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Imputation of single-cell gene expression with an autoencoder neural network

Quantitative Biology 2020年第1期8卷 78-94页

作者： Md.Bahadur Badsha Rui Li Boxiang Liu Yang ILi Min Xian Nicholas EBanovich audrey qiuyan fu Department of Statistical Science Institute for Bioinformatics and Evolutionary StudiesInstitute for Modeling Collaboration&InnovationUniversity of IdahoMoscowID 83844USA Department of Biology Stanford UniversityStanfordCA 94305USA Section of Genetic Medicine University of ChicagoChicagoIL 60637USA Department of Computer Science University of IdahoIdaho FallsID 83401USA The Translational Genomics Research Institute PhoenixAZ 85004USA

Background:Single-cell RNA-sequencing(scRNA-seq)is a rapidly evolving technology that enables measurement of gene expression levels at an unprecedented *** the explosive growth in the number of cells that can be assayed by a single experiment,scRNA-seq still has several limitations,including high rates of dropouts,which result in a large number of genes having zero read count in the scRNA-seq data,and complicate downstream ***:To overcome this problem,we treat zeros as missing values and develop nonparametric deep learning methods for ***,our LATE(Learning with AuToEncoder)method trains an autoencoder with random initial values of the parameters,whereas our TRANSLATE(TRANSfer learning with LATE)method further allows for the use of a reference gene expression data set to provide LATE with an initial set of parameter ***:On both simulated and real data,LATE and TRANSLATE outperform existing scRNA-seq imputation methods,achieving lower mean squared error in most cases,recovering nonlinear gene-gene relationships,and better separating cell *** are also highly scalable and can efficiently process over 1 million cells in just a few hours on a ***:We demonstrate that our nonparametric approach to imputation based on autoencoders is powerful and highly efficient.

关键词： single-cell gene expression deep learning autoencoder

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基于Uptane的汽车软件在线升级优化框架

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计算机研究与发展 2024年第9期61卷 2145-2155页

作者：谢勇胡秋燕李仁发谢国琪肖甫南京邮电大学计算机学院南京210003 万集科技股份有限公司北京100193 湖南大学信息科学与工程学院长沙410082

“新四化”使得车内电子系统的复杂性骤增,因电子系统的功能安全问题和网络安全问题导致的汽车召回事件频发,这给整车厂商造成巨大的经济损失和用户体验下降.在线升级技术借助于无线网络实现自动驾驶功能更新、车载软件更新和车载安全... 详细信息

“新四化”使得车内电子系统的复杂性骤增,因电子系统的功能安全问题和网络安全问题导致的汽车召回事件频发,这给整车厂商造成巨大的经济损失和用户体验下降.在线升级技术借助于无线网络实现自动驾驶功能更新、车载软件更新和车载安全系统升级等场景下的系统固件和软件的远程升级,可避免汽车召回造成的影响,但是如何保障在线升级的安全和高效实现是汽车行业亟待解决的关键问题.Uptane开源框架是汽车软件在线升级的行业参考规范,但该框架仍存在安全性和系统资源开销过大等不足.分别从加密算法选择和引入基于联盟链的验证机制2个方面对Uptane框架进行优化,以降低实现开销和提升安全性.通过原型实现和测试验证了所提出Uptane优化框架的安全性,并通过与原Uptane框架的对比分析可知,所提出优化框架的内存开销和时延开销分别降低了6.9%和28.6%.

关键词：智能网联汽车软件在线升级系统资源优化区块链加密算法

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我国教育治理现代化的内涵、成效及发展路径

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社会治理 2024年第2期 101-109页

作者：傅王倩赵秋雁北京师范大学教育学部北京师范大学社会学院中国社会管理研究院

教育治理现代化是教育现代化的重要组成部分,是建设教育强国的重要途径之一。我国教育治理现代化以人的全面发展为价值导向,以完善和提升教育治理体系与教育治理能力现代化为关键维度。党的十八大以来我国教育治理现代化取得了显著成效... 详细信息

教育治理现代化是教育现代化的重要组成部分,是建设教育强国的重要途径之一。我国教育治理现代化以人的全面发展为价值导向,以完善和提升教育治理体系与教育治理能力现代化为关键维度。党的十八大以来我国教育治理现代化取得了显著成效,在治理主体上形成了多元治理,更加彰显社会主义民主;在治理依据上依法治理,逐步完善治理法律体系;在治理方式上科学治理,更加遵循教育发展规律;在治理权责上均衡治理,转变政府职能、深化简政放权;在治理结果上系统治理,多项教育指数稳步提升。加快推进教育治理现代化应坚持“以人民为中心”,构建合理的“政府—学校—社会—家庭”协同治理体系,通过制度设计、创新,形成科学完备的体制机制,形成治理工具箱,建设治理组织合作网络体系。

关键词：教育治理现代化内涵成效路径

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NICU机械通气早产儿喂养不耐受发生现状及其影响因素分析

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青岛医药卫生 2024年第4期56卷 285-289页

作者：盛文红付芳邓秋燕江西省儿童医院NICU 江西南昌330006

目的探讨新生儿重症监护病房(NICU)机械通气早产儿喂养不耐受(FI)发生现状及其影响因素。方法选择2021年2月至2023年10月在江西省儿童医院NICU行机械通气早产儿88例,收集资料,调查NICU机械通气早产儿FI发生现状,将发生FI患儿纳入FI组,... 详细信息

目的探讨新生儿重症监护病房(NICU)机械通气早产儿喂养不耐受(FI)发生现状及其影响因素。方法选择2021年2月至2023年10月在江西省儿童医院NICU行机械通气早产儿88例,收集资料,调查NICU机械通气早产儿FI发生现状,将发生FI患儿纳入FI组,未发生FI患儿纳入非FI组,两组资料,对有统计学差异项目行Logistic回归分析,明确影响NICU机械通气早产儿FI发生的危险因素。结果88例NICU机械通气早产儿中发生FI 29例(32.95%),未发生FI 59例(67.05%);单因素分析显示,NICU机械通气早产儿宫内窘迫、胎龄、出生体质量、黄疸、开奶时间、新生儿呼吸窘迫、加奶量与其发生FI有关(P0.05);多Logistic回归分析显示,胎龄20ml/kg(OR=3.355,95%CI:1.153~9.768)是NICU机械通气早产儿FI发生的高危因素(P<0.05)。结论NICU机械通气早产儿易发生FI,其发生与胎龄、出生体质量、宫内窘迫、开奶时间、黄疸、新生儿呼吸窘迫、加奶量多因素有关,针对上述因素制定相应的干预对策,可能减少或避免早产儿发生FI。

关键词：早产儿喂养不耐受机械通气

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异甘草酸镁调控氧化应激和凋亡改善小鼠心肌重构的机制

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中国医院药学杂志 2024年第6期44卷 648-655页

作者：周星宇何艺林付丹孙赛格刘秋嫣徐力钱凯宜春学院化学与生物工程学院江西宜春336000 宜春学院医学院江西宜春336000 江西承葛生物科技有限公司江西宜春336000

目的:探讨异甘草酸镁(magnesium isoglycyrrhizinate,MgIG)治疗异丙肾上腺素(isoproterenol,ISO)诱导的的小鼠心肌重构的机制。方法:选用SPF级雄性小鼠随机分组法分为4组,即对照(control)组、阳性(control+MgIG)组、模型(ISO)组、治疗(ISO+MgIG)组。试剂盒检测血清中谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、肌酸激酶同工酶(creatine kinase isoenzyme,CK-MB)、丙二醛(malondialdehyde,MDA)和乳酸脱氢酶(lactate dehydrogenase,LDH)的含量。苏木精-伊红/马松(HE/Masson)染色检测心脏组织的病理变化。Western blot检测心脏组织中相关蛋白的表达。结果:通过血清检测、HE/Masson染色和蛋白表达发现,ISO可造成小鼠心肌损伤:心脏体积、心脏质量、MDA、LDH、Ⅰ型胶原纤维(collagenⅠ)、磷酸化磷脂酰肌醇-3-激酶(phosphorylated phosphatidylinositol-3-kinase,p-PI3K)、半胱氨酸蛋白酶-3激活型(cleaved caspase-3)和磷酸化蛋白激酶B(p-AKT1)等表达量均高于control组(P<0.05),GSH-Px、B淋巴细胞瘤-2(Bcl-2)、环氧合酶-2(COX-2)和超氧化物歧化酶(SOD1)等表达量均低于control组(P<0.05)。MgIG能逆转ISO对心脏的损伤,使小鼠各项指标得以改善(P<0.05)。结论:对于ISO诱导的的心肌重构,异甘草酸镁具有改善作用,其作用机制可能与抑制PI3K/AKT1通路调控细胞凋亡和氧化应激有关。

关键词：异甘草酸镁心肌重构细胞凋亡氧化应激异丙肾上腺素 PI3K/AKT1

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Open land-use map:a regional land-use mapping strategy for incorporating OpenStreetMap with earth observations

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Geo-Spatial Information Science 2017年第3期20卷 269-281页

作者： Di Yang Chiung-Shiuan fu audrey C.Smith Qiang Yu Department of Geography University of FloridaGainesvilleFLUSA Land Use and Environmental Change Institute University of FloridaGainesvilleFLUSA Beijing Key Laboratory of Precision Forestry Beijing Forestry UniversityBeijingChina

A land-use map at the regional scale is a heavy computation task yet is critical to most landowners,researchers,and decision-makers,enabling them to make informed decisions for varying *** are two major difficulties in generating land classification maps at the regional scale:the necessity of large data-sets of training points and the expensive computation cost in terms of both money and *** Geographic Information opens a new era in mapping and visualizing the physical world by providing an open-access database valuable georeferenced information collected by volunteer *** one of the most well-known VGI initiatives,OpenStreetMap(OSM),contributes not only to road network distribution information but also to the potential for using these data to justify and delineate land ***,most large-scale mapping approaches-including regional and national scales–confuse“land cover”and“land-use”,or build up the land-use database based on modeled land cover data-sets,in this study,we clearly distinguished and differentiated land-use from land *** focusing on our prime objective of mapping land-use and management practices,a robust regional land-use mapping approach was developed by integrating OSM data with the earth observation remote sensing *** novel approach incorporates a vital temporal component to large-scale land-use mapping while effectively eliminating the typically burdensome computation and time/money demands of such ***,our novel approach in regional scale land-use mapping produced robust results in our study area:the overall internal accuracy of the classifier was 95.2%and the external accuracy of the classifier was measured at 74.8%.

关键词： OpenStreetMap(OSM) Volunteered Geographic Information(VGI) crowdsourced data Random Forest Google Earth Engine(GEE)

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HMGB3 is a potential diagnostic marker for early cervical lesion screening

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Genes & Diseases 2023年第6期10卷 2202-2205页

作者： Qianwen Cui Jiarong Zhao Qingmei Deng Yu Liu Changfang fu Qiang Wu qiuyan Sun Haiyan Weng Haiming Dai Wulin Yang Anhui Province Key Laboratory of Medical Physics and Technology Institute of Health and Medical TechnologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China Science Island Branch Graduate School of University of Science and Technology of ChinaHefeiAnhui 230026China Medical Pathology Center Hefei Cancer HospitalChinese Academy of SciencesHefeiAnhui 230031China The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Department of Pathology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230601China

Despite the spread of effective vaccination strategies,cervical cancer remains the second leading cause of cancer death among women aged 20 to 39.1 clinical diagnosis of cervical lesions relies on the P16INK4a(P16)marker,but its sensitivity to low-grade cervical intraepithelial neoplasia(CIN)is *** more sensitive and specific molecular markers is still a challenge in cervical lesion *** this study,we found that HMGB3 could effectively label pathological cells in different cervical lesions,especially for early ***,HMGB3 has the potential to be used as a novel marker for the early screening of cervical lesions.

关键词： cervical diagnosis clinical

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纺织染整助剂中5种异噻唑啉酮类化合物的高效液相色谱法测定

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印染助剂 2024年第1期41卷 52-56页

作者：林宁婷卫敏朱峰连秋燕付世伟廖礼荣林金美福建省纤维检验中心福建福州350026 福建省纺织产品检测技术重点实验室福建福州350026 福建省产品质量检验研究院福建福州350002

建立了纺织染整助剂产品中5种异噻唑啉酮类化合物的高效液相色谱-二极管阵列检测器(HPLC-DAD)检测方法。该方法采用甲醇作为溶剂,经超声波提取纺织染整助剂产品中的目标分析物,再进行HPLC-DAD测定。结果表明,5种异噻唑啉酮类化合物在0.5... 详细信息

建立了纺织染整助剂产品中5种异噻唑啉酮类化合物的高效液相色谱-二极管阵列检测器(HPLC-DAD)检测方法。该方法采用甲醇作为溶剂,经超声波提取纺织染整助剂产品中的目标分析物,再进行HPLC-DAD测定。结果表明,5种异噻唑啉酮类化合物在0.5~10.0 mg/L范围内线性相关系数大于0.999。方法检出限为7.5 mg/kg,定量限为25.0 mg/kg,加标回收率为87.06%~112.79%,相对标准偏差为1.07%~8.14%。该方法灵敏度高、重现性好、操作简便,可以满足纺织染整助剂中异噻唑啉酮类化合物的检测要求。

关键词：高效液相色谱-二极管阵列检测器纺织染整助剂异噻唑啉酮类化合物

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Unique electronic structure of Mg/O co-decorated amorphous carbon nitride enhances the photocatalytic tetracycline hydrochloride degradation

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Chinese Journal of Catalysis 2019年第5期40卷 776-785页

作者： Xiaolu Wu Min fu Peng Lu qiuyan Ren Cheng Wang College of Environment and Resources Chongqing Key Laboratory of Catalysis and New Environmental MaterialsChongqing Technology and BusinessUniversityChongqing 400067China

g-C3N4 is a hot visible light photocatalyst. However, the fast recombination of photogenerated electron- hole pairs leads to unsatisfactory photocatalytic efficiencies. In this study, Mg/O co-decorated amorphous carbon nitride (labeled as MgO-CN) with a unique electronic structure was designed and prepared via a combined experimental and theoretical approach. The results showed that the MgO-CN exhibited an increased light absorption ability and promoted charge separation efficiency. The Mg and O co-decoration created a unique structure that could generate localized electrons around O atoms and enhance the reactant activation capacities via the C→O←Mg route. This could dramatically promote the O2 molecule activation on the catalyst surface to generate reactive species (?O2 –/?OH). The optimized MgO-CN exhibited a high photocatalytic activity for the degradation of tetracycline hydrochloride in water, which was five times higher than that of pristine g-C3N4. The present work could provide a new strategy for modifying the electronic structure of g-C3N4 and enhancing its performance for environmental applications.

关键词： g-C3N4 Electronic structure Visible light photocatalysis Tetracycline hydrochloride degradation Environmental remediation

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Definition of colorectal anastomotic leakage: A consensus survey among Dutch and Chinese colorectal surgeons

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World Journal of Gastroenterology 2017年第33期23卷 6172-6180页

作者： Stefanus J van Rooijen audrey CHM Jongen Zhou-qiao Wu Jia-fu Ji Gerrit D Slooter Rudi MH Roumen Nicole D Bouvy Department of Surgery Máxima Medical Center NUTRIM School of Nutrition and Translational Research in Metabolism Department of Surgery Maastricht University Medical Center Key laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Ward I of Gastrointestinal Cancer CenterPeking University Cancer Hospital and Institute

AIM To determine the level of consensus on the definition of colorectal anastomotic leakage(CAL) among Dutch and Chinese colorectal *** Dutch and Chinese colorectal surgeons were asked to partake in an online questionnaire. Consensus in the online questionnaire was defined as > 80% agreement between respondents on various statements regarding a general definition of CAL,and regarding clinical and radiological diagnosis of the *** Fifty-nine Dutch and 202 Chinese dedicated colorectal surgeons participated in the online survey. Consensus was found on only one of the proposed elements of a general definition of CAL in both countries: ‘extravasation of contrast medium after rectal enema on a CT scan'. Another two were found relevant according to Dutch surgeons: ‘necrosis of the anastomosis found during reoperation',and ‘a radiological collection treated with percutaneous drainage'. No consensus was found for all other proposed elements that may be included in a general *** There is no universally accepted definition of CAL in the Netherlands and China. Diagnosis of CAL based on clinical manifestations remains a point of discussion in both countries. Dutch surgeons are more likely to report ‘subclinical' leaks as CAL,which partly explains the higher reported Dutch CAL rates.

关键词： Colorectal anastomotic leakage Colorectal surgery Definition Complication

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