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Ia型遗传性运动感觉神经病的临床严重程度和轴突功能障碍

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世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 30-30页

作者： Verhamme C. van Schaik I.N. Koelman J.H.T.M. 袁海峰 dept. Neurol. Clin. Neurophysiol. Academic Medical Centre University of Amsterdam PO Box 22700 1100 DE Amsterdam Netherlands

Background: Hereditary motor and sensory neuropathy type Ia (HMSN Ia) is known as a primarily demyelinating peripheral nerve disease. Evidence is accumulating that axonal involvement determines the course of the disease process. Methods: Fifty- one patients were investigated. Physical disability and impairments were scored. Nerve conduction velocities (NCVs) were used as indirect measures for myelination status and compound muscle/sensory nerve action potential (CMAP/SNAP) amplitudes served as indirect measures for axonal function. Results: Median age was 39 years (range 6- 69). Muscle weakness and sensory dysfunction was more severe in the legs than in the arms and distally more than proximally. However, more than 40 % of the patients had proximal muscle weakness in the legs. Three point grip was used as representative of combined distal arm muscle groups. CMAP amplitude was the most important independent variable in a multiple linear regression model (forward selection) to explain the relation between three point grip strength and four different features, i. e., CMAP amplitude of the abductor pollicis brevis, median nerve MNCV, gender, and duration of signs and symptoms. The severity of axonal dysfunction was nerve length- dependent and was related to the myelination status. The mild physical disability due to both muscle weakness and sensory dysfunction was also related to axonal dysfunction. Conclusions: In HMSN Ia, clinical disease severity at the impairment and disability levels is related to the severity of axonal dysfunction. Our data support the hypothesis that the myelination status is one of the factors that determine the extent of axonal dysfunction later in life. Proximal weakness of the legs is encountered in a considerable proportion of our patients.

关键词：运动感觉 Ia 临床严重程度功能障碍下肢近端肌神经传导速度正中神经肌无力髓鞘复合动作电位

缺血性卒中出现类似急性心肌梗死的症状:诊断上的难点

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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 39-39页

作者： van der Bilt I.A.C. Raaphorst J. Wouda E.J. Visser F.C. 尹涛 department of Cardiology VU University Medical Center6D120De Boelelaan 1117Amsterdam 1081 HVNetherlands

Neurocardiogenic dysfunction is described in acute neurological injury. We rep ort a case of ischemic stroke mimicking acute myocardial infarction.

关键词：急性心肌梗死缺血性卒中症状神经系统损伤诊断性功能障碍病例

生物钟缺陷的Cry-null小鼠的盐敏感性高血压的发生与肾上腺Hsd3b6的功能失调有关

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中华高血压杂志 2010年第7期18卷 699-699页

作者：张玲玉叶鹏 Doi M Takahashi Y Komatsu R Yamazaki F Yamada H Haraguchi S Emoto N Okuno Y Tsujimoto G Kanematsu A Ogawa O Todo T Tsut-sui K van der Horst GT Okamura H

生物钟功能失调与多种疾病的发生有关。缺乏主要生物钟组成成分隐花色素1(Cryptochrome-1,Cry1)和隐花色素2(Cryptochrome-2,Cry2)的小鼠(Cry-null mice),由于肾上腺不正常地,过高地合成盐皮质激素醛固酮,从而发生盐敏感性高血压。为寻... 详细信息

生物钟功能失调与多种疾病的发生有关。缺乏主要生物钟组成成分隐花色素1(Cryptochrome-1,Cry1)和隐花色素2(Cryptochrome-2,Cry2)的小鼠(Cry-null mice),由于肾上腺不正常地,过高地合成盐皮质激素醛固酮,从而发生盐敏感性高血压。为寻求上述现象的发生机制,通过大量的研究发现,小鼠的Ⅳ型3-β羟基类固醇脱氢酶(3beta-hydroxyl-steroid de-hydrogenase,Hsd3b6)是新的高血压危险因子。Hsd3b6仅表达于醛固酮生成细胞,其转录受生物钟调控。[第一段]

关键词：盐敏感性高血压生物钟调控功能失调小鼠肾上腺醛固酮发生机制类固醇脱氢酶隐花色素

右心室功能的半定量评估与三维容积法对照:心血管磁共振研究

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国际医学放射学杂志 2009年第1期32卷 84-84页

作者： R. Nijveldt T. Germans G.P. McCann A.M. Beek A.C. van Rossum 赵峰 department of Cardiology VU University Medical Center De Boelelaan 1117 1081 HV Amsterdam The Netherlands

心血管磁共振（CMR）被认为是测量右心室（RV）容积的金标准，但是数据采集和分析是个费时的过程。因此本研究的目的是通过对照标准的定量测量方法来研究心血管磁共振半定量评估右心室功能的准确性和表现。75名受试者中包括肺动脉高压1... 详细信息

心血管磁共振（CMR）被认为是测量右心室（RV）容积的金标准，但是数据采集和分析是个费时的过程。因此本研究的目的是通过对照标准的定量测量方法来研究心血管磁共振半定量评估右心室功能的准确性和表现。75名受试者中包括肺动脉高压15例、前壁心肌梗死15例、下壁心肌梗死15例、Brugada综合征15例、正常受试者15名，

关键词：心血管磁共振右心室机能三尖瓣环收缩期运动幅度

基于van Leer+AUSM混合格式求解三维N-S方程

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航空计算技术 2010年第6期40卷 30-34页

作者：王学德谭俊杰唐振华张声奇王志伟南京理工大学动力工程学院江苏南京210094

基于多块粘性结构网格,开展了三维N-S方程数值算法的研究。控制方程的空间离散采用有限体积法,在前人工作的基础上,发展了van Leer+AUSM混合格式并应用到对流通量的离散中,粘性项采用中心格式离散并利用格林定理计算粘性通量中的导数项... 详细信息

基于多块粘性结构网格,开展了三维N-S方程数值算法的研究。控制方程的空间离散采用有限体积法,在前人工作的基础上,发展了van Leer+AUSM混合格式并应用到对流通量的离散中,粘性项采用中心格式离散并利用格林定理计算粘性通量中的导数项,时间推进采用五步R-K法,湍流模型为S-A一方程模型。最后,以M6机翼和某超声速弹丸的粘性流场作为数值算例,计算表明:发展的数值算法对跨声速、超声速流场均具有较高的分辨率,适用于跨、超声速流场的数值模拟。

关键词： N-S方程粘性结构网格 van Leer+AUSM格式 S-A湍流模型

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尼洛替尼衍生物与牛血清白蛋白的相互作用

新乡医学院学报 2015年第10期32卷 899-902,906页

作者：李娜崔柳苏杨丽娟王倩倩刘巍孙祥德新乡医学院药学院河南新乡453003 新乡医学院基础医学院河南新乡453003

目的探讨尼洛替尼衍生物4-甲氧基-N-[4-(3-吗啉基丙氧基)苯基]-3-[4-(吡啶-3-基)嘧啶-2-基氨基]苯甲酰胺(lz)与牛血清白蛋白(BSA)的相互作用。方法模拟生理条件(p H=7.4),25、37℃测定荧光光谱和吸收光谱。利用Stern-Volmer方程判断荧... 详细信息

目的探讨尼洛替尼衍生物4-甲氧基-N-[4-(3-吗啉基丙氧基)苯基]-3-[4-(吡啶-3-基)嘧啶-2-基氨基]苯甲酰胺(lz)与牛血清白蛋白(BSA)的相互作用。方法模拟生理条件(p H=7.4),25、37℃测定荧光光谱和吸收光谱。利用Stern-Volmer方程判断荧光猝灭类型;求出结合常数和结合位点数;根据Frster非辐射能量转移理论求出其作用距离r;根据基本热力学参数ΔG、ΔH和ΔS判断lz和BSA作用力类型;根据同步荧光光谱分析lz对BSA构象的影响。结果 lz对BSA的内源荧光有较强的动态猝灭作用,并得出了结合常数(Ka)及结合位点数(n),结合作用主要靠氢键和范德华力驱动,结合距离r=3.20 nm,发生能量转移,引起了BSA构象的变化。结论本研究为进一步改造设计尼洛替尼,寻找新的药物小分子提供了一定的实验依据。

关键词： 4-甲氧基-N-[4-(3-吗啉基丙氧基)苯基]-3-[4-(吡啶-3-基)嘧啶-2-基氨基]苯甲酰胺牛血清白蛋白相互作用荧光光谱同步荧光光谱紫外吸收光谱

Search for the rare decay B^(0)→J/ψФ

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Chinese Physics C 2021年第4期45卷 47-60页

作者： R.Aaij C.Abellin Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnial C.A.Aidala S.Aiola Z.Ajaltouni S.Akar J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelle S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmaver J.J.Back S.Baker P.Baladron Rodriguez V.Balagura W.Baldinit J.Baptista Leite R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschis I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bizzeti M.Biorn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguezs M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Burschee A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana D.H.Campora Perez A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbonel G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovska M.Cruz Centro Brasileiro de Pesquisas Fisicas(CBPF) Riode JaneiroBrazil Universidade Federal do Riode Janeiro(UFRJ) Riode JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute Of High Energy Physics(IHEP) BejingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance Universite Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Universitq Paris-Saclay CNRS/IN2P3IJCLabOrsayFrance LPNHE Sorbonne UniversiteParis Diderot Sorbonne Paris CiteCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut fir Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati Frascatiltaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano Bicocca Milanolaly INFN Sezione di Milano MilanoItaly INFN Sezione di Cagliari Monserratoltaly Universita degli Studi di Padova Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma Tor Vergata RomaItaly INFN Sezione di Roma La Sapienza RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences KrakowPoland AGH-University of Science and Technology Faculty of Physics and Applied Computer Science

A search for the rare decay B^(0)→J/ψФis performed using Pp collision data collected with the LHCb dete-ctor at centre-of-mass energies of 7,8 and 13 TeV,corresponding to an integrated luminosity of9 *** significant signal of the decay is observed and an upper limitof 1.1x 10^(-7)at 90%confidence level is set on the branching fraction.

关键词： B physics flavour physics rare decay ω-Фmixing branching fraction

改良CPSSS量表对急性前循环大血管闭塞性脑梗死的预测价值分析

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中国卒中杂志 2021年第7期16卷 687-693页

作者：刘婷廖娟刘莉赵立波刘曙东徐露周婷杨德雨重庆医科大学附属永川医院神经内科重庆402160 脑血管病研究重庆市重点实验室重庆医科大学附属永川医院健康管理科西藏昌都市人民医院内一科

目的在辛辛那提院前卒中严重程度量表(Cincinnati prehospital stroke severity scale,CPSSS)基础上加入心房颤动项目构建改良CPSSS(modified CPSSS,mCPSSS),评估mCPSSS对急性前循环大血管闭塞(large vessel occlusion,LVO)的预测能力。方法回顾性分析2019年5月-2020年4月在重庆医科大学附属永川医院国家高级卒中中心就诊的急性前循环脑梗死患者的临床资料,运用单因素和二元logistic回归分析检验CPSSS量表项目及心房颤动与LVO的相关性,构建加入心房颤动指标的mCPSSS。通过ROC曲线及曲线下面积(areas under the curve,AUC)评估mCPSSS及CPSSS,视野、失语、忽视量表(vision,aphasia,neglect,van),三项内容卒中量表(3 item stroke scale,3I-SS)和快速动脉闭塞量表(rapid arterial occlusion evaluation,RACE)等卒中量表对前循环LVO的预测价值。结果共纳入263例患者。凝视、意识水平及提问、上肢无力、心房颤动是前循环LVO的独立预测因素。将心房颤动纳入CPSSS,并根据ROC曲线分析结果将其取值为1分(心房颤动取值1分,AUC=0.955;心房颤动取值2分,AUC=0.950)。mCPSSS总分≥2分预测前循环LVO的灵敏度为90.16%,特异度为94.33%。mCPSSS的预测价值高于CPSSS、van、3I-SS和RACE量表(均PdeLong’s检验)。结论mCPSSS量表对前循环LVO的预测价值优于其他常用卒中量表,可能有助于急性前循环LVO患者的院前识别、急救及院内分诊。

关键词：卒中量表大血管闭塞急性缺血性卒中心房颤动辛辛那提院前卒中严重程度量表

在进行子宫内激光凝固疗法治疗双胞胎间输血综合征后诊断的回肠闭锁和血栓栓塞性肝脏钙化:2例报道

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世界核心医学期刊文摘（儿科学分册） 2005年第11期1卷 57-57页

作者： Schnater J.M. van Zalen-Sprock R.M. Schaap A.H.P. D.C. Aronson 李丹 Pediatric Surgical Center of Amsterdam Location Emma Children's Hospital AMC PO Box 22700 1100 DE Amsterdam Netherlands

Ileal atresia is considered to be an acquired anomaly. It is thought to be caused by a mesenteric vascular accident during fetal life which leads to necrosis of downstream tissues. We present a case in which ileal atresia occurred after intrauterine laser coagulation therapy for a twin-to-twin transfusion syndrome. The laser treatment might have been the etiological factor of the atresia. A second case in which thrombo-embolic calcifications were found in the liver is presented as well.

关键词：肠闭锁激光凝固疗法栓塞性肠系膜血管胎儿期钙化点