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Effect of crocin carotenoid on BDNF and CREB gene expression in brain ventral tegmental area of morphine treated rats

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Asian Pacific Journal of Tropical Biomedicine 2018年第8期8卷 387-393页

作者： Marzieh Rezai Mehdi Mahmoodi ayat kaeidi Mojgan Noroozi Karimabad Alireza Khoshdel Mohammad Reza Hajizadeh Department of Clinical Biochemistry Faculty of Medicine Rafsanjan University of Medical Sciences Department of Clinical Biochemistry Afzalipoor Faculty of Medicine Kerman University of Medical Sciences Molecular Medicine Research Center Research Institute of Basic Medical Sciences Rafsanjan University of Medical Sciences Physiology-Pharmacology Research Center Research Institute of Basic Medical Sciences Rafsanjan University of Medical Sciences Department of Physiology and Pharmacology School of Medicine Rafsanjan University of Medical Sciences Department of Clinical Biochemistry Faculty of Medicine and Pistachio Safety Research Center Rafsanjan University of Medical Sciences

Objective: To investigate the effect of crocin carotenoid on BNDF and CREB gene expression in the brain ventral tegmental area(VTA) and the serum level of BDNF in morphine-treated rats compared to control. Methods: In this study, 40 male Wistar rats(200-250 g) were used in 5 experimental groups: 1) non morphine treat rats(control); 2) non morphine-treated rats with 25 mg/kg crocin carotenoid(i.p., for 21 d); 3) morphine treated rats(10 mg/kg twice a day, s.c., 21 d); 4 and 5) morphine-treated rats with 12.5 and 25 mg/kg crocin carotenoid, respectively. By the end of research, BDNF and CREB expression was determined by real-time-PCR method. ELISA analysis was also applied for assessing the serum BDNF level. Results: The data indicated that morphine treatment could cause a significant decrease in BDNF and CREB gene expression(P<0.01 and P<0.001, respectively) in brain VTA as well as serum level of BDNF(P<0.01) in comparison to control group. Treatment with 25 mg/kg crocin carotenoid caused a significant enhancement in BDNF and CREF gene expression(P<0.01 and P<0.05, respectively) and serum level of BDNF(P<0.01) in morphine-treated rats in comparison to morphine-treated group. Conclusions: Regarding to obtained results, crocin carotenoid can inhibit unfavorable effects of morphine on the neural system to some extent through enhancing BDNF and CREB gene expression in brain VTA and serum level of BDNF.

关键词： Morphine BDNF CREB Crocin Ventral tegmental area Rat

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