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World Journal of Clinical Oncology 2018年第8期9卷 200-207页

作者： Mohamed H Khattab Alexander D Sherry Carolyn G Ahlers austin n kirschner Department of Radiation Oncology Vanderbilt University Medical Center Vanderbilt University School of Medicine

BACKGROUnD Epithelial-myoepithelial carcinoma (EMC) is a rare, low-grade, malignant tumor that constitutes less than one percent of all salivary gland tumors. To date, only one other case report has described radiation-associated EMC in the English language medical *** SUMMARY In this report, we describe the case of a 56-year-old male patient who presented with a neck mass diagnosed as EMC of the left submandibular gland approximately 30 years after mantle field radiation and chemotherapy for Hodgkin lymphoma. Treatment included resection, re-resection with nodal dissection, and adjuvant chemoradiotherapy. This patient was also diagnosed with 4 other secondary malignancies, including stage IV diffuse large B cell lymphoma in the abdomen with subsequent brain metastases, low-grade neuroendocrine carcinoma of the lung, Hurthle cell adenoma, and small B cell lymphoma before the patient expired. This case provides important information regarding the pathology, clinical sequelae, and management of a patient diagnosed with radiation-associated EMC amidst four concurrent *** Further investigation is needed on the efficacy of adjuvant radiotherapy in EMC,especially atypical EMC.

关键词： Secondary malignancy Radiation-associated malignancy Epithelialmyoepithelial carcinoma Cancer survivorship Case report

A comprehensive review of dwell time optimization methods in computer-controlled optical surfacing

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Light(Advanced Manufacturing) 2024年第3期5卷 142-171页

作者： Tianyi Wang Xiaolong Ke Lei Huang Qingqing Cui Zili Zhang Chunjin Wang Hyukmo Kang Weslin Pullen Heejoo Choi Daewook Kim Vipender negi Qian Kemao Yi Zhu Stefano Giorgio Philip Boccabella nathalie Bouet Corey austin Mourad Idir national Synchrotron Light Source II(nSLS-II) Brookhaven National LaboratoryP.O.Box 5000UptonNY 11973USA School of Mechanical and Automotive Engineering Xiamen University of TechnologyXiamen 361024China State Key Laboratory of Ultra-precision Machining Technology Department of Industrial Systems and EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina James C.Wyant College of Optical Sciences University of Arizona1630 E.University Blvd.P.O.Box 210094TucsonAZ 85721-0094USA Large Binocular Telescope Observatory University of ArizonaTucsonAZ 85721USA Department of Astronomy and Steward Observatory University of Arizona933 N.Cherry Ave.TucsonAZ85721USA Indian Institute of Technology Delhi Hauz KhasNew Delhi 110016India School of Computer Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798

Dwell time plays a vital role in determining the accuracy and convergence of the computer-controlled optical surfacing ***,optimizing dwell time presents a challenge due to its ill-posed nature,resulting in non-unique *** address this issue,several well-known methods have emerged,including the iterative,Bayesian,Fourier transform,and matrix-form *** their independent development,these methods share common objectives,such as minimizing residual errors,ensuring dwell time's positivity and smoothness,minimizing total processing time,and enabling flexible dwell *** paper aims to comprehensively review the existing dwell time optimization methods,explore their interrelationships,provide insights for their effective implementations,evaluate their performances,and ultimately propose a unified dwell time optimization methodology.

关键词： Dwell time optimization Computer-controlled optical surfacing Finishing Polishing Optical fabrication

Extent of morbidity associated with schistosomiasis infection in Malawi: a review paper

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Infectious Diseases of Poverty 2015年第1期4卷 185-192页

作者： austin H n Mtethiwa Gamba nkwengulila Jared Bakuza Daniel Sikawa Abigail Kazembe Lilongwe University of Agriculture and natural Resources(LUAnAR) Bunda CampusPO Box 219LilongweMalawi Zoology Department University of Dar es SalaamCollege of Natural and Applied SciencePO Box 35064Dar es SalaamTanzania Biological Sciences Unit Dar es Salaam University College of Education(DUCE)PO Box 2329Dar es SalaamTanzania University of Malawi Kamuzu College of NursingPrivate Bag 1LilongweMalawi

Data on the extent of the burden due to schistosomiasis is sparse in most Sub-Saharan African ***,this data is crucial for triggering medical attention.A review of extent of morbidity and determinants associated with schistosomiasis in Malawi was therefore conducted to quantify the infection in order to concretise the need for medical intervention.A systematic and traditional search strategy was used to find literature for the review,whilst exclusion and inclusion criteria were used to identify appropriate *** regression curves of epidemiological model Y=(a+bxc)/(1+bxc)and the recommendation that schistosomiasis prevalence can be used to estimate morbidity were employed to quantify morbidity at various infection *** was quantified as a direct proportion of the population and the respective national schistosomiasis *** showed that both *** and *** are present in Malawi with the latter highly prevalent(50%).Furthermore,out of the estimated population of 16,829 million,approximately 8.4 million have schistosomiasis,with about 4.4 million of these aged 18 years and *** most frequent manifestation is Katayama syndrome,while ascites is the lowest,impacting about 3.0 million and 960 individuals,*** studies on association of schistosomiasis infection to risk factors such as occupation,age and gender found odds ratio(OR)ranging from 1.29 to *** due to schistosomiasis is high in *** is therefore recommended that a more detailed study on the determinants of high schistosomiasis and re-evaluation of the current control measures be conducted if the current morbidity statistics are to be remarkably reduced.

关键词： Schistosomiasis Morbidity Risk factors Quantification Burden Extent

Unmixing detrital zircon U-Pb ages reveals tectonic and climatic depositional influences on the Carboniferous Ansilta Formation,Calingasta-Uspallata Basin,Western Argentina

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Geoscience Frontiers 2024年第4期15卷 61-77页

作者： J.R.Malone J.E.Malone J.L.Isbell D.H.Malone J.P.Craddock K.n.Pauls Department of Geological Sciences Jackson School of GeosciencesUniversity of Texas at AustinAustinTX 78712USA Iowa Geological Survey University of IowaIowa CityIA 52240USA Department of Geosciences University of Wisconsin-MilwaukeeMilwaukeeWI 53211USA Department of Geography Geology and the EnvironmentIllinois State UniversityNormalIL 61790-4400USA

The Late Paleozoic Ice Age(LPIA)was a principal control of sedimentation across Gondwana from the late Devonian through early *** assess the hypothesis that glacial to interglacial transitions in western Argentina were the primary control influencing sediment routing patterns among the various Carboniferous-Permian basins in western *** Carboniferous Ansilta Formation consists of glaciomarine,nearshore,and fluvial systems deposited during the LPIA along the eastern margin of the Calingasta-Uspallata Basin in *** lower,glacially influenced succession of the Ansilta Formation records at least five glacial advances;the upper succession of consists of progradational shallow marine,deltaic,and fluvial *** combine 1225 new U-Pb zircon ages from six samples of the Carboniferous Ansilta Formation in the Calingasta-Uspallata Basin with 5864 U-Pb ages from 147 pub-lished samples in the detrital Pymix forward mixture model to characterize provenance *** the glacially influenced lower Ansilta Formation,sediment was derived locally from the Protoprecordillera,which was a prominent highland with alpine glaciers flowing west and east into the Calingasta-Uspallata and Paganzo basins,***,there was little or no connection between these two basins during Serpukhovian-Bashkirian *** fluvial/deltaic upper Ansilta had distal sediment sources in the Sierras ***,our results support the collapse of the Protoprecordillera topographic barrier,enabling drainage patterns connecting the Paganzo and Calingasta-Uspallata basins by late Pennsylvanian-early Permian time.

关键词： Late Paleozoic Ice Age Argentina Calingasta-Uspallata Basin Ansilta Formation Detrital zircon provenance

CO2 activation on bimetallic Cuni nanoparticles

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Progress in natural Science:Materials International 2016年第5期26卷 487-492页

作者： natalie austin Brandon Butina Giannis Mpourmpakis Department of Chemical Engineering University of Pittsburgh

Density functional theory calculations have been performed to investigate the structural, electronic, and CO2adsorption properties of 55-atom bimetallic Cu ni nanoparticles（nPs） in core-shell and decorated architectures,as well as of their monometallic counterparts. Our results revealed that with respect to the monometallic Cu55and ni55parents, the formation of decorated Cu12ni43and core-shell Cu42ni13are energetically favorable. We found that CO2chemisorbs on monometallic ni55, core-shell Cu13ni42, and decorated Cu12ni43and Cu43ni12,whereas, it physisorbs on monometallic Cu55and core-shell Cu42ni13. The presence of surface ni on the nPs is key in strongly adsorbing and activating the CO2molecule（linear to bent transition and elongation of C=O bonds）. This activation occurs through a charge transfer from the nPs to the CO2molecule, where the local metal d-orbital density localization on surface ni plays a pivotal role. This work identifies insightful structureproperty relationships for CO2activation and highlights the importance of keeping a balance between nP stability and CO2adsorption behavior in designing catalytic bimetallic nPs that activate CO2.

关键词： Density functional theory Alloys CO2adsorption Catalysis Stability

Compositional Effect of ZrO_2 nanofillers on a PVDF-co-HFP Based Polymer Electrolyte System for Solid State Zinc Batteries

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Chinese Journal of Polymer Science 2016年第3期34卷 332-343页

作者： M.Johnsi S.austin Suthanthiraraj Department of Energy University of MadrasGuindy Campus

Composite polymer electrolytes（CPEs） comprising poly（vinilydene fluoride-hexafluoro propylene）, PVDF-coHFP and zinc triflate, Zn（CF3SO3）2 with varying concentrations of ZrO_2 nanofillers were prepared by solution casting technique with n,n-dimethyl formamide（DMF） as the common solvent. The polymer electrolyte specimen with the particular composition 75 wt% PVDF-co-HFP： 25 wt% Zn Tf ＋ 7 wt% Zr O2 showed the highest conductivity of 4.6 × 10-4 S/cm at 298 K as confirmed from impedance measurements and favored by the rich amorphous phase of the CPE revealed from room temperature X-ray diffraction analysis（XRD）. The electrical conductivity relaxation time and its distribution within the materials have been evaluated from the electric modulus M 2 and impedance Z＂ data which showed the occurrence of non-Debye type of relaxation phenomenon. The changes in the surface morphology of the CPEs were examined using scanning electron microscopy（SEM）. The electrochemical stability window of CPE is found to be 2.6 V with a thermal stability up to 300 °C. An electrochemical cell has been fabricated based on Zn/MnO_2 electrode couple under a constant load of 1 MΩ and its discharge characteristics have been evaluated.

关键词： nanocomposites Dielectric properties Thermal stability Electrochemical stability Batteries

DEGREE OF APPROXIMATIOn BY SUPERPOSITIOnS OF A SIGMOIDAL FUnCTIOn

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Analysis in Theory and Applications 1993年第3期9卷 17-28页

作者： Chen Debao (University of Texas at austin,USA) Department of Mathematics University of Texas at Austin Austin U.S.A.

In this paper we study the degree of approximation by superpositions of a sigmoidal *** mainly consider the univariate *** f is a continuous function,we prove that for any bounded sigmoidal function σ,d_(n,σ)(f)≤‖σ‖ω(f,1/(n+1)).For the Heaviside function H(x),we prove that d_(n,H)(f)≤ω(f,1/(2(n+1))). If f is a continuous funnction of bounded variation,we prove that d_(n,σ)(f)≤‖σ‖/(n+1)V(f)and d_(n,H)(f)≤ 1/(2(n+1))V(f).For he Heaviside function,the coefficient 1 and the approximation orders are the best *** compare these results with the classical Jackson and Bernstein theorems,and make some conjec- tures for further study.

关键词： DEGREE OF APPROXIMATIOn BY SUPERPOSITIOnS OF A SIGMOIDAL FUnCTIOn

Is the propensity to emit alarm calls associated with health status?

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Current Zoology 2020年第6期66卷 607-614页

作者： austin L.nash Alexandra H.M.Jebb Daniel T.BLUMSTEIn Department of Ecology and Evolutionary Biology University of Colorado265 UCBBoulderCO 80309USA School of Biological Sciences University of AberdeenZoology BuildingTillydrone AvenueAberdeenAB242TZUK The Rocky Mountain Biological Laboratory Box 519 Crested ButteCO 81224USA Department of Ecology and Evolutionary Biology University of California621 Young Drive SouthLos AngelesCA 90095-1606USA

The production and structure of animal signals may depend on an individual's health status and may provide more than one type of information to *** alarm calls are not typically viewed as health condition dependent,recent studies have suggested that their structure,and possibly their propensity to be emitted,depends on an individual,s health condition and *** asked whether the propensity of yellow-bellied marmots(Marmota flaviventer)to emit calls is influen ced by their immuno logical or parasite status,by quantifying both trap-elicited and n atural calling rates as a function of their neutrophil-to-lymphocyte(nL)ratio,the presence of a blood borne trypanosome,and the presenee of several intestinal parasites(Eimeria sp.,Entamoeba sp.,and Ascaris sp.).We fitted mixed effects models to determine if the health measures we collected were associated with the probability of calling in a trap and with annual rates of natural alarm *** infected with a blood-borne trypanosome were marginally more likely to call naturally and when trapped,while those infected with the intestinal parasite Ascaris were less likely to call when *** ratio was not directly associated with in-trap calling probability,but males were more likely to call when they had higher nL ***,health conditions,such as parasite infection and immune system activation,can modulate the production of alarm signals and potentially provide in formation to both predators and prey about the caller's *** experiments are required to confirm if receivers use such information.

关键词： alarm calling animal communication antipredator behavior condition dependenee immune function parasites

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan Juan Alec C.Bancroft Ji Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard Juhoon Lee Sowmya Ramesh Aaron W.James David Hudson Kevin n.Dalby Lin Xu Robert J.Tower Benjamin Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RnA sequencing(scRnA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRnA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

Multi-targeted anti-inflammatory drugs for the treatment of neurological disorders

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neural Regeneration Research 2023年第4期18卷 805-806页

作者： austin Lui Omar Alzayat Timothy Do David Perekopskiy Meghan Gann Taiseer Saad Elgokhy Jie Gao DaZhi Liu Department of neurology University of California at DavisSacramentoCAUSA Department of neuroscience The Ohio State UniversityColumbusOHUSA

Inflammation and kinase pathophysiology in neurological disorders:Inflammation is one of the common features of various acute and degenerative neurological disorders,such as stroke,traumatic brain injury(TBI),Alzheimer’s disease(AD),Parkinson’s disease(PD),and *** inflammatory responses are manifested as the synthesis of inflammation mediators,recruitment of leukocytes,and other secondary *** evidence shows that a large number of inflammation mediators(e.g.,thrombin,reactive oxygen species,cytokines,chemokines,and other molecules)are implicated in the pathophysiological processes in neurological disorders(Liu and Ander,2012)(Figure 1).These increased inflammation mediators stimulate their downstream transmembrane receptors(e.g.,protease-activated receptors,cytokine receptors,and others),and further activate the intracellular downstream effector kinases,such as Src family kinase,Rho-associated protein kinase,Jun n-terminal kinase,extracellular signal-regulated kinase,cyclin-dependent kinase(CDK),and others(Liu and Ander,2012)(Figure 1).Aside from overlapping in different neurological disorders,numerous inflammatory molecules and multiple kinase-involved signaling pathways can be linked to a single neurological disorder such as AD(Heneka et al.,2015).Because of their pivot roles in the process of inflammation,kinases have been regarded as anti-inflammatory targets to improve outcomes of neurological disorders.

关键词： neurological inflammation inflammatory