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Psycho-Emotional Aspects and Risk Factors Associated with the Onerous Nature of Retirement Concerning Civil Servants within the Public Administration in Parakou (Benin)

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Open Journal of Psychiatry 2016年第2期6卷 143-150页

作者： Anselme djidonou Tchégnonsi Francis Tognon Ahoya Christophe Fabien Gounongbé Thierry Adoukonou Elie Iréti Nethania Ataïgba Houédénou Brice Thierry Hounlèlou Prosper Gandaho Benjamin Fayomi Simon Ayélèroun Akpona Faculty of Medicine University of Parakou Parakou Benin Faculty of Health Science University of Abomey Calavi Abomey Calavi Benin

Background: In 20% of cases, retirement is experienced as a life event with risk of isolation and loneliness. The objective is to study the psycho-emotional aspects and risk factors associated with civil servants onerous retirement. Methods: It was a descriptive and cross-sectional study which involved 233 pensioners met at the Public Treasury’s Revenue Office in Parakou from June 1 to August 30, 2013. data were collected through an interview on vulnerability criteria, and.hamilton depression Rating Scale was used in assessing both anxiety level and depressed mood. Results: Pensioners’ average age was 61.1 ± 6.7 years. Males aged 50 to 60 years represented 47.2%. Following the announcement of retirement, 88.9% had feelings of fear, and 75.8% showed moderate to severe anxiety prevalence of which 88.2% were females and 73.9% males. The distribution according to professional categories was as follow: A (77.3%);B (72.6%);C (69.2%);(85.5%);E (85.7%). Retirement risk factors were: dependants (73.1%), age-related disorders (40.3%), lack of health insurance coverage (24.6%) resulting in a depressed mood (36%) strongly associated with a feeling of family and social abandon (87.8% P = 0.02). Conclusion: depending on job onerousness in each professional category and associated psycho-social risk factors, it is important to implement an adequate action plan in view of promoting pensioners mental health.

关键词： Retirement Anxiety Onerousness Vulnerability Mental Health

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亚组效应可信吗？评估亚组分析可信度的最新标准

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英国医学杂志中文版 2010年第4期13卷 229-234页

作者： Xin Sun Matthias Briel Stephen d Walter Gordon H Guyatt 何慧婧(译) 何海青(译) 单广良(校) department of Clinical Epidemiology and Biostatistios McMaster University Hamilton ON Canada Center for Clinical Epidemiology and Evidence-Based Medicine West China Hospital Sichuan University Chengdu China Basel Institute for Clinical Epidemiology and Biostatistics University Hospital Basel Basel Switzedand department of Medicine McMaster University Hamihon Canada 协和医科大学流行病学教研室

我们怎样才能区分亚组效应的真伪？本文提出了评价亚组分析可信度的新标准和一个参照表；

关键词：可信度亚组分标准评估

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对比1次/d噻吗心安与拉坦前列腺素对夜间眼压的作用

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世界核心医学期刊文摘（眼科学分册） 2005年第3期1卷 33-34页

作者： Liu J.H.K. Kripke d.F. Weinreb R.N. 秦雪娇 hamilton Glaucoma Ctr. dept. O. La Jolla CA United States Dr

Purpose To compare the nocturnal effects of once-daily timolol and latanopros t on intraocular pressure (IOP) in patients with ocular hypertension or early gl aucomatous changes. design Prospective, open label, experimental study with cro ssover design. Methods Eighteen patients with ocular hypertension or early glauc omatous changes (aged 41 to 79 years) each received topical treatments with timo lol (0.5%Timoptic XE), latanoprost (0.005%Xalatan), and no IOP lowering medi cation, for at least 4 weeks. Timolol was given once in the morning upon awakeni ng and latanoprost once in the evening at bedtime. At the end of each treatment period, the patient was housed in a sleep laboratory for 24 hours and IOP was me asured every 2 hours using a pneumatonometer. Measurements were taken sitting an d supine during the 16 hour diurnal/wake period and only supine during the 8 h our nocturnal/sleep period. Mean diurnal and nocturnal IOP levels were compared among the treatments with timolol, latanoprost, and no medication. Results In th e diurnal period, the mean IOP under the timolol or the latanoprost treatment wa s significantly less than the mean IOP under no medication in both the sitting a nd the supine positions. There was no statistical difference between the timolol and latanoprost treatments. In the nocturnal period, supine IOP with timolol tr eatment was not different from the supine IOP with no medication but was signifi cantly higher than supine IOP with the latanoprost treatment. Conclusion Althoug h both once daily timolol and latanoprost were effective in lowering IOP during the diurnal period, only latanoprost reduced IOP during the nocturnal period.

关键词：拉坦前列腺素噻吗心安青光眼病气体眼压计仰卧位交叉对照安慰剂无显著性差异

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Improving ITS sequence data for identification of plant pathogenic fungi

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Fungal diversity 2014年第4期67卷 11-19页

作者： R.Henrik Nilsson Kevin d.Hyde Julia Pawlowska Martin Ryberg Leho Tedersoo Anders Bjornsgard Aas Siti A.Alias Artur Alves Cajsa Lisa Anderson Alexandre Antonelli A.Elizabeth Arnold Barbara Bahnmann Mohammad Bahram Johan Bengtsson-Palme Anna Berlin Sara Branco Putarak Chomnunti Asha dissanayake Rein drenkhan Hanna Friberg Tobias Guldberg Froslev Bettina Halwachs Martin Hartmann Beatrice Henricot Ruvishika Jayawardena Ari Jumpponen Havard Kauserud Sonja Koskela Tomasz Kulik Kare Liimatainen Bjorn d.Lindahl daniel Lindner Jian-Kui Liu Sajeewa Maharachchikumbura dimuthu Manamgoda Svante Martinsson Maria Alice Neves Tuula Niskanen Stephan Nylinder Olinto Liparini Pereira danilo Batista Pinho Teresita M.Porter Valentin Queloz Taavi Riit Marisol Sánchez-García Filipe de Sousa Emil Stefańczyk Mariusz Tadych Susumu Takamatsu Qing Tian dhanushka Udayanga Martin Unterseher Zheng Wang Saowanee Wikee Jiye Yan Ellen Larsson Karl-Henrik Larsson Urmas Koljalg Kessy Abarenkov department of Biological and Environmental Sciences University of GothenburgBox 46140530 GothenburgSweden Institute of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand department of Plant Systematics and Geography Faculty of BiologyUniversity of WarsawAl.Ujazdowskie 400-478 WarsawPoland department of Organismal Biology Uppsala UniversityNorbyvagen 18D75236 UppsalaSweden Institute of Ecology and Earth Sciences University of TartuLai 40Tartu 51005Estonia Microbial Evolution Research Group University of OsloBlindernveien 310371 OsloNorway Institute of Biological Sciences University of Malaya50603 Kuala LumpurMalaysia department of Biology CESAMUniversity of Aveiro3810-193 AveiroPortugal School of Plant Sciences The University of Arizona1140 E South Campus DriveForbes 303TucsonAZ 85721USA Laboratory of Environmental Microbiology Institute of Microbiology ASCRVídeňská108314220 Prague 4Czech Republic department of Infectious diseases Institute of BiomedicineSahlgrenska AcademyUniversity of GothenburgGuldhedsgatan 1041346 GoteborgSweden department of Forest Mycology and Plant Pathology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden University of California at Berkeley 321 Koshland Hall University of CaliforniaBerkeleyCA 94720-3102USA Agriculture and Forestry Sciences Beijing 100097China Institute of Forestry and Rural Engineering Estonian University of Life SciencesKreutzwaldi551014 TartuEstonia Natural History Museum of denmark Øster Voldgade 5-71350 København KDenmark Institute for Genomics and Bioinformatics Graz University of Technology8010 GrazAustria Core Facility Bioinformatics Austrian Centre of Industrial Biotechnology8010 GrazAustria Forest Soils and Biogeochemistry Swiss Federal Research Institute WSLZuercherstrasse 1118903 BirmensdorfSwitzerland Molecular Ecology Institute for Sustainability SciencesAgroscopeReckenholzstrasse 191

Plant pathogenic fungi are a large and diverse assemblage of eukaryotes with substantial impacts on natural ecosystems and human *** taxa often have complex and poorly understood life cycles,lack observable,discriminatory morphological characters,and may not be amenable to in vitro *** a result,species identification is frequently ***(dNA sequence)data have emerged as crucial information for the taxonomic identification of plant pathogenic fungi,with the nuclear ribosomal internal transcribed spacer(ITS)region being the most popular ***,international nucleotide sequence databases are accumulating numerous sequences of compromised or low-resolution taxonomic annotations and substandard technical quality,making their use in the molecular identification of plant pathogenic fungi *** we report on a concerted effort to identify high-quality reference sequences for various plant pathogenic fungi and to re-annotate incorrectly or insufficiently annotated public ITS sequences from these fungal lineages.A third objective was to enrich the sequences with geographical and ecological *** results-a total of 31,954 changes-are incorporated in and made available through the UNITE database for molecular identification of fungi(http://***),including standalone FASTA files of sequence data for local BLAST searches,use in the next-generation sequencing analysis platforms QIIME and mothur,and related *** present initiative is just a beginning to cover the wide spectrum of plant pathogenic fungi,and we invite all researchers with pertinent expertise to join the annotation effort.

关键词： Phytopathogenic fungi Molecular identification ITS Taxonomy Annotation

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Progression of Cognitive deficit in Older People with Mild Cognitive Impairment Treated with Cerebrolysin

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Health 2014年第19期6卷 2581-2591页

作者： Irina S. Boksha Svetlana I. Gavrilova Igor V. Kolykhalov Iana B. Fedorova Iaroslav B. Kalyn Natalia d. Selezneva Andrei V. Samorodov Serge N. Miasoedov Elizabeta B. Mukaetova-Ladinska Laboratory of Neurochemistry Moscow Russia department of Alzheimer’s disease and Related disorders Moscow Russia department of Bioengineering and Medical Equipment and Systems Moscow State Technical University Moscow Russia Laboratory of Biostatistics and Evidence Based Medicine Mental Health Research Center of Russian Academy of Medical Sciences Moscow Russia Institute of Neurocience Newcastle University Institute for Ageing Newcastle University Campus for Ageing and Vitality Newcastle upon Tyne UK

Objectives: Although people with amnestic mild cognitive impairment (aMCI) benefit from cerebrolysin treatment, some still develop dementia. The aim of the current study was to identify most informative clinical assessment tests to predict the therapy efficacy in aMCI subjects treated with cerebrolysin. Methods: We studied patients with amnestic mild cognitive impairment (aMCI;n = 53) who had regular neurocognitive and clinical psychiatric assessments and were treated with cerebrolysin i.v. infusions 20 × 30 ml twice a year over three years period. data were analyzed using non-parametric statistics, cluster and linear discriminant analyses. Results: Combined mathematical modeling enabled to predict cognitive decline from aMCI to dementia in the cerebrolysin-treated patients based on their initial neurocognitive assessment scores. We identified a “dementia risk group” with fast cognitive decline (i.e. low efficacy of the treatment). Lower baseline scores in the Mattis dementia Rating Scale Memory subtest, Mini-Mental State Examination (MMSE), 10 word list immediate recall, and Frontal Assessment Battery tests when accompanied by higher depression score (hamilton depression Rating Scale) suggest poor prognosis for aMCI patients treated with cerebrolysin. Changes in scores on the MMSE, Boston naming test, digit span forward, and Wechsler scale subtest “Categorical associations” during the treatment course are more characteristic for patients who convert to dementia than their initial scores. Conclusions: aMCI subjects treated with cerebrolysin with lower baseline cognitive functioning and subclinical depression have poor prognosis in terms of converting to dementia. Changes in the MMSE, Boston naming test, digit span forward, and Wechsler scale subtest “Categorical associations” scores during the treatment course are more informative to identify patients who will develop dementia than their initial scores.

关键词： Mild Cognitive Impairment Cerebrolysin dementia Cluster Analysis Linear discriminant Analysis

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指南制定中专家意见与专家证据的区别

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英国医学杂志中文版 2020年第6期23卷 314-318页

作者： Holger J Schünemann Yuqing Zhang Andrew d Oxman 王瑞(译者) 张崇凡(译者) 夏君(译者) 张誉清(译者) McMaster GRAdE Centre and department of Health Research Methods Evidenceand ImpactMcMaster University Health Sciences CentreHamiltonOntarioCanada department of Medicine McMaster University Health Sciences CentreHamiltonOntarioCanada Ningbo GRAdE Centre Nottingham Health China CentreUniversity of Nottingham NingboChina Centre for Informed Health Choices Norwegian Institute of Public HealthOsloNorway University of Oslo OsloNorway 复旦大学附属儿科医院临床实践指南制作和评议中心《中国循征儿科杂志》编辑部宁波诺丁汉大学GRAdE中心

Holger J Schünemann及其同事表示,制定指南时,专家经验非常有用,但需要有明确的使用方法,以避免意见和证据的混淆。循证指南制定团队应该包括临床、公共卫生或其他相关领域的专家,团队具备对证据进行综合判断的能力。对做出一系列判... 详细信息

Holger J Schünemann及其同事表示,制定指南时,专家经验非常有用,但需要有明确的使用方法,以避免意见和证据的混淆。循证指南制定团队应该包括临床、公共卫生或其他相关领域的专家,团队具备对证据进行综合判断的能力。对做出一系列判断的依据——证据,进行识别、选择、评价和归纳的过程应以系统和透明的方式进行呈现。但针对证据可能尚未发表、间接证据、疾病罕见、背景信息缺失,或资源有限等情况,系统而透明地呈现证据则存在一定难度。在这种情况下,使用专家提供的证据是有效的,即专家可能是证据的唯一或主要来源。

关键词：专家证据间接证据信息缺失公共卫生综合判断资源有限团队透明

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Erbium-doped TeO2-coated Si3N4 waveguide amplifiers with 5 dB net gain:erratum

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Photonics Research 2020年第6期8卷 1022-1022页

作者： HENRY C.FRANKIS HAMIdU M.MBONdE dAWSON B.BONNEVILLE CHENGLIN ZHANG RICHARd MATEMAN ARNE LEINSE JONATHAN d.B.BRAdLEY department of Engineering Physics McMaster UniversityHamiltonOntario L8S 4L7Canada LioniX International BV Enschede AL 7500The Netherlands

This erratum corrects typos that appeared in ***.8,127(2020)in the text,a figure showing the experimental setup,and a table listing the absorption and emission cross section values used in simulations.

关键词： waveguide Erbium amplifiers

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把握机会窗口期减缓气候变化对中国居民健康影响

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科学通报 2023年第15期68卷 1899-1905页

作者：蔡闻佳张弛张诗卉艾思奇白玉琪鲍俊哲常楠陈彬陈慧琪程亮亮崔学勤戴瀚程 Bawuerjiang danna 底骞董伟董文轩窦德景范维澄范星房小怡高仝高源耿阳关大博郭亚菲 Ian hamilton 胡艺馨华峻翊黄存瑞黄弘黄建斌蒋俏蕾姜晓朋柯丕煜 Gregor Kiesewetter Pete Lampard 李传玺李瑞奇李双利梁璐林波荣林华亮刘欢刘起勇刘小波刘心远刘昱甫刘钊刘竹楼书含鲁晨曦罗勇罗震宇马伟 Alice McGushin 牛彦麟任超阮增良 Wolfgang Schöpp 单钰理苏婧孙韬淳王灿王琼文三妹谢杨熊辉徐冰徐朦颜钰杨军杨廉平杨秀俞乐岳玉娟曾仪娉张镜张少辉张曜张仲宸赵继尧赵亮赵梦真赵琦赵哲周景博朱征宏陈冯富珍宫鹏清华大学地球系统科学系北京100084 北京理工大学管理与经济学院北京100081 中山大学公共卫生学院广州510080 郑州大学公共卫生学院郑州450001 南京医科大学公共卫生学院南京211166 北京师范大学环境学院北京100875 北京大学环境工程学院北京100871 清华大学新闻与传播学院北京100084 清华大学万科公共卫生学院北京100084 浙江大学地球科学学院杭州310058 清华大学公共安全研究所北京100084 清华大学工程物理系北京100084 百度研究院北京100091 山东师范大学环境与生态研究院济南250013 中国气象科学研究院气象影响与风险研究中心北京100086 山东师范大学商学院济南250013 中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室北京102206 清华大学建筑学院北京100084 中国疾病预防控制中心环境与人群健康重点实验室环境与健康相关产品安全所北京102206 Energy Institute University College LondonLondon WC1E 6BTUK 南方科技大学统计与数据科学系深圳518055 香港大学建筑学院中国香港999077 世界卫生组织驻华代表处北京100600 Pollution Management Research Group EnergyClimateand Environment ProgramInternational Institute for Applied Systems Analysis(IIASA)Schlossplatz 1-A-2361 LaxenburgAustria department of Health Sciences University of YorkYork YO105DDCanada 山东大学齐鲁医学院公共卫生学院流行病学系济南250002 中国科学技术大学计算机科学与技术学院合肥230027 department of Geography and the Environment University of North TexasDenton TX 76203-5017USA 清华大学环境学院北京100084 Geography College of Life and Environmental SciencesUniversity of ExeterExeter EX12LUUK 山东大学气候变化与健康研究中心济南250002 Institute for Global Health University College LondonLondon WC1H 0ALUK School of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham B152TTUK 清华大学人文学院北京100084 北京航空航天大学经济与管理学院北京100083 香港科技大学(广州)信息枢纽人工智能学域广州511443 暨南大学环境与气候研究所广州510632 清华大学气候变化与可持续发展研究院北京100084 清华大学苏世民学院北京100084 清华大学体育学部北京100084 中国科学院大气物理研究所大气科学和地球流体力学数值模拟国家重点实验室北京100029 香港大学地球科学系和地理系中国香港999077

随着中国总人口的不断增加以及改革开放以来经济的飞速发展,中国面临来自气候变化的健康威胁也在不断上升.与此同时,中国也处于一个独特的机遇窗口期,如果能够有效应对气候变化带来的健康风险,将造福今后几代人的健康.反之,如果没有及... 详细信息

随着中国总人口的不断增加以及改革开放以来经济的飞速发展,中国面临来自气候变化的健康威胁也在不断上升.与此同时,中国也处于一个独特的机遇窗口期,如果能够有效应对气候变化带来的健康风险,将造福今后几代人的健康.反之,如果没有及时、充分的应对措施,气候变化对中国居民健康和生命的威胁将与日俱增.为了推动更及时且有利于改善人群健康的气候应对行动,由清华大学牵头建立的柳叶刀倒计时亚洲中心在全球柳叶刀倒计时工作的基础上[1,2],从2020年开始,聚焦气候变化对中国人群健康的影响进行全面且系统的评估[3,4].

关键词：减缓气候变化人群健康柳叶刀居民健康窗口期倒计时应对措施把握机会

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World Journal of Critical Care Medicine 2022年第4期11卷 236-245页

作者： Vincent Issac Lau Jeffrey A Johnson Sean M Bagshaw Oleksa G Rewa John Basmaji Kimberley A Lewis M Elizabeth Wilcox Kali Barrett Francois Lamontagne Francois Lauzier Niall d Ferguson Simon J W Oczkowski Kirsten M Fiest daniel J Niven Henry T Stelfox Waleed Alhazzani Margaret Herridge Robert Fowler deborah J Cook Bram Rochwerg Feng Xie department of Critical Care Medicine University of AlbertaEdmonton T6G 2B7ABCanada School of Public Health Inst Hlth EconUniversity of AlbertaEdmonton T6G 2B7ABCanada department of Medicine Division of Critical CareWestern UniversityLondon N6A 5W9Canada division of Critical Care McMaster UniversityHamilton L8N 4A6Canada Interdepartmental division of Critical Care University of TorontoToronto M5T 2S8Canada department of Medicine University SherbrookeSherbrooke J1H 5N4Canada departments of Medicine and Anesthesiology University LavalLaval G1V 4G2Canada department Critical Care Medicine University of TorontoToronto M5G 2C4Canada department of Medicine McMaster ClinHamilton Gen HospMcMaster UniversityHamilton L8N 4A6Canada department of Community Health Sciences&Institute for Public Health University of CalgaryCalgary T2N 2T9Canada department of Critical Care Medicine University CalgaryCalgary T2N 2T9Canada department of Community Health Sciences University of CalgaryCalgary T2N 2T9Canada department of Medicine McMaster UniversityHamilton L8N 4A6Canada Indepartmental division of Critical Care University Health NetworkToronto M5G 2C4Canada departments of Medicine and Critical Care Medicine Sunnybrook Health Sciences CenterInstitute of Health Policy Management and EvaluationUniversity of TorontoToronto M4N 3M5Canada Health Research Methods Evidence and ImpactMcMaster UniversityHamilton L8N 3Z5Canada

Mortality is a well-established patient-important outcome in critical care *** contrast,morbidity is less uniformly reported(given the myriad of critical care illnesses and complications of each)but may have a common end-impact on a patient’s functional capacity and health-related quality-of-life(HRQoL).Survival with a poor quality-of-life may not be acceptable depending on individual patient values and ***,as mortality decreases within critical care,it becomes increasingly important to measure intensive care unit(ICU)survivor *** measurements with a preference-based scoring algorithm can be converted into health utilities on a scale anchored at 0(representing death)and 1(representing full health).They can be combined with survival to calculate quality-adjusted life-years(QALY),which are one of the most widely used methods of combining morbidity and mortality into a composite *** QALYs have been use for health-technology assessment decision-making,an emerging and novel role would be to inform clinical decision-making for patients,families and healthcare providers about what expected HRQoL may be during and after ICU *** care randomized control trials(RCTs)have not routinely measured or reported HRQoL(until more recently),likely due to incapacity of some patients to participate in patient-reported outcome *** differences in HRQoL measurement tools can lead to non-comparable *** this end,we propose the validation of a gold-standard HRQoL tool in critical care,specifically the *** combined health-utility and mortality(disaggregated)and QALYs(aggregated)can be reported,with disaggregation allowing for determination of which components are the main drivers of the QALY *** use of HRQoL,health-utility,and QALYs in critical care RCTs has the potential to:(1)Increase the likelihood of finding important effects if they exist;(2)improve research efficiency;and(3)help inform optimal m

关键词： Critical care health-related quality of life Quality-adjusted life-years Health-utility Mortality Morbidity Kaplan-Meier curves

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帕罗西汀联合音乐治疗中重度烧伤患者:抑郁情绪与炎症因子的关系

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中国组织工程研究与临床康复 2007年第52期11卷 10527-10529页

作者：王东吴孝苹宋中金孙充洲肖晓兰王才明何友德孙学礼绵阳市中心医院四川省绵阳市621000 攀枝花钢铁公司总医院四川省攀枝花市617000 四川大学华西精神卫生中心四川省成都市610041

目的:观察帕罗西汀联合音乐治疗后中重度烧伤患者情绪状况,并分析烧伤患者血清肿瘤坏死因子、白细胞介素6水平的变化及其影响因素。方法:选择2003-04/2005-04在绵阳市中心医院、攀枝花钢铁公司总医院烧伤专科住院的中重度热力烧伤患者8... 详细信息

目的:观察帕罗西汀联合音乐治疗后中重度烧伤患者情绪状况,并分析烧伤患者血清肿瘤坏死因子、白细胞介素6水平的变化及其影响因素。方法:选择2003-04/2005-04在绵阳市中心医院、攀枝花钢铁公司总医院烧伤专科住院的中重度热力烧伤患者84例。①于烧伤后3d内行汉密顿抑郁量表、汉密顿焦虑量表测定(汉密顿抑郁量表>9分,汉密顿焦虑量表>8分为有焦虑抑郁情绪),将患者分为有焦虑抑郁情绪患者和不伴有焦虑抑郁情绪患者。将有焦虑抑郁情绪患者随机分为治疗组28例及抑郁对照组27例,不伴有焦虑抑郁的患者为烧伤对照组29例。②各组患者均采用相似的液体复苏、营养支持、抗感染及手术治疗。治疗组在此基础上,于第4天合用帕罗西汀及音乐治疗。帕罗西汀用量20～40mg/d,共治疗30d。音乐治疗用感应性音乐聆听,1h/d,15d为1个疗程,连续听2个疗程。③比较3组患者治疗前后汉密顿抑郁量表、汉密顿焦虑量表评分。采用酶联免疫吸附法检测血清肿瘤坏死因子、白细胞介素6水平,并应用逐步回归分析判断影响血清肿瘤坏死因子、白细胞介素6水平的主要因素。结果:治疗组1例,抑郁对照组3例,烧伤对照组2例因经费困难中断治疗。最后纳入分析治疗组27例,抑郁对照组24例,烧伤对照组27例。①治疗后治疗组汉密顿抑郁量表评分低于抑郁对照组(4.74±1.99,14.79±5.28,P0.05)。②治疗后第21天治疗组血清肿瘤坏死因子、白细胞介素6水平低于抑郁对照组。③逐步回归分析选出影响肿瘤坏死因子水平的3个主要因素,即治疗前抑郁分值、治疗后抑郁分值和治疗后白细胞介素6水平;影响白细胞介素6水平的为烧伤后血清肿瘤坏死因子水平。结论:帕罗西汀联合音乐治疗能改善抑郁情绪,同时降低血清肿瘤坏死因子、白细胞介素6水平,改善烧伤后生理功能状态。

关键词：帕罗西汀音乐治疗烧伤焦虑抑郁肿瘤坏死因子α 白细胞介素6

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