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Chemotherapy Induced Amenorrhea in Women Treated with Chemotherapy for Breast Carcinoma in Yalgado Ouédraogo Teaching Hospital in Ouagadougou, Burkina Faso

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Open Journal of Obstetrics and Gynecology 2017年第1期7卷 129-138页

作者： augustin tozoula bambara Hyacinthe Zamané Yobi Alexis Sawadogo Hierrhum Aboubacar bambara Awa Mien Nayi Zongo Abdoul Azize Diallo Ali Ouédraogo Si Simon Traoré General and Digestive Surgery of Yalgado Ouedraogo Teaching Hospital Ouagadougou Burkina Faso Obstetrics and Gynecology of Yalgado Ouedraogo Teaching Hospital Ouagadougou Burkina Faso

Background: We conducted this study to identify factors associated with the onset and reversibility of chemotherapy-induced amenorrhea in Yalgado Ouédraogo Teaching Hospital of Ouagadougou. Methods: A historical cohort study was performed and covered the period from 1 January 2014 to 31 July 2015. No menopausal patients managed for a histologically confirmed breast carcinoma and having benefited from chemotherapy were included in the study. Logistic regression analysis was used to determine the factors associated with the occurrence of chemotherapy-induced amenorrhea as well as its reversibility. Results: Seventy patients were included. The mean age was 38.5 years. Thirteen patients were obese and 19 (40.4%) had their menarche after age of 15 years. Adjuvant chemotherapy was administered to 31 patients while 12 had received neoadjuvant chemotherapy. Sequential chemotherapy with an anthracycline and a taxanetherapeutic protocol was the most used. Forty-seven patients had a chemotherapy-induced amenorrhea. The risk of having a chemotherapy-induced amenorrhea increases by 25% for each additional year of age at diagnosis of cancer (p = 0.0001). Obesity and menarche after age 15 were found to be protective factors. After adjusting these variables together, age, obesity, and age at menarche were factors independently associated with the occurrence of the chemotherapy-induced amenorrhea. The reversibility was effective in 11 cases (37.9%) and especially concerned patients younger than 40 years (p = 0.03). Conclusion: Age is the primary risk factor. Reliable markers of ovarian function need to be developed to better select fertility conservation protocols.

关键词： Amenorrhea Chemotherapy Breast Carcinoma

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Clinical, Prognostic and Socio-Economic Aspects of T4 Breast Cancers in Ouagadougou, Burkina Faso: A Retrospective Study

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Advances in Breast Cancer Research 2023年第4期12卷 142-151页

作者： augustin tozoula bambara Dagnagnewende Dieudonne Kabore Michel Ilboudo Titavouro Nafissatou Prisca Hien Faiza Abba-Ousmane Alice Cynthia Sama Health Sciences Training and Research Unit Joseph Ki-Zerbo University Ouagadougou Burkina Faso Cancerology Department Yalgado Ouedraogo University Hospital Ouagadougou Burkina Faso

Breast cancers classified T4 according to the TNM code are frequent in Burkina Faso. A better knowledge of these cancers would help to better organize the fight against breast cancer in general. We conducted this study to present the clinical and prognostic aspects of T4 breast cancer in Ouagadougou. It was a descriptive retrospective study based on the medical record of patients received from January 1, 2017 to December 31, 2021 in the cancer department of Yalgado Ouedraogo University Hospital. Patients followed for histologically confirmed breast cancer who were classified in the cT4 category of the TNM code 8e edition were included. We collected a total of 286 patients. Non-salaried patients accounted for 90.56%. In this study, 53.3% of patients lived in urban area and 36.7% in rural area. Menopausal patients accounted for 56.8% of cases. One hundred and thirty-three (46.5%) patients were overweight or obese and 121 (42.3%) patients had a normal weight. The average consultation time, which is the time between the first signs and consultation in a specialized center, was 12 months, with a median of 11 months. According to category T of the TNM code, 19 patients (6.6%) were classified T4d, 176 (61.5%) were classified T4c, 69 (24.1%) were classified T4b and 22 (7.7%) T4a. One hundred and twenty patients (42%) were metastatic. The median overall survival of all patients in our sample was 20 months. In univariate analysis, metastatic status was risk factor for death, while obesity and surgery were protective factors. In multivariate analysis, obesity, surgery and metastatic status were independently associated with survival;obesity and surgery were protective factors. Survival is poor due to advanced stages and difficulties in the management of these cancers. Measures to facilitate access to care would improve the prognosis of these cancers.

关键词： T4 Breast Cancer Prognosis Clinical Burkina Faso

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Testicular Seminoma and Peritonitis about One Case at the Yalgado Ouedraogo University Hospital of Ouagadougou

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Open Journal of Urology 2015年第12期5卷 220-223页

作者： Nayi Zongo Moussa Bazongo Mamadou Windsouri Mousa Kaboré Edgar Ouangré Maurice Zida Aimé Sosthène Ouédraogo Aboubacar Hirrhum bambara augustin tozoula bambara Si Simon Traore Ahmadou Dem Division of General Surgery Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso Division of Pathologic Anatomy Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso Oncology Institue Joliot Curie Dakar Senegal

Introduction: Testicular seminoma is a highly lymphophilic germ cell tumor. It is the most common germ cell tumor in young adults. We are reporting one case of testicular seminoma complicated with an acute generalized peritonitis (AGP), in order to describe the circumstances of diagnosis and discuss about treatment. Observation: It involved a 39-year-old patient, admitted for vague abdominal pains that were evolving since 72 hours with a history of right orchiectomy because of testicular seminoma in 2011. The analysis revealed a peritoneal syndrome, a right inguinal lymphadenopathy of 10 cm diameter and an empty right scrotum. The exploration revealed fistulized necrotic retro-peritoneal lymphadenopathies in the peritoneal cavity and ileal perforation on contact with these lymphadenopathies. Necrosectomy and ileal resections were performed. After the operation, the scanner revealed a conglomeration of retro-peritoneal adenomegalies extending to the right femoral region associated with bilateral pleurisy. The β-HCG and the LDH were 8000 IU/L and 24,500 IU/L, respectively. The seminoma was ranked T3N3M1. The immediate post-operative care was uneventful. The patient was lost from sight for a month and was readmitted in a context of alteration of his general condition. He died before the end of the pre-chemotherapeutic assessment. Conclusion: Scrotal mass is the usual way of revelation of testicular seminoma. In poorly followed-up cases, exceptional complications such as peritonitis may occur and are direct consequences of poor prognosis.

关键词： Seminoma Testicle Peritonitis Treatment Prognosis

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Evaluation of Clinical and Radiological Tumour Response during Neo-Adjuvant Breast Cancer Chemotherapy at Yalgado Ouedraogo University Hospital

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Advances in Breast Cancer Research 2022年第4期11卷 183-194页

作者： bambara augustin tozoula Ouedraogo Nina-Astrid Atenguena Okobalemba Etienne Kabore Bernard Akanni Fayçal Sama Alice Cynthia Ousseini Diallo Laboratory of Non-Communicable Diseases Training and Research Unit in Health Sciences Joseph Ki Zerbo University Ouagadougou Burkina Faso Department of Cancerology Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso Laboratory of Radiodiagnosis and Medical Imaging Training and Research Unit in Health Sciences Joseph Ki Zerbo University Ouagadougou Burkina Faso Medical Imaging Department Bogodogo University Hospital Ouagadougou Burkina Faso Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Medical Imaging Department of Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso

Background: Neoadjuvant chemotherapy (NAC) is one of the treatment options for breast cancer. Its aim is to significantly reduce the size of the tumour in preparation for surgery. The aim of this work is to analyze the conditions of clinical and radiological evaluation of NAC at the Yalgado Ouédraogo University Hospital (CHUYO). Patients and Methods: This was a descriptive cross-sectional study based on the medical records of patients followed up in the cancer department of the CHUYO from 1 January 2013 to 31 December 2021. All patients followed for histologically proven, non-metastatic breast cancer and having received at least one course of NAC were included in this study. The variables were related to the socio-demographic characteristics of the patients, the indications, the protocols of NAC and the sequences of evaluation of the tumour response (clinical, radiological and anatomopathological). Results: We collected 105 cases. The average age of the patients concerned was 44 years. The most frequent histological type was non-specific invasive carcinoma in 97.1% of cases. Immunohistochemically, triple-negative patients accounted for 51.4%. At the initial stage, all patients underwent clinical exploration. Clinical measurement of the tumour was performed in 70.5% of cases. The radiological size of the tumour was determined by ultrasound in 59.1% of cases. One patient had a breast MRI. Thirty-one patients were lost to follow-up after the initial evaluation. At mid-term and at the end of treatment, clinical tumour size was performed in 38.6% and 45.6% of cases respectively. There was no breast imaging performed at mid- and end-of-treatment. CT scans were performed in all cases at baseline, mid-term and end of treatment for extension assessment but did not mention the breast tumour. The tumour response rate was not recorded. Conclusion: Clinical assessment of tumour response is almost always empirical and not quantified. Medical imaging examinations are prescribed sp

关键词： Tumour Response Neoadjuvant Chemotherapy Breast Imaging Burkina Faso

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Evaluation of CT Scans Reports in Pancreatic Tumors at Ouagadougou (Burkina Faso)

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Open Journal of Medical Imaging 2022年第4期12卷 180-189页

作者： Ouedraogo Nina-Astrid bambara augustin tozoula Louguet Alimata Tall Mohamed Kambou Tiemtore Benilde Marie Ange Diallo Ousseini Cisse Rabiou Laboratory of Radiodiagnosis and Medical Imaging Training and Research Unit in Health Sciences Joseph Ki Zerbo University Ouagadougou Burkina Faso Radiology Department University Hospital of Bogodogo Ouagadougou Burkina Faso Cancerology Department Yalgado Ouedraogo University Hospital Ouagadougou Burkina Faso Radiology Department Yalgado Ouedraogo University Hospital Ouagadougou Burkina Faso

Background: There are no recommendations for the use of standardised CT reports in oncology in our country. The aim of this study was to evaluate CT reports of pancreatic tumors in the city of Ouagadougou. Materials and Methods: Descriptive, multicenter, cross-sectional study conducted from 1st January 2013 to 31 December 2021. It concerned CT scan reports from five public and private imaging centers in the city of Ouagadougou. During the study period, 41 reports of pancreatic tumors were collected. We evaluated the reports using the standardized model developed by the Society of Abdominal Radiology and the American Pancreatic Association as a reference. Results: CT scan reports were not standardised. The writing style was free. Concerning the lesion, the aspect of the tumor at the pancreatic time was the item with the least information (24.4%). The status of the superior mesenteric artery was mentioned in 17%, the celiac trunk and the portal trunk in 12.2% of cases and 9.7% for the superior mesenteric vein. No report noted the appearance of the common hepatic artery. The status of the lymph nodes, liver and peritoneal cavity was mentioned in all reports. The exact location of the lymph nodes was not specified. The analysis of the reports classified them into two groups: potentially resectable tumours in the absence of secondary locations in 31.7% of cases and locally advanced tumours or presence of metastases in 68.3% of cases. Conclusion: The CT reports were not standardized. The items allowing evaluating the loco-regional extension of the tumor were the least specified. This may suggest the high rate of potentially resectable tumours in our study.

关键词： Pancreatic Cancer CT Scan Report Ouagadougou

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Survey on the Knowledge, Attitudes, Primary Prevention Practices and Screening of Skin Cancers in Albinos in Burkina Faso

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Journal of Cancer Therapy 2016年第11期7卷 812-823页

作者： Smaila Ouédraogo Nayi Zongo Nina Korsaga-Somé Seraphine Marie Suzanne Kaboré Edgar Ouangré Maurice Zida A. S. Ouédraogo Aboubacar Hierrum bambara augustin Touzoula bambara Si Simon Traoré Pascal Niamba Adama Traoré Ahmadou Dem Public Health Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso General and Digestive Surgery Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso Dermatology and Venerology Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso Pathological Anatomy and Forensic Unit Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso Oncology Institute Joliot Curie of Dakar Dakar Senegal

The objective is to study the knowledge that albinos have on skin cancers, and their attitudes in terms of primary prevention and the screening practices for skin cancers in Burkina Faso. Methods: This is a cross-sectional and descriptive KAP study conducted from May 18th to July 7th 2015. It involved albinos aged at least 12 years. Their general knowledge, prevention attitudes and screening practices were considered. Results: All the responding albinos had already heard about skin cancers. Their main source of information was health workers (65.6%). They were showing at least two risk factors (99.2%) but only 68.3% affirmed having already undergone screening for skin cancer. Ignorance of the existence of screening was the main obstacle to it (16/26). The prevention means used was sun avoidance, the use of cream and protection clothing respectively in 84%, 41.5% and 51.2%. The skin lesions found were hyperpigmented macules (77.8%) then actinic keratosis (40.7%) and finally cheilitis (35.8%). We detected 4 cases of skin cancers confirmed by biopsy. Conclusion: Risk factors are frequent. Participation to screening is still insignificant. A lot is still to be done to extend the protection means. A good awareness-raising campaign and the accessibility to protection means remain for all, the best defense in the fight against skin cancers in albinos.

关键词： Albinos Screening Prevention Skin Cancers

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Evaluation of Clinical and Radiological Tumour Response during Neo-Adjuvant Breast Cancer Chemotherapy at Yalgado Ouedraogo University Hospital

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Advances in Breast Cancer Research（乳腺癌） 2022年第4期

作者： bambara augustin tozoula ouedraogo nina-astrid atenguena okobalemba etienne kabore bernard akanni fayçal sama alice cynthia ousseini diallo

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