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Human leukocyte antigen class-Ⅱ DRB1 alleles and Giardia lamblia infection in children: A case-control study

Asian Pacific Journal of Tropical Medicine 2020年第2期13卷 56-61页

作者： Samar N.El-Beshbishi ayat a.elblihy Raefa A.Atia Ahmed Megahed Fatma A.Auf Department of Medical Parasitology Faculty of MedicineMansoura UniversityMansoura 35516Egypt Pediatric Gastroenterology and Hepatology Unit Mansoura University Children's HospitalFaculty of MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pathology Faculty of MedicineMansoura UniversityMansoura 35516Egypt

Objective:To compare the genotype frequencies of HLA class-ⅡDRB1 alleles in Giardia(G.)lamblia-infected ***:A total of 490 Egyptian children aged 2-16 years were subjected to microscopic stool examination to detect *** infection,and to exclude other intestinal *** the basis of their microscopic findings,a group of 80 children were chosen as giardiasis cases,another 80 children were confirmed as Giardia free control group by immunochromatographic test,and the remaining children were *** giardiasis and control groups were then subjected to blood examination to identify their genetic type of HLA-DRB1 ***:HLA class-ⅡDRB1*03:01 and DRB1*13:01 alleles were significantly associated with *** infection(P<0.001 for each variable).On the other hand,HLA class-ⅡDRB1*04:02,DRB1*10:01,DRB1*14:01 and DRB1*15:01 alleles were significantly demonstrated in Giardia free ***,other HLA-DRB1 alleles did not show any significant association with ***:HLA class-ⅡDRB1*03,DRB1*13,DRB1*04,DRB1*10,DRB1*14 and DRB1*15 alleles may be involved in the establishment of host immune response to *** infection.

关键词： Giardia lamblia Giardiasis Human leukocyte antigen HLA class-ⅡDRB1 alleles Children

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