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Proteome analysis of human mesenchymal stem cells undergoing chondrogenesis when exposed to the products of various magnesium-based materials degradation

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bioactive Materials 2019年第1期4卷 168-188页

作者： Adela Helvia Martínez Sánchez Maryam Omidi Marcus Wurlitzer Marceline Manka Fuh Frank Feyerabend Hartmut Schlüter regine Willumeit-Römer bérengère j.c.luthringer Division of Metallic biomaterials Institute of Material ResearchHelmholtz-Zentrum GeesthachtMax Planck Strasse 121502GeesthachtGermany Institute of clinical chemistry and Laboratory Medicine Mass Spectrometric ProteomicsUniversity Medical Center Hamburg-EppendorfMartinistraße 5220246HamburgGermany

Treatment of physeal fractures(15%–30%of all paediatric fractures)remains a challenge as in approximately 10%of the cases,significant growth disturbance may *** Magnesium-based implants represent a strategy to minimize damage(i.e.,load support until bone healing without second surgery).Nevertheless,the absence of harmful effects of magnesium-implants and their degradation products on the growth plate should be ***,the proteome of human mesenchymal stem cells undergoing chondrogenesis was evaluated when exposed to the products of various Magnesium-based materials *** results of this study indicate that the materials induced regulation of proteins associated with cell chondrogenesis and cartilage formation,which should be beneficial for cartilage regeneration.

关键词： Stem cells differentiation chondrogenesis Proteomics Magnesium biomaterial biodegradable implant

corrosion behaviour and cytocompatibility of selected binary magnesium-rare earth alloys

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journal of Magnesium and Alloys 2021年第2期9卷 581-591页

作者： Hiba Azzeddine Abdelkader Hanna Achour Dakhouche bérengère luthringer-Feyerabend Department of Physics Faculty of SciencesUniversity of Mohamed BoudiafM’silaAlgeria Inorganic Materials Laboratory Department of ChemistryFaculty of SciencesUniversity of Mohamed BoudiafM’silaAlgeria Metallic biomaterials Institute of Material ResearchHelmholtz-Zentrum Geesthacht21502 GeesthachtGermany

The corrosion behaviour of as-cast binary Mg–0.3 ce,Mg–1.44 Nd,Mg–0.63 Gd and Mg–0.41 Dy(wt%)alloys was investigated in DMEM+10%FbS solution using electrochemical and weight loss *** results revealed that the alloys with heavy re elements(Gd and Dy)exhibited the lowest corrosion rate compared to the alloys with light re elements(ce and Nd).The cytocompatibility of the Mg–re alloys was assessed via live/dead straining after 3 and 7 *** results show that Mg–0.63 Gd alloy is a suitable candidate for biomedical applications.

关键词： corrosion cytotoxicity Magnesium alloys Rare earth element Weight loss test

controlled release of hydrogen by implantation of magnesium induces P53-mediated tumor cells apoptosis

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bioactive Materials 2022年第3期7卷 385-396页

作者： Rui Zan Hao Wang Weijie cai jiahua Ni berengere j.c.luthringer-Feyerabend Wenhui Wang Hongzhou Peng Weiping ji jun Yan jiazeng Xia Yang Song Xiaonong Zhang State Key Laboratory of Metal Matrix composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China Institute of Metallic biomaterials Department of Biological CharacterisationHelmholtz-Zentrum Geesthacht(HZG)Geesthacht21502Germany Department of General Surgery and Translational Medicine center Wuxi No.2 People’s HospitalAffiliated Wuxi Clinical College of Nantong UniversityJiangsu214002China Orthopaedic Department Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200233China Department of General Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200233China Suzhou Origin Medical Technology co.Ltd. Suzhou215513China

Hydrogen has been used to suppress tumor growth with considerable *** of hydrogen gas and oral ingestion of hydrogen-rich saline are two common systemic routes of hydrogen *** have developed a topical delivery method of hydrogen at targeted sites through the degradation of magnesium-based ***,the underlying mechanism of hydrogen’s role in cancer treatment remains ***,we investigate the mechanism of tumor cell apoptosis triggered by the hydrogen released from magnesium-based *** find that the localized release of hydrogen increases the expression level of P53 tumor suppressor proteins,as demonstrated by the in vitro RNA sequencing and protein expression ***,the P53 proteins disrupt the membrane potential of mitochondria,activate autophagy,suppress the reactive oxygen species in cancer cells,and finally result in tumor *** anti-tumor efficacy of magnesium-based biomaterials is further validated in vivo by inserting magnesium wire into the subcutaneous tumor in a *** also discovered that the minimal hydrogen concentration from magnesium wires to trigger substantial tumor apoptosis is 91.2μL/mm^(3)per day,which is much lower than that required for hydrogen *** together,these findings reveal the release of H2 from magnesium-based biomaterial exerts its anti-tumoral activity by activating the P53-mediated lysosome-mitochondria apoptosis signaling pathway,which strengthens the therapeutic potential of this biomaterial as localized anti-tumor treatment.

关键词： biodegradable magnesium Hydrogen Tumor apoptosis Underlying mechanism P53

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural regeneration research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory Hborschel SickKids research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of biomaterials and biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Status and prospects for symmetric organic redox flow batteries

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journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFbs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFbs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. by providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFbs.

关键词： redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural regeneration research 2025年第9期20卷 2596-2597页

作者： christopher j.O’connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle college of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TbI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(capizzi et al.,2020).TbIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(capizzi et al.,2020).

关键词： sustained orange dynamic

金属注射成型生物医用Ti-22Nb合金的表面形貌和细胞相容性（英文）

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Transactions of Nonferrous Metals Society of china 2018年第7期28卷 1342-1350页

作者：赵大鹏陈钰凯常可可 Thomas EbEL bérengère jcLUTHRIGNER-FEYERAbEND regine WILLUMEIT-R?MER Florian PYcZAK 湖南大学生物学院 Institute of Materials research Helmholtz-Zentrum Geesthacht 中国科学院宁波材料技术与工程研究所

采用金属注射成型(MIM)工艺制备Ti-22Nb(质量分数,%)和商业纯钛(cP-Ti)参比样,并选取电弧熔炼后抛光的Ti-22Nb作为另一种参比样。采用激光共聚焦显微镜、扫描电子显微镜和酶联免疫检测仪检测每组样品的表面拓扑结构和细胞相容性。结果显... 详细信息

采用金属注射成型(MIM)工艺制备Ti-22Nb(质量分数,%)和商业纯钛(cP-Ti)参比样,并选取电弧熔炼后抛光的Ti-22Nb作为另一种参比样。采用激光共聚焦显微镜、扫描电子显微镜和酶联免疫检测仪检测每组样品的表面拓扑结构和细胞相容性。结果显示,MIM工艺可以得到微米级粗糙度,而且采用混合元素粉而不是单一钛粉作为原料可以获得更高的表面粗糙度和比表面积。所有测试样品都不存在细胞毒性。人原代细胞在MIM Ti-22Nb样品表面(特别是在闭孔附近)的吸附效果更好。

关键词：金属注射成型 Ti-Nb合金表面拓扑结构细胞吸附细胞增殖

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural regeneration research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan bouchi juan Pablo de Rivero Vaccari jennifer c.Munoz Pareja Andrew reisner Laura blackwell Yehia Mechref Kevin K.Wang j.Adrian Tyndall binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of chemistry and biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural regeneration research 2025年第7期20卷 2011-2012页

作者： Sharon j.brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and bioengineering Keele UniversityKeeleUK Wolfson center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute