was achieved. The PQS60 μm diameter WG laser generated a record output power of 150 m W at 1846.8 nm with η = 34.6%. The conversion efficiency with respect to the CW mode was 87.6%. The best pulse characteristics(energy/duration)were 105.6 nJ/98 ns at a repetition rate of 1.42 MHz.

关键词：激光技术波导技术发展现状通讯技术

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多孔沥青混合料堵塞规律离散元仿真

交通运输工程学报 2023年第2期23卷 78-91页

作者：何亮周子栋 VAN DEN bERGH Wim bALIEU Romain CANNONE FALCHETTO Augusto 朱继青 ALEXIADIS Alessio KOWALSKI Karol valentin Jan 蔡皓东李后君乔亚宁重庆交通大学交通土建工程材料国家地方联合工程研究中心重庆400074 安特卫普大学应用工程学院安特卫普2000 KTH皇家理工学院土木与建筑工程学院斯德哥尔摩11428 阿尔托大学土木工程学院南芬兰赫尔辛基02150 瑞典国家道路与交通研究院东约特兰林雪平58195 伯明翰大学化学工程学院阿拉巴马伯明翰B152TT 华沙理工大学土木工程学院马佐夫舍华沙00-637 捷克理工大学土木工程学院布拉格16629

为揭示多孔沥青混合料孔隙堵塞机理,开展了多孔沥青混合料堵塞模型试验与仿真模拟结合研究;基于电子计算机断层扫描与离散元软件PFC3D V5.0分析了多孔沥青混合料孔隙特征,得到了多孔沥青混合料的孔隙数据;在PFC3D V5.0中投放各粒径集料... 详细信息

为揭示多孔沥青混合料孔隙堵塞机理,开展了多孔沥青混合料堵塞模型试验与仿真模拟结合研究;基于电子计算机断层扫描与离散元软件PFC3D V5.0分析了多孔沥青混合料孔隙特征,得到了多孔沥青混合料的孔隙数据;在PFC3D V5.0中投放各粒径集料并根据孔隙特征生成压实虚拟试件,以MATLAb切片对比实际试件孔隙图像验证模型准确性;在自重条件下设置特定级配组成堵塞物侵入多孔沥青混合料试件模拟仿真,并以室内试验结果对照验证,改变投放堵塞物粒径,分析了试件孔隙衰变率,找出了堵塞敏感颗粒;在自重条件下引入流体模拟仿真试验,改变了流体渗流速度,分析了试件堵塞变化规律。研究结果表明:PFC3D V5.0生成的虚拟试件具备较高的精确度,仿真揭示了试件堵塞规律,小颗粒除堆积于喉孔处产生堵塞外,还会在嵌挤成型后与大粒径颗粒积聚产生堵塞;自重条件下的堵塞主要集中在混合料试件上层30 mm处,相应堵塞敏感颗粒粒径分布为0.150~0.600 mm,堵塞颗粒粒径分布对堵塞结果影响较大;在重力与流体条件下,随着渗流速度从0.005 m·s^(-1)增加到0.030 m·s^(-1),孔隙衰变率变化速度增加,残留在混合料内部的堵塞物减少,孔隙衰变率减小,排水沥青路面在设计与养护时也需将当地降雨条件带入考虑。

关键词：路面工程多孔沥青混合料孔隙特征孔隙堵塞离散元仿真堵塞敏感颗粒

Structural Characterization of Ulvan Polysaccharide from Cultivated and Collected <i>Ulva fasciata</i>(Chlorophyta)

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Advances in bioscience and biotechnology 2020年第5期11卷 206-216页

作者： Tiphane Andrade Figueira Antonio Jorge Ribeiro da Silva Alex Enrich-Prast Yocie Yoneshigue-valentin Vinícius Peruzzi de Oliveira Multiuser Unit of Environmental Analysis Institute of Biology Federal University of Rio de Janeiro Rio de Janeiro Brazil Institute for Research on Natural Products Federal University of Rio de Janeiro Rio de Janeiro Brazil Department of Thematic Studies—Environmental Change Link?ping University Link?ping Sweden Marine Macroalgae Laboratory Department of Botany Federal University of Rio de Janeiro Rio de Janeiro Brazil

Ulvan is a sulfated heteropolysaccharide present in the cell wall of Ulva species with unique structural properties and technological potential. Here we characterized by FTIR and NMR analysis the structure of ulvan from Ulva fasciata collected in natural environment (SEA) and after in vitro biomass cultivation in nutrient enriched water (CULT). FTIR spectrum of CULT ulvan presented stronger signals of sulfate groups than SEA. 1H and 13C NMR showed that both ulvan are composed mainly of ulvanobiuronic acid 3-sulfate type A and type b. SEA ulvan presented signals characteristics of xylose, suggesting the presence of ulvanobiose in its structure, while CULT presented most signals of type A disaccharide. The cultivation of Ulva could be an alternative to suffice the emerging demand for ulvan meeting requirements of quality and quantity.

关键词： Sulfated Polysaccharide Aquaculture FTIR Analysis NMR Analysis biotechnology

Establishment of head and neck squamous cell carcinoma mouse models for cetuximab resistance and sensitivity

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Cancer Drug Resistance 2023年第4期6卷 709-728页

作者： Hannah Zaryouh Ines De Pauw Hasan baysal Joran Melis valentin Van den bossche Christophe Hermans Ho Wa Lau Hide Lambrechts Celine Merlin Cyril Corbet Marc Peeters Jan baptist Vermorken Jorrit De Waele Filip Lardon An Wouters Center for Oncological Research(CORE) Integrated Personalized&Precision Oncology Network(IPPON)University of AntwerpCampus Drie EikenAntwerp 2610Belgium Pole of Pharmacology and Therapeutics(FATH) Institut de Recherche Experimentale et Clinique(IREC)UCLouvainBrussels B-1200Belgium institut Roi Albert Il Department of Medical OncologyCliniques Universitaires Saint-LucBrussels B-1200Belgium Department of Medical Oncology Antwerp University HospitalEdegem 2650Belgium

Aim:Acquired resistance to the targeted agent cetuximab poses a significant challenge in finding effective anti-cancer treatments for head and neck squamous cell carcinoma(HNSCC).To accurately study novel combination treatments,suitable preclinical mouse models for cetuximab resistance are key yet currently *** study aimed to optimize an acquired cetuximab-resistant mouse model,with preservation of the innate immunity,ensuring intact antibody-dependent cellular cytotoxicity(ADCC)***:Cetuximab-sensitive and acquired-resistant HNSCC cell lines,generated in vitro,were subcutaneously engrafted in Rag2 knock-out(KO),bALb/c Nude and Cb17 Scid mice with/without Matrigel or *** tumor growth was established,mice were intraperitoneally injected twice a week with cetuximab for a maximum of 3 *** addition,immunohistochemistry was used to evaluate the tumor and its ***:Despite several adjustments in cell number,cell lines and the addition of Matrigel,Rag2 KO and bALb/C Nude mice proved to be unsuitable for xenografting our HNSCC cell *** tumor growth of resistant SC263-R cells could be induced in Cb17 Scid ***,these cells had lost their resistance phenotype in *** revealed a high infiltration of macrophages in cetuximab-treated SC263-R ***-S and FaDu-R cells successfully engrafted into Cb17 Scid mice and maintained their sensitivity/resistance to ***:We have established in vivo HNSCC mouse models with intact ADCC functionality for cetuximab resistance and sensitivity using the FaDu-R and FaDu-S cell lines,*** models serve as valuable tools for investigating cetuximab resistance mechanisms and exploring novel drug combination strategies.

关键词： HNSCC cetuximab resistance xenograft mouse model immunodeficient mice

Molecular Analysis of Clerodendrum formicarum Effects in Painful Diabetic Neuropathy in Rat

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World Journal of Neuroscience 2015年第4期5卷 258-269页

作者： Ghislain Loubano-Voumbi Mor Diaw valentin Ouedraogo Abdou Khadir Sow Aissatou Seck Luc Magloire Anicet boumba Abdoulaye ba Abdoulaye Samb Laboratory of Physiology and Functional Exploration Faculty of Medicine of Pharmacy and OdontologyCheikh Anta Diop University of DakarDakarSenegal Laboratory of Molecular biology of the Loandjili Hospital Pointe NoireRepublic of Congo

The pathophysiology of diabetic neuropathic pain is due to primarily metabolic and vascular factors. There is an increase in sorbitol and fructose, glycated end products, reactive oxygen species and activation of protein kinase C in the diabetic state. All these factors lead to direct damage to the nerves. Taking effective clinical management of neuropathic pain is based on a pharmacological treatment that has shown their limits and many side effects. The hypothesis of central sensitization inhibited by Clerodendrum formicarum, an African pharmacopoeia plant used to treat headaches, arthritis, epilepsy and chronic pain could act on astrocytes and microglial cells. The objective of this work is to study the effect of Clerodendrum formicarum (100, 150 and 200 mg/kg body weight) on astrocytes and microglial cells in a model of diabetic neuropathic pain induced by alloxan monohydrate (150 mg/kg). We noted a suppression of mechanical allodynia and mechanical hyperalgesia respectively by the Von Frey filaments test and the pressure test on the paw by the Clerodendrum formicarumextracts (ECF) at different doses from 2 h at the first injection of the ECF. After 5 days of treatment, we expressed by Western blot bands of different proteins and by quantitative RT-PCR, we determined inhibition of the expression of GFAP, CD11b and isoforms 1 and 2 of cyclooxygenase. These results suggest that ECF inhibits the activation of astrocytes, microglial cells and cyclooxygenase signaling pathway.

关键词： Clerodendrum formicarum Astrocytes Microglial Cells Diabetic Neuropathy Pain Cyclooxygenase

内蒙古鄂尔多斯高原古冰缘遗迹科学考察研究进展

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冰川冻土 2021年第1期43卷 263-273页

作者：何瑞霞金会军蒋观利张泽陈雪梅 Raul David SERbAN Mihaela SERbAN Jef VANDENbERGHE valentin V.SPEKTOR Hugh M.FRENCH 中国科学院西北生态环境资源研究院冻土工程国家重点实验室甘肃兰州730000 东北林业大学东北多年冻土区地质环境系统教育部野外科学观测研究站(内蒙古额尔古纳)/土木工程学院/寒区科学与工程研究院黑龙江哈尔滨100040 Applied Geomorphology and Interdisciplinary Research Centre Department of GeographyWest University of TimisoaraTimis 300223Romania Department of Earth Sciences VU UniversityDe Boelelaan 10851081 HV AmsterdamNetherlands Laboratory of General Geocryology Melnikov Permafrost InstituteRussian Academy of SciencesYakutsk 677010SakhaRussia Departments of Geography and Earth Sciences University of OttawaOntarioCanada Department of Geography University of VictoriaBritish ColumbiaCanada

冰缘遗迹(特别是冷生楔形构造及融冻褶皱)是重建古气候及第四纪晚期多年冻土环境的重要证据。内蒙古鄂尔多斯高原是我国北方地区冰缘现象最为发育的地区之一。为准确了解鄂尔多斯高原冰缘遗迹类型及其分布特征、区域冻土演化历史等,中... 详细信息

冰缘遗迹(特别是冷生楔形构造及融冻褶皱)是重建古气候及第四纪晚期多年冻土环境的重要证据。内蒙古鄂尔多斯高原是我国北方地区冰缘现象最为发育的地区之一。为准确了解鄂尔多斯高原冰缘遗迹类型及其分布特征、区域冻土演化历史等,中国科学院西北生态环境资源研究院和荷兰自由大学共同组成科研小组,于2018年5—6月组织了"鄂尔多斯高原冰缘遗迹科学考察"。考察区域涉及靖边—城川—乌审旗—鄂尔多斯东胜区一带约12000km2的范围。考察内容主要包括鄂尔多斯高原冰缘遗迹类型及特征、分布区域、各类型冰缘遗迹所指示的气候条件的初步推断等。结果表明:冻融褶皱和冷生楔体构造是鄂尔多斯高原主要存在的两大类冰缘遗迹。基于本次考察中关于冰缘遗迹的分布与特征等新发现,并综合前人研究成果,初步推断:在气温极低、多年冻土非常发育的时段,有利于形成各类冷生楔状构造,如冰楔假形和大型原生砂楔等;在气候转暖、多年冻土退化,但还没有全部融化完阶段,可能形成融冻褶皱;区域性大面积分布和成群出现的融冻褶皱一般反映较暖气候环境下,多年冻土层上部已退化到一定程度。基于光释光(OSL)年代测试结果,结合冰缘遗迹的特征及其所指示的古气候环境,初步重建了鄂尔多斯5万年以来的冻土环境变化序列。区内多年冻土在多年冻土最大期(LPM,25~19ka bP)时最发育,以大面积连续多年冻土为主;之后,随气温转暖,总趋势呈退化状态,多年冻土分布逐渐变为片状→岛状→零星斑状,直至现今全部融完变为深季节冻土区。

关键词：内蒙古鄂尔多斯古冰缘遗迹冷生楔形构造冻融褶皱科学考察

瓦氏骨外固定支架三角形有限性固定技术在胫腓骨骨折中的应用

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中华创伤骨科杂志 2010年第3期12卷 233-236页

作者：刘长山任彦俊 Vinogradov valentin 内蒙古满洲里市平安创伤医院 021400 俄罗斯伊尔库茨克州国立医学

目的通过对俄罗斯骨科环形外固定支架的学习,探讨瓦氏骨外固定支架三角形有限性固定技术治疗胫腓骨骨折的疗效. 方法回顾性分析2005年12月至2007年12月期间,使用瓦氏骨外固定支架三角形有限性固定技术治疗54例胫腓骨骨折患者,男48例,... 详细信息

目的通过对俄罗斯骨科环形外固定支架的学习,探讨瓦氏骨外固定支架三角形有限性固定技术治疗胫腓骨骨折的疗效. 方法回顾性分析2005年12月至2007年12月期间,使用瓦氏骨外固定支架三角形有限性固定技术治疗54例胫腓骨骨折患者,男48例,女6例年龄18～54岁,平均34岁（18～54岁）.骨折类型按AO分类：41-C3型2例（其中1例合并43-b2型,另1例合并43-A3型） 42-A型17例,42-b型13例,42-C型12例 43-b型5例,43-C型5例.开放性损伤26例,按Gustilo-Anderson分型：Ⅱ型13例,ⅢA型10例,ⅢC型3例闭合性损伤28例,按Tscherne分类：Ⅰ级8例,Ⅱ级20例.均采用闭合复位瓦氏骨外固定支架骨圆针三角形有限性固定治疗. 结果 28例闭合性损伤患者1周肿胀消退 26例开放损伤创口一期愈合24例,1例经换药后4周愈合,1例截肢.50例患者术后获3～14个月（平均10个月）随访,4例失访.50例患者骨折愈合时间为2～6个月,平均3个月.1例患者发生骨不连,经改单臂外固定支架固定后12周骨折获愈合.本组无功能障碍患者. 结论瓦氏骨外固定支架三角形有限性固定技术在复杂胫腓骨骨折中的应用价值较高,其器械的三维调整力学性能使闭合复位变得容易,损伤小,骨愈合快,固定稳定可靠,感染率低,并发症少.

关键词：胫骨骨折腓骨外固定器骨折固定术

A chromosome-scale genome assembly of Rauvolfia tetraphylla facilitates identification of the complete ajmaline biosynthetic pathway

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Plant Communications 2024年第4期5卷 129-132页

作者： Enzo Lezin Ines Carqueijeiro Clement Cuello Mickael Durand Hans JJansen valentin Verges Caroline birer Williams Audrey Oudin Thomas Duge de bernonville Julien Petrignet Noemie Celton benoit St-Pierre Nicolas Papon Chao Sun Ron P.Dirks Sarah Ellen O’Connor Michael Krogh Jensen Sebastien besseau Vincent Courdavault biomole´cules et biotechnologies Vegetales EA2106Universite´de Tours37200 ToursFrance Future Genomics Technologies 2333 BE Leidenthe Netherlands Laboratoire Synthe se et Isolement de Molecules bioActives(SIMbA EA 7502)Universitede Tours37200 ToursFrance Laboratoire de Cytoge´netique Constitutionnelle CHRU de Tours-Hopital Bretonneau37044 ToursFrance University Angers University BrestIRFSFR ICAT49000 AngersFrance Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 2800China Department of Natural Product biosynthesis Max Planck Institute for Chemical Ecology07745 JenaGermany Novo Nordisk Foundation Center for biosustainability Technical University of Denmark100193 Kgs LyngbyDenmark Present address:Limagrain Center de RechercheRoute d’EnnezatChappesFrance These authors contributed equally to this article

Dear Editor,Rauvolfia tetraphylla(aka the Devil pepper)(Supplemental Figure 1)is a well-known medicinal plant that produces monoterpenoid indole alkaloids(MIAs).This MIA biosynthesis occurs in several organs,including leaves,stems,fruit,and roots,which accumulate the famous antiarrhythmic ajmaline(Kumar et al.2016a,2016b;Kumara et al.,2019).MIAs are natural products notably involved in plant adaptation to the environment and defense against *** mainly results from their high biological activities,which also explain their pharmacological properties.

关键词： properties Figure roots

The Giant Radio Array for Neutrino Detection(GRAND):Science and design

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Science China(Physics,Mechanics & Astronomy) 2020年第1期Mechanics & Astronomy) .卷 5-47页

作者： Jaime álvarez-Mu?iz Rafael Alves batista Aswathi balagopal V. Julien bolmont Mauricio bustamante Washington Carvalho Jr. Didier Charrier Isma?l Cognard valentin Decoene Peter b.Denton Sijbrand De Jong Krijn D.De Vries Ralph Engel Ke Fang Chad Finley Stefano Gabici Quan bu Gou Jun Hua Gu Claire Guépin Hong bo Hu Yan Huang Kumiko Kotera Sandra Le Coz Jean-Philippe Lenain Guo Liang Léü Olivier Martineau-Huynh Miguel Mostafá Fabrice Mottez Kohta Murase valentin Niess Foteini Oikonomou Tanguy Pierog Xiang Li Qian bo Qin Duan Ran Nicolas Renault-Tinacci Markus Roth Frank G.Schr ?der Fabian Schüssler Cyril Tasse Charles Timmerman Matías Tueros Xiang Ping Wu Philippe Zarka Andreas Zech b.Theodore Zhang Jian Li Zhang Yi Zhang Qian Zheng Anne Zilles Departamento de Física de Partículas & Instituto Galego de Física de Altas Enerxías Universidad de Santiago de Compostela Instituto de Astronomia Geofísica e Ciências Atmosféricas Universidade de S?o Paulo Department of Physics—Astrophysics University of Oxford DWB Institute of Experimental Particle Physics (ETP) Karlsruhe Institute of Technology (KIT) Laboratoire de Physique Nucléeaire et de Hautes Energies (LPNHE) Sorbonne Université Université Paris Diderot Sorbonne Paris Cité Niels bohr International Academy and DARK Niels Bohr Institute Discovery Center Niels Bohr Institute Center for Cosmology and Astro Particle Physics (CCAPP) & Department of Physics Ohio State University Universidade de Santiago de Compostela SUbATECH Institut Mines-Telecom Atlantique – CNRS/IN2P3 – Université de Nantes Laboratoire de Physique et Chimie de l’Environnement et de l’Espace LPC2E CNRS-Université d’Orléans Station de Radioastronomie de Nan?cay Observatoire de Paris Sorbonne Université UMR 7095 Institut d’Astrophysique de Paris Institute for Mathematics Astrophysics and Particle Physics (IMAPP) Radboud Universiteit Nationaal Instituut voor Kernfysica en Hoge Energie Fysica (NIKHEF) IIHE/ELEM Vrije Universiteit Brussel Institute for Nuclear Physics (IKP) Karlsruhe Institute of Technology (KIT) Einstein Fellow Stanford University Department of Astronomy University of Maryland Joint Space-Science Institute Oskar Klein Centre Stockholm University Department of Physics Stockholm University Astro Particule et Cosmologie (APC) Université Paris Diderot CNRS/IN2P3 CEA/Irfu Observatoire de Paris Institute of High Energy Physics Chinese Academy of Sciences National Astronomical Observatories Chinese Academy of Sciences School of Physical Science and Technology Xinjiang University Center for Particle and Gravitational Astrophysics Pennsylvania State University Department of Physics Pennsylvania State University Department of Astronomy & Astrophysics Pennsylvania State University LUTH Observatoire de Paris

The Giant Radio Array for Neutrino Detection（GRAND） is a planned large-scale observatory of ultra-high-energy（UHE） cosmic particles, with energies exceeding 10～8 Ge V. Its goal is to solve the long-standing mystery of the origin of UHE cosmic rays. To do this, GRAND will detect an unprecedented number of UHE cosmic rays and search for the undiscovered UHE neutrinos and gamma rays associated to them with unmatched sensitivity. GRAND will use large arrays of antennas to detect the radio emission coming from extensive air showers initiated by UHE particles in the atmosphere. Its design is modular: 20 separate, independent sub-arrays, each of 10000 radio antennas deployed over 10000 km2. A staged construction plan will validate key detection techniques while achieving important science goals early. Here we present the science goals, detection strategy, preliminary design, performance goals, and construction plans for GRAND.

关键词： radio telescopes neutrinos in astronomical observations cosmic rays in astronomical observations radiowave radiation: sources galactic and extragalactic cosmic rays