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Perturbations in the earthworm metabolite profile during a two-week exposure to metformin

Emerging Contaminants 2024年第3期10卷 221-229页

作者： J.D.Gillis G.w.Price S.O.Prasher Department of bioresource Engineering McGill UniversityFaculty of Agricultural and Environmental SciencesMacdonald-Stewart Building MS1-02721111 Lakeshore RoadSainte-Anne-de-BellevueQuebecH9X 3V9Canada Department of Engineering Dalhousie UniversityFaculty of Agriculture39 Cox RoadPO Box 550TruroNova ScotiaB2N 5E3Canada

Metformin is among the most prescribed pharmaceuticals in many countries,and as a result has shown up in biosolids derived from municipal wastewater treatment that are destined for land *** humans taking metformin,the effects include reduced glucose uptake in the intestine,a reduction in gluconeogenesis,increased oxidation of fatty acids,and reduced fatty acid *** effects of metformin on soil-dwelling organisms are not well *** study tested the effects of metformin exposure(0,10,40,160,640μg g^(-1))on the earthworm(***)at four time points(6 h,2 d,7 d,and 14 d)using GC-MS to reveal sub-lethal effects and elucidate potential modes of action for *** were no mortalities observed,and earthworms exposed to the highest concentrations(160 and 640μg g^(-1))gained weight relative to the control on days 7 and *** reductions on day 7 were observed for glucose and malic acid(consistent with a reduction in gluconeogenesis),and for palmitic and margaric acid(consistent with increased oxidation and reduced synthesis of fatty acids).Lactic acid ranked first and second among canonicals 1 and 2 respectively and led to significant differences in discriminant scores across concentration and *** levels increased to equal or greater than the control on day 14,likely caused by reduced exposure as metformin is reported to be readily transformed by microorganisms under aerobic *** observations were consistent with the known effects of metformin in humans,and suggests that a similar mode of action exists in earthworms.

关键词： Metabolites Toxicity Earthworms Metformin GC-MS

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应用钆布醇的稳态MR血管成像评估股骨头缺血性坏死病人的血供变化

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国际医学放射学杂志 2024年第1期 129-130页

作者： Z.H.Liao C.Liu b.wu C.Ma b.Ming q.Zhou 陈莉

摘要目的探讨应用钆布醇行稳态（SS）MR血管成像（MRA）评价股骨头坏死（ONFH）血供变化的可行性。方法前瞻性纳入2021年12月—2022年5月招募的参与者。比较

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Reduction of epinephrine in the lumbar spinal cord follow.ng repetitive blast-induced traumatic brain injury in rats

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Neural Regeneration Research 2024年第7期19卷 1548-1552页

作者： Shigeharu Tsuda Mustafa Golam Jiamei Hou Kevin K.w.w.ng Floyd J.Thompson Prodip bose brain Rehabilitation Research Center Malcom Randall VA Medical CenterNorth Florida/South Georgia Veterans Health SystemGainesvilleFLUSA Department of Anesthesiology College of MedicineUniversity of FloridaGainesvilleFLUSA Department of Emergency Medicine University of FloridaGainesvilleFLUSA Department of Neuroscience University of FloridaGainesvilleFLUSA Department of Neurology University of FloridaGainesvilleFLUSA

Traumatic brain inju ry-induced unfavorable outcomes in human patients have independently been associated with dysregulated levels of monoamines,especially epinephrine,although few preclinical studies have examined the epinephrine level in the central nervous system after traumatic brain *** has been shown to regulate the activities of spinal motoneurons as well as increase the heart rate,blood pressure,and blood flow to the hindlimb ***,the purpose of the present study was to determine the impact of repeated blast-induced traumatic brain injury on the epinephrine levels in seve ral function-s pecific central nervous system regions in *** three repeated blast injuries at 3-day intervals,the hippocampus,motor cortex,locus coeruleus,vestibular nuclei,and lumbar spinal cord were harvested at post-injury day eight and processed for epinephrine assays using a high-sensitive electrochemical detector cou pled with high-performance liquid *** results showed that the epinephrine levels were significantly decreased in the lumbar spinal cord tissues of blast-induced traumatic brain injury animals compared to the levels detected in age-and sex-matched sham *** other function-specific central nervous system regions,although the epinephrine levels were slightly altered follow.ng blast-induced tra u matic brain injury,they were not statistically *** results suggest that blast injury-induced significant downregulation of epinephrine in the lumbar spinal cord could negatively impact the motor and cardiovascular *** is the first repo rt to show altered epinephrine levels in the spinal cord follow.ng repetitive mild blast-induced traumatic brain injury.

关键词： balance blood flow cardiovascular system central nervous system epinephrine ischemic damage lumbar spinal cord muscle tone repeated blast spasticity traumatic brain injury

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Multi-scale simulation of columnar-to-equiaxed transition during laser selective melting of rare earth magnesium alloy

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Journal of Materials Science & Technology 2022年第24期119卷 11-24页

作者： w.L.w.ng w.q.Liu X.Yang R.R.Xu q.Y.Dai School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China

A model of coupling macro finite volume method(FVM) and cellular automata(CA) is proposed in this paper to explore the columnar-to-equiaxed transition(CET) during selective laser melting(SLM) of rare earth magnesium *** into account the impact of recoil pressure and Marangoni convection on the molten pool temperature field,the grain structure is *** suggested by the simulation results,with the undissolved Zr serving as heterogeneous nucleation sites,the liquid undercooled layer under the combined action of forced cooling,the temperature gradient and the liquid solute concentration gradient leads to *** considering the dissolution of Zr in magnesium matrix,the results demonstrate that the dissolution of element Zr is effective in significantly inhibiting the growth of columnar crystals and ensuring the sufficient constitutional supercooling(CS) required for *** addition,to raise the preheating temperature contributes to enhancing the outcome of nucleation and incresing the grain *** the interdependence model(IM),with the cooling rate gradually increasing in the SLM process of magnesium alloy,the nucleation-free zone(NFZ) reduces by decreasing the solute diffusion layer in the front of the solid/liquid(SL) interface and the temperature *** reduction in temperature gradient can promote undercooling for nucleation and facilitate the development of equiaxed *** simulation results are qualitatively verified as highly consistent through experimentation.

关键词： Multi-scale simulation Columnar-to-equiaxed transition Selective laser melting Rare earth magnesium alloy Constitutional supercooling

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MICROSTRUCTURAL CHARACTERISTICS ASSOCIATED wITH HIGH- STRAIN-RATE PLASTIC DEFORMATION IN THE ELECTROFORMED COPPER LINER OF SHAPED CHARGES

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Acta Metallurgica Sinica(English Letters) 2005年第5期18卷 620-626页

作者： A.L. Fan w.H. Tian q. Suns b.S. w.ng Department of Materials Physics and Chemistry University of Science and Technology Beijing Beijing 100083 China Taiyuan University of Science and Technology Taiyuan 030024 China 210 Institute The Chinese Ordnance Industry Institute Beijing 100081 China

The microstructures of electroformed copper liners of shaped charges that had undergone high-strain-rate deformation were observed by optical microscopy （OM） and scanning electron microscopy （SEM）. Meanwhile, the orientation distribution of the grains in the recovered jet was examined by electron backscattering Kikuchi pattern （EbSP） technique. EbSP analysis reveals that the fibrous texture observed in the as-electroformed copper liners disappeared after explosive detonation deformation. OM observation shows that the microstructure evolves system- atically from the jet center to its perimeter during cooling from high temperatures after explosive detonation deformation. This microstructural characteristic is similar to that of solidification, i.e. there exist equiaxed grains in the center of the jet and significant columnar grains around the equiaxed grains. The result reveals that there is melting-related phenomenon in the jet center. Corresponding microhardness variations from the jet center to its perimeter is also determined. All the phenomena can be explained by a strong gradient of temperature across the section of the jet during plastic deformation at high-strain-rate.

关键词： jetting electroformation microstructure hardness,ultra-high strain rate deformation

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Microstructure and mechanical optimization of probeless friction stir spot welded joint of an Al-Li alloy

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Journal of Materials Science & Technology 2018年第10期34卷 1739-1746页

作者： q. Chu w.Y. Li X.w. Yang J.J. Shen A. Vairis w.Y. Feng w.b. w.ng State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of Friction Welding Technologies Northwestern Polytechnical University Xi'an710072 China Helmholtz-Zentrum Geesthacht Institute of Materials Research Materials Mechanics Geesthacht 21502 Germany Mechanical Engineering Department TEl of Crete Heraklion Crete 71004 Greece China PSw Center Beijing 100024 China

In this work, a third generation AI-Li alloy has been successfully spot welded with probeless friction stir spot welding （P-FSSw）, which is a variant of conventional friction stir welding. The box-behnken exper-imental design in response surface methodology （RSM） was applied to optimize the P-FSSw parameters to attain maximum tensile/shear strength of the spot joints. Results show that an optimal failure load of 7.83 kN was obtained under a dwell time of 7.2 s, rotation speed of 950 rpm and plunge rate of 30 mm/rain. Sufficient dwell time is essential for heat conduction, material flow and expansion of the stir zone to form a sound joint. Two fracture modes were observed, which were significantly affected by hook defect. In addition to mechanical testing, electron backscattering diffraction （EbSD） and differential scanning calorimetry （DSC） were used for microstructure evolution and property analysis. The precipitation of GP zone and AI3Li as well as the ultrafine grains were responsible for the high microhardness in the stir zone.

关键词： Probeless friction stir spot welding Precipitation Mechanical property Fracture mechanism

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Three- and Four-Dimensional Generalized Pythagorean Numbers

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Advances in Pure Mathematics 2024年第1期14卷 1-15页

作者： Alfred wünsche Institute of Physics Humboldt University Berlin Germany

The Pythagorean triples (a, b | c) of planar geometry which satisfy the equation a2+b2=c2 with integers (a, b, c) are generalized to 3D-Pythagorean quadruples (a, b, c | d) of spatial geometry which satisfy the equation a2+b2+c2=d2 with integers (a, b, c, d). Rules for a parametrization of the numbers (a, b, c, d) are derived and a list of all possible nonequivalent cases without common divisors up to d2 is established. The 3D-Pythagorean quadruples are then generalized to 4D-Pythagorean quintuples (a, b, c, d | e) which satisfy the equation a2+b2+c2+d2=e2 and a parametrization is derived. Relations to the 4-square identity are discussed which leads also to the N-dimensional case. The initial 3D- and 4D-Pythagorean numbers are explicitly calculated up to d2, respectively, e2.

关键词： Number Theory Pythagorean Triples Tesseract 4-Square Identity Diophantine Equation

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An analysis of the chaotic motion of particles of different sizes in a gas fluidized bed

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Particuology 2008年第6期6卷 549-556页

作者： Y.q. Feng A.b. Yu Lab for Simulation and Modelling of Particulate Systems School of Materials Science and Engineering University of New South Wales Sydney NSW 2052 Australia

The dynamic behavior of individual particles during the mixing/segregation process of particle mixtures in a gas fluidized bed is analyzed. The analysis is based on the results generated from discrete particle simulation, with the focus on the trajectory of and forces acting on individual particles. Typical particles are selected representing three kinds of particle motion： a flotsam particle which is initially at the bottom part of the bed and finally fluidized at the top part of the bed; a jetsam particle which is initially at the top part of the bed and finally stays in the bottom de-fluidized layer of the bed; and a jetsam particle which is intermittently joining the top fluidized and bottom de-fluidized layers. The results show that the motion of a particle is chaotic at macroscopic or global scale, but can be well explained at a microscopic scale in terms of its interaction forces and contact conditions with other particles, particle-fluid interaction force, and local flow structure. They also highlight the need for establishing a suitable method to link the information generated and modeled at different time and length scales.

关键词： Fluidization Segregation Discrete particle simulation Granular dynamics

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Interfacial stress engineering toward enhancement of ferroelectricity in Al doped HfO_(2)thin films

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Chinese Physics b 2024年第9期33卷 637-643页

作者： S X Chen M M Chen Y Liu D w Cao G J Chen Department of Microelectronics Jiangsu UniversityZhenjiang 212013China Department of Physics Jiangsu UniversityZhenjiang 212013China Guangdong–Hong Kong–Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology Foshan UniversityFoshan 528225China

Ferroelectric HfO_(2)has attracted much attention ow.ng to its superior ferroelectricity at an ultra-thin thickness and good compatibility with Si-based complementary metal-oxide-semiconductor(CMOS)***,the crystallization of polar orthorhombic phase(o-phase)HfO_(2)is less competitive,which greatly limits the ferroelectricity of the as-obtained ferroelectric HfO_(2)thin ***,the crystallization of o-phase HfO_(2)can be thermodynamically modulated via interfacial stress *** this paper,the growth of improved ferroelectric Al doped HfO_(2)(HfO_(2):Al)thin films on(111)-oriented Si substrate has been *** analysis has suggested that nonpolar monoclinic HfO_(2):Al grown on(111)-oriented Si substrate suffered from a strong compressive strain,which promoted the crystallization of(111)-oriented o-phase HfO_(2)in the as-grown HfO_(2):Al thin *** addition,the in-plane lattice of(111)-oriented Si substrate matches well with that of(111)-oriented o-phase HfO_(2),which further thermally stabilizes the o-phase HfO_(2).Accordingly,an improved ferroelectricity with a remnant polarization(2P_(r))of 26.7C/cm^(2) has been *** results shown in this work provide a simple way toward the preparation of improved ferroelectric HfO_(2)thin films.

关键词： improved ferroelectricity interfacial stress engineering compressive strain HfO_(2)

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On Identical Problems of Natural Convection in Enclosures and Applications of the Identity Character

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Journal of Thermal Science 1993年第2期2卷 116-125页

作者： Yang, M. Tao, w.q. w.ng, q.w. Lui, S.S. Xi'an Jiaotong Univ Xi'an China

In this paper, a concept of 'identical problems' of natural convection in enclosures is presented. A pair of problems of natural convection in enclosures is said to be identical if they look different in appearance but with appropriate selection of coordinates and appropriate definition of dimensionless variables for each problem, they will have identical geometric configurations and identical dimensionless governing equations and related boundary conditions. The identical characteristics of a pair of problems of natural convection in enclosures with an internal isolated island are demonstrated via dimensionless mathematical formulation and flow visualization results. Numerical computations are performed and the predicted streamlines agree with the flow visualization results. A number of other possible pairs of identical problems are also presented. Applications of the identical character are provided and assumptions under which the identical problems may exist are discussed.

关键词： natural convection enclosure flow identical problems

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