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The Effect of a Novel Complex, Composed of Ceramide, Energizing Peptide and Camu Camu Extract, on Epidermal Barrier Function and Dermal Antiaging Properties in Ex Vivo Human Skin Small Live Cohort

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第1期14卷 1-11页

作者： Landau Marina Landau-Blum Shir Samuel Kassirer audrey le mestr Armelle Perrin Julien Verdon Laurine Bergeron Corinne Morel Isabelle Imbert Arena Dermatology Herzliya Israel American Medical Program Tel Aviv University Tel Aviv-Yafo Israel Ashland Ashland Specialty Ingredients Sophia Antipolis France

The skin’s primary function is to protect the body against a spectrum of environmental stressors, including mechanical insults, microorganisms, chemicals, and allergens. Located in the outermost layers, the primary structures and components responsible for the skin’s barrier function are susceptible to environmental variables, dermatological conditions, and the aging process. The ensuing alterations to structure, composition, and organizational attributes of the epidermal barrier can impact its integrity and functionality. The aim of this study was to assess the effect of a novel complex composed of a ceramide, energizing peptide, and Camu Camu extract (SUPCERATTM complex) on specific markers of epidermal barrier integrity, as well as epidermal and dermal function. All the experiments were conducted on fresh human abdominal skin explants. Intradermal production of hyaluronic acid, epidermal claudin-1, and ceramide synthase 3 expressions, as well as epidermal lipids content were assessed using specific fluorescent stainings on ex vivo skin after the application of the complex or placebo. Additionally, dermal elastase and collagenase activities were assessed using in tubo enzymatic assays. Lastly, the effect of a cosmetic cream containing SUPCERATTM complex was assessed using subjective Global Aesthetic Improvement Scale (GAIS) in a small cohort of patients after 60 days of use. The application of the SUPCERATTM complex on ex vivo skin led to significant increase in dermal hyaluronic acid content and epidermal activity of claudin-1, ceramide synthase 3 and epidermal ceramide content. Furthermore, in tubo enzymatic assays demonstrated inhibition of both dermal elastase and collagenase activities. In addition, the patient-reported results indicated significant improvements in skin quality and appearance. .

关键词： SUPCERATTM Complex Epidermal Skin Barrier Moisturization Antiaging Ceramide Camu Camu Extract

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Do astrocytes respond to light,sound,or electrical stimulation?

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Neural Regeneration Research 2023年第11期18卷 2343-2347页

作者： audrey le Naour Emilien Beziat Jaimie Hoh Kam Pierre Magistretti Alim-Louis Benabid John Mitrofanis UniversitéGrenoble Alpes Fonds de dotationClinatecGrenobleFrance King Abdullah University of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Astrocytes are not only the most populous cell type in the human brain,but they also have the most extensive and dive rse sets of connections,across synapses,axons,blood vessels,as well as having their own internal ***,they are associated with many brain functions;from the synaptic transmission to energy metabolism and fluid homeostasis,and from cerebral blood flow and blood-brain barrier maintenance to neuroprotection,memory,immune defenses and detoxification,slee p,and early *** yet,notwithstanding these key roles,so many current therapeutic approaches to a range of brain disorders have largely neglected their potential *** this review,we consider the role of astrocytes in three brain therapies;two are emerging treatments(photobiomodulation and ultrasound),while the other is well-established(deep brain stimulation).In essence,we explore the issue of whether external sources,such as light,sound,or electricity,can influence the function of astrocytes,as they do *** find that,when taken all together,each of these external sources can influence many,if not,all of the functions associated with *** include influencing neuronal activity,prompting neuroprotection,reducing inflammation(astrogliosis) and potentially increasing cerebral blood flow and stimulating the glymphatic *** suggest that astrocytes,just like neurons,can respond positively to each of these external applications and that their activation co uld each impart many beneficial outcomes on brain function;they are likely to be key playe rs underpinning the mechanisms behind many therapeutic strategies.

关键词： deep brain stimulation high frequency infrared mitochondria red ultrasound

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Prognostic impact of circulating tumor cells in patients with soft-tissue sarcomas:a prospective study

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Cancer Communications 2023年第3期43卷 391-394页

作者： Julie Blanchi audrey Laroche-Clary Francois le Loarer Benjamin Bonhomme Antoine Italiano SARCOTARGET team INSERM U1312 BRICBordeauxFrance Sarcoma Unit Institut BergoniéBordeauxGirondeFrance Department of Pathology Institut BergoniéBordeauxGirondeFrance Faculty of Medicine University of BordeauxBordeauxGirondeFrance

Dear Editor,Sarcomas represent a heterogenous group of tumors accounting for about 1%of cancer in adults and 15%in children[1].However,despite adequate locoregional treatment,up to 40%of patients develop metastatic *** used in the advanced setting have very limited efficacy,with a response rate of<10%and progression-free survival of<4 months and are mainly used for palliative purposes[1].It is,therefore,important to monitor individual therapy responses to avoid inefficient therapy and unnecessary *** monitoring is currently based on repeated CT imaging which may represent an important burden for patients with advanced disease[2].

关键词： patients impact accounting

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Eyelid Wounds: Epidemiological, Clinical and Etiological Aspects

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Open Journal of Ophthalmology 2024年第1期14卷 55-62页

作者： Aly Mbara Ka Jean Pierre Diagne Aissatou Aw El Hadji Malick Sy Soda Mbaye Hawo Madina Diallo audrey Samra Aboubacry Sadikh Sow Joseph Matar Mass Ndiaye Ousmane Ndiaga Senghor Lamine Ndiaye Mohamed Ndiaye Serigne Sohibou Gaye Papa Amadou Ndiaye Ophthalmology Department of Abass Ndao Hospital Dakar Senegal Ophthalmology Department of Aristide le Dantec Hospital Dakar Senegal

Purpose: The aim is to show epidemiological, clinical and etiological characteristics of palpebral wounds. Methodology: This was a retrospective study focusing on patients with an eyelid wound, over a 10-year period from 2012 to 2021. We collected and analyzed the data using Excel. Results: The frequency of eyelid wounds was 0.1%. The average age of our patients was 19.38 years with a range of 1 and 62 years. The sex ratio was 3.7. Eighty-one percent of patients lived in Dakar. Fifty-seven percent (57%) of patients consulted less than 24 hours after the trauma and 7% of patients on D1. The circumstances were brawls (11%), domestic accidents (9%), road accidents (6%), and work accidents (6%). We noted 1 case of dog bite. Thirteen patients presented with post-traumatic decreased visual acuity. Involvement of the isolated upper eyelid was noted in 40% of cases and both eyelids in 15% of cases. Involvement of the lacrimal ducts was noted in 17% of cases, and that of the free edge in 21% of cases. Eyelid wounds were associated with eyeball damage in 21% of cases. Various associated lesions were observed. Ninety-one percent of patients received surgical treatment. Three cases of superinfections, 1 case of conjunctival granuloma and 1 case of phthysis of the eyeball with postoperative retinal detachment were noted. Conclusion: Eyelid sores are relatively common in our context. They require rapid surgical treatment in order to preserve the functional and aesthetic prognosis. .

关键词： Eyelid Wounds Epidemiology Clinic Etiologies

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Gene expression profiling improves prognostication by nomogram in patients with soft-tissue sarcomas

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Cancer Communications 2022年第6期42卷 563-566页

作者： Amandine Crombé Mariella Spalato-Ceruso audrey Michot Yech’an Laizet Carlo Lucchesi Maud Toulmonde Kevin Bourcier Francois le Loarer Antoine Italiano Department of Imaging Institut BergoniéBordeauxNouvelle-Aquitaine F-33076France Department of Medicine Institut BergoniéBordeauxNouvelle-Aquitaine F-33076France Department of Surgery Institut BergoniéBordeauxNouvelle-Aquitaine F-33076France Bioinformatics Unit BordeauxNouvelle-Aquitaine F-33076France Department of Pathology Institut BergoniéBordeauxNouvelle-Aquitaine F-33076France University of Bordeaux BordeauxNouvelle-Aquitaine F-33000France

Dear Editor,Surgery remains the cornerstone of treatment for softtissue sarcomas(STS)[1].However,despite adequate locoregional treatment,30%-40%of the patients eventually develop metastases[2,3].Accurate risk assessment is crucial to tailor therapeutic strategies and to identify high-risk patients who may benefit from perioperative ***,several efforts have been made to develop prognostic nomograms that enable individual prognosis prediction;representing an important decision-making aid for oncologists and surgeons involved in sarcoma care[4-6].

关键词： patients sarcoma Surgery

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Added value of molecular karyotype in childhood acute lymphoblastic leukemia

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Cancer Innovation 2023年第6期2卷 513-523页

作者： Margaux Camuset Baptiste le Calvez Olivier Theisen Catherine Godon audrey Grain Caroline Thomas Marie-Laure Couec Marie C.Béné Fanny Rialland Marion Eveillard Pediatric Oncology CHU NantesNantes UniversitéUniv AngersINSERMCNRSCRCI2NANantesFrance Hematology Biology CHU NantesNantes UniversitéUniv AngersINSERMCNRSCRCI2NANantesFrance

Background:Thanks to an improved therapeutic regimen in childhood B-cell precursor acute lymphoblastic leukemia(BCP-ALL),5 year-overall survival now exceeds 90%.Unfortunately,the 25%of children who relapse have an initial poor prognosis,potentially driven by pre-existing or emerging molecular *** latter are initially and essentially identified by ***,some subtle alterations are not visible through ***:Single nucleotide polymorphisms(SNP)array is an alternative way of chromosomal analysis allowing for a more in-depth evaluation of chromosomal modifications such as the assessment of copy number alterations(CNA)and loss of heterozygosity(LOH).This method was applied here in retrospective diagnosis/relapse paired samples from seven children with BCP-ALL and in a prospective cohort of 38 newly diagnosed childhood ***:In the matched study,compared to the initial karyotype,SNP array analysis reclassified two patients as poor prognosis *** during relapse was seen for 4 CNA and 0.9 *** the prospective study,SNP reclassified the 10 patients with intermediate karyotype as 7 good prognosis and 3 poor ***,in all the children tested,SNP array allowed to identify additional anomalies compared to conventional karyotype,refine its prognostic value and identify some druggable anomalies that could be used for precision ***,the anomalies detected could be segregated in four groups respectively involved in B-cell development,cell proliferation,transcription and molecular ***:SNP therefore appears to be a method of choice in the integrated diagnosis of BCP ALL,especially for patients initially classified as intermediate *** complementary method of both cytogenetics and high throughput sequencing allows to obtain further classified information and can be useful in case of failure of these techniques.

关键词： BCP-ALL karyotype pediatric patients prognosis SNP array

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Endothelin increases the proliferation of rat olfactory mucosa cells

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Neural Regeneration Research 2020年第2期15卷 352-360页

作者： Bertrand Bryche audrey Saint-Albin Claire le Poupon Schlegel Christine Baly Patrice Congar Nicolas Meunier Neurobiologie de l'olfaction Institut National de Recherche Agronomique (INRA)Université Paris-SaclayJouy-en-JosasFrance Université de Versailles Saint-Quentin en Yvelines Département de BiologieVersaillesFrance

The olfactory mucosa holds olfactory sensory neurons directly in contact with an aggressive environment. In order to maintain its integrity, it is one of the few neural zones which are continuously renewed during the whole animal life. Among several factors regulating this renewal, endothelin acts as an anti-apoptotic factor in the rat olfactory epithelium. In the present study, we explored whether endothelin could also act as a proliferative factor. Using primary culture of the olfactory mucosa, we found that an early treatment with endothelin increased its growth. Consistently, a treatment with a mixture of BQ123 and BQ788(endothelin receptor antagonists) decreased the primary culture growth without affecting the cellular death level. We then used combined approaches of calcium imaging, reverse transcriptase-quantitative polymerase chain reaction and protein level measurements to show that endothelin was locally synthetized by the primary culture until it reached confluency. Furthermore, in vivo intranasal instillation of endothelin receptor antagonists led to a decrease of olfactory mucosa cell expressing proliferating cell nuclear antigen(PCNA), a marker of proliferation. Only short-term treatment reduced the PCNA level in the olfactory mucosa cells. When the treatment was prolonged, the PCNA level was not statistically affected but the expression level of endothelin was increased. Overall, our results show that endothelin plays a proliferative role in the olfactory mucosa and that its level is dynamically regulated. This study was approved by the Comité d’éthique en expérimentation animale COMETHEA(COMETHEA C2 EA-45;protocol approval #12-058) on November 28, 2012.

关键词： autocrine factor cell culture cellular dynamics endothelin olfaction olfactory basal cells olfactory epithelium olfactory mucosa primary culture

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Cross-sectional associations between cortical thiclmess and physical activity in older adults with spontaneous memory complaints:The MAPT Study

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Journal of Sport and Health Science 2023年第3期12卷 324-332页

作者： Jérémy Raffin Yves Rolland Clara Fischer Jean-Francois Mangin audrey Gabelle Bruno Vellas Philipe de Souto Barreto the MAPT/DSA Group Gérontopôle de Toulouse Institut du VieillissementCentre Hospitalo-Universitaire de ToulouseToulouse 31000France UniversitéPaul-Sabatier/Institut National de la Santéet de la Recherche Médicale UnitéMixte de Recherche 1027 Facultéde médecineUniversity of Toulouse ⅢToulouse 31000France Centre pour l'Acquisition et le Traitement des Images Multicenter Neuroimaging Platform NeurospinUniversitéParis-SaclayGif sur Yvette 91191France Memory Resources and Research Center Montpellier University HospitalMontpellier 34295France Institut National de la Santéet de la Recherche Médicale Unité1061 i-site Montpellier Universitéd'Excellence University of MontpellierMontpellier 34090France 不详

Background:Age-related changes in brain structure may constitute the starting point for cerebral function *** activity(PA)demonstrated favorable associations with total brain volume,but its relationship with cortical thickness(CT)remains *** investigated the cross-sectional associations between PA level and CT in community-dwelling people aged 70 years and ***:A total of 403 older adults aged 74.8±4.0 years(mean±SD)who underwent a baseline magnetic resonance imaging examination and who had data on PA and confounders were *** was assessed with a *** were categorized according to PA *** linear regressions were used to compare the brain CT(mm)of the inactive group(no PA at all)with 6 active groups(growing PA levels)in 34 regions of ***:Compared with inactive persons,people who achieved PA at a level of 1500-1999 metabolic equivalent task-min/week(i.e.,about6-7 h of brisk walking for exercise) and those who achieved it at 2000-2999 metabolic equivalent task-min/week(i.e.,8-11 h of brisk walking for exercise)had higher CT in the fusiform gyrus and the temporal ***,dose-response associations between PA and CT were found in the fusiform gyrus(B=0.011,SE=0.004,adj.p=0.035),the temporal pole(B=0.026,SE=0.009,adj.p=0.048),and the caudal middle frontal gyrus,the entorhinal,medial orbitofrontal,lateral occipital,and insular ***:This study demonstrates a positive association between PA level and CT in temporal areas such as the fusiform gyrus,a brain region often associated to Alzheimer’s disease in people aged 70 years and *** investigations focusing on PA type may help to fulfil remaining knowledge gaps in this field.

关键词： Alzheimer's disease Brain aging Cortical thickness Physical activity

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Effectiveness and safety of therapeutic plasma exchange to modify the functionality of heparin-induced thrombocytopenia antibodies and correct profound thrombocytopenia:A case report and literature review

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Journal of Intensive Medicine 2023年第4期3卷 373-375页

作者： audrey Graser Anne Bauters Jean-Luc Auffray Caroline Vayne François Provot Merce Jourdain Laurent Robriquet Department of Intensive Care Medicine CHU LilleLille F-59000France Service d'Hémostase-Transfusion Institut d'HématologieCentre de Biologie Pathologie GénétiqueBoulevard du Professeur Jules LeclercqCentre Hospitalier Universitaire de LilleLille 59037France Service de Cardiologie Institut Coeur PoumonBoulevard du Professeur Jules LeclercqCentre Hospitalier Universitaire de LilleLille 59037France Service d'Hématologie-Hémostase Centre Hospitalier Universitaire de ToursUniversitéde ToursTours EA4245 T2IFrance Pôle de Néphrologie Hôpital Albert CalmetteBoulevard du Professeur Jules LeclercqCentre Hospitalier Universitaire de LilleLille 59037France Department of Intensive Care Medicine Univ LilleInsermCHU LilleLille F-59000France

Introduction Heparin-induced thrombocytopenia(HIT)is a rare but life-threatening complication of heparin *** IgG antibodies recognize heparin-modified platelet factor 4(PF4/H IgG)and activate the platelets,increasing ... 详细信息

关键词： heparin antibodies thrombocytopenia

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Pediatric Clinical Features of Covid-19 in Cameroon

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Open Journal of Pediatrics 2022年第1期12卷 231-237页

作者： Meguieze Claude-audrey Nseme Etouckey Eric Mekone Nkwele Isabelle Kalla Ginette Claude Mireille Kamgaing Noubi Nelly Ngo Nyeki Adèle-Rose Onambele Paul Ntoukem Mbakop Carlin Koki Ndombo Paul Pediatric Department Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaounde Cameroon Department of Morphological Sciences and Anatomopathology Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaounde Cameroon Department of Ophthalmology-ENT Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaounde Cameroon Nkolndongo District Health Service Yaounde Cameroon

Introduction: The Covid-19 pandemic is a public health emergency characterized by severe acute respiratory distress syndrome. It has many clinical forms and affects all age groups. Despite the magnitude of this pandemic, data from pediatric cohorts in Cameroon remain sparse. Objective: The aim of this study was to describe the clinical presentation of Covid-19 in the pediatric population of the Nkolndongo health district. Materials and method: A cross-sectional study was conducted for a duration of 5 months from January to May 2021 and covered a period of 9 months (March to December 2020). All patients aged 0 to 19 years, suspected of having Covid-19, confirmed by real-time RT-PCR targeting the N and ORF1 ab viral genes and managed in the Nkolndongo health district were included. The results were analyzed using IBM SPSS.23.0 software and the data expressed as frequencies, percentages, and means. The threshold of statistical significance was set at 0.05. Results: This study revealed that 48 patients out of 154 suspected cases were tested positive. The most affected age group was adolescents aged 13 - 19 years (92.85%). The most frequent symptoms were cough (33%), fever (42%) and nasal discharge (25%). Infants were the least affected. 58% of patients were asymptomatic, 47.91% were in mild stage, 8.33% in moderate stage and 4.16% in severe stage. All the children tested positive survived. Patients with comorbidity were 20 times more likely to develop moderate to severe clinical forms, this being statistically significant. Conclusion: The clinical presentation reported mainly fever, cough and anterior nasal discharge. There was a significant association between the presence of comorbidity and the moderate to severe degrees of severity.

关键词： Covid-19 Children Clinical Presentation Cameroon Sub Saharan Africa

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