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The Larix kaempferi genome reveals new insights into wood properties

Journal of Integrative Plant Biology 2022年第7期64卷 1364-1373页

作者： Chao Sun Yun-Hui Xie Zhen Li Yan-Jing Liu Xiao-Mei Sun Jing-Jing Li Wei-Peng Quan Qing-Yin Zeng Yves van de Peer Shou-Gong Zhang State Key Laboratory of Tree Genetics and Breeding Chinese Academy of ForestryBeijing 100091China Key Laboratory of Tree Breeding and Cultivation of the State Forestry and Grassland Administration Research Institute of ForestryChinese Academy of ForestryBeijing 100091China department of Plant Biotechnology and Bioinformatics Ghent UniversityGent B‐9052Belgium VIB Center for Plant Systems Biology Ghent B‐9052Belgium Nextomics Biosciences Co. LtdWuhan 430073China department of Biochemistry Genetics and MicrobiologyPretoriaSouth Africa

Here,through single-molecule real-time sequencing,we present a high-quality genome sequence of the Japanese larch(Larix kaempferi),a conifer species with great value for wood production and ecological *** assembled genome is 10.97 Gb in size,harboring 45,828 protein-coding *** the genome,66.8%consists of repeat sequences,of which long terminal repeat retrotransposons are dominant and make up 69.86%.We find that tandem duplications have been responsible for the expansion of genes involved in transcriptional regulation and stress responses,unveiling their crucial roles in adaptive *** transcriptome analysis reveals that lignin content in *** is mainly determined by the process of monolignol *** expression values of six genes(LkC OMT7,LkC OMT8,LkL AC23,LkL AC102,LkP RX148,and LkP RX166)have significantly positive correlations with lignin *** results indicated that the increased expression of these six genes might be responsible for the high lignin content of the larches’***,this study provides new genome resources for investigating the evolution and biological function of conifer trees,and also offers new insights into wood properties of larches.

关键词： evolution gene expression genome Larix kaempferi wood properties

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The response of stromatolites to seismic shocks： Tomboliths from the Palaeoproterozoic Chaibasa Formation, E India

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Journal of Palaeogeography 2016年第4期5卷 381-390页

作者： A.J. (Tom) van Loon Rajat Mazumder Shuvabrata de Geocom Consultants Valle del Portet 17 03762 Benitachell Spain department of Applied Geology Faculty of Science and Engineering Curtin University Sarawak CDT 250 98009 Miri Sarawak Malaysia Indian Institute of Science Education and Research Department of Earth and Environmental Sciences Bhopal By-pass Road Bhopal 462066 Madhya Pradesh India

It is demonstrated here for the first time how Palaeoproterozoic stromatolites survived seismic disturbance of their substrate. The stromatolites under study could have been cyanobacteria or any other photo-autotrophic microbes, which formed mats that covered a substrate of very fine-grained sandstones and mudstones of the Chaibasa Fm. in eastern India. The sediments represent a shelf environment. The local abundance of the stromatotites suggests that the tow-energy environment formed a suitable habitat. The common phases of tectonic quiescence were, however, occasionally interrupted by seismic shocks. These were sufficiently strong to deform the mat layers, the tower parts of which might already have been （semi-） consolidated. The mats became partly folded, partly faulted, and already consolidated parts of the stromatotite layers broke off. This can be deduced from the angular shapes of part of the broken-off fragments. It appears, however, that part of these fragments were stilt sufficiently soft to become rounded and deformed by rotting over the seafloor, probably under the influence of tidal currents. When come to rest, these fragments served as a new substrate for new generations of the microorganisms. These micro-organisms thus survived by continued growth on the reworked fragments and built up new stromatolites that may show an ‘angular disconformity＇ with the stromatotites of their substrate. It thus is shown that stromatotites have an adequate response to a sudden disturbance of their habitat, and that they survive earthquakes by colonization of broken-off fragments. We call the ‘healed＇ fragments ‘tombotiths＇（tumbled stones）.

关键词： Stromatolites Seismic shocks Soft-sediment deformation structures Pataeoproterozoic Singhbhum craton Tombotiths India

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Should primary anastomosis be considered more?A retrospective analysis of anastomotic complications in young children

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World Journal of Pediatric Surgery 2023年第4期6卷 224-230页

作者： Laurens D.Eeftinck Schattenkerk Gijsbert D.Musters Wouter J.de Jonge L.W.(Ernest)van Heurn Joep PM derikx department of Pediatric Surgery Emma Children’s HospitalAmsterdam UMCUniversity of Amsterdam and Vrije Universiteit AmsterdamAmsterdamThe Netherlands Tytgat Institute for Liver and Intestinal Research Amsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands department of General VisceralThoracic and Vascular SurgeryUniversity Hospital BonnBonnGermany

Objective Little is known about intestinal anastomotic leakage and stenosis in young children(≤3 years of age).The purpose of this study is to answer the following questions:(1)what is the incidence of anastomotic stenosis and leakage in infants?(2)which surgical diseases entail the highest incidence of anastomotic stenosis and leakage?(3)what are perioperative factors associated with anastomotic stenosis and leakage?Methods Patients who underwent an intestinal anastomosis during primary abdominal surgery in our tertiary referral centre between 1998 and 2018 were retrospectively *** general incidence and incidence per disease of anastomotic complications were *** risk factors(location and type of anastomosis,mode of suturing,and suture resorption time)were evaluated by multivariate Cox regression for anastomotic *** and American Society of Anaesthesiology(ASA)score of≥Ⅲwere evaluated byχ^(2)test for anastomotic *** In total,477 patients underwent an *** most prominent diseases are intestinal atresia(30%),Hirschsprung’s disease(29%),and necrotizing enterocolitis(14%).Anastomotic stenosis developed in 7%(34/468)of the patients with highest occurrence in necrotizing enterocolitis(14%,9/65).Colonic anastomosis was associated with an increased risk of anastomotic stenosis(hazard ratio(HR)=3.6,95%CI 1.8 to 7.5).No technical features(type of anastomosis,suture resorption time and mode of suturing)were significantly associated with stenosis *** leakage developed in 5%(22/477)of the patients,with the highest occurrence in patients with intestinal atresia(6%,9/143).An ASA score of≥Ⅲ(p=0.03)and male gender(p=0.03)were significantly associated with anastomotic *** Both anastomotic stenosis and leakage are major surgical *** more patient specific factors can result in better treatment selection,which should not solely be based on the type of disease.

关键词： anastomosis anastomotic complications

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Medically unexplained dyspnea:psychophysiological characteristics and role of breathing therapy

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Chinese Medical Journal 2004年第1期117卷 6-13页

作者：韩江娜朱元珏李舜伟雒冬梅胡征 van Diest I de Peuter S van de Woestijne KP van den Bergh O Laboratory of Respiratory Psychophysiology Department of PneumologyPeking Union Medical College HospitalChinese Academy of Medical Sciences department of Psychology University of Leuven department of Pneumology UZ Gasthuisberg

Background Medically unexplained dyspnea occurs commonly in medical settings and remains poorly understood. This study was conducted to investigate the psychophysiological characteristics of medically unexplained dyspnea and the efficacy of breathing retraining for these patients. Methods A group of patients with medically unexplained dyspnea were compared to patients with a variety of organic lung diseases and healthy subjects. In another group of patients,the influence of breathing therapy on complaints,anxiety, and breath-holding was evaluated for an average of 1.5 years. Results Patients with medically unexplained dyspnea reported more intense dyspnea than patients with a variety of organic lung diseases. Additionally,they were anxious and presented a broad range of symptoms in daily life and under challenge,for instance voluntary hyperventilation. More than one third of them qualified for panic disorder. They had shorter breath-holding time at rest,less increase in breath-holding time and higher chances of showing a “paradoxical” decrease of breath-holding time after hyperventilation. A combination of PaO2,forced expiratory volume in one second (FEV_1),and anxiety measures distinguished them from organic dyspnea. Breathing retraining profoundly improved their symptoms and decreased the level of state and trait anxiety. Moreover,they better tolerated the voluntary hyperventilation and the symptoms induced were also markedly decreased after therapy. Breath-holding time was prolonged and PetCO2 in a representative group of patients increased. Conclusions Patients with medically unexplained dyspnea appear to have the feature of a “psychosomatic” patient: an anxious patient with a wide variety of symptoms of different organ systems that do not have an organic basis. They can be distinguished from organic dyspnea using a small set of physiological and psychological measures. Breathing retraining turns out to be an effective therapy for those “difficult to

关键词： dyspnea·somatization·anxiety·hyperventilation·breathing therapy

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On the Threshold： Urban Exchange and Intervention in Flora Lau＇s Bends （2013）

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2017年第1期11卷 180-205页

作者： Danica van de Velde School of Humanities The University of Western Australia Crawley WA 6009 Australia

The metaphor at the heart of Hong Kong filmmaker Flora Lau＇s debut feature film, Bends （2013）, set in the border spaces of Hong Kong and Shenzhen, is that of intersection. By constructing a quietly observant view of life on both sides of the Sam Chun River, which separates Hong Kong and the Chinese mainland, Lau＇s film inhabits this metaphor by cutting through the public and private domains with a narrative of intimacy and connection at the nexus of wider socioeconomic concerns. delving into Hong Kong-mainland relations, Bends inserts the real-life social issues of immigration, border control, economic privilege, and China＇s one-child policy into its diegesis to capture Hong Kong at a moment in time. In considering the intertwined relationship between identity, politics, and urban space, this paper employs the trope of disappearance perpetuated in critical discourses on Hong Kong as a point of departure to explore the distinct filmic topography of Bends, which attempts to cinematically preserve the dynamics of the city under Chinese administration. In so doing, this paper also examines Lau＇s interest in giving marginalized female groups narrative agency to shed light on an alternative perspective of the special administrative region and its unfolding relationship with the motherland.

关键词： archival gender politics Hong Kong cinema identity urban space

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Preclinical concepts and results with the GABA_A antagonist S44819 in a mouse model of middle cerebral artery occlusion

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Neural Regeneration Research 2019年第9期14卷 1517-1518页

作者： Dirk M.Hermann Barbara Saba aurore Sors Claudio L.Bassetti departments of Neurology University Hospital EssenEssenGermany Institut de Recherches Internationales Servier SuresnesFrance University Hospital(Inselspital)Berne BerneSwitzerland

Recent advancements in recanalizing therapies,i.e.,the combination of thrombolytic drugs with interventional thrombectomy,have considerably improved neurological outcome in ischemic stroke *** this progress,the large majority of stroke patients still exhibit neurological deficits in the long run,and ischemic stroke continues to be the most frequent cause of long-term ***,there is an unmet need for therapies that allow enhancing neurological recovery and brain plasticity in the post-acute stroke phase(Hermann and Chopp,2012).Preclinical studies,e.g.,delivering growth factors(Reitmeir et al.,2011)or neural precursor cells(NPC)(Bacigaluppi et al.,2016),have shown that brain plasticity can be successfully stimulated in the post-acute stroke phase,resulting in functional neurological *** findings raised the question whether it is possible to promote neurological recovery and brain plasticity in stroke patients.

关键词： Recent advancements interventional thrombectomy stroke patients

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Management of extracranial carotid artery stenosis during endovascular treatment for acute ischaemic stroke:results from the MR CLEAN Registry

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Stroke & Vascular Neurology 2023年第3期8卷 229-237,I0074-I0085页

作者： Sabine L Collette Michael P Rodgers Marianne A A van Walderveen Kars C J Compagne Paul J Nederkoorn Jeannette Hofmeijer Jasper M Martens Gert J de Borst Gert Jan R Luijckx Charles B L M Majoie Aad van der Lugt Reinoud P H Bokkers Maarten Uyttenboogaart University Medical Centre Groningen University of GroningenGroningenThe Netherlands Leiden University Medical Centre LeidenThe Netherlands Erasmus MC University Medical CentreRotterdamThe Netherlands Amsterdam University Medical Centres University of AmsterdamAmsterdamThe Netherlands Rijnstate Hospital ArnhemThe Netherlands University Medical Centre Utrecht University of UtrechtUtrechtThe Netherlands

Background The optimal management of ipsilateral extracranial internal carotid artery(ICA)stenosis during endovascular treatment(EVT)is *** compared the outcomes of two different strategies:EVT with vs without carotid artery stenting(CAS).Methods In this observational study,we included patients who had an acute ischaemic stroke undergoing EVT and a concomitant ipsilateral extracranial ICA stenosis of≥50%or occlusion of presumed atherosclerotic origin,from the Dutch Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands(MR CLEAN)Registry(2014-2017).The primary endpoint was a good functional outcome at 90 days,defined as a modified Rankin Scale score≤*** endpoints were successful intracranial reperfusion,new clot in a different vascular territory,symptomatic intracranial haemorrhage,recurrent ischaemic stroke and any serious adverse *** Of the 433 included patients,169(39%)underwent EVT with *** 123/168(73%)patients,CAS was performed before intracranial *** 42/224(19%)patients who underwent EVT without CAS,a deferred carotid endarterectomy or CAS was *** with and without CAS were associated with similar proportions of good functional outcome(47%vs 42%,respectively;adjusted OR(aOR),0.90;95%CI,0.50 to 1.62).There were no major differences between the groups in any of the secondary endpoints,except for the increased odds of a new clot in a different vascular territory in the EVT with CAS group(aOR,2.96;95%CI,1.07 to 8.21).Conclusions Functional outcomes were comparable after EVT with and without *** during EVT might be a feasible option to treat the extracranial ICA stenosis but randomised studies are warranted to prove non-inferiority or superiority.

关键词： stenosis carotid treatment

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Large-scale transportation and storage of wood pellets:Investigation of the change in physical properties

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Particuology 2021年第4期19卷 146-156页

作者： Hamid Gilvari Coen H.H.van Battum Simon A.van Dijk Wiebren de Jong Dingena L.Schott Section of Transport Engineering and Logistics Department of Maritime and Transport TechnologyFaculty of MechanicalMaritime and Materials EngineeringDelft University of TechnologyThe Netherlands Chemical Services Uniper Benelux NVThe Netherlands Section of Large Scale Energy Storage Department of Process&EnergyFaculty of MechanicalMaritime and Materials EngineeringDelft University of TechnologyThe Netherlands

The change in physical properties of wood pellets,with a focus on particle size distributions due to pellet breakage and attrition,was studied in a large-scale(∼450 ton/h)transportation *** locations with a high probability of breakage through the whole transportation system were chosen and sampled to study the effect of transportation system design and operation on the mechanical properties of *** density,mechanical durability,moisture content,and particle size distribution of pellets were characterized for each *** of variance showed that there were significant differences between the percentages of small particles(de deviation in the mechanical durability values,between a minimum of 90.8%and a maximum of 98.7%,which were not correlated to the sampling points but related to pellet *** can be concluded that pellet transportation systems require more dedicated design strategies to prevent breakage and attrition.

关键词： Wood pellets Large-scale transportation Durability Fines and dust Breakage Mechanical degradation

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Integrity of the hip capsule measured with magnetic resonance imaging after capsular repair or unrepaired capsulotomy in hip arthroscopy

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World Journal of Orthopedics 2022年第4期13卷 400-407页

作者： Niels H Bech Lode A van Dijk Sheryl de Waard Gwendolyn Vuurberg Inger N Sierevelt Gino MMJ Kerkhoffs Daniël Haverkamp department of Orthopedic Surgery Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands department of Orthopedic Surgery Xpert Orthopedic Surgery ClinicAmsterdam 1101 EANetherlands department of Orthopedic Surgery Tergooi ZiekenhuisHilversum 1213 XZNetherlands department of Radiology and Nuclear Medicine Rijnstate HospitalArnhem 6815 ADNetherlands department of Radiology and Nuclear Medicine Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Centre for Orthopaedic Research Spaarne ZiekenhuisHoofddorp 2134 TMNetherlands Academic Center for Evidence-Based Sports Medicine Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Amsterdam Collaboration on Health and Safety in Sports Amsterdam UMC/IOC Research CenterAmsterdam 1105 AZNetherlands

BACKGROUND Current literature shows no clear answer on the question how to manage the capsule after hip *** patient reported outcome measures there seems to be no difference between capsular repair or unrepaired *** To evaluate and compare the integrity of the hip capsule measured on a magnetic resonance imaging(MRI)scan after capsular repair or unrepaired *** A case series study was performed;a random sample of patients included in a trial comparing capsular repair vs unrepaired capsulotomy had a postoperative MRI *** presence of a capsular defect and gap size were independently evaluated on *** A total of 28 patients(29 hips)were *** demographics were comparable between treatment *** were 2 capsular defects in the capsular repair group and 7 capsular defects in the unrepaired capsulotomy group(P=0.13).In the group of patients with a defect,median gap sizes at the acetabular side were 5.9 mm(range:2.7-9.0)in the repaired and 8.0 mm(range:4.5-18.0)in the unrepaired group(P=0.462).At the muscular side gap sizes were 6.6 mm(range:4.1-9.0)in the repaired group and 11.5 mm(range:3.0-18.0)in the unrepaired group(P=0.857).The calculated Odds ratio(OR)for having a capsular defect with an increasing lateral center-edge(CE)angle was 1.12(P=0.06).The OR for having a capsular defect is lower in the group of patients that underwent a labral repair with an OR of 0.1(P=0.05).CONCLUSION There is no significant difference in capsular defects between capsular repair or unrepaired *** clinical characteristics our case series shows that a larger CE angle increases the likelihood of a capsular defect and the presence of a labral repair decreases the likelihood of a capsular defect.

关键词： Hip Arthroscopy Magnetic resonance imaging Capsule Thickness

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defining the Value of Extracorporeal Liver Support in Acute and Acute-on-chronic Liver Failure

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 517-520页

作者： Bart van Hoek department of Gastroenterology and Hepatology C4-Pand Transplantation CenterLeiden University Medical CenterLei denthe Netherlands

Next to acute liver failure(ALF)without previous liver dis-ease,the concept of acute-on-chronic liver failure(ACLF)has been developed.1,2 In most cases patients developing ACLF first have acute decompensation(AD)of cirrhosis,of-ten with ascites,hepatic encephalopathy,variceal bleeding,or hepatorenal *** can be induced by infection or other factors,like hepatitis *** ALF and ACLF develop rapidly,ALF within 26 weeks of onset,ACLF in 2-4 weeks,and both conditions share the symptoms of a fail-ing *** detoxification with jaundice and hepatic encephalopathy,and impaired synthetic capacity of the liver with changes in coagulation parameters are part of these *** both ALF and ACLF multi-organ failure can de-velop,including hemodynamic instability,respiratory failure and acute kidney injury,and patients become susceptible to *** standard medical treatment(SMT)in the intensive care unit has improved over the years,2,3 both con-ditions often lead toward death,unless a timely liver trans-plantation(LT)is possible.4,5.

关键词： acute impaired Acute

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