检索结果-南通市图书馆

Molecular design of an ultra-strong tissue adhesive hydrogel with tunable multifunctionality

Bioactive Materials 2023年第11期29卷 214-229页

作者： Yuting Zheng avijit baidya Nasim Annabi Department of Chemical and Biomolecular Engineering University of Californi1Los AngelesLos AngelesCA90095United States Department of Bioengineering University of Californi1Los AngelesLos AngelesCA90095United States

Designing adhesive hydrogels with optimal properties for the treatment of injured tissues is challenging due to the tradeoff between material stiffness and toughness while maintaining adherence to wet tissue surfaces. In most cases, bioadhesives with improved mechanical strength often lack an appropriate elastic compliance, hindering their application for sealing soft, elastic, and dynamic tissues. Here, we present a novel strategy for engineering tissue adhesives in which molecular building blocks are manipulated to allow for precise control and optimization of the various aforementioned properties without any tradeoffs. To introduce tunable mechanical properties and robust tissue adhesion, the hydrogel network presents different modes of covalent and noncovalent interactions using N-hydroxysuccinimide ester (NHS) conjugated alginate (Alg-NHS), poly (ethylene glycol) diacrylate (PEGDA), tannic acid (TA), and Fe^(3+) ions. Through combining and tuning different molecular interactions and a variety of crosslinking mechanisms, we were able to design an extremely elastic (924%) and tough (4697 kJ/m3) multifunctional hydrogel that could quickly adhere to wet tissue surfaces within 5 s of gentle pressing and deform to support physiological tissue function over time under wet conditions. While Alg-NHS provides covalent bonding with the tissue surfaces, the catechol moieties of TA molecules synergistically adopt a mussel-inspired adhesive mechanism to establish robust adherence to the wet tissue. The strong adhesion of the engineered bioadhesive patch is showcased by its application to rabbit conjunctiva and porcine cornea. Meanwhile, the engineered bioadhesive demonstrated painless detachable characteristics and in vitro biocompatibility. Additionally, due to the molecular interactions between TA and Fe3+, antioxidant and antibacterial properties required to support the wound healing pathways were also highlighted. Overall, by tuning various molecular interactions, we wer

关键词： Molecular engineering Tough hydrogel Bioadhesive Multifunctionality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment

引用

Bioactive Materials 2023年第5期23卷 314-327页

作者： Reihaneh Haghniaz Han-Jun Kim Hossein Montazerian avijit baidya Maryam Tavafoghi Yi Chen Yangzhi Zhu Solmaz Karamikamkar Amir Sheikhi Ali Khademhosseini Department of Bioengineering University of CaliforniaLos Angeles410 Westwood PlazaLos AngelesCA90095United States California NanoSystems Institute University of CaliforniaLos Angeles570 Westwood PlazaLos AngelesCA90095United States Terasaki Institute for Biomedical Innovation 11570 W Olympic BoulevardLos AngelesCA90024United States Department of Chemical Engineering The Pennsylvania State UniversityUniversity ParkPA16802United States Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPA16802United States

Blood loss by hemorrhaging wounds accounts for over one-third of~5 million trauma fatalities worldwide every *** not controlled in a timely manner,exsanguination can take lives within a few *** new biomaterials that are easy to use by non-expert patients and promote rapid blood coagulation is an unmet medical ***,biocompatible,and biodegradable microneedle arrays(MNAs)based on gelatin methacryloyl(GelMA)biomaterial hybridized with silicate nanoplatelets(SNs)are developed for hemorrhage *** SNs render the MNAs hemostatic,while the needle-shaped structure increases the contact area with blood,synergistically accelerating the clotting time from 11.5 min to 1.3 min in *** engineered MNAs reduce bleeding by~92%compared with the untreated injury group in a rat liver bleeding ***-containing MNAs outperform the hemostatic effect of needle-free patches and a commercial hemostat in vivo via combining micro-and nanoengineered ***,the tissue adhesive properties and mechanical interlocking support the suitability of MNAs for wound closure *** hemostatic MNAs may enable rapid hemorrhage control,particularly for patients in developing countries or remote areas with limited or no immediate access to hospitals.

关键词： Hemostat Microneedles Hemorrhage Bleeding Gelatin methacryloyl Silicate nanoplatelets

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：