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Highly efficient passive Tesla valves for microfluidic applications

Microsystems & Nanoengineering 2022年第5期8卷 125-136页

作者： Sebastian Bohm Hai Binh Phi ayaka moriyama Erich Runge Steffen Strehle Jörg König Christian Cierpka Lars Dittrich Theoretical Physics I Technische Universität IlmenauWeimarer Straße 2598693 IlmenauGermany Research and Development 5microns GmbHMargarethenstraße 698693 IlmenauGermany Institute of Micro-and Nanotechnologies Gustav-Kirchhoff-Straße 798693 IlmenauGermany Microsystems Engineering Technische Universität IlmenauMax-Planck-Ring 1298693 IlmenauGermany Physics and Astronomy Carleton CollegeOne North CollegeNorthfield 55057 MinnesotaUSA Engineering Thermodynamics Technische Universität IlmenauAm Helmholtzring 198693 IlmenauGermany

A multistage optimization method is developed yielding Tesla valves that are efficient even at low flow rates,characteristic,e.g.,for almost all microfluidic systems,where passive valves have intrinsic advantages over active *** report on optimized structures that show a diodicity of up to 1.8 already at flow rates of 20μl s^(−1) corresponding to a Reynolds number of *** of the design is a topological optimization based on the finite element *** is set-up to yield easy-to-fabricate valve structures with a small footprint that can be directly used in microfluidic *** numerical two-dimensional optimization takes into account the finite height of the channel approximately by means of a so-called shallow-channel *** on the threedimensionally extruded optimized designs,various test structures were fabricated using standard,widely available microsystem manufacturing *** manufacturing process is described in detail since it can be used for the production of similar cost-effective microfluidic *** the experimentally fabricated chips,the efficiency of the different valve designs,i.e.,the diodicity defined as the ratio of the measured pressure drops in backward and forward flow directions,respectively,is measured and compared to theoretical predictions obtained from full 3D calculations of the Tesla *** agreement is *** addition to the direct measurement of the diodicities,the flow profiles in the fabricated test structures are determined using a two-dimensional microscopic particle image velocimetry(μPIV)***,a reasonable good agreement of the measured flow profiles with simulated predictions is observed.

关键词： backward Highly optimization

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Prediction of return of spontaneous circulation in outof-hospital cardiac arrest with non-shockable initial rhythm using point-of-care testing: a retrospective observational study

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World Journal of Emergency Medicine 2023年第2期14卷 89-95页

作者： Kota Shinada Hiroyuki Koami ayaka Matsuoka Yuichiro Sakamoto Department of Emergency and Critical Care Medicine Faculty of MedicineSaga UniversitySaga CitySaga Prefecture 849-8501Japan Division of Translational Research in Intensive Care Medicine Faculty of MedicineSaga UniversitySaga CitySaga Prefecture 849-8501Japan

BACKGROUND:Out-of-hospital cardiac arrest(OHCA) is a public health concern, and many studies have been conducted on return of spontaneous circulation(ROSC) and its prognostic *** thromboelastometry(ROTEM?), a point-of-care testing(POCT) method, has been useful for predicting ROSC in patients with OHCA, but very few studies have focused on patients with non-shockable rhythm. We examined whether the parameters of POCT could predict ROSC in patients with OHCA and accompanying non-shockable ***:This is a single-center, retrospective observational study. Complete blood count,blood gas, and ROTEM POCT measurements were used. This study included patients with nontraumatic OHCA aged 18 years or older who were transported to the emergency department and evaluated using POCT between January 2013 and December 2021. The patients were divided into the ROSC and non-ROSC groups. Prehospital information and POCT parameters were compared using receiver operating characteristic(ROC) curve analysis, and further logistic regression analysis was ***:Sixty-seven and 135 patients were in the ROSC and non-ROSC groups,respectively. The ROC curves showed a high area under the curve(AUC) for K^(+) of 0.77(95%confidence interval [CI]:0.71–0.83) and EXTEM amplitude 5 min after clotting time(A5) of 0.70(95%CI:0.62–0.77). The odds ratios for ROSC were as follows:female sex 3.67(95%CI:1.67–8.04);K^(+)0.64(95%CI:0.48–0.84);and EXTEM A5 1.03(95%CI:1.01–1.06).CONCLUSION:In OHCA patients with non-shockable rhythm, K^(+) level and the ROTEM parameter EXTEM A5 may be useful in predicting ROSC.

关键词： Rotational thromboelastometry Blood coagulation disorders Extrinsic pathway Potassium

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Disseminated carcinomatosis of the bone marrow caused by granulocyte colony-stimulating factor:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2022年第10期14卷 2077-2084页

作者： Kengo Fujita ayaka Okubo Toshitsugu Nakamura Nobumichi Takeuchi Department of Medical Oncology Ina Central HospitalNagano 396-8555Japan Department of Diagnostic Pathology Ina Central HospitalNagano 396-8555Japan

BACKGROUND Disseminated carcinomatosis of the bone marrow(DCBM)is a widespread metastasis with a hematologic disorder that is mainly caused by gastric *** it commonly occurs as a manifestation of recurrence long after curative treatment,the precise mechanism of relapse from dormant status remains *** colony-stimulating factor(G-CSF)can promote cancer progression and invasion in various ***,the potential of G-CSF to trigger recurrence from a cured malignancy has not been *** SUMMARY A 55-year-old Japanese woman was diagnosed with Ewing sarcoma localized on the fifth lumbar vertebrae 6 years after curative gastrectomy for T1 gastric *** palliative surgery to release nerve compression,pathological diagnosis of the resected specimen was followed by curative radiation and *** treatment,G-CSF was administered 32 times for severe neutropenia *** months after completing definitive treatment,she complained of severe back pain and was diagnosed as multiple bone metastases with DCBM from gastric *** palliative chemotherapy,she died of disseminated intravascular coagulation 13 d after the *** examination of the autopsied bone marrow confirmed a diffuse positive staining for the G-CSF receptor(G-CSFR)in the relapsed gastric cancer cell cytoplasm,whereas the primary lesion cancer cells showed negative staining for *** this case,G-CSF administration may have been the key trigger for the disseminated relapse of a dormant gastric *** administering G-CSF to cancer survivors,recurrence of a preceding cancer should be monitored even after curative treatment.

关键词： Disseminated bone marrow carcinomatosis Gastric cancer Granulocyte colony-stimulating factor Cancer survivor Immunostaining Case report

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Painting image browser applying an associate-rule-aware multidimensional data visualization technique

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Visual Computing for Industry,Biomedicine,and Art 2020年第1期3卷 18-30页

作者： ayaka Kaneko Akiko Komatsu Takayuki Itoh Florence Ying Wang Ochanomizu University 2-1-1 OtsukaBunkyo-ku1128610 TokyoJapan CSIRO Julius Ave.2113 North RydeNSWAustralia

Exploration of artworks is enjoyable but often time *** example,it is not always easy to discover the favorite types of unknown painting *** is not also always easy to explore unpopular painting works which looks similar to painting works created by famous *** paper presents a painting image browser which assists the explorative discovery of user-interested painting *** presented browser applies a new multidimensional data visualization technique that highlights particular ranges of particular numeric values based on association rules to suggest cues to find favorite painting *** study assumes a large number of painting images are provided where categorical information(e.g.,names of artists,created year)is assigned to the *** presented system firstly calculates the feature values of the images as a preprocessing *** the browser visualizes the multidimensional feature values as a heatmap and highlights association rules discovered from the relationships between the feature values and categorical *** mechanism enables users to explore favorite painting images or painting images that look similar to famous painting *** case study and user evaluation demonstrates the effectiveness of the presented image browser.

关键词： Painting image Multi-dimensional data visualization Association rule

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Comparison of minimally invasive glaucoma surgery with trabecular micro-bypass stent and microhook ab interno trabeculotomy performed in conjunction with cataract surgery

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1082-1088页

作者： Naoto Tokuda Yasushi Kitaoka ayaka Tsukamoto Yasuhiro Toyoda Yusuke Yamada Kana Sase Hitoshi Takagi Department of Ophthalmology St Marianna University School of Medicine2-16-1 Sugao Miyamae-ku Kawasaki-shiKanagawa 216-8851Japan

AIM: To evaluate the effectuality and safety of cataract surgery combined with either ab interno trabeculotomy by the microhook(μLOT) or a single i Stent? trabecular bypass implantation(i Stent) in eyes with cataract and mild-tomoderate glaucoma. METHODS: This study enrolled subjects with mild-tomoderate open angle glaucoma with visually significant cataract who used two or more ophthalmic antiglaucoma agents between 60 and 90 y of age. Patients underwent cataract surgery cooperated with either implantation of an i Stent(i Stent-phaco) or excisional goniotomy with the μLOT(μLOT-phaco). Patients underwent μLOT-phaco in the eye with lower the mean deviation, according to the Humphrey field analyzer, while i Stent-phaco was carried out on the other eye. Intraocular pressure(IOP) pre-and post-surgery, alterations in anterior chamber flare(ACF), and corneal endothelial cell density(ECD) were ***: Twenty subjects were enrolled(mean age: 73.6±7.3 y). The mean medicated preoperative IOP was 16.7 mm Hg in the μLOT and 16.2 mm Hg in the i Stent eyes. The mean final IOP at 12 mo was 13.6 mm Hg in the μLOT eyes and 13.6 mm Hg in the i Stent eyes, representing a 17.8% and 17.2% reduction, respectively. The preoperative ACF in the μLOT eyes was 9.5 pc/ms and it returned to normal in 30 d postoperatively, with a value of 11.4 pc/ms. In the i Stent eyes, ACF was 9.6 pc/ms preoperatively and it returned to normal by 7 d postoperatively(11.2 pc/ms atday 7), demonstrating that postoperative inflammation was less in the i Stent eyes. The corneal ECD in both groups was not significantly ***: In this study, i Stent and μLOT are both effective through 12 mo of follow-up. Safety is more favorable in the i Stent eyes, based on early anterior chamber inflammation.

关键词： minimally invasive glaucoma surgery iStent ab interno trabeculotomy

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Effects of alginate and laminaran on the microbiota and antioxidant properties of human faecal cultures

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Food Bioscience 2022年第3期47卷 1244-1251页

作者： Gayang Lee Mika Harada Yuko Midorikawa Mahiro Yamamoto ayaka Nakamura Hajime Takahashi Takashi Kuda Department of Food Science and Technology Tokyo University of Marine Science and Technology4-5-7 KonanMinato-kuTokyo108-8477Japan

Alginate and laminaran are water soluble dietary fibres in brown *** a previous study,pure cultures of Bacteroides xylanisolvens,Bacteroides uniformis,and Erysipelaclostridium ramosum increased antioxidant capacities in the broth with alginate and/or laminaran *** study was conducted to evaluate the presence of the alginate-and laminaran-responsive human gut indigenous bacteria(RIB)and their ***,human stool samples were cultured in media without(control),or with 1%(w/v)alginate or laminaran at 37℃ for 24 h under anaerobic *** showed that during incubation,the pH of the culture reduced with the *** production was clearly suppressed via laminaran supplementation in the faecal sample *** 16S rRNA(V4)gene amplicon sequencing confirmed that ***-,*** and ***-like bacteria were alginate-and/or laminaran-RIB in human gut,although their read numbers differed among ***,some butyrate-producers,such as Faecalibacterium and Roseburia,were also detected as the RIB in alginate and laminaran cultures,*** increased 1,1-diphenyl-2-picrylhydrazyl and superoxide anion radical-scavenging capacities and the Fe-reducing power of the culture ***,the fermented cultures increased the nitric oxide secretion in macrophage like RAW 264.7 cells *** results suggest that the interaction of alginate and laminaran with their RIB may have desirable effects on the host as next generation prebiotics when brown algae are ingested.

关键词： Alginate Laminaran Human gut microbiota Antioxidant capacity Faecal culture

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New native tissue repair for pelvic organ prolapse:Medium-term outcomes of laparoscopic vaginal stump-round ligament fixation

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World Journal of Clinical Cases 2023年第15期11卷 3457-3463页

作者： Toshiyuki Kakinuma ayaka Kaneko Kaoru Kakinuma Ken Imai Nobuhiro Takeshima Michitaka Ohwada Department of Obstetrics and Gynecology International University of Health and WelfareNasushiobara 329-2763Japan

BACKGROUND Laparoscopic sacrocolpopexy for pelvic organ prolapse(POP)is a new and widely used approach;however,ever since the United States Food and Drug Administration warned against the use of surgical mesh,repairs performed using patients’tissues[*** tissue repair(NTR)]instead of mesh have attracted much *** our hospital,laparoscopic sacrocolpopexy(the Shull method)was introduced in ***,patients with more severe POP who have a long vaginal canal and overextended uterosacral ligaments may not be candidates for this *** To validate a new NTR treatment for POP,we examined patients undergoing laparoscopic vaginal stump–round ligament fixation(the Kakinuma method).METHODS The study patients were 30 individuals with POP who underwent surgery using the Kakinuma method between January 2020 and December 2021 and who were followed up for>12 mo after *** retrospectively examined surgical outcomes for surgery duration,blood loss,intraoperative complications,and incidence of *** Kakinuma method involves round ligament suturing and fixation on both sides,effectively lifting the vaginal stump after laparoscopic *** The patients’mean age was 66.5±9.1(45-82)years,gravidity was 3.1±1.4(2-7),parity was 2.5±0.6(2-4)times,and body mass index was 24.5±3.3(20.9-32.8)kg/*** to the POP quantification stage classification,there were 8 patients with stage Ⅱ,11 with stage Ⅲ,and 11 with stage Ⅳ.The mean surgery duration was 113.4±22.6(88-148)min,and the mean blood loss was 26.5±39.7(10-150)*** were no perioperative *** of the patients exhibited reduced activities of daily living or cognitive impairment after hospital *** cases of POP recurrence were observed 12 mo after the *** The Kakinuma method,similar to conventional NTR,may be an effective treatment for POP.

关键词： Pelvic organ prolapse Native tissue repair Laparoscopic surgery Round ligament Kakinuma method

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Favorable response after radiation therapy for intraductal papillary mucinous neoplasms manifesting as acute recurrent pancreatitis:A case report

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World Journal of Clinical Cases 2022年第30期10卷 11116-11121页

作者： ayaka Harigai Kiyoshi Kume Noriyoshi Takahashi So Omata Rei Umezawa Keiichi Jingu Atsushi Masamune Department of Radiation Oncology Tohoku University Graduate School of MedicineSendai 980-8574Japan Division of Gastroenterology Tohoku University Graduate School of MedicineSendai 980-8574Japan

BACKGROUND There has been an increasing number of elderly patients with intraductal papillary mucinous neoplasm(IPMN),who are surgically intolerant and require less invasive treatment options,which are *** the present study,we report a case of IPMN presenting with acute recurrent pancreatitis(ARP),in which radiation therapy effectively prevented further attacks of ARP and reduced tumor *** SUMMARY An 83-year-old man was referred to our hospital with an asymptomatic incidental pancreatic *** ultrasound imaging and magnetic resonance cholangiopancreatography revealed a multiloculated tumor in the head of the pancreas,with dilated pancreatic ducts and mural *** patient was diagnosed with mixed-type IPMN,and five years later,he developed *** endoscopic pancreatic ductal balloon dilatations failed to prevent further ARP *** was considered clinically inappropriate because of his old age and *** was referred to our department for radiation therapy targeted at those lesions causing intraductal hypertension and radiation was administered at a dose of 50 *** magnetic resonance imaging scan taken ten weeks after treatment revealed a decrease in tumor size and improvement of pancreatic duct *** months later,he remains symptom-free from *** This case highlights the important role of radiation therapy in mitigating the signs and symptoms of ARP in patients with inoperable IPMN.

关键词： Intraductal papillary mucinous neoplasm Acute recurrent pancreatitis Pancreas Radiation therapy Case report

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Effectiveness of treating menorrhagia using microwave endometrial ablation at a frequency of 2.45 GHz

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World Journal of Clinical Cases 2023年第24期11卷 5653-5659页

作者： Toshiyuki Kakinuma ayaka Kaneko Kaoru Kakinuma Yoshio Matsuda Kaoru Yanagida NobuhiroTakeshima Michitaka Ohwada Department of Obstetrics and Gynecology International University of Health and Welfare HospitalNasushiobara 329-2763Japan

BACKGROUND Microwave endometrial ablation(MEA)is a minimally invasive treatment for *** has been covered by the national insurance in Japan since April 2012,and its demand has been increasing as the importance of women’s health has advanced in *** To examine the efficacy of MEA as a treatment option for *** In this study,we retrospectively analyzed 76 patients who underwent MEA between January 2016 and March 2020 in our *** was performed in the lithotomy position,under general anesthesia,and with transabdominal ultrasound guidance,including the entire endometrial circumference while confirming endometrial *** Microtaze AFM-712 and the Sounding Applicator CSA-40CBL-1006200C were used for MEA,and the endometrium was ablated using a Microtaze output of 70 W and coagulation energization time of 50 s per *** visual analog scale(VAS)was used to evaluate menorrhagia,menstrual pain,and treatment ***,the hemoglobin(Hb)levels before and after MEA and associated complications were *** The average age of the patients was 44.8±4.0 *** 14 patients had functional menorrhagia,62 had organic menorrhagia,of whom 14 had endometrial polyps,40 had uterine fibroids,and 8 had *** VAS score before MEA and 3 and 6 mo after the procedure were 10,1.3±1.3,and 1.3±1.3,respectively,for menorrhagia and 10,1.3±1.8,and 1.3±1.8,respectively,for menstrual pain,both showing improvements(P<0.001).The MEA Hb level significantly improved from 9.2±4.2 g/dL before MEA to 13.4±1.2 g/dL after MEA(P=0.003).Treatment satisfaction was high,with a VAS score of 9.6±*** was observed in one patient after surgery and was treated with *** MEA is a safe and effective treatment for menorrhagia.

关键词： Menorrhagia Visual analog scale Dysmenorrhea Endometrial ablation techniques Microwaves Leiomyoma Adenomyosis

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Laser speckle flowgraphy findings in a patient with radiation retinopathy

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 172-174页

作者： Satoru Kase ayaka Hasegawa Kiriko Hirooka Hiroaki Endo Kousuke Noda Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan Department of Ophthalmology Teine Keijinkai HospitalSapporo 006-0811Japan

Dear Editor,I am Satoru Kase, from Hokkaido University Hospital, Japan. Choroidal melanoma is a serious intraocular tumor, which threatens patients’ vision and life. Treatments for choroidal melanoma consist of surge... 详细信息

关键词： melanoma surgery intraocular

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