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Reactive oxygen species and senescence modulatory effects of rice bran extract on 4T1 and NIH-3T3 cells co-treatment with doxorubicin

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Asian Pacific Journal of Tropical Biomedicine 2021年第4期11卷 174-182页

作者： Ummi Maryam Zulfin ave rahman Mila Hanifa Rohmad Yudi Utomo Sari Haryanti Edy Meiyanto Cancer Chemoprevention Research Center Faculty of PharmacyUniversitas Gadjah Mada(UGM)Sekip UtaraYogyakarta 55281Indonesia Laboratory of Medicinal Chemistry Department of Pharmaceutical ChemistryFaculty of PharmacyUGMSekip UtaraYogyakarta 55281Indonesia Medicinal Plant and Traditional Medicinal Research and Development Centre Ministry of HealthRepublic of Indonesia Laboratory of Macromolecular Engineering Department of Pharmaceutical ChemistryFaculty of PharmacyUGMSekip UtaraYogyakarta 55281Indonesia

Objective:To determine the effect of rice bran extract(RBE)in combination with doxorubicin on 4 T1 triple-negative breast cancer cells and NIH-3 T3 ***:RBE was obtained by maceration with *** phytochemical profile of RBE was observed using highperformance liquid *** effect of RBE was evaluated through MTT *** addition,flow cytometry was used for cell cycle and apoptosis *** senescence was observed using SA-β-Gal assay and intracellular reactive oxygen species(ROS)levels were evaluated using DCFDA *** pro-oxidant property of RBE was also evaluated through 1-chloro-2,4-dinitrobenzene spectrophotometry and molecular ***:RBE was obtained with a yield of 18.42%w/w and contained tocotrienols as the major *** exerted no cytotoxic effect on 4 T1 and NIH-3 T3 ***,RBE in combination with doxorubicin decreased 4 T1 cell viability synergistically(combination index<0.9)and induced apoptosis and senescence on 4 T1 *** significantly decreased senescence in doxorubicin-treated NIH-3 T3 ***,RBE did not increase ROS levels in doxorubicin-treated 4 T1 ***,the combination of RBE and doxorubicin reduced ROS levels in NIH-3 T3 *** significantly reduced glutathione-S-transferase activity and alpha-tocotrienol interacted with glutathione-Stransferase in the glutathione binding ***:Rice bran may be used as a co-chemotherapeutic agent to improve the therapeutic effectiveness of doxorubicin while protecting against the cellular senescence effects of doxorubicin on healthy cells.

关键词： Rice bran extract ROS Senescence Doxorubicin 4T1 NIH-3T3

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Stable Fano-like plasmonic resonance: its impact on the reversal of far-and near-field optical binding force

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Communications in Theoretical Physics 2020年第4期72卷 89-105页

作者： Hamim Mahmud Rivy M R C Mahdy Nabila Masud Ziaur rahman Jony Saikat Chandra Das Department of Electrical&Computer Engineering North South UniversityBashundharaDhaka1229Bangladesh School of Electrical and Electronic Engineering Nanyang Technological University50 Nanyang Ave639798 Singapore Pi Labs Bangladesh LTD ARA Bhaban39Kazi Nazrul Islam AvenueKawran BazarDhaka 1215Bangladesh

Even for a 100 nm interparticle distance or a small change in particle shape,optical Fano-like plasmonic resonance mode usually vanishes *** would be remarkable if stable Fano-like resonance could somehow be achieved in distinctly shaped nanoparticles for more than 1μm interparticle distance,which corresponds to the far electromagnetic field *** such far-field Fano-like plasmonic resonance can be achieved,controlling the reversal of the far-field binding force can be attained,like the currently reported reversals for near-field *** this work,we have proposed an optical set-up to achieve such a robust and stable Fano-like plasmonic resonance,and comparatively studied its remarkable impact on controlling the reversal of near-and far-field optical binding *** our proposed set-up,the distinctly shaped plasmonic tetramers are half immersed(***-benzene)in an inhomogeneous dielectric interface and illuminated by?circular?polarized *** have demonstrated significant differences between near-and far-field optical binding forces along with the Lorentz force field,which partially depends on the object’s shape.A clear connection is shown between the far-field binding force and the resonant modes,along with a generic mechanism to achieve controllable Fano-like plasmonic resonance and the reversal of the optical binding force in both far-and near-field configurations.

关键词： Fano resonance optical binding force Lorentz force plasmonic tetramer

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Unraveling the nature of sensing in electrostatic MEMS gas sensors

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Microsystems & Nanoengineering 2024年第3期10卷 109-117页

作者： Yasser S.Shama Sasan rahmanian Hamza Mouharrar Rana Abdelrahman Alaaeldin Elhady Eihab M.Abdel-rahman Systems Design Engineering University of Waterloo200 University Ave WWaterloo N2L 3G1 ONCanada Mechanical Engineering Benha Faculty of EngineeringBenha UniversityBenha 13511Egypt

This paper investigates the fundamental sensing mechanism of electrostatic MEMS gas *** compares among the responsivities of a set of MEMS isopropanol sensors before and after functionalization,and in the presence and absence of electrostatic fields when operated in static and dynamic detection *** the static mode,we found that the sensors do not exhibit a measurable change in displacement due to added *** the other hand,bare sensors showed a clear change in displacement in response to isopropanol *** the dynamic mode,functionalized sensors showed a measurable frequency shift due to the added mass of isopropanol *** the presence of strong electrostatic fields,the measured frequency shift was found to be threefold larger than that in their absence in response to the same concentration of isopropanol *** enhanced responsivity of dynamic detection allows the sensors to measure the vapor mass captured by the functional material,which is not the case for static *** detection of isopropanol by bare sensors in static mode shows that change in the medium permittivity is the primary sensing *** enhanced responsivity of dynamic mode sensors when operated in strong electrostatic fields shows that their sensing mechanism is a combination of a weaker added mass effect and a stronger permittivity *** findings show that electrostatic MEMS gas sensors are independent of the direction of the gravitational field and are,thus,robust to changes in *** is erroneous to refer to them as‘gravimetric’sensors.

关键词： mechanism electrostatic measurable

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Effect of the antenna slot numbers and position on the performance of microwave ablation

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Medicine in Novel Technology and Devices 2023年第4期20卷 105-113页

作者： Sabiha Binte Aziz Md Rejvi Kaysir Md Jahirul Islam Torikul Islam Mahmudur rahman Department of Biomedical Engineering(BME) Khulna University of Engineering&TechnologyKhulna-9230Bangladesh Photonics Research Group Department of EEEKhulna University of Engineering&TechnologyKhulna-9230Bangladesh Department of Electrical and Computer Engineering Waterloo Institute for NanotechnologyUniversity of Waterloo200 University AveWaterlooONCanada Department of Biomedical Engineering(BME) New Jersey Institute of TechnologyNewarkNJUSA Department of Electrical and Electronic Engineering Dhaka University of Engineering&TechnologyGazipur 1707Bangladesh

Microwave ablation(MWA)is a type of thermal ablation used for cancer treatment in interventional *** induce localized tissue heating MWA employs electromagnetic waves within the microwave energy spectrum,which is done by the precisely designed *** study substantially emphasizes the design and performance ameliorating of slot(both single and double)antennae and compares the results with conventional monopole antennae in terms of temperature distribution,specific absorption ratio(SAR),and thermal tissue damage *** simulation has been done in COMSOL by solving the Bioheat equation along with Maxwell electromagnetic equations using the finite element *** simulation results reveal that the double-slot antenna has the most accurate and directional heat dissipation for liver tumors as well as the highest tissue damage rate and *** highest SAR was found to be 3500 W/kg and 3350 W/kg at the implant depth of 61 mm and 63 mm for double and single-slot antennae,*** addition,the fastest tissue damage occurred near the upper slot of the double-slot *** study helps to understand the basic design parameters for enhancing single and doubleslot antennae performance.

关键词： Microwave ablation(MWA) Finite element method(FEM) Liver tumor Microwave antenna Specific absorption rate(SAR)

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