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The significance of metabolic fingerprinting in carcinogenesis

Cancer Advances 2024年第1期7卷 1-6页

作者： ayodele ademola adelakun Princess Adekunbi Owokalade Department of Medical Laboratory Science Ladoke Akintola University of TechnologyOgbomoso 210001Nigeria Department of Medical Laboratory Science Babcock UniversityIlishan-Remo 121103Nigeria

Carcinogenesis describes the process through which normal cells transform into malignant cells(cancer).There were an estimated 18.1 million new cases of cancer(all cancers combined excluding non-melanoma skin cancer)worldwide in 2020:8.8 million(48%)in females and 9.3 million(52%)in males,giving a male:female ratio of 10:*** may be initiated by the action of biological,physical,or chemical agents that cause a non-lethal,permanent,DNA error on the cell with a consequence of altered cell *** altered cell metabolism include the Warburg effect,altered lipid and amino acid metabolism and production of various *** also results in unique metabolic dependencies that,in some cases,can be targeted with precision medicine and nutrition,including drugs that selectively target metabolic *** fingerprinting has been applied to the study of carcinogenesis and is particularly helpful in early diagnosis,staging and choice of treatment,thus improving health *** technology could therefore be harnessed effectively while combining with other omics technologies.

关键词： cancer metabolomics prognosis diagnosis fingerprint

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Personalized medicine approach to osteoporosis management in women: integrating genetics, pharmacogenomics, and precision treatments

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Clinical Research Communications 2023年第3期6卷 22-29页

作者： Seyi Samson Enitan Esther Ngozi Adejumo John Osaigbovoh Imaralu ayodele ademola adelakun Oluwakemi Anike Ladipo Comfort Bosede Enitan Department of Medical Laboratory Science Babcock UniversityIlishan-Remo 121103Nigeria Department of Gynaecology and Obstetrics Babcock University Teaching HospitalIlishan-Remo 121103Nigeria Department of Chemical Pathology Babcock University Teaching HospitalIlishan-Remo 121103Nigeria

Osteoporosis has emerged as a significant health issue among postmenopausal *** this concern necessitates a multifaceted approach encompassing genetics,pharmacogenomics,bone turnover markers,lifestyle factors,concurrent medical conditions,biomarkers,and advanced imaging ***,challenges in terms of cost-effectiveness and ethical considerations do ***,the convergence of technological progress and research endeavors offers a promising *** integration of genetic testing and pharmacogenomics into clinical practice holds substantial *** integration empowers healthcare professionals to forecast treatment responses and pinpoint individuals with elevated susceptibility,thereby enabling the implementation of tailored and efficacious interventions that optimize outcomes–personalized *** the intricate nature of osteoporosis,personalized strategies stand to greatly benefit women grappling with this *** research and collaborative efforts are imperative to propel advancements within this domain,paving the way for further breakthroughs.

关键词： osteoporosis management personalized medicine pharmacogenomics women

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