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Mandibular Embryonal Rhabdomyosarcoma Confused with a Vascular Malformation: About a Case

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Journal of Biosciences and Medicines 2023年第6期11卷 103-107页

作者： Massilia Bouhmidi Hajar Boudarbala ayad ghannam Aziza Elouali Abdeladim Babakhouya Maria Rkain Noufissa Benajiba Mother-Child Hospital CHU Mohamed VI Oujda Morroco

Malignant mesenchymal tumors (MTM) in children represent 5% to 10% of malignant tumors in children. They constitute a heterogeneous group of tumors of various differentiations depending on their supposed tissue of origin. They mainly include tumors of muscular origin, those derived from connective, vascular, nervous, or adipose tissue. Rhabdomyosarcoma (RMS) is the most common mesenchymal tumor in children and adolescents (60% to 70% of them). And it accounts for 5.8% of all malignant solid tumors in children. Almost half of rhabdomyosarcomas occur in the head and neck. The prognosis for this type of tumor is particularly poor. A case of rhabdomyosarcoma in the mandible with extension to the abdominal wall and unilateral testis in a 6-month-old infant is reported with evolution since birth. It is a purplish lesion at the level under the right chin which was initially taken for vascular malformation, evolving very quickly towards a mandibular mass deforming the painful face with inflammatory signs, followed by the appearance of a hard swelling under the skin on the left flank taking on the same aspect of the mandibular mass. This observation illustrates the need to know how to systematically think about tumor causes in the face of atypical aspects and to carry out an anatomopathological examination.

关键词： Rhabdomyosarcoma Mandible Mesenchymal Tissue Vascular Malformation Abdominal Wall Testis

Unilateral Ptosis in a Child with Wilm’s Tumor Induced by Vincristine

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Journal of Cancer Therapy 2022年第12期13卷 649-653页

作者： Aziza El Ouali Karim Lahrache Zohair El Haddar ayad ghannam Abdeladim Babakhouya Maria Rkain Noufissa Benajiba Department of Pediatrics Mohammed VI University Hospital Center of Oujda Oujda Morocco

Vincristine is a chemotherapy drug belonging to the group of Vinca alkaloids which also includes vinblastine and vindesine. It is used in hematological malignancies and solid tumors. The Vinca alkaloids are neurotoxic, usually causing peripheral neuropathy, and rarely cranial neuropathies. We report a case of a 33-month-old male child diagnosed with Wilms’ tumor, who had an isolated unilateral right ptosis following vincristine, with a good improvement after stopping it.

关键词： Wilms’ Tumor Vincristine Neuropathy Ptosis

Hematochezia Revealing an Adenocacinoma

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Open Journal of Pediatrics 2023年第3期13卷 428-431页

作者： Amal Hamami Madiha Benhachem ayad ghannam Aziza El Ouali Abdeladim Babakhouya Noura Seghrouchni Nassira Karich Amal Bennani Maria Rkain Department of Pediatrics Faculty of Medicine and Pharmacy of Oujda Mohammed First University Oujda Morocco Laboratory of Pathological Anatomy Faculty of Medicine and Pharmacy of Oujda Mohammed First University Oujda Morocco

Colorectal carcinoma (CRC) is a common pathology in the adult population but remains a very rare neoplasia in childhood with delayed diagnosis and advanced stage with grim prognosis that can be fatal, research regarding pediatric adenocarcinoma remain very rare. IT represents approximately 1% of pediatric neoplasms. It is usually associated with predisposing genetic factors;this pathology is closely linked with the inheritance of familial syndromes. The pediatric clinical presentations are nonspecific, with a grim prognosis. This review aimed to report a case of a 10-year-old girl who presented with constipation and hematochezia evolving since three months’ diagnosis with rectal adenocarcinoma.

关键词： Adenocarcinoma Colorectal Cancer Rare Child Grim Prognosis

Acute Lymphoblastic Leukemia in Childhood Following Pyoderma Gangrenosum

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Journal of Cancer Therapy 2020年第11期11卷 715-721页

作者： Aziza El Ouali Manal Azizi Nadia Bouhafs Mounia Rimani ayad ghannam Abdeladim Babakhouya Maria Rkain Noufissa Benajiba Hematology and Oncology Unit Departments of Pediatric UHC Mohammed VI Medical School of OUJDA University Mohamed I Oujda Morocco Hassan Pathological Anatomy Center Rabat Morocco

Pyoderma gangrenosum (PG) is a rare but serious ulcerating skin disease that occurs either idiopathically or associated with various systemic diseases and malignant tumors. Although the association of PG with myeloid malignant tumors is well known, their association with lymphoid malignant tumors, especially in children is extremely rare. We present here a case of PG in a 4-year and 4 months female child, diagnosed in the Pediatrics department, which had initially evolved well with oral corticosteroid therapy and a local dermocorticoid. The development was marked 7 months after stopping corticosteroid treatment by the occurrence of acute lymphoblastic leukemia. This case of PG is presented in the intention of increasing awareness of this uncommon condition with may oc

关键词： Pyoderma Gangrenosum Childhood Leukemia