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Identifying and validating MMP family members(MMP2,MMP9,MMP12,and MMP16)as therapeutic targets and biomarkers in kidney renal clear cell carcinoma(KIRC)

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Oncology Research 2024年第4期32卷 737-752页

作者： KUNLUN LI DANDAN LI BARBOD HAFEZ MOUNIR M.SALEM BEKHIT YOUSEF A.bin JARDAN FARS KAED ALANAZI EHAB I.TAHA SAYED H.AUDA FAIQAH RAMZAN MUHAMMAD jamil The Second Affiliated Hospital of Harbin Medical University Harbin Medical UniversityHarbinChina Department of Pharmaceutical Engineering Jiangsu Ocean UniversityLianyungangChina Department of Biological Engineering University of SalfordSalfordUK Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadhSaudi Arabia Department of Animal and Poultry Production Faculty of Veterinary and Animal SciencesGomal UniversityDera Ismail KhanPakistan Department of Arid Zone Research PARC instituteDera Ismail KhanPakistan

Kidney Renal Clear Cell Carcinoma(KIRC)is a malignant tumor that carries a substantial risk of morbidity and *** MMP family assumes a crucial role in tumor invasion and *** study aimed to uncover the mechanistic relevance of the MMP gene family as a therapeutic target and diagnostic biomarker in Kidney Renal Clear Cell Carcinoma(KIRC)through a comprehensive approach encompassing both computational and molecular ***,Cytoscape,UALCAN,GEPIA,OncoDB,HPA,cBioPortal,GSEA,TIMER,ENCORI,DrugBank,targeted bisulfite sequencing(bisulfite-seq),conventional PCR,Sanger sequencing,and RT-qPCR based analyses were used in the present study to analyze MMP gene family members to accurately determine a few hub genes that can be utilized as both therapeutic targets and diagnostic biomarkers for *** performing STRING and Cytohubba analyses of the 24 MMP gene family members,MMP2(matrix metallopeptidase 2),MMP9(matrix metallopeptidase 9),MMP12(matrix metallopeptidase 12),and MMP16(matrix metallopeptidase 16)genes were denoted as hub genes having highest degree *** analyzing MMP2,MMP9,MMP12,and MMP16 via various TCGA databases and RT-qPCR technique across clinical samples and KIRC cell lines,interestingly,all these hub genes were found significantly overexpressed at mRNA and protein levels in KIRC samples relative to *** notable effect of the up-regulated MMP2,MMP9,MMP12,and MMP16 was also documented on the overall survival(OS)of the KIRC ***,targeted bisulfite-sequencing(bisulfite-seq)analysis revealed that promoter hypomethylation pattern was associated with up-regulation of hub genes(MMP2,MMP9,MMP12,and MMP16).In addition to this,hub genes were involved in various diverse oncogenic *** MMP gene family members(MMP2,MMP9,MMP12,and MMP16)may serve as therapeutic targets and prognostic biomarkers in KIRC.

关键词： KIRC MMP gene family Chemotherapy Overall survival

Dysprosium oxide,alumina,and graphene oxide reinforced polycaprolactone thin films:Thermal stability,morphology,and cell viability

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Journal of Rare Earths 2024年第7期42卷 1337-1343,I0005页

作者： Mohamed Tharwat Elabbasy Mohamed R.Atteya Mai A.Samak Mousa abdelrahman Tahani AlMahmoud M.A.El-Morsy A.A.Menazea M.F.H.abd El-Kader Department of Public Health College of Public Health and Health InformaticsUniversity of Ha'ilHa'il2440Saudi Arabia Food Control Department Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Department of Physical Therapy College of Applied Medical SciencesUniversity of Ha'ilHa'ilSaudi Arabia Department of Histology and Cell Biology Faculty of MedicineZagazig UniversityZagazig44519Egypt College of Nursing University of Ha'ilHa'ilSaudi Arabia College of Science and Humanities in Al-Kharj Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics Department Faculty of ScienceUniversity of DamiettaNew Damietta34517Egypt Spectroscopy Department Physics Research InstituteNational Research CentreDokki12622GizaEgypt Biophysics Department Faculty of ScienceCairo UniversityGizaEgypt

Developing a biomaterial for wound healing applications is still a ***,dysprosium oxide(Dy_(2)O_(3)),aluminum oxide(Al_(2)O_(3)),and graphene oxide(GO)were embedded in cast films based on polycaprolactone(PCL)to be examined for wound dressing *** techniques were used to characterize the fabricated films including X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),Raman,and scanning electron microscopy(SEM),besides their biological *** thermogravimetric analysis(TGA)exhibits high thermal stability as the scaffold weight decreases slightly to 98.6%after raising the temperature from room temperature to 280℃.The cell viability was investigated and it is shown that the viable cells grow up to approximately 93%at 75μg/***,the cell attachment shows excellent behavior as the cells attach on most of the surface of the modified PCL which shows high biocompatibility.

关键词： Wound healing Polycaprolactone Dy_(2)O_(3) Al_(2)O_(3) Biocompatible Rare earths

Impact of land uses on water quality in Malaysia: a review

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Ecological Processes 2019年第1期8卷 128-137页

作者： Moriken Camara Nor Rohaizah jamil Ahmad Fikri bin abdullah Faculty of Environmental Studies Universiti Putra Malaysia UPM43400 SerdangSelangorMalaysia Department of Biological and Agricultural Engineering Faculty of EngineeringUniversiti Putra Malaysia(UPM)43400SerdangSelangorMalaysia.

Land use changes in urbanization,industrialization,and agricultural processes will continue to have negative impacts on water quality at all *** impact of land use changes on water quality is generally studied by analyzing the relationships between land use and water quality ***,the purpose of this research was to review and analyze the main relationships between land use and water quality,as well as to visualize the major sources and processes of water quality pollution in *** achieve our goal,we evaluated the significance of both land use and water quality attributes used in the past studies and correlated them to understand their relationship from another angle of *** results revealed that 87%of the reviewed studies indicated urban land use as a major source of water pollution,while 82%indicated agricultural land use,77%indicated forest land use,and 44%indicated other land ***,the results of correlation analysis showed that agricultural and forest-related activities more affected water quality through their significant positive correlation with physical and chemical indicators of water quality,while urban development activities had a greater impact on water quality through altering hydrological processes such as runoff and *** findings would provide decision-makers with useful information for managing water pollution processes rather than sources only.

关键词： Land use Water quality Malaysia

Destructive and non-destructive evaluation of concrete for optimum sand to aggregate volume ratio

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Frontiers of Structural and Civil Engineering 2021年第6期15卷 1400-1414页

作者： Tarek Uddin MOHAMMED Aziz Hasan MAHMOOD Mohammad Zunaied-bin-HARUN jamil Ahmed JOY MdAsif AHMED Department of Civil and Environmental Engineering Islamic University of Technology(IUT)Organization of Islamic Cooperation(OIC)Board BazarGazipur 1704Bangladesh Centre for Infrastructure Engineering and Safety School of Civil and Environmental EngineeringThe University of New South WalesSydneyNSW 2052Australia Department of Civil Engineering European University of BangladeshMirpurDhaka 1216Bangladesh

Aggregates are the biggest contributor to concrete volume and are a crucial parameter in dictating its mechanical *** such,a detailed experimental investigation was carried out to evaluate the effect of sand-toaggregate volume ratio(s/a)on the mechanical properties of concrete utilizing both destructive and non-destructive testing(employing UPV(ultrasonic pulse velocity)measurements).For investigation,standard cylindrical concrete samples were made with different s/a(0.36,0.40,0.44,0.48,0.52,and 0.56),cement content(340 and 450 kg/m^(3)),water-to-cement ratio(0.45 and 0.50),and maximum aggregate size(12 and 19 mm).The effect of these design parameters on the 7,14,and 28 d compressive strength,tensile strength,elastic modulus,and UPV of concrete were *** careful analysis demonstrates that aggregate proportions and size need to be optimized for formulating mix designs;optimum ratios of s/a were found to be 0.40 and 0.44 for the maximum aggregate size of 12 and 19 mm,respectively,irrespective of the W/C(water-to-cement)and cement content.

关键词： aggregates non-destructive testing sand-to-aggregate volume ratio(s/a) maximum aggregate size(MAS)

TelG Mote: A Green Wireless Sensor Node Platform for Smart Home and Ambient Assisted Living

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Journal of Electronic Science and Technology 2016年第3期14卷 211-219页

作者： Mohd Rozaini bin abd Rahim Rozeha A.Rashid Norsheila Fisal Zubair Khalid abdul Hadi Fikri abd Hamid Universiti Teknologi Malaysia

The wireless sensor network （WSN） consists of sensor nodes that interact with each other to collectively monitor environmental or physical conditions at different locations for the intended users. One of its potential deployments is in the form of smart home and ambient assisted living （SHAAL）to measure patients or elderly physiological signals, control home appliances, and monitor home. This paper focuses on the development of a wireless sensor node platform for SHAAL application over WSN which complies with the IEEE 802.15.4 standard and operates in 2.4 GHz ISM （industrial, scientific, and medical） band. The initial stage of SHAAL application development is the design of the wireless sensor node named TelG mote. The main features of TelG mote contributing to the green communications include low power consumption, wearable, flexible, user-friendly, and small sizes. It is then embedded with a self-built operating system named WiseOS to support customized operation. The node can achieve a packet reception rate （PRR） above 80% for a distance of up to 8 m. The designed TelG mote is also comparable with the existing wireless sensor nodes available in the market.

关键词： Smart home and ambient assisted living wireless sensor network wireless sensor node.

First Record of the Belemnite Genus Hibolithes from Late Jurassic–Early Cretaceous Turbidites from Malaysia

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Acta Geologica Sinica(English Edition) 2021年第2期95卷 333-341页

作者： Muhammad MURTAZA abdul Hadi abd RAHMAN Joerg MUTTERLOSE Najiatun NAJLA Mazshurraiezal bin NASIR Department of Earth and Environmental Sciences Hazara UniversityMansehraKhyber Pakhtunkhwa 21120Pakistan Department of Geosciences Universiti Teknologi PETRONAS.Bandar Seri IskandarTronohPerak 31750Malaysia Department of Geology Mineralogy and GeophysicsRuhr-Universitat BochumUniversitatsstrasse 150Bochum 44801Germany

Discovery of the remains of belemnites referred to the Hibolithes *** the Jurassic–Cretaceous Pedawan Formation in Sarawak,on the island of Borneo(Malaysia)comprises four fragments of belemnite *** specimens are characterized by multiple fractures and vein *** fragments measuring about 130 mm are relatively intact,with only part of the alveolar region missing;a third piece represents the middle part of a rostrum,and the fourth specimen is too fragmentary to be assigned to any specific part of the *** on specimen characteristics,a Tithonian–Hauterivian age is *** sedimentary succession that yielded the belemnite material comprises thick shale that reflects the Te division of Bouma *** occurrence of a Hibolithes taxon in the uppermost Jurassic to lowermost Cretaceous Pedawan Formation sediments in Borneo reflects a near to global palaeobiogeographic distribution of this genus.

关键词： invertebrate paleontology Belemnitida Hibolithes turbidites Pedawan Formation Tithonian-Hauterivian Sarawak Borneo

An assessment of the concentrations of particulate polycyclic aromatic hydrocarbons (PAHs) in the aftermath of a chemical store fire incident

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Journal of Environmental Sciences 2004年第5期16卷 751-754页

作者： M. Radzi bin Abas Nasr Yousef M. J. Omar M. jamil Maah Department of Chemistry University of Malaya 50603 Kuala Lumpur MalaysiaDepartment of Chemistry University of Malaya 50603 Kuala Lumpur MalaysiaDepartment of Chemistry University of Malaya 50603 Kuala Lumpur Malaysia

PM 10 airborne particles and soot deposit collected after a fire incident at a chemical store were analyzed in order to determine the concentrations of polycyclic aromatic hydrocarbons(PAHs). The samples were extracted with 1∶1 hexane-dichloromethane by ultrasonic agitation. The extracts were then subjected to gas chromatography-mass spectrometric(GC-MS) analysis. The total PAHs concentrations in airborne particles and soot deposit were found to be 3.27±1.55 ng/m 3 and 12.81±24.37 μg/g, respectively. Based on the molecular distributions of PAHs and the interpretation of their diagnostic ratios such as PHEN/(PHEN + ANTH), FLT/(FLT + PYR) and BeP/(BeP + BaP), PAHs in both airborne particles and soot deposit may be inferred to be from the same source. The difference in the value of IP/(IP + BgP) for these samples indicated that benzo[g,h,i]perylene and coronene tend to be attached to finer particles and reside in the air for longer periods. Comparison between the molecular distributions of PAHs and their diagnostic ratios observed in the current study with those reported for urban atmospheric and roadside soil particles revealed that they are of different sources.

关键词： airborne particles soot deposit PAHs

Magnetic,thermal stability and dynamic mechanical properties of beta isotactic polypropylene/natural rubber blends reinforced by NiZn ferrite nanoparticles

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Defence Technology（防务技术） 2019年第6期15卷 958-963页

作者： Lih-Jiun Yu Sahrim Hj Ahmad Ing Kong Mouad ATarawneh Shamsul Bahri bin abd Razak Elango Natarajan Chun Kit Ang Department of Mechanical Engineering Faculty of EngineeringTechnology and Built EnvironmentUCSI UniversityNo 1Jalan Menara GadingUCSI Heights(Taman Connaught)Cheras56000Kuala LumpurMalaysia School of Applied Physics Faculty of Science and TechnologyUniversity Kebangsaan Malaysia43600BangiSelangor Darul EhsanMalaysia School of Engineering and Mathematical Sciences La Trobe UniversityBundooraVIC3086Australia Department of Physics College of ScienceAl-Hussein Bin Talal UniversityP.O Box 20Ma'anJordan Department of Food Science and Technology University Malaysia TerengganuKuala NerusTerengganuMalaysia

The dispersion of magnetic nanoparticles in matrix is crucial to ensure optimum performance of the *** difficulty level of achieving good dispersion is further increase when a multi-phases of matrix is present.A pre-coating technique of magnetic nanoparticles with polypropylene using ball-mill prior to melt-blending process was employed to prepare a multi-phases thermoplastic natural rubber *** effect of filler loading(2 wt%-10 wt%) on morphology,structure,magnetic properties,thermal stability and dynamic mechanical properties of the composites were *** was found that the NiZn ferrite nanoparticles act as nucleating agent to form beta isostatic polypropylene thermoplastic *** composites’ magnetic properties are directly dependent on the filler *** dispersion of magnetic fillers in polymer matrix plays role in affecting the magnetic properties and thermal *** preference of filler to locate at amorphous phase has distorted the chain orientation of natural rubber and ***,the polymorphism and crystallinity of the matrix varied as the filler loading increased,affecting the dynamic mechanical *** was found that 8 wt% NiZn nanocomposite exhibits highest E’ and tanδ,indicating the dynamic mechanical properties of NiZn nanocomposite are affected by β-phase degree.

关键词： Magnetic Thermoplastic natural rubber Nanoparticles Composites

Wear properties of copper and copper composites powders consolidated by high-pressure torsion

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Friction 2020年第2期8卷 433-450页

作者： Mohamed Ibrahim abd El AAL Mechanical Engineering Department College of EngineeringPrince Sattam Bin Abdulaziz UniversityWadi Addawaser 11991Saudi Arabia Mechanical Design&Production Department Faculty of EngineeringZagazig UniversityZagazig 44519Egypt

The wear characteristics of Cu and Cu-SiC composite microsize powders consolidated by cold compaction combined with sintering or high-pressure torsion(HPT)were *** HPT processed(HPTed)samples with bimodal and trimodal microstructures and fine Cu grains and SiC particle sizes have superior hardness,reasonable ductility level,and high wear *** wear mass loss and coefficient of friction of HPTed samples were remarkably lower than that of cold-compacted and sintered samples as well as that of micro and nano Cu and Cu-SiC composites from previous *** sample fabrication method has an apparent influence on the wear *** wear mechanism was converted from adhesive,delamination,three-body mechanism,grooves(take off the SiC particles),and cracks into abrasive wear after *** can be considered a dominant wear mechanism in all *** worn surface morphology and analysis support the relationship between wear mechanism and characteristics.

关键词： Cu-SiC composite powders high-pressure torsion(HPT) fine and coarse grains wear characteristics worn surface morphology