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Polymorphisms in oxidative pathway related genes and susceptibility to inflammatory bowel disease

World Journal of Gastroenterology 2017年第47期23卷 8300-8307页

作者： Nezha Senhaji Sellama Nadifi Younes Zaid aurora serrano Daniel Arturo Leon Rodriguez Nadia Serbati Mehdi Karkouri Wafaa Badre Javier Martín Laboratory of Genetic and Molecular Pathology Faculty of Medicine and Pharmacy of CasablancaHassanⅡUniversity Mohammed VI University of Health Sciences Instituto de Parasitología y Biomedicina López-Neyra Consejo Superior de Investigaciones Científicas Department of Pathology CHU Ibn Rochd Department of Gastroenterology CHU Ibn Rochd

AIM To investigate whether common variants in the oxidative pathway genes influence inflammatory bowel disease(IBD) risk among Moroccan patients. METHODS The distribution of(TAAA)n_rs12720460 and(CCTTT)n_rs3833912 NOS2 A microsatellite repeats, HIF-1 A_rs11549467 and NFKB1-94 ins/delA TTG_rs28362491 was analyzed in 507 subjects grouped in 199 IBD and 308 healthy controls. Genotyping was performed withpolymerase chain reaction-fluorescent method and the TaqMan~? allelic discrimination *** The allele and genotype frequencies of HIF1 A_ rs11549467, NFKB1_rs28362491 and NOS2 A_(TAAA)n did not differ significantly between patients and controls. Analysis of NOS2 A_(CCTTT)n markers evidenced differences between patients and healthy controls. A preferential presence of the(CCTTT)8(P = 0.02; OR = 1.71, 95%CI: 1.07-2.74),(CCTTT)14(P = 0.02; OR = 1.71, 95%CI: 1.06-2.76) alleles in IBD,(CCTTT)8(P = 0.008; OR = 1.95, 95%CI: 1.17-3.23) in CD and(CCTTT)7(P = 0.009; OR = 7.61, 95%CI: 1.25-46.08),(CCTTT)11(P = 0.05; OR = 0.51, 95%CI: 0.25-1.01),(CCTTT)14(P = 0.02; OR = 2.05, 95%CI: 1.07-3.94),(CCTTT)15(P = 0.01; OR = 2.25, 95%CI: 1.16-4.35) repeats in UC patients indicated its possible association with higher disease risk which need to be confirmed in a larger sample size. CONCLUSION Our results suggest that the NOS2 A_(CCTTT)n gene variations may influence IBD susceptibility in the Moroccan population.

关键词： HIF1A NFKB1 NOS2A Inflammatory bowel disease Moroccan patients

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GOECP/SEOR clinical recommendations for lung cancer radiotherapy during the COVID-19 pandemic

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World Journal of Clinical Oncology 2020年第8期11卷 510-527页

作者： Felipe Couñago Arturo Navarro-Martin Javier Luna Nuria Rodríguez de Dios aurora Rodríguez Francesc Casas Rafael García Antonio Gómez-Caamaño Jorge Contreras Javier serrano Department of Radiation Oncology Hospital Universitario Quirónsalud MadridPozuelo de AlarcónMadrid 28223Spain Clinical Department Hospital La LuzMadridFaculty of BiomedicineUniversidad EuropeaMadrid 28223Spain Department of Radiation Oncology Institut Catalád’OncologiaL’Hospitalet de LlobregatBarcelona 08908Spain Department of Radiation Oncology Hospital Fundación Jiménez DíazMadrid 28040Spain Department of Radiation Oncology Hospital del MarBarcelona 08003Spain Department of Radiation Oncology Hospital Ruber InternacionalMadrid 28034Spain Department of Radiation Oncology Thoracic UnitHospital ClínicBarcelona 08036Spain Department of Radiaiton Oncology Hospital Ruber InternacionalMadrid 28034Spain Department of Radiation Oncology Hospital Clínico Universitario Santiago de CompostelaA Coruña 15706Spain Department of Radiation Oncology Hospital Regional Universitario de Málaga29010Spain Department of Radiation Oncology Clínica Universidad de NavarraMadrid 28027Spain

The coronavirus disease 2019 crisis has had a major and highly complex impact on the clinical practice of radiation oncology *** is one of the countries hardest hit by the virus,with devastating *** is an urgent need to share experiences and offer guidance on decision-making with regard to the indications and standards for radiation therapy in the treatment of lung *** the present article,the Oncological Group for the Study of Lung Cancer of the Spanish Society of Radiation Oncology reviews the literature and establishes a series of consensus-based recommendations for the treatment of patients with lung cancer in different clinical scenarios during the present pandemic.

关键词： Lung cancer COVID-19 Pandemic Radiotherapy Recommendations

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Multi Corpora Robustness Analysis of Attributes Selection Applied to Speech Emotion Classification

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通讯和计算机（中英文版） 2011年第10期8卷 877-894页

作者： Casale Salvatore Russo Alessandra serrano Salvatore Department of Electrical Electronic and Computer Science Engineering University ofCatania Catania Italy Department of Matter Physics and Electronic Engineering University of Messina Messina Italy

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