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International Journal of Mining Science and Technology 2020年第1期30卷 93-98页

作者： Carolina Brücker axel preuβe Institute for Mine Surveying Mining Subsidence Engineering and Geophysics in MiningRWTH Aachen UniversityWüllnerstr.2Aachen 52062Germany

The topic of ground movements in Germany has been studied extensively in the past,especially in the field of active *** active hard coal mines in Germany were finally shut down in 2018 and lignite mining is expected to take place only until *** so-called long-term liabilities of the mine operators in Germany include,among other things,the long-term guarantee of stability and thus the monitoring of ground *** far,the economic use of underground mining in Germany was mainly the supply of raw *** the future,the underground storage of compressed air,methane or hydrogen will play an important role in renewable energy supply and climate ***,the underground storage space will become more important and the spatial planning is essential to ensure availability of safe underground openings for the various options of environmentally friendly energy ***,this renewed usage of underground openings may also bring new and sometimes unknown challenges of geomechanical *** aftermath of hard coal and lignite mining will be an increasing challenge in mining subsidence *** the other hand,new possibilities due to underground spatial planning may lead to subsidence and/or heaving of the upper surface.

关键词： Mining Surveying Underground spatial planning Mining engineering Renewable energies

NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Cryptic exon inclusion in TDP-43 proteinopathies:opportunities and challenges

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Neural Regeneration Research 2025年第7期20卷 2003-2004页

作者： Lorena Decker Sonja Menge axel Freischmidt Department of Neurology Ulm UniversityUlmGermany

TDP-43 proteinopathies and cryptic exons:Transactive response DNA binding protein of 43 kDa(TDP-43)is a ubiquitously expressed RNA/DNA binding protein crucial for coding and non-coding RNA metabolism including transcription,splicing,transport,translation,and ***-43 shuttles between the nucleus and cytoplasm,but is predominantly localized in the *** diseases(NDs)may be accompanied by nuclear loss and possible cytoplasmic accumulation and aggregation of TDP-43 in vulnerable neurons and *** neuropathology is the hallmark of most individuals suffering from amyotrophic lateral sclerosis(ALS),frontotemporal dementia(FTD)with TDP-43-immunoreactive pathology(FTD-TDP),limbic-predominant age-related TDP-43 encephalopathy(LATe)and Perry syndrome,but also coexists with the primary pathology in subsets of patients suffering from other NDs,such as Alzheimer’s disease,Lewy body dementias,or Huntington’s *** in the gene encoding TDP-43(TARDBP)are the cause of ALS and/or FTD in some rare cases substantiating the importance of this protein in aging *** is still controversial if loss of nuclear,or increased cytoplasmic and/or aggregating TDP-43 is more harmful to neurons(Nag and Schneider,2023).Recently,the role of nuclear TDP-43 in repressing the inclusion of intronic sequences,named cryptic exons(Ces),into mature mRNAs gained much attention.

关键词： Huntington metabolism TDP

Alternative fuels—a new field for mine surveying

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中国有色金属学会会刊：英文版 2005年第S1期15卷 289-293页

作者： A. preuβe C. Herzog Institute for Mine Surveying Mining Subsidence Engineering and Geophysics in Mining (IFM) RWTH Aachen University Wüllnerstr. 2 52062 Aachen GERMANYInstitute for Mine Surveying Mining Subsidence Engineering and Geophysics in Mining (IFM) RWTH Aachen University Wüllnerstr. 2 52062 Aachen GERMANY

Due to the public’s increased interest in renewable energies and the “erneuerbare energien Gesetz” (eeG) from February 2000, geothermal energy and other alternative or renewable energies gain more and more importance. As far as Germany is concerned, geothermal energy and coal bed/mine methane are considered as mineral resources according to the German mining law. This demands the participation of mine surveyors/mineral resources managers from the planning to the production stage and even beyond it. The main tasks that have to be fulfilled are, among others, applications for exploration and production licences as well as the evaluation of the resource’s potential. This paper indicates the tasks of mine surveyors/mineral resources managers in the wide area of the renewable energies in Germany, especially concerning the use of geothermal energy and methane.

关键词： mine surveying mineral resources management renewable energies geothermal energy methane

Advances and challenges in diagnosing and managing adult autoimmune enteropathy

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World Journal of Gastroenterology 2025年第2期31卷 128-131页

作者： Grigorios Christodoulidis Sara e Agko Marina N Kouliou Konstantinos e Koumarelas Dimitris Zacharoulis Department of General Surgery University Hospital of LarissaLarissa 41110Greece Department of Intensive Care Unit Asklepios Paulinen Clinic WiesbadenWiesbaden 65197Germany Department of emergency Medicine General Hospital of LarissaLarissa 41221Greece Department of Surgery University Hospital of LarissaLarissa 41334Greece

Autoimmune enteropathy(AIe)is a rare immune mediated disorder primarily affecting children,characterized by chronic diarrhea,malabsorption,vomiting,weight loss and villous *** has also been observed in adults presenting diagnostic and treatment challenges due to its overlap with other gastrointestinal disorders such as celiac *** diagnostic criteria for AIe include small bowel villous atrophy,lack of response to dietary restrictions,presence of anti-enterocyte antibodies,and predisposition to autoimmunity without severe *** criteria emphasize characteristic histological findings and exclusion of other causes of villous *** is associated with various autoimmune disorders and can present with overlapping features with Celiac disease,including villous atrophy but without significant intraepithelial *** primarily involves immunosuppression using corticosteroids,calcineurin inhibitors,and anti-tumor necrosis factor therapy,alongside nutri-tional *** the challenges,understanding AIe’s diverse manifest-ations and improving diagnostic criteria are essential for effective management and improved patient *** research is needed to elucidate the pathogenesis,disease progression and long-term outcomes of AIe.

关键词： Autoimmune enteropathy Diagnosis Prognosis Adult autoimmune enter-opathy and challenges Autoimmune enteropathy and treatment Autoimmune enteropathy and diagnostic criteria Pathophysiology of autoimmune enteropathy

Tetranuclear yttrium and gadolinium 2-acetylcyclopentanoate clusters：Synthesis and their use as spin-coating precursors for metal oxide film formation for field-effect transistor fabrication

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Journal of Rare earths 2018年第10期36卷 1098-1105页

作者： elaheh Pousaneh Andrea preuβ Khaybar Assim Tobias Rüffer Marcus Korb Jana Tittmann-Otto Sascha Hermann Stefan e.Schulz Heinrich Lang Technische Universitat Chemnitz Faculty of Natural Sciences Institute of Chemistry Inorganic Chemistry D-09107 Chemnitz Germany Technische Universitiat Chemnitz Center for Mierotechnologies D-09107 Chemnitz Germany Fraunhofer Institute for electronic Nano Systems eNAS Technologie-Campus 3 D-09126 Chemnitz Germany

Lanthanide clusters [Ln4（μ3-OH）2（η2-accp）4（（μ-O）-η2-accp）6]（Ln = Y（4）,Gd（5）; accp = 2-acetylcyclopentanoate） are accessible by treatment of [M（NO33·6 H2 O]（M = Y（1）,Gd（2）） with 3 equiv. of Haccp（3） in presence of NaOH. The molecular structures of 4 and 5） in the solid-state are discussed. The thermal behavior of 4 and 5 was studied by TG under Ar and O2, showing multistep decomposition processes. Additionally, DSC studies were carried out under an atmosphere of O2. PXRD measurements of the TG residues confirm the formation of Ln2 ***-coating experiments were carried out with 4 and 5 for Ln2 O3 film deposition on silicon substrates. The layers are smooth, close and are of thicknesses of 18.87±1.13 nm and 25.59 ± 4.55 nm for Ln = Y and Gd, which was evidenced by SeM and eDX studies. Field-effect transistors were successfully fabricated by deposition of carbon nanotubes on top of the Y2 O3 films and formation of palladium contacts by a lift-off procedure. An on/off ratio of more than 4 orders of magnitude is achieved without considerable leakage currents. These results demonstrate the potential use of spin-coated Y2 O3 as a gate dielectric in electronic devices.

关键词： β-Diketonates Yttrium Gadolinium Thermal analysis Spin coating CNT transistor

exactly Solvable Combinations of Scalar and Vector Potentials for the Dirac equation Interrelated by Riccati equations

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Chinese Physics Letters 2006年第6期23卷 1365-1368页

作者： axel Schulze-Halberg Department of Science University of Colima Bernal Diaz del Castillo 340 Col. Villas San Sebastian C.P. 28045 Colima Col. Mexico

New classes of solvable scalar and vector potentials for the Dirac equation are obtained, together with the associated exact Dirac spinors. The method of derivation is based on an a priori constraint between the solutions, leading to an interrelation between the scalar and vector potential in the form ofa Riccati equation. The present note generalizes a series of former articles.

关键词： exactly Solvable Combinations Riccati equations

[Y(dbm)_(3)(H_(2)O)]:Synthesis,thermal behavior and spin-coating precursor for Y_(2)O_(3)layer formation

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Journal of Rare earths 2017年第12期35卷 1248-1254页

作者： elaheh Pousaneh Andrea preuβ Khaybar Assim Julian Noll Alexander Jakob Tobias Rüffer Heinrich Lang Technische Universitat Chemnitz Faculty of Natural SciencesInstitute of ChemistryInorganic Chemistry

The synthesis,structure and thermal behavior of [Y（dbm）3（H2 O）]（3）（dbm = 1,3-diphenyl-1,3-propandionate） and its use as a spin-coating precursor for Y2 O3 deposition is reported. Complex 3 was prepared by the reaction of [Y（NO3）3·6 H2 O]（1） with 3 equiv of Hdbm（2） in presence of NaOH. The molecular structure of 3 in the solid-state was determined by single X-ray crystal diffraction. Both C1 symmetric crystallographically independent species of 3 possess a YO7 coordination setup with minor deviation from an ideal capped octahedron coordination geometry（∧ enantiomer）. Complex 3 forms a1 D chain, due to intermolecular hydrogen bonds between the coordinated H2 O molecule and the 0 atom of the dbm ligand, respectively. The thermal decomposition behavior of 3 was investigated by thermogravimetric studies in the temperature range of 40-800 ℃ and 40-1300 ℃ under an oxygen and argon atmosphere, respectively. Powder X-ray diffraction（PXRD） measurements of the residues confirmed the formation of Y2 O3. Complex 3 was applied as a spin-coating precursor for yttrium oxide film formation on either Si wafers with a continuous 100 nm thick SiO2 film, or with a native oxide *** as-deposited Y2 O3 layers are smooth, conformal, dense and transparent and are of a thickness of 27 and 30 nm, respectively.

关键词： Yttrium β-Diketonate Yttrium oxide Spin-coating Solid-state structure Vapor pressure

Buffered microclimate determines the presence of Salamandra corsica

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Journal of Forestry Research 2021年第3期32卷 1089-1093页

作者： Daniel escoriza axel Hernandez GReCO Institute of Aquatic EcologyUniversity of Girona17071 GironaSpain Department of environmental Sciences University Pasquale Paoli20250 CorteFrance

Numerous amphibian species occupy microhabitats with buffered thermal and moisture conditions,typically under forest ***,we assessed whether the insular endemic Salamandra corsica also uses this type of habitat,which could have important implications for its *** used data loggers to record the air temperature and air humidity at 4 h intervals over a period of 2 years,at 13 stations with a confirmed presence of *** data were compared with those recorded at Corsican weather stations and those generated by a climate model(WorldClim 2).The weather station data showed significant deviations from the probe data,by an average of-1.26℃(minimum temperature),+2.61℃(maximum temperature),and-0.04%(relative humidity).Similarly,the WorldClim 2 data showed significant deviations from the probe data,by an average of-2.49°C(minimum temperature)and+1.69℃(maximum temperature).These discrepancies refl ect the use of densely vegetated and topographically complex habitats by ***,which reduce temperature ***,our results highlight the importance of natural vegetal cover in the conservation of populations of this endemic salamander.

关键词： Fire salamander Island endemic Microclimate Probe Threatened species

Using hierarchical spatial models to assess the occurrence of an island endemism: the case of Salamandra corsica

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ecological Processes 2019年第1期8卷 199-209页

作者： Daniel escoriza axel Hernandez GReCO Institute of Aquatic EcologyUniversity of Girona17071 GironaSpain Department of environmental Sciences University Pasquale Paoli20250 CorteFrance.

Background:Island species are vulnerable to rapid extinction,so it is important to develop accurate methods to determine their occurrence and habitat *** this study,we assessed two methods for modeling the occurrence of the Corsican endemic Salamandra corsica,based on macro-ecological and fine habitat *** expected that models based on habitat descriptors would better estimate *** occurrence,because its distribution could be influenced by micro-environmental *** occurrence of *** was modeled according to two ensembles of variables using random ***:Salamandra corsica was mainly found in forested habitats,with a complex vertical *** habitats are associated with more stable environmental *** model based on fine habitat descriptors was better able to predict occurrence,and gave no false *** model based on macro-ecological variables underestimated the occurrence of the species on its ecological boundary,which is important as such locations may facilitate interpopulation ***:Implementing fine spatial resolution models requires greater investment of resources,but this is advisable for study of microendemic species,where it is important to reduce type II error(false negatives).

关键词： Amphibian Corsica Mediterranean islands Microhabitat Salamander