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Rare dentin defects:Understanding the pathophysiological mechanisms of COLXVA1 mutations

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Genes & Diseases 2024年第5期11卷 1-5页

作者： Isaac Maximiliano Bugueno Tristan Rey Alexandra Jimenez-Armijo Marzena Kawczynski Naji Kharouf Marie-Cecile Maniere yann Herault Agnes Bloch-Zupan Virginie HaushalterLaugel Institute of Genetics and Molecular and Cellular Biology(IGBMC) CNRS-UMR7104INSERM U1258Universitede StrasbourgIllkirch 67400France Faculty of Dentistry Universitede StrasbourgStrasbourg 67000France Institute of Advanced Studies(USIAS) Universitede StrasbourgStrasbourg 67045France Reference Center for Rare Oral and Dental Diseases(CRMR-O-Rares) Oral Medicine and Surgery DepartmentHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Rare Diseases Health Network“TETE COU”&European Reference Network ERN CRANIO Strasbourg 67000France “Institut de Genetique Medicale d’Alsace” Laboratory of Genetic DiagnosticHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Biomaterials and Bioengineering Laboratory Inserm UMR_S 1121Strasbourg 67000France Orofacial Development and Regeneration Faculty of MedicineInstitute of Oral BiologyCentre of Dental MedicineUniversity of ZurichZurich 8032Switzerland

Dentin is a mineralized tissue with a chemical composition similar to bone but with a higher mineralized density and *** constitutes the central structure of the tooth between the internal pulp and external enamel toward the oral cavity or cementum toward the underlying *** dentin defects occur in a variety of rare genetic *** can manifest as“isolated”occurrences such as in dentinogenesis imperfecta(DI)or dentin dysplasia(DD)or can be associated with other symptoms in diseases such as osteogenesis imperfecta,Goldblatt syndrome,microcephalic osteodysplastic primordial dwarfism type Ⅱ,among others.

关键词： diseases den rigidity

Association of the immediate perioperative dynamics of circulating DNA levels and neutrophil extracellular traps formation in cancer patients

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Precision Clinical Medicine 2024年第2期7卷 93-108页

作者： Andrei Kudriavtsev Brice Pastor Alexia Mirandola Ekaterina Pisareva yann Gricourt Xavier Capdevila Alain R.Thierry Philippe Cuvillon Institut de Recherche en Cancerologie de Montpellier INSERM U1194Universite de MontpellierMontpellier 34298France Institut regional du Cancer de Montpellier Montpellier 34298France Department of Anaesthesiology and Pain Management Centre Hospitalo-Universitaire(CHU)CaremeauPlace du Professeur DebreNimes 30400France University of Montpellier Montpellier 34298France Division of Anaesthesia Intensive Care Pain and Emergency MedicineMontpellier University HospitalMontpellier 34090France Montpellier NeuroSciences Institute INSERMU1298University of MontpellierMontpellier 34295Franc

Objectives:Elevated circulating DNA(cirDNA)concentrations were found to be associated with trauma or tissue damage which suggests involvement of inflammation or cell death in post-operative cirDNA *** carried out the first prospective,multicenter study of the dynamics of cirDNA and neutrophil extracellular trap(NETs)markers during the perioperative period from 24 h before surgery up to 72 h after curative surgery in cancer ***:We examined the plasma levels of two NETs protein markers[myeloperoxidase(MPO)and neutrophil elastase(NE)],as well as levels of cirDNA of nuclear(cir-nDNA)and mitochondrial(cir-mtDNA)origin in 29 colon,prostate,and breast cancer patients and in 114 healthy individuals(HI).Results:The synergistic analytical information provided by these markers revealed that:(i)NETs formation contributes to post-surgery conditions;(i)post-surgery cir-nDNA levels were highly associated with NE and MPO in colon cancer[r=0.60(P<0.001)and r=0.53(P<0.01),respectivelyl,but not in prostate and breast cancer;(i)each tumor type shows a specific pattern of cir-nDNA and NETs marker dynamics,but overall the pre-and post-surgery median values of cir-nDNA,NE,and MPO were significantly higher in cancer patients than in ***:Taken as a whole,our work reveals the association of NETs formation with the elevated cir-nDNA release during a cancer patient's perioperative period,depending on surgical procedure or cancer *** contrast,cir-mtDNA is poorly associated with NETs formation in the studied perioperative period,which would appear to indicate a different mechanism of release or suggest mitochondrial dysfunction.

关键词： circulating DNA perioperative period neutrophil extracellular traps neutrophil elastase myeloperoxidase minimal residualdisease

Physicochemical and Thermal Properties of Some Key Tropical Sawdust Woods for Energy Production

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Journal of Sustainable Bioenergy Systems 2024年第1期14卷 1-22页

作者： Davy Fiwa Kaoke yann Le Brech Emmanuel Talla Anthony Dufour Patrick Mountapmbeme Kouotou Department of Chemical Engineering School of Chemical Engineering and Mineral Industries University of Ngaoundere Ngaoundere Cameroon National Advanced School of Engineering of Maroua University of Maroua Maroua Cameroon Laboratory of Reactions and Process Engineering University of Lorraine-France Nancy France Higher Institute of Agriculture Wood Water and Environment University of Ebolowa Ebolowa Cameroon

In South Saharan countries, 85% of the population uses biomass as a primary energy source. Cameroon presents one of the highest biomass energy and sawmills produce important sawdust resources which are not used and are burnt in piles leading to significant air toxic emissions. Therefore, we have to valorize industrially these available sawdusts. This study focuses on the physicochemical and thermochemical analysis of Ayous, Sapelli and Tali sawdust. The proximate and ultimate analysis, particle size, structural composition, as well as heavy metal content and calorific value were determined. In addition, the thermogravimetric mass losses were also estimated. The results showed that high water contents (24% - 41%) were recorded in the raw sawdust, and the thermal treatment reduced these contents from 78% to values in the range of 4% - 9%. The values for ash and volatile matter content were respectively between 0.25% - 0.74% and 68% - 76%. The LHV is higher in Ayous (17.5 MJ/kg) and Sapelli (16.8 MJ/kg) than that of Tali (15.7 MJ/kg). The concentration of heavy metals is very low in each species. Extractives are more present in Tali (16.06%) than in the other sawdusts. Pyrolysis of sawdust shows the typical decomposition of hemicellulose (270˚C - 325˚C), cellulose (325˚C - 400˚C) and lignin (200˚C - 550˚C) with a maximum loss of 75% at 370˚C and the melting point is 320˚C. The results of the sawdust parameters determined in the paper can be valorized to reduce pollutants emissions by developing the efficiency and effectiveness of biomass energy processes and promoting the use of biomass as a sustainable alternative to traditional fossil fuels.

关键词： Wood Sawmills Sawdust Combustion Energy

Multivariate Approach to Characterizing Soil Quality of Gabonese’s Ferralitic Soils

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Open Journal of Soil Science 2024年第4期14卷 237-268页

作者： Neil-Yohan Musadji Rolf Gaël Mabicka Obame Michel Mbina Mounguengui Jean aubin Ondo Lydie-Stella Koutika Eric Ravire Claude Geffroy Laboratoire De Chimie Des Milieux et Des Mat&#233riaux Inorganiques Laboratoire D&#8217Analyse Des Sols et Environnement D&#233partement Des Sciences Fondamentales De L&#8217Ing&#233nieur Institut National D&#8217Agronomie et De Biotechnologies Universit&#233 Des Sciences et Techniques De Masuku Franceville Gabon Institut De Chimie Des Milieux et Maté riaux De Poitiers (IC2MP) Universit&#233 De Poitiers Poitiers France Laboratoire De Chimie Des Milieux et Des Mat&#233riaux Inorganiques Laboratoire D&#8217Analyse Des Sols et Environnement D&#233partement De Phytotechnologie Institut National D&#8217Agronomie et De Biotechnologies Universit&#233 Des Sciences et Techniques De Masuku Franceville Gabon Dé partement De G&#233ologie Facult&#233 Des Sciences Universit&#233 Des Sciences et Techniques De Masuku Franceville Gabon Laboratoire Pluridisciplinaire Des Sciences Ecole Normale Sup&#233rieure Libreville Gabon Centre De Recherche Sur La Productivité et La Durabilit&#233 Des Plantations Industrielles Pointe Noire Republic of Congo Sucaf Gabon Somdiaa Franceville Gabon

Assessing soil quality is essential for crop management and soil temporal changes. The present study aims to evaluate soil quality in the Ferralitic soils context countrywide. This assessment was done using multivariate soil quality indice (SQI) models, such as additive quality index (AQI), weighted quality indexes (WQIadd and WQIcom) and Nemoro quality index (NQI), applied to two approaches of indicator selection: total data set (TDS) and minimum data set (MDS). Physical and chemical soil indicators were extracted from the ORSTOM’s reports resulting from a sampling campaign in different provinces of Gabon. The TDS approach shows soil quality status according to eleven soil indicators extracted from the analysis of 1,059 samples from arable soil layer (0 - 30 cm depth). The results indicated that 87% of all provinces presented a very low soil quality (Q5) whatever the model. Among soil indicators, exchangeable K+ and Mg2+, bulk density and C/N ratio were retained in MDS, using principal component analysis (PCA). In the MDS approach, 50 to 63% of provinces had low soil quality grades with AQI, WQIadd and NQI, whereas the total was observed with WQIcom. Only 25% of provinces had medium soil quality grades with AQI and NQI models, while 12.5% (NQI) and 25% (AQI) presented high quality grades. Robust statistical analyses confirmed the accuracy and validation (0.80 r P ≤ 0.016) of AQI, WQIadd and NQI into the TDS and MDS approaches. The same sensitivity index value (1.53) was obtained with AQI and WQIadd. However, WQIadd was chosen as the best SQI model, according to its high linear regression value (R2 = 0.82) between TDS and MDS. This study has important implications in decision-making on monitoring, evaluation and sustainable management of Gabonese soils in a pedoclimatic context unfavorable to plant growth.

关键词： Gabon Ferralitic Soil Soil Indicators Standard Score Function Soil Quality Indices Sustainable Soil Soil Management

High-speed silicon photonic electro-optic Kerr modulation

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Photonics Research 2024年第1期12卷 51-60页

作者： JONATHAN PELTIER WEIWEI ZHANG LEOPOLD VIROT CHRISTIAN LAFFORGUE LUCAS DENIEL DELPHINE MARRIS-MORINI GUY aubin FARAH AMAR DENH TRAN XINGZHAO YAN CALLUM G.LITTLEJOHNS CARLOS ALONSO-RAMOS KE LI DAVID J.THOMSON GRAHAM REED LAURENT VIVIEN University Paris-Saclay CNRSCentre for Nanoscience and Nanotechnology(C2N)Palaiseau 91120France University Grenoble Alpes CEALETIGrenoble 38000France Optoelectronics Research Centre Zepler Institute for Photonics and NanoelectronicsFaculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK

Silicon-based electro-optic modulators contribute to easing the integration of high-speed and low-power consumption circuits for classical optical communications and data *** the plasma dispersion modulation,an alternative solution in silicon is to exploit the DC Kerr effect,which generates an equivalent linear electro-optical effect enabled by applying a large DC electric *** some theoretical and experimental studies have shown its existence in silicon,limited contributions relative to plasma dispersion have been achieved in high-speed modulation so *** paper presents high-speed optical modulation based on the DC Kerr effect in silicon PIN *** contributions of both plasma dispersion and Kerr effects have been analyzed in different waveguide configurations,and we demonstrated that the Kerr induced modulation is dominant when a high external DC electric field is applied in PIN ***-speed optical modulation response is analyzed,and eye diagrams up to 80 Gbit/s in NRZ format are obtained under a *** of 30 *** work paves the way to exploit the Kerr effect to generate high-speed Pockels-like optical modulation.

关键词： waveguide dispersion effect

National Soil Organic Carbon Stocks Inventories under Different Mangrove Forest Types in Gabon

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Open Journal of Forestry 2024年第2期14卷 127-140页

作者： Rolf Gaël Mabicka Obame Neil-Yohan Musadji Jean Hervé Mve Beh Lydie-Stella Koutika Jean aubin Ondo Farrel Nzigou Boucka Michel Mbina Mounguengui Claude Geffroy Dé partement de Phytotechnologie Institut National d&#8217Agronomie et de Biotechnologies Universit&#233 des Sciences et Techniques de Masuku Franceville Gabon Dé partement des Sciences Fondamentales de l&#8217Ing&#233nieur Institut National d&#8217Agronomie et de Biotechnologies Universit&#233 des Sciences et Techniques de Masuku Franceville Gabon Institut Agronomiques et Forestiè res Centre National des Recherches Scientifiques et Technologiques Libreville Gabon Research Centre on the Durability and the Productivity of Industrial Plantations (CRDPI) Pointe Noire Republic of Congo Laboratoire Pluridisciplinaire des Sciences &#201cole Normale Sup&#233rieure Libreville Gabon Agence Gabonaise d’ &#201tude et d&#8217Observation Spatiale Immeuble les Arcades Libreville Gabon Dé partement de G&#233ologie Faculte des Sciences Universit&#233 des Sciences et Techniques de Masuku Franceville Gabon Institut de Chimie des Milieux et Maté riaux de Poitiers (IC2MP) Universit&#233 de Poitiers Poitiers France

Gabonese’s estuary is an important coastal mangrove setting and soil plays a key role in mangrove carbon storage in mangrove forests. However, the spatial variation in soil organic carbon (SOC) storage remain unclear. To address this gap, determining the SOC spatial variation in Gabonese’s estuarine is essential for better understanding the global carbon cycle. The present study compared soil organic carbon between northern and southern sites in different mangrove forest, Rhizophora racemosa and Avicennia germinans. The results showed that the mean SOC stocks at 1 m depth were 256.28 ± 127.29 MgC ha−1. Among the different regions, SOC in northern zone was significantly (p p −1) than upper layers (55.42 ± 25.37 MgC ha−1). The study highlights that low deforestation rate have led to less CO2 (705.3 Mg CO2e ha−1 - 922.62 Mg CO2e ha−1) emissions than most sediment carbon-rich mangroves in the world. These results highlight the influence of soil texture and mangrove forest types on the mangrove SOC stocks. The first national comparison of soil organic carbon stocks between mangroves and upland tropical forests indicated SOC stocks were two times more in mangroves soils (51.21 ± 45.00 MgC ha−1) than primary (20.33 ± 12.7 MgC ha−1), savanna and cropland (21.71 ± 15.10 MgC ha−1). We find that mangroves in this study emit lower dioxide-carbon equivalent emissions. This study highlights the importance of national inventories of soil organic carbon and can be used as a baseline on the role of mangroves in carbon sequestration and climate change mitigation but the variation in SOC stocks indicates the need for further national data.

关键词： Mangroves Forest Soil Organic Carbon Stocks Rizophora Racemose Avicenia germinans Gabon

Thermophysical, Mechanical and Durability Characterization of Adobe Bricks Reinforced with Fonio (Digitaria exilis) Sounds

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Advances in Materials Physics and Chemistry 2024年第8期14卷 146-164页

作者： Colbert Babé Etienne yanné Souaibou Mojonda Lémankréo Bakaiyang Bernard Kola Gustave Assoualaye Layndé Tawé Raidandi Danwé Dieudonné Kidmo Kaoga Noël Djongyang Department of Renewable Energy National Advanced School of Engineering of Maroua University of Maroua Maroua Cameroon Department of Civil Engineering and Architecture National Advanced School of Engineering of Maroua University of Maroua Maroua Cameroon University Institute of Wood Technology University of Yaound I Yaound Cameroon Energy Rsearch Laboratory Institute of Geological and Mining Research Yaound Cameroon

Buildings constructed using modern materials such as cement are energy-intensive, facilitate heat transfer and thus promote warming inside the building. However, the Sudano-Sahelian regions have a hot climate occupying a large period of the year, thus requiring not only sustainable construction materials, but also which provide thermal comfort in the building by limiting the energy demand for air conditioning. These qualifications are important for sub-Saharan African countries in general and those of the Sudano-Sahelian zone in particular, which need ecological materials with good thermal performance to limit heating inside buildings. This study is an energy recovery of agricultural waste in buildings with a view to offering the populations of the northern regions of Cameroon suitable materials at lower cost for the construction of buildings. The soil used for this study was extracted from the locality of Yagoua where the populations make abundant use of mud bricks. Fonio waste was incorporated at low levels into the earth bricks, particularly at 0%, 1%, 2%, 3%, and 4%, with a view to strengthening their thermophysical and mechanical properties. The results obtained indicate that earth bricks reinforced with 4% waste showed better thermal and mechanical insulation properties compared to other formulations with an improvement of 16% and 78% respectively compared to the unreinforced samples. This research allows us to conclude that fonio waste can be used practically without expense in the building with a view to its energy recovery and will promote not only thermal comfort and the limitation of the energy supply for air conditioning, but the construction of more sustainable buildings with a cleaner environment.

关键词： Durability Thermal Comfort Building Soil Fonio Faste

Breast Cancer in a Supernumerary Breast at the Yaoundé Gynaeco-Obstetric and Paediatric Hospital: About a Case

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Advances in Breast Cancer Research 2024年第3期13卷 43-48页

作者： Michel Auguste Mouelle Sarah Gaëlle Adiang Esther Meka Isidore Tompeen Christelle Djapa Claude Hector Mbia yann Eng Julius Sama Dohbit Zacharie Sando Oncology Department of the Yaound Gynaeco-Obstetric and Paediatric Hospital Yaound Cameroon Faculty of Medicine and Biomedical Sciences of Yaound University of Yaound I Yaound Cameroon Obstetrics and Gynaecology Department of the Yaound Gynaeco-Obstetric and Paediatric Hospital Yaound Cameroon Radiology and Medical Imaging Department of the Yaound Gynaeco-Obstetric and Paediatric Hospital Yaound Cameroon Pathology Department of the Yaound Gynaeco-Obstetric and Paediatric Hospital Yaound Cameroon

Accessory or ectopic breast tissue is an anomaly in the development of the breast. It is a rare condition that occurs along the embryological mammary line. In less than 1% of all breast cancers, supernumerary breast cancer is reported, with the axillary location being the most common in 60% to 90% of cases. Cancerous degeneration of this supernumerary breast tissue can pose a dual diagnostic and therapeutic problem. We report the case of locally advanced adenocarcinoma in a right supernumerary breast. This is a 75-year-old, grand-multiparous, postmenopausal, and known hypertensive patient on treatment. Family history was remarkable for brain cancer in her sister and oesophageal cancer in her mother. She consulted for a mass in the right axillary cavity on supernumerary breast evolving for a year. Clinical examination revealed a large, fixed, budding and haemorrhagic-ulcerated mass of the right axilla, with long axis measuring about 15 cm. There was as wella supernumerary breast on the left, but without particularity. A soft tissue ultrasound showed a large hypoechoicmass in the right axillary region of 116 mm with areas of central necrobiosis. Morphologically, the breasts were normal. A breast MRI revealed a subcutaneous mass in the right axillary cavity with skin ulceration and satellite lymphadenopathy. The extension assessment revealed liver metastases, and a biopsy of the mass revealed a breast adenocarcinoma. The case was the subject of a multidisciplinary consultation meeting following which a wide excision of the mass was indicated. The histo-pathology analysis results of the surgical specimen were in favour of a triple negative papillary adenocarcinoma. After a post-operative multidisciplinary consultation meeting, adjuvant chemotherapy was indicated. The development of supernumerary breasts depends on hormones, just like normal breasts. Breast cancer in accessory breast tissue is quite rare with the incidence being 6%. The most common pathology is invasive

关键词： Adjuvant Chemotherapy Papillary Adenocarcinoma Surgery Supernumerary Breast Treatment of Supernumerary Breast Cancer