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Microscopic features of colorectal neoplasia in inflammatory bowel diseases

World Journal of Gastroenterology 2014年第12期20卷 3164-3172页

作者： aude Bressenot Virginie Cahn Silvio Danese Laurent Peyrin-Biroulet Department of pathology University Hospital of Nancy IBD Center Division of GastroenterologyHumanitas Clinical and Research Center Inserm U954 and Department of Hepato-Gastroenterology University Hospital of Nancy

The risk of developing dysplasia leading to colorectal cancer (CRC) is increased in both ulcerative colitis and Crohn’s disease. The prognosis of CRC may be poorer in patients with inflammatory bowel disease (IBD) than in those without IBD. Most CRCs, in general, develop from a dysplastic precursor lesion. The interpretation by the pathologist of the biopsy will guide decision making in clinical practice: colonoscopic surveillance or surgical management. This review summarizes features of dysplasia (or intraepithelial neoplasia) with macroscopic and microscopic characteristics. From an endoscopic (gross) point of view, dysplasia may be classified as flat or elevated (raised); from a histological point of view, dysplasia is separated into 3 distinct categories: negative for dysplasia, indefinite for dysplasia, and positive for dysplasia with low- or high-grade dysplasia. The morphologic criteria for dysplasia are based on a combination of cytologic (nuclear and cytoplasmic) and architectural aberrations of the crypt epithelium. Immunohistochemical and molecular markers for dysplasia are reviewed and may help with dysplasia diagnosis, although diagnosis is essentially based on morphological criteria. The clinical, epidemiologic, and pathologic characteristics of IBD-related cancers are, in many aspects, different from those that occur sporadically in the general population. Herein, we summarize macroscopic and microscopic features of IBD-related colorectal carcinoma.

关键词： Inflammatory bowel disease Dysplasia Colorectal cancer Microscopic features

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Four odontocete species change hearing levels when warned of impending loud sound

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Integrative Zoology 2018年第2期13卷 160-165页

作者： Paul E.NACHTIGALL Alexander Ya.SUPIN aude F.PACINI Ronald A.KASTELEIN Hawaii Institute of Marine Biology University of HawaiiKaneohe HawaiiUSA Institute of Ecology and Evolution of the Russian Academy of Sciences MoscowRussia Sea Mammal Research Company(SEAMARCO) Harderwijkthe Netherlands

Hearing sensitivity change was investigated when a warning sound preceded a loud sound in the false killer whale(Pseudorca crassidens),the bottlenose dolphin(Tursiops truncatus),the beluga whale(Delphinaperus leucas)and the harbor porpoise(Phocoena phocoena).Hearing sensitivity was measured using pip-train test stimuli and auditory evoked potential *** the test/warning stimuli preceded a loud sound,hearing thresholds before the loud sound increased relative to the baseline by 13 to 17 *** with multiple frequencies of exposure and shift provided evidence of different amounts of hearing change depending on frequency,indicating that the hearing sensation level changes were not likely due to a simple stapedial reflex.

关键词： change dolphin hearing loud sound

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Insights in living-donor liver transplantation associated with two-stage total hepatectomy:First case in neuroendocrine tumor metastases and functional assessment techniques

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 392-395页

作者： Laurent Coubeau Samuele Iesari Paulina Henry Philippe D’Abadie aude Vanbuggenhout Raymond Reding aTransplantation Abdominale Cliniques Universitaires Saint-LucUniversite catholique de LouvainBrusselsBelgium Pole de Chirurgie Experimentale et Transplantation Institut de Recherche Experimentale et CliniqueUniversite catholique de LouvainBrusselsBelgium Department of Biotechnological and Applied Clinical Sciences University of L’AquilaL’AquilaItaly Service d’anatomo-pathologie Cliniques Universitaires Saint-LucUniversite catholique de LouvainBrusselsBelgium Service de medecine nucleaire Cliniques Universitaires Saint-LucUniversite catholique de LouvainBrusselsBelgium

To the Editor:While organ shortage commonly dooms patients on waiting list,alternative options as living-donor liver transplantation(LDLT)are assiduously *** principles of liver surgery rule LDLT:there must be suffici... 详细信息

关键词： donor liver surgery

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Ballistic tests on hot-rolled Ti-6Al-4V plates:Experiments and numerical approaches

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Defence Technology（防务技术） 2023年第8期26卷 39-53页

作者： Alexander Janda Benjamin James Ralph Yael Demarty Marcel Sorger Stefan Ebenbauer aude Prestl Ingo Siller Martin Stockinger Helmut Clemens Department of Materials Science Montanuniversitat LeobenFranz Josef-Straße 188700 LeobenAustria Department Product Engineering Montanuniversitat LeobenFranz Josef-Straße 188700 LeobenAustria French-German Research Institute of Saint-Louis 5 Rue du General Cassagnou68300 Saint-LouisFrance voestalpine BOEHLER Bleche GmbH&Co KG Boehler-Gasse 18680MürzzuschlagAustria

Superior ballistic performance and the lightweight character of Ti alloys are considered as main reasons for their use in armour applications against a broad spectrum of ballistic threats,***,fragment or blast *** dynamic loading caused by typical penetrators is characterized by high strain rates,only specific test methods allow a closer investigation of the respective material *** the present study,quasi-static and dynamic compression tests as well as ballistic tests were conducted on a twophase a+βalloy Ti-6Al-4V(in m%)manufactured by ***-deformation heat treatments,influencing microstructure and mechanical properties were applied in order to compare three different microstructural configurations:as-rolled,mill-annealed and ***,on the one hand,ballistic tests were employed for the determination of the ballistic limit velocity v_(50),compression tests,on the other hand,delivered essential input parameters for the application of the Johnson-Cook constitutive model in a finite element simulation of the impact *** comparison of experimental results to simulation results was supplemented by means of microstructural characterization of tested samples with the focus set on the prevalently observed deformation and damage mechanisms,as for example adiabatic shearing.

关键词： Ti-6Al-4V Ballistic performance Split Hopkinson pressure bar FE simulation Adiabatic shear bands Intermetallic phase

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Productive and physiological implications of top-dress addition of branched-chain amino acids and arginine on lactating sows and offspring

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Journal of Animal Science and Biotechnology 2023年第3期14卷 1080-1101页

作者： Diana Luise Federico Correa Claudio Stefanelli aude Simongiovanni Tristan Chalvon-Demersay Maddalena Zini Luciano Fusco Paolo Bosi Paolo Trevisi Department of Agricultural and Food Sciences University of Bologna40127 BolognaItaly Department for Life Quality Studies Alma Mater StudiorumUniversity of Bologna47921 RiminiItaly Metex Noovistago 32 Rue Guersant75017 ParisFrance Department of Biomedical and Neuromotor Sciences Alma Mater StudiorumUniversity of Bologna40126 BolognaItaly Freelancer Reggio nell’EmiliaItaly.

Background Branched-chain amino acids(BCAAs),including L-leucine(L-Leu),L-isoleucine(L-Ile),L-valine(L-Val),and L-arginine(L-Arg),play a crucial role in mammary gland development,secretion of milk and regulation of the catabolic state and immune response of lactating ***,it has recently been suggested that free amino acids(AAs)can also act as microbial *** study aimed at evaluating whether the supplementation of lactating sows with BCAAs(9,4.5 and 9 g/d/sow of L-Val,L-Ile and L-Leu,respectively)and/or L-Arg(22.5 g/d/sow),above the estimated nutritional requirement,could influence the physiological and immunological parameters,microbial profile,colostrum and milk composition and performance of sows and their *** At d 41,piglets born from the sows supplemented with the AAs were heavier(P=0.03).The BCAAs increased glucose and prolactin(P<0.05)in the sows’serum at d 27,tended to increase immunoglobulin A(IgA)and IgM in the colostrum(P=0.06),increased the IgA(P=0.004)in the milk at d 20 and tended to increase lymphocyte%in the sows’blood at d 27(P=0.07).Furthermore,the BCAAs tended to reduce the Chao1 and Shannon microbial indices(P<0.10)in the sows’*** BCAA group was discriminated by Prevotellaceae_UCG-004,Erysipelatoclostridiaceae UCG-004,the Rikenellaceae_RC9_gut_group and *** reduced piglet mortality pre-(d 7,d 14)and post-weaning(d 41)(P<0.05).Furthermore,Arg increased the IgM in the sow serum at d 10(P=0.05),glucose and prolactin(P<0.05)in the sow serum at d 27 and the monocyte percentage in the piglet blood at d 27(P=0.025)and their jejunal expression of NFKB2(P=0.035)while it reduced the expression of GPX-2(P=0.024).The faecal microbiota of the sows in Arg group was discriminated by *** combination of BCAAs and Arg tended to increase spermine at d 27(P=0.099),tended to increase the Igs(IgA and IgG,P<0.10)at d 20 in the milk,favoured the faecal colonisation of Oscillospiraceae UCG

关键词： Microbiota Post-weaning mortality Prolactin Sows diet

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Response of life-history traits to artificial and natural selection for virulence and nonvirulence in a Drosophila parastitoid, Asobara tabida

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Insect Science 2018年第2期25卷 317-327页

作者： Joffrey Moiroux Joan van Baaren Mathilde Poyet aude Couty Patrice Eslin Genevieve Prevost Jeremy Sguin Vincent Le Roux FRE 3498 EDYSAN CNRS-Universite de Picardie Jules Verne 33 rue St Leu Amiens Cedex France UMR 6553 ECOBIO CNRS- Universite Rennes 1 Campus de Beaulieu avenue du G~n~ral Leclerc Rennes Cedex France UMR 7263 IMBE AMU - CNRS - IRD - UAPV Universite d＇Avignon et des Pays de Vaucluse 301 rue Baruch de Spinoza 84916 Avignon Cedex 09 Franc

Co-evolution of host-parasitoid interactions is determined by the costs of host resistance, which received empirical evidence, and the costs ofparasitoid virulence, which have been mostly hypothesized. Asobara tabida is a parasitoid, which mainly parasitizes Drosophila melanogaster and D. subobscura, the first species being able to resist to the parasitoid development while the second species is not. To parasitize resistant hosts, including D. melanogaster, A. tabida develops sticky eggs, which prevent encapsulation, but this virulence mechanism may be costly. Interindividual and interpopulation variation in the proportion of sticky eggs respectively allowed us to （i） artificially select and compare life-history traits of a virulent and a nonvirulent laboratory strain, and （ii） compare a virulent and a nonvirulent field strain, to investigate the hypothetical costs of virulence. We observed strong differences between the 2 laboratory strains. The nonvirulent strain invested fewer resources in reproduction and walked less than the virulent one but lived longer. Concerning the field strains, we observed that the nonvirulent strain had larger wings while the virulent one walked more and faster. All together, our results suggest that virulence may not always be costly, but rather that different life histories associated with different levels of virulence may coexist at both intra- and interDoDulation levels.

关键词： encapsulation geographic variation host resistance trade-offs

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Very early family-based intervention for anxiety:two case studies with toddlers

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General Psychiatry 2019年第6期32卷 349-355页

作者： Dina R Hirshfeld-Becker aude Henin Stephanie J Rapoport Timothy E Wilens Alice S Carter Child CBT Program Department of PsychiatryMassachusetts General HospitalBostonMassachusettsUSA Department of Psychiatry Harvard Medical SchoolBostonMassachusettsUSA Division of Child and Adolescent Psychiatry Department of PsychiatryMassachusetts General HospitalBostonMassachusettsUSA Department of Psychology University of Massachusetts BostonBostonMassachusettsUSA

Anxiety disorders represent the most common categor of psychiatric disorder in children and adolescents and contribute to distress,impairment and *** Anxiety disorders or their temperamental precursors are often evident in early childhood,and anxiety can impair functioning,even during preschool age and in toddlerh A growing number of investigators have shown that anxiety in preschoolers can be treated efficaciously using cognitive-behavioural therapy(CBT)administere either by training the parents to apply CBT strategies with their children or through direct intervention with parents and *** date,most investigators have drawn the line at offering direct CBT to children under the age of ***,since toddlers can also present with impairing symptoms,and since behaviour strategi can be applied in older preschoolers with poor languag ability successfully,it ought to be possible to apply CBT anxiety to younger children as *** therefore prese two cases of very young children with impairing anxiet(ages 26 and 35 months)and illustrate the combinatio parent-only and parent-child CBT sessions that compri their *** treatment was well tolerated by parents and children and showed promise for reducing anxiety symptoms and improving coping skills.

关键词： distress behaviour apply

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Appadtion of the NAC Transcription Factors Predates the Emergence of Land Plants

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Molecular Plant 2016年第9期9卷 1345-1348页

作者： aude Maugarny-Cales Beatriz Gonqalves Stefan Jouannic Michael Melkonian Gane Ka-Shu Wonge Patrick Laufs Institut Jean-Pierre Bourgin INRA AgroParisTech CNRS Universite ParisSaclay RD10 78026 Versailles Cedex France Univ. Pads-Sud Universite Paris-Saclay 91405 Orsay France IRD UMR DIADE 911 Avenue Agropolis BP6450134394 Mbntpellier Cedex 5 France LMI RICE IRD USTH National Key Laboratory for Plant Cell Biotechnology Agronomical Genetics Institute Pham Van Dong Road Hanoi Vietnam Botany Department Cologne Biocenter University of Cologne 50674 Cologne Germany Beijing Genomics Institute-Shenzhen Shenzhen 518083 China Department of Biological Sciences University of Alberta Edmonton AB T6G 2E9 Canada Department of Medicine University of Alberta Edmonton AB T6G 2E Canada These authors contributed equally to this article.

Dear Editor The NAC （for NO APICAL MERISTEM [NAM], Arabidopsis TRANSCRII^TION ACTIVATOR FACTOR [ATAF] and CUP- SHAPED COTYLEDON [CUC]） proteins are one of the largest families of plant-specific transcription factors （Nagata et aL, 2015）. They are involved in many different biological processes including development and the response to biotic and abiotic stresses. To date, NAC transcription factors have only been identified in land plants （Zhu et al., 2012; Nagata et al., 2015）; and some of them control land-plant-specific processes, such as the formation of specialized water-conducting systems （Xu et al., 2014）. Therefore, it has been suggested that their appearance accompanied the emergence of land plants. Here, we exploited the transcriptomic data generated within the 1000 plants project （***, Wickett et al., 2014） to revisit the origin of NAC proteins. Our careful analysis shows that NAC transcription factors appeared before the ernergence of land plants as we detected their homologs in several groups of streptophyte green algae. The possible significance of this finding is discussed.

关键词： ADAPTATION ORIGIN

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Pancreatic head cancer in patients with chronicpancreatitis

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Hepatobiliary & Pancreatic Diseases International 2014年第2期13卷 192-197页

作者： aude Merdrignac Laurent Sulpice Michel Rayar Tanguy Rohou Emmanuel Quéhen Ayman Zamreek Karim Boudjema Bernard Meunier Service de Chirurgie Hépatobiliaire et Digestive H pital PontchaillouCentre Hospitalier Universitaire INSERM UMR991 FoieMétabolismes et Cancer Service d'Imagerie Médicale H pital Pontchaillou

BACKGROUND: Chronic pancreatitis (CP) is a risk factor of pancreatic adenocarcinoma (PA). The discovery of a pancreatic head lesion in CP frequently leads to a pancreaticoduo denectomy (PD) which preceded by a multidisciplinary meeting(MM). The aim of this study was to evaluate the relevance between this indication of PD and the definitive pathological ***: Between 2000 and 2010, all patients with CP who underwent PD for suspicion of PA without any histological proof were retrospectively analyzed. The operative decision has always been made at an MM. The definitive pathological finding was retrospectively confronted with the decision made at an MM, and patients were classified in two groups according to this concordance (group 1) or not (group 2). Clinical and biological parameters were analyzed, preoperative imaging were reread and confronted to pathological findings in order to identify predictive factors of malignant ***: During the study period, five of 18 (group 1) patients with CP had PD were histologically confirmed to have PA, and the other 13 (group 2) did not have PA. The median age was52.5 ±8.2 years (gender ratio 3.5). The main symptoms were pain (94.4%) and weight loss (72.2%). There was no patient’s death. Six (33.3%) patients had a major complication (ClavienDindo classification ≥3). There was no statistical difference in clinical and biological parameters between the two groups. The rereading of imaging data could not detect efficiently all patients with ***: Our results confirmed the difficulty in detecting malignant transformation in patients with CP before surgery and therefore an elevated rate of unnecessary PD was found. A uniform imaging protocol is necessary to avoid PD as a less invasive treatment could be proposed.

关键词： chronic pancreatitis adenocarcinoma pancreaticoduodenectomy

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全球海洋硅循环及研究中面临的主要挑战

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地学前缘 2022年第5期29卷 47-58页

作者：朱东栋 Jill NSUTTON aude LEYNAERT Paul J.TREGUER 刘素美中国海洋大学深海圈层与地球系统前沿科学中心和海洋化学理论与工程技术教育部重点实验室山东青岛266100 青岛海洋科学与技术国家实验室海洋生态与环境科学功能实验室山东青岛266237 法国西布列塔尼大学海洋环境科学实验室普卢扎内29280

海洋硅循环是海洋生物地球化学循环的关键过程之一,对调控全球二氧化碳浓度、海洋酸碱度和多种元素(氮、磷、铁、铝等)的循环具有重要作用。在当今气候变化和人类活动影响日益增强的背景下,硅循环与“生物泵”及碳循环的紧密联系,是其... 详细信息

海洋硅循环是海洋生物地球化学循环的关键过程之一,对调控全球二氧化碳浓度、海洋酸碱度和多种元素(氮、磷、铁、铝等)的循环具有重要作用。在当今气候变化和人类活动影响日益增强的背景下,硅循环与“生物泵”及碳循环的紧密联系,是其成为地球科学领域研究热点的主要原因。海洋中硅的外部来源主要为河流、地下水、大气沉降、海底玄武岩风化作用和海底热液输送5个途径,在全球气温变暖趋势的影响下,极地冰川融化成为高纬度海域不可忽视的硅源。生物硅在沉积物中的埋藏、硅质海绵和生物硅的反风化作用是重要的海洋硅移除过程。海洋硅循环过程复杂,受生物(生物吸收、降解)、物理(吸附、溶解)和化学(矿化分解和反风化作用)多重因素的影响,针对海洋硅循环关键过程的研究有助于综合评估海洋硅的“源-汇”和收支。本文总结了海洋硅循环的主要过程及海洋硅的收支,根据国际和国内研究现状讨论了当前海洋硅循环研究中面临的主要问题和挑战。现有研究成果显示,海洋硅的外源输入和输出通量比以往的评估分别增加了2.4和2.2倍。在短时间尺度内(<8 ka),全球海洋中硅的收支大致平衡,海洋硅循环基本处于稳定状态。气候变化和人类活动导致河流输送至陆架边缘海的硅通量发生变化,可能影响硅藻等海洋浮游植物种群结构,是未来海洋硅循环研究需要关注的问题之一。陆架边缘海较高沉积速率和强烈的反风化作用提高了该区域生物硅的埋藏效率,准确评估该区域生物硅的埋藏通量仍是亟须解决的难题。目前的研究评估了全球海洋浮游硅藻、硅质海绵以及放射虫生产力,而海洋底栖硅藻生产力的贡献受到忽视,未来需要关注底栖硅藻对生物硅的贡献及其在海洋硅的生物地球化学过程中的作用。

关键词：海洋硅循环收支生物硅海洋

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