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GC/MS-based differential metabolic profiling of human peptic ulcer disease to study Helicobacter pylori-induced metabolic perturbations

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BIOCELL 2021年第5期45卷 1299-1311页

作者： GAGANJOT GUPTA DEEPAK BANSAL ANSHULA SHARMA TAWSEEF AHMAD atul sachdev AJAZ AHMAD HAMED A.EL-SEREHY BALJINDER KAUR Department of Biotechnology Punjabi UniversityPatiala147002India Department of General Medicine Government Medical College and HospitalChandigarh160047India Department of Clinical Pharmacy College of PharmacyKing Saud UniversityRiyadh11451Saudi Arabia Department of Zoology College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia

Helicobacter pylori infection has been significantly linked to Peptic Ulcer Disease and Gastric Cancer.Metabolomic fingerprinting may offer a principal way of early diagnosis and to understand the molecular mechanism of H.pylori-induced pathogenicity.The rationale of the study is to explore the underlying distinct metabolic mechanisms of H.pylori-induced PUD and to identify potential biomarkers for disease diagnosis and associated risks using Gas chromatography/mass spectrometry.GC/MS-based analytical method was used to compare metabolic profiles of healthy controls(N=20)and peptic ulcer patients(N=45).Acquired metabolomic data were analyzed by constructing a diagnostic model using principal component analysis and a non-parametric two-tailed paired Wilcoxon analysis to identify disease-specific metabolic biomarkers.A total of 75 low-molecular-weight endogenous metabolites were detected during comparative metabolomic analysis of PUD vs.healthy gut tissues,among which 16 metabolites are being proposed to be diagnostic markers of Human PUD.Perturbations related to amino acids,carbohydrates,fatty acids,organic acids,and sterol metabolism were significantly revealed during this differential metabolomic profiling.Results convincingly suggest that metabolic profiles can contribute immensely in early diagnosis of the disease and understanding molecular mechanisms of disease progression for predicting novel drug targets for prophylactic and anaphylactic measures.

关键词： Peptic ulcer disease Gastric cancer Helicobacter pylori Metabolic profiling Perturbations Stomach ulcers

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Molecular biomarkers for vascular cognitive impairment and dementia:the current status and directions for the future

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Neural Regeneration Research 2024年第12期19卷 2579-2580页

作者： Satoshi Hosoki Perminder Ssachdev Centre for Healthy Brain Ageing Discipline of Psychiatry and Mental HealthSchool of Clinical MedicineFaculty of Medicine and HealthUniversity of New South WalesSydneyAustralia Department of Neurology National Cerebral and Cardiovascular CenterOsakaJapan

Dementia is a syndrome with various underlying pathologies acting independently or in concert to cause cognitive dysfunction.The development of disease-specific treatments and targeted prevention strategies requires precise clinical sub-typing via etiology and pathophysiological processes.Furthermore,recent research advances in biomarkers,especially for Alzheimer's disease(AD)diagnosis,have improved diagnostic precision for dementia.

关键词： prevention diagnosis impairment

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Performance Analysis of Machine Learning Algorithms for Classifying Hand Motion-Based EEG Brain Signals

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Computer Systems Science & Engineering 2022年第9期42卷 1095-1107页

作者： Ayman Altameem Jaideep Singh sachdev Vijander Singh Ramesh Chandra Poonia Sandeep Kumar Abdul Khader Jilani Saudagar Department of Computer Science College of Applied StudiesKing Saud UniversityRiyadh11495Saudi Arabia Department of Computer Science and Engineering Manipal University JaipurJaipur303007India Department of Computer Science CHRIST(Deemed to be University)Bangalore560029India Department of Computer Science and Engineering CHRIST(Deemed to be University)Bangalore560074India Information Systems Department Imam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia

Brain-computer interfaces (BCIs) records brain activity using electroencephalogram (EEG) headsets in the form of EEG signals;these signals can berecorded, processed and classified into different hand movements, which can beused to control other IoT devices. Classification of hand movements will beone step closer to applying these algorithms in real-life situations using EEGheadsets. This paper uses different feature extraction techniques and sophisticatedmachine learning algorithms to classify hand movements from EEG brain signalsto control prosthetic hands for amputated persons. To achieve good classificationaccuracy, denoising and feature extraction of EEG signals is a significant step. Wesaw a considerable increase in all the machine learning models when the movingaverage filter was applied to the raw EEG data. Feature extraction techniques likea fast fourier transform (FFT) and continuous wave transform (CWT) were usedin this study;three types of features were extracted, i.e., FFT Features, CWTCoefficients and CWT scalogram images. We trained and compared differentmachine learning (ML) models like logistic regression, random forest, k-nearestneighbors (KNN), light gradient boosting machine (GBM) and XG boost onFFT and CWT features and deep learning (DL) models like VGG-16, DenseNet201 and ResNet50 trained on CWT scalogram images. XG Boost with FFTfeatures gave the maximum accuracy of 88%.

关键词： Machine learning brain signal hand motion recognition braincomputer interface convolutional neural networks

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Palliative surgical bypass for unresectable periampullary carcinoma

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Hepatobiliary & Pancreatic Diseases International 2008年第3期7卷 308-312页

作者： Shivendra Singh Ajay Kumar sachdev Adarsh Chaudhary Anil Kumar Agarwal Department of Gastrointestinal Surgery Govind Ballabh Pant Hospital&Maulana Azad Medical CollegeNew Delhi 110002India

BACKGROUND:Around 60%to 80%of patients with periampullary carcinoma are unresectable either due to distant metastasis or local vascular invasion.With the advancement of endoscopic interventional procedures,the role of surgical bypass has diminished.However,surgical bypass is still appropriate in patients with unresectable disease discovered at the time of surgery.This study was conducted to assess the results of palliative surgical bypass for patients with unresectable periampullary carcinoma at our hospital,a tertiary referral center of Northern India. METHOD:The study group comprised 204 patients who had undergone surgical bypass for advanced periampullary carcinoma over the last 15 years. RESULTS:Between January 1990 and December 2004,204 patients(128 males,76 females)consisting of 179 patients with carcinoma of head of the pancreas,14 patients with ampullary carcinoma,8 patients with lower end cholangiocarcinoma and 3 patients with duodenal carcinoma underwent surgical bypass.Their average age was 51 years (range 20-78 years).Both biliary and gastric bypasses were done in 158(77.45%),biliary bypass alone in 37(18.13%) and gastric bypass alone in 9(4.32%).Biliary bypass was done by Roux-en-Y hepaticojejunostomy,and gastric bypass by retrocolic gastrojejunostomy.The overall postoperative mortality and morbidity were 0.98%and 26.9%,respectively The patients who died had undergone previously endoscopic intervention.Complications included wound infection in 12.25%of the patients,bile leak in 5.12%,delayed gastric emptying in 5.38%,ascitic leak from drains in 8.8%,and upper gastrointestinal bleeding in 1.96%.The incidences of wound infection and bile leak both were significantly higher in patients who had had preoperative biliary stenting None of the patients who had undergone Roux-en-Y hepati cojejunostomy+retrocolic gastrojejunostomy required any intervention later in their life.CONCLUSIONS:Surgical bypass is a safe procedure with negligible mortality and minimal morbidity.It has not lost its relevance and is an

关键词： surgical bypass periampullary carcinoma

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Lipid-polymer hybrid nanoparticles: Development & statistical optimization of norfloxacin for topical drug delivery system

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Bioactive Materials 2017年第4期2卷 269-280页

作者： Vivek Dave Renu Bala Yadav Kriti Kushwaha sachdev Yadav Swapnil Sharma Udita Agrawal Department of Pharmacy Banasthali UniversityBanasthaliRajasthanIndia Sagar Institute of Research and Technology-Pharmacy Bhopal462041India

Poly lactic acid is a biodegradable, biocompatible, and non-toxic polymer, widely used in many pharmaceuticalpreparations such as controlled release formulations, parenteral preparations, surgicaltreatment applications, and tissue engineering. In this study, we prepared lipid-polymer hybrid nanoparticlesfor topical and site targeting delivery of Norfloxacin by emulsification solvent evaporationmethod (ESE). The design of experiment (DOE) was done by using software to optimize the result, andthen a surface plot was generated to compare with the practical results. The surface morphology, particlesize, zeta potential and composition of the lipid-polymer hybrid nanoparticles were characterized bySEM, TEM, AFM, and FTIR. The thermal behavior of the lipid-polymer hybrid nanoparticles was characterizedby DSC and TGA. The prepared lipid-polymer hybrid nanoparticles of Norfloxacin exhibited anaverage particle size from 178.6 ± 3.7 nm to 220.8 ± 2.3 nm, and showed very narrow distribution withpolydispersity index ranging from 0.206 ± 0.36 to 0.383 ± 0.66. The surface charge on the lipid-polymerhybrid nanoparticles were confirmed by zeta potential, showed the value from t23.4 ± 1.5 mVto t41.5 ± 3.4 mV. An Antimicrobial study was done against Staphylococcus aureus and Pseudomonasaeruginosa, and the lipid-polymer hybrid nanoparticles showed potential activity against these two.Lipid-polymer hybrid nanoparticles of Norfloxacin showed the %cumulative drug release of 89.72% in24 h. A stability study of the optimized formulation showed the suitable condition for the storage oflipid-polymer hybrid nanoparticles was at 4 ± 2 C/60 ± 5% RH. These results illustrated high potential oflipid-polymer hybrid nanoparticles Norfloxacin for usage as a topical antibiotic drug carriers.

关键词： Lipid-polymer hybrid nanoparticles Norfloxacin Antimicrobial activity Carbopol gel

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Use of omental patch and endoscopic closure technique as an alternative to surgery after endoscopic full thickness resection of gastric intestinal stromal tumors: A series of cases

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World Journal of Clinical Cases 2020年第1期8卷 120-125页

作者： Amit H sachdev Shahzad Iqbal Igor Braga Ribeiro Diogo Turiani Hourneaux de Moura Division of Gastroenterology Hepatology and EndoscopyBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Good Samaritan Hospital NY 11795United States Gastrointestinal Endoscopy Unit Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 05403-000Brazil

BACKGROUND Gastrointestinal stromal tumors(GISTs)originate from interstitial cells of Cajal.GISTs can occur anywhere along the gastrointestinal tract.Large lesions have traditionally been removed surgically.However,with recent innovations in advanced endoscopy,GISTs located within the stomach are now removed endoscopically.We describe a new innovative endoscopic technique to close large and hard to access defects after endoscopic full-thickness resection of gastric GISTs.CASE SUMMARY We present a series of three patients who were diagnosed with a gastric GIST.All patients underwent full-thickness endoscopic resection.In all cases,for closure of the surgical bed,conventional endoscopic techniques including hemoclips,endoloop and suturing were unsuccessful.We performed a new technique in which we pulled omental fat into the gastric lumen and completely closed the defect using endoscopic devices.All patients performed well post-procedure and computed tomography was carried out one day after the procedures which showed no extravasation of contrast.CONCLUSION The omental plug technique may be used as an alternative to surgery in selected cases of gastric perforation.

关键词： Gastric perforation Gastrointestinal stromal tumors Gastric tumor Surgery Endoscopy Suturing

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A Mesh Adjustment Scheme for Embedded Boundaries

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Communications in Computational Physics 2007年第6期2卷 1095-1124页

作者： J.S.sachdev C.P.T.Groth University of Toronto Institute for Aerospace Studies 4925 Dufferin StreetTorontoOntarioM3H 5T6Canada.

An adaptive meshing technique and solution method is proposed in which a two-dimensional body-fitted multi-block mesh is locally adjusted to arbitrarily embedded boundaries that are not necessarily aligned with the mesh.Not only does this scheme allow for rapid and robust mesh generation involving complex embedded boundaries,it also enables the solution of unsteady flow problems involving bodies and interfaces moving relative to the flow domain.This scheme has been implemented within a block-based adaptive mesh refinement(AMR)numerical framework which can ease computational expense while maintaining a detailed representation of the embedded boundary and providing an accurate resolution of the spatial characteristics of the fluid flow.Rigid body motion and evolving motion due to physical processes are considered.A block-based AMR level set method is used to deal with evolving embedded boundaries.Numerical results for various test problems are presented to verify the validity of the scheme as well as demonstrate the capabilities of the approach for predicting complex two-dimensional inviscid and laminar fluid flows.

关键词： Dynamic and stationary embedded boundaries mesh adjustment algorithm blockbased adaptive mesh refinement.

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MD simulation of asymmetric nucleation and motion of h011] superdislocations in TiAl

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Chinese Science Bulletin 2014年第15期59卷 1725-1737页

作者： Dongsheng Xu Hao Wang Rui Yang Anil K.sachdev Institute of Metal Research Chinese Academy of Sciences General Motors Research & Development Center

The nucleation and propagation of h011]superdislocations in intermetallic TiAl were investigated using molecular dynamics simulations and static energetics calculation,as part of our systematic effort to understand the twining and dislocation behavior of alloys based on c-TiAl.It was found that compared to ordinary dislocations in disordered crystals,superdislocations in ordered TiAl lattice behave differently when sheared in the two opposite senses along[0"11]direction.This difference is due to the lower L10lattice symmetry compared with the face-centered cubic(fcc)lattice that it based on,with different yield stress and strain,and dislocation core dissociation and motion.Superdislocations nucleated in the form of loops dissociated in a planar manner into four Shockley partials separated by three kinds of faults:superlattice intrinsic stacking fault(SISF),anti-phase domain boundary(APB)and complex stacking fault(CSF),with partial separations depending on the sense of shearing and dislocation character.During loop expansion,the dislocation core changes both in width and dissociation manner depending on the character of the segment in the loop.The core contains four partials close to edge orientation,gradually changing to three fold near 60°,and finally into twofold dissociationaround 30°character.Superdislocations may have multiple critical resolved shear stresses(CRSS)for motion depending on dissociation and shearing sense even for the same slip system,with lower critical stress for the motion when SISF is in leading position.

关键词： MD模拟 TIAI γ-TiAl基合金对称核分子动力学模拟普通位错剪切应力故障分离

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Advanced casting technologies for lightweight automotive applications

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China Foundry 2010年第4期7卷 463-469页

作者： Alan A.Luo Anil K.sachdev Bob R.Powell General Motors Global Research and Development Center

This paper provides an overview of alloy and process developments in aluminum and magnesium castings for lightweight automotive applications. Wear-resistant aluminum alloys, creep-resistant and high strength/ductility magnesium alloys have been developed for automotive applications. On the process front, vacuumassisted die casting and high vacuum die casting technologies have been developed for high-integrity body and chassis applications. Thin-wall and hollow casting components are being produced by low-pressure die casting processes for structural applications. Overcasting technology is gaining traction and has enabled mixed material designs for automotive sub-systems such as engine cradles and instrument panel beams. Simulation tools developed to predict the interfacial interactions of the dissimilar components and the structural integrity of the overcast systems are being validated in the casting trials.

关键词：铸造技术汽车应用轻型镁合金铸件界面相互作用应用程序压铸技术结构完整性

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Alveolar echinococcosis with portal vein thrombosis:An unusual cause for liver transplantation

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Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 671-672页

作者： Bhawna Jha Lipika Lipi Smeeta Gajendra Rashi Sharma Ritesh sachdev Department of Pathology and Laboratory Medicine Medanta-The MedicitySector -38GurgaonHaryana 122 001India

Alveolar echinococcosis(AE),caused by larval stage of Echinococcus multilocularis,is a very aggressive and potentially fatal infestation which affects primarily the liver and can metastasize to any part of the body through hematogenous spread.It displays a prolonged latency period before clinical presentation,behaving like a slow-growing liver cancer with subsequent invasion of liver

关键词： echinococcosis Echinococcus subsequent potentially presentation latency invasion fatal prolonged affects

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