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The optimal stent pusher position to achieve successful ureteral stent insertion under fluoroscopic guidance

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Asian Journal of Urology 2024年第2期11卷 311-315页

作者： Makoto taguchi Kaneki Yasuda Hidefumi Kinoshita Department of Urology Osaka Saiseikai Izuo Hospital Based on Social Welfare Organization“Saiseikai”Imperial Gift Foundation Inc.OsakaJapan Department of Urology and Andrology Kansai Medical UniversityHirakataOsakaJapan

Objective: To examine factors to predict the optimal stent pusher position when inserting ureteral stents under ***: We retrospectively reviewed 327 patients who underwent ureteral stent insertion. We considered the pubic bone as a useful anatomical landmark to insert ureteral stents under fluoroscopic guidance. Thus, we categorized patients into three groups (proximal, middle, and distal groups) according to the position of the radiopaque tip of the push catheter when inserting the ureteral stent. Success was defined as a completely curled ureteral stent tail. We compared stent insertion success rates among the three groups. A multivariate analysis was performed to identify the factors affecting stent insertion ***: In men, 36 (63.2%) cases were deemed successful in the proximal group compared with 40 (80.0%) cases in the middle group and 12 (20.7%) cases in the distal group (p<0.001). In women, 26 (45.6%) cases were deemed successful in the proximal group compared with 54 (98.2%) cases in the middle group and 38 (76.0%) cases in the distal group (p<0.001). With the multivariate analysis, the stent pusher position was the most significant factor influencing successful stent insertion (men: odds ratio 6.00, 95% confidence interval 2.66-13.51, p<0.001;women: odds ratio 37.80, 95% confidence interval 4.94-289.22, p<0.001).Conclusion: The position of the stent pusher affects stent insertion success. The middle of the pubic symphysis is the optimal position for the radiopaque tip of the pusher when inserting ureteral stents under fluoroscopic guidance.

关键词： Stent Cystoscopy Fluoroscopy Ureter

Recent trends in bone metastasis treatments:A historical comparison using the new Katagiri score system

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World Journal of Clinical Cases 2024年第15期12卷 2499-2505页

作者： Kenji Matsuda Kazuhiro Shimazu Hanae Shinozaki Koji Fukuda Taichi Yoshida Daiki taguchi Kyoko Nomura Hiroyuki Shibata Department of Clinical Oncology Akita University Graduate School of MedicineAkita 010-8543Japan Department of Environmental Health Science and Public Health Akita University Graduate School of MedicineAkita 010-8543Japan Department of Comprehensive Cancer Control Akita University Graduate School of MedicineAkita 010-8543Japan

BACKGROUND Bone metastasis has various negative *** of daily living(ADL)and quality of life(QOL)can be significantly decreased,survival may be impacted,and medical expenses may *** is estimated that at least 5%cancer patients might be suffering from bone *** 2016,we published the Comprehensive Guidelines for the Diagnosis and Treatment of Bone *** then,the therapeutic outcomes for patients have gradually *** life expectancy is a major determinant of surgical intervention,the strategy should be modified if the prolongation of survival is to be *** To monitor how bone metastasis treatment has changed before and after launch of our guidelines for bone *** For advanced cancer patients with bone metastasis who visited the Department of Clinical Oncology at Akita University hospital between 2012 and 2023,parameters including the site and number of bone metastases,laboratory data,and survival time,were extracted from electronic medical records and the Katagiri score was *** association with survival was determined for each *** Data from 136 patients were *** 1-year survival rate for the poor prognosis group with a higher Katagiri score was 20.0%in this study,which was 6%and an apparent improvement from 2014 when the scoring system was *** factors significantly affecting survival included five or more bone metastases than less(P=0.0080),and treatment with chemotherapy(P<0.001),bone modifying agents(P=0.0175)and immune checkpoint inhibitors(P=0.0128).In recent years,advances in various treatment methods have extended the survival period for patients with advanced *** is necessary not only to simply extend survival time,but also to maintain ADL and improve *** Various therapeutic interventions including surgical approach for bone metastasis,which is a disorder of locomotor organs,are increasingly *** and scoring system for p

关键词： Bone metastasis New Katagiri scoring system Prognosis Immune check point inhibitors Survival

Coordinated control between a grid forming inverter and grid following inverters suppling power in a standalone microgrid

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Global Energy Interconnection 2022年第3期5卷 259-265页

作者： Junichi Arai Yasuhiro taguchi Kogakuin University 1-24-2 Nishi-ShinjukuShinjukuTokyo 163-8677Japan Energy and Environment Technology Research Institute 1-22-2 Nishi-Waseda ShinjukuNishi-Waseda East Wing 106Tokyo 169-0051Japan

Battery energy storage systems,fuel cells,and photovoltaic generators are being adopted in distribution networks to achieve CO;emission *** power sources require inverters to connect to AC ***,sub-networks,such as a microgrids containing inverter power sources,may be disconnected from the utility network and operated in a standalone mode during extended *** study focuses on a standalone microgrid supplied by inverter power sources without a synchronous generator and proposes a new microgrid inverter *** this inverter control,a single grid forming inverter is operated as a master power source to determine frequency and voltage,and other inverters,called grid following inverters,are operated as subordinate power sources with active and reactive power *** necessary functions in the energy management system are examined,and the coordinated operation of all inverters in the microgrid is demonstrated via simulation.

关键词： Inverter control Microgrid Standalone operation Energy management system Grid forming inverter Grid following inverter

Designer enzyme for green materials innovation： Lactatepolymerizing enzyme as a key catalyst

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Frontiers of Chemical Science and Engineering 2017年第1期11卷 139-142页

作者： Seiichi taguchi Graduate School of Engineering Hokkaido University Hokkaido 060-0808 Japan JST CREST 5 Sanbancho Chiyoda-ku Tokyo 102-0075 Japan

Establishment of the regeneratable whole-cell catalyst platform for the production ofbiobased polymeric materials is a typical topic of synthetic biology. In this commentary, discovery story of a ＂lactate-polymerizing enzyme＂（LPE） and LPE-based achievements for creating a new variety of polyesters with incorporated unnatural monomers are presented. Besides the importance of microbial platform itself is discussed referring to the ＂ballooning＂-Escherichia coli.

关键词： synthetic biology enzyme evolutionary engi-neering polyhydroxyalkanoate

Verification of Subseasonal-to-Seasonal Forecasts for Major Stratospheric Sudden Warmings in Northern Winter from 1998/99 to 2012/13

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Advances in Atmospheric Sciences 2020年第3期37卷 250-258页

作者： Masakazu taguchi Department of Earth Science Aichi University of Education

This study reports verification results of hindcast data of four systems in the subseasonal-to-seasonal(S2S)prediction project for major stratospheric sudden warmings(MSSWs)in northern winter from 1998/99 to 2012/*** report deals with average features across all MSSWs,and possible differences between two MSSW types(vortex displacement and split types).Results for the average features show that stratospheric forecast verifications,when further averaged among the four systems,are judged to be successful for lead times around 10 d or *** systems are skillful for lead times around 5 d,whereas the results vary among the systems for longer lead times.A comparison between the MSSW types overall suggests larger forecast errors or lower skill for MSSWs of the vortex split type,although the differences do not have strong statistical significance for almost all *** limitation is likely to at least partly reflect the small sample size of the MSSWs available.

关键词： major stratospheric sudden warmings forecast verification subseasonal-to-seasonal prediction project vortex displacement and split warmings

Laparoscopic retroperitoneal lymph node dissection versus open retroperitoneal lymph node dissection for testicular cancer:A comparison of clinical and perioperative outcomes

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Asian Journal of Urology 2022年第2期9卷 119-124页

作者： Toshihide Shishido Takatsugu Okegawa Kenjiro Hayashi Kazuki Masuda Satoru taguchi Yu Nakamura Mitsuhiro Tambo Hiroshi Fukuhara Department of Urology Hachioji Medical CenterTokyo Medical University1163TatemachiHachiojiTokyoJapan Department of Urology Kyorin University School of Medicine6-20-2 ShinkawaMitakaTokyoJap

Objective:This study was performed to evaluate the clinical and perioperative outcomes of laparoscopic retroperitoneal lymph node dissection(L-RPLND)and open retroperitoneal lymph node dissection(O-RPLND)performed by one surgeon at a single ***:We evaluated 30 patients with stage IIA germ cell tumors who underwent retroperitoneal lymph node dissection(15 underwent L-RPLND and 15 underwent O-RPLND)at our institution between April 1,2010 and March 31,*** clinical parameters were compared between patients who underwent L-RPLND using the retroperitoneal approach and those who underwent O-RPLND using the transperitoneal *** were no significant differences in the background characteristics of the two groups except for the median follow-up duration(46 months for L-RPLND and 71 months for O-RPLND,p=0.02).Results:L-RPLND was associated with a shorter mean operative time(mean 222 min for L-RPLND vs.453 min for O-RPLND,p<0.001).There was significantly less blood loss during surgery in the L-RPLND group compared to the O-RPLND group(mean 165 mL for L-RPLND vs.403 mL for O-RPLND,p<0.001).Parameters related to postoperative recovery were significantly better for the L-RPLND group than for the O-RPLND *** were no differences in the histopathological characteristics between the two *** patients in either group exhibited disease ***:Patients who underwent L-RPLND had more rapid recovery,and shorter hospital stay compared to those who underwent O-RPLND;complications were comparable between the two groups.L-RPLND is an efficient procedure with the benefits of minimally invasive surgery.

关键词： Laparoscopic surgery Retroperitoneal lymph node dissection Testicular tumor

Yield of OH radicals in water under heavy ion *** on mass,specific energy,and elapsed time

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Nuclear Science and Techniques 2007年第1期18卷 35-38页

作者： Mitsumasa taguchi Takuji KOJIMA Organic Pollutant Removal Technology Group Japan Atomic Energy Agency1233 WatanukiTakasakiGunma370-1292 Japan

Dependence of yields of OH (hydroxyl) radicals on the mass and specific energy of heavy ions and elapsed time after irradiation was investigated,to understand chemical reactions of aqueous *** yields of irradiation products of phenol,super-linearly increased with the incident energy of He,C,and Ne ions ranging from 2 to 18 MeV/*** yields of the OH radicals were estimated by analyzing the yields of the irradiation products of phenol. The yields of the OH radicals increased with the specific energy for each ion,but decreased both with the mass of each ion at the same specific energy and elapsed time after irradiation.

关键词：重离子辐射水辐射分解羟自由基产率质量耗用时间

Comparative Gene Expression Analysis of Mouse and Human Cardiac Maturation

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Genomics, Proteomics & Bioinformatics 2016年第4期14卷 207-215页

作者： Hideki Uosaki Y-h taguchi Division of Cardiology The Johns Hopkins University School of Medicine Department of Physics Chuo University

Understanding how human cardiomyocytes mature is crucial to realizing stem cell-based heart regeneration, modeling adult heart diseases, and facilitating drug discovery. However, it is not feasible to analyze human samples for maturation due to inaccessibility to samples while cardiomyocytes mature during fetal development and childhood, as well as difficulty in avoiding variations among individuals. Using model animals such as mice can be a useful strategy; nonetheless, it is not well-understood whether and to what degree gene expression profiles during maturation are shared between humans and mice. Therefore, we performed a comparative gene expression analysis of mice and human samples. First, we examined two distinct mice microarray platforms for shared gene expression profiles, aiming to increase reliability of the analysis. We identified a set of genes displaying progressive changes during maturation based on principal component analysis. Second, we demonstrated that the genes identified had a differential expression pattern between adult and earlier stages （e.g., fetus） common in mice and humans. Our findings provide a foundation for further genetic studies of cardiomyocyte maturation.

关键词： Cardiac maturation Comparative gene expressionanalysis Microarray meta analysis Principal component analysis Feature selection

Involvement of insulin receptor substrates in cognitive impairment and Alzheimer’s disease

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Neural Regeneration Research 2019年第8期14卷 1330-1334页

作者： Daisuke Tanokashira Wataru Fukuokaya Akiko taguchi Department of Integrative Aging Neuroscience National Center for Geriatrics and Gerontology Obu Aichi Japan Division of Neurology Endocrinology and Metabolism Faculty of Medicine University of Miyazaki Miyazaki Japan

Type 2 diabetes一associated with impaired insulin/insulin-like growth factor-1 (IGF1) signaling (IIS)一is a risk factor for cognitive impairment and dementia including Alzheimer's disease (AD). The insulin receptor substrate (IRS) proteins are major components of IIS, which transmit upstream signals via the insulin receptor and/or IGF1 receptor to multiple intracellular signaling pathways, including AKT/protein kinase B and extracellular-signal-regulated kinase cascades. Of the four IRS proteins in mammals, IRS1 and IRS2 play key roles in regulating growth and survival, metabolism, and aging. Meanwhile, the roles of IRS1 and IRS2 in the central nervous system with respect to cognitive abilities remain to be clarified. In contrast to IRS2 in peripheral tissues, inactivation of neural IRS2 exerts beneficial effects, resulting in the reduction of amyloid p accumulation and premature mortality in AD mouse models. On the other hand, the increased phosphorylation of IRS 1 at several serine sites is observed in the brains from patients with AD and animal models of AD or cognitive impairment induced by type 2 diabetes. However, these serine sites are also activated in a mouse model of type 2 diabetes, in which the diabetes drug metformin improves memory impairment. Because IRS1 and IRS2 signaling pathways are regulated through complex mechanisms including positive and negative feedback loops, whether the elevated phosphorylation of IRS1 at specific serine sites found in AD brains is a primary response to cognitive dysfunction remains unknown. Here, we examine the associations between IRS 1 /1 RS2-mediated signaling in the central nervous system and cognitive decline.

关键词： type 2 diabetes insulin/insulin^like growth factor-1 insulin receptor substrate Alzheimer's disease aging serine phosphorylation metformin neuroprotective effects high-fat-diet