检索结果-南通市图书馆

Bulbine frutescens phytochemicals as novel ABC-transporter inhibitor:a molecular docking and molecular dynamics simulation study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2021年第1期7卷 20-32页

作者： Prem Prakash Kushwaha Santosh kumar Maurya Amit singh kumari Sunita Prajapati atul kumar singh Mohd Shuaib Shashank kumar Molecular Signaling&Drug Discovery Laboratory Department of BiochemistryCentral University of PunjabBathinda 151401India Department of Computational Sciences Central University of PunjabBathinda 151401India.

Aim:The present in silico study aimed to evaluate the ATP-binding cassette(ABC)transporter inhibition potential of Bulbine frutescens(B.frutescens)phytochemicals.Methods:Several previous studies and databases were used to retrieve the ligands and target protein structure.The molecular docking study was performed using the Auto Dock Tools,and the GROMACS package was applied to accomplish molecular dynamics simulation.Results:Utilizing the molecular docking and simulation approach,~25 phytochemicals were screened against the ABC transporter protein.Docking score analysis revealed that B.frutescens phytochemical 4’-Demethylknipholone 2’-β-D-glucopyranoside exhibited strong binding on the ABC transporter protein with a minimum binding score-9.8 kcal/mol in comparison to the standard ABC transporter inhibitor diltiazem(-6.86 kcal/mol).Furthermore,molecular dynamics simulation for 4’-Demethylknipholone 2’-β-D-glucopyranoside showed an acceptable root mean square deviation,radius of gyration,root mean square fluctuation,and hydrogen bond,in addition to other lead compounds.Conclusion:The in-silico study demonstrated that B.frutescens phytochemical 4’-Demethylknipholone 2’-β-D-glucopyranoside possesses anti-drug resistance properties and requires further testing in preclinical settings.

关键词： Cancer drug resistance ABC-transporter natural inhibitors Bulbine frutescens MM-GBSA

Numerical Analysis of Phase Change and Container Materials for Thermal Energy Storage in the Storage Tank of Solar Water Heating System

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第2期33卷 408-421页

作者： singh Shailendra ANAND Abhishek SHUKLA Amritanshu SHARMA atul Non-Conventional Energy Laboratory Rajiv Gandhi Institute of Petroleum TechnologyJais Amethi229304India

This study evaluates the effectiveness of phase change materials(PCMs) inside a storage tank of warm water for solar water heating(SWH) system through the theoretical simulation based on the experimental model of S.Canbazoglu et al.The model is explained by five fundamental equations for the calculation of various parameters like the effectiveness of PCMs,the mass of hot water,total heat content,and duration of charging.This study simulated eleven PCMs to analyze their effectiveness like Sodium hydrogen phosphate dodecahydrate(SHPD),OM 37,N-Eicosane(NE),Lauric acid(LA),Paraffin wax(PW),OM 48,Paraffin wax C_(20-33)(PW-C20-33),Sodium acetate trihydrate(SAT),Palmitic acid(PA),Myristic acid(MA),and Stearic acid(SA).Among all PCMs,the SHPD has found the highest value of effectiveness factor of 3.27.So,it is the most recommended PCM for the storage tank of the SWH system.The study also includes the melt fraction analysis of all enumerated PCMs corresponding to container materials of stainless steel,glass,aluminum mixed,tin,aluminum,and copper.This melt fraction analysis is performed by making a coding program in the FORTRAN programming language.Through the analysis,copper container material is found to have high melting rate for all PCMs so it is superior to other container materials.

关键词： theoretical model solar water heating system phase change material effectiveness factor melt fraction

A comprehensive review on pharmacognosy, phytochemistry and pharmacological activities of 8 potent Prunus species of southeast Asia

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2024年第3期44卷 620-628页

作者： Shikha Agrawal Adarsh kumar Ankit kumar singh Harshwardhan singh Suresh Thareja Pradeep kumar Department of Pharmaceutical Sciences and Natural Products Central University of Punjab

Genus Prunus comprising around 430 species is a vast important genus of family Rosaceae, subfamily amygdalaoidae. Among all 430 species, around 19 important species are commonly found in Indian subcontinent due to their broad nutritional and economic importance. Some most common species of genus Prunus are Prunus amygdalus, Prunus persica, Prunus armeniaca, Prunus avium, Prunus cerasus, Prunus cerasoides, Prunus domestica, Prunus mahaleb, etc. A newly introduced species of Prunus i.e Prunus sunhangii is recently discovered which is morphologically very similar to Prunus cerasoides. Plants of Prunus species are short to medium-sized deciduous trees mainly found in the northern hemisphere. In India and its subcontinent,it extends from the Himalayas to Sikkim, Meghalaya,Bhutan, Myanmar etc. Different Prunus species have been extensively studied for their morphological,microscopic, pharmacological and phytoconstituents characteristics. Total phenolic content of Prunus species explains the presence of phenols in high quantity and pharmacological activity due to phenols. Phytochemical screening of species of genus Prunus shows the presence of wide phytoconstituents which contributes in their pharmacological significance and reveals the therapeutic potential and traditional medicinal significance of this genus. Genus Prunus showed a potent antioxidant activity analyzed by 1,1-diphenyl-2-picryl-hydrazyl radical assay. Plant species belonging to the genus Prunus is widely used traditionally for the treatment of various disorders. Some specific Prunus species possess potent anticancer, anti-inflammatory,hypoglycemic etc. activity which makes the genus more interesting for further research and findings. This review is an attempt to summarize the comprehensive study of Prunus species from its distribution, morphological characters to phytoconstituents, and pharmacological activity.

关键词： Prunus Rosaceae antineoplastic agents distribution hypoglycemic agents phytochemistry review

Comparison of rare earths doping(neodymium and samarium) on structural and magnetic properties of Ni-Zn-Bi nanoferrites

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Rare Earths 2024年第3期42卷 534-542,I0004页

作者： Shilpa Taneja Preeti Thakur Dinesh kumar Yassine Slimani atul Thakur NanoLatticeX Amity University HaryanaGururam122413HaryanaIndia Nanotechnology Wing Innovative Science Research SocietyShimla177002India Centre for Nanotechnology Amity University HaryanaGururam122413HaryanaIndia Department of Biophysics Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia School of Electronics and Information Engineering Nanjing University of Information Science&TechnologyNanjing210044China

Excellent magnetic properties in ferrites are required for high-frequency applications and for wastewater treatment. Thus, the present study shows the comparison of magnetic and structural properties of Nd and Sm substituted Ni-Zn-Bi ferrites with the series Ni_(0.5)Zn_(0.5)Bi_(0.04)Nd_(x)Fe_(1.96-x)O_4(with step size 0.002)and Ni_(0.5)Zn_(0.5)Bi_(0.04)Sm_(x)Fe_(1.96-x)O_4(with step size 0.02) prepared using citrate precursor method. The impact of the substitution of rare earth ions(Nd and Sm) on magnetic properties of the synthesized samples is observed using a vibrating sample magnetometer(VSM). The saturation magnetization values enhance considerably from 52 to 58 emu/g for Nd^(3+)ions and 39 to 57 emu/g for Sm^(3+) ions, thus, making these materials magnetically hard. Further, the higher value of coercivity is also observed ranging from133 to 167 Oe for Nd^(3+)ions and 81 to 155 Oe for Sm^(3+) ions. The shape of hysteresis loops indicates a super paramagnetic and ferromagnetic behavior in the obtained samples. The squareness ratio value is<0.5, suggesting the uniaxial anisotropy of particles and hence, these ferrites are suitable for microwaveabsorbing and in permanent magnetic materials. The X-ray diffraction(XRD) pattern shows the formation of pure cubic crystallites, where, lattice parameters range from 0.840 to 0.839 nm and from 0.838to 0.839 nm for Nd^(3+)and Sm^(3+) ions substitution, respectively. The crystallite size ranges between 28.63to 29.89 nm and 18.33 to 26.23 nm, for substitution of Nd^(3+)and Sm^(3+) ions, respectively. Field emission scanning electron microscopy(FESEM) shows the formation of homogeneous grains, whereas, energy dispersive spectrometer(EDS) counts describe the purity of the samples. The Sm concentration x = 0.10has the maximum surface area with value of 42.6 m^(2)/g which proves to be having good data storage application due to high surface area. The zero-field cooled(ZFC) and field cooled(FC) data show that Nddoped Ni-Zn-Bi nanoferrites show superparamagnetic behaviour in the

关键词： Citrate precursor X-ray diffraction Vibrating sample magnetometer Coercivity Field emission scanning electron microscopy Rare earths

Effect of cooling media on bead geometry,microstructure,and mechanical properties of wire arc additive manufactured IN718 alloy

在线全文

学校读者我要写书评

暂无评论

Advances in Manufacturing 2024年第1期12卷 124-149页

作者： Parveen kumar Satish kumar Sharma Ratnesh kumar Raj singh Department of Mechanical Engineering Thapar Institute of Engineering and TechnologyPatialaPunjab147004India

This work aims to present and explore thermal management techniques for the wire arc additive manufacturing(WAAM)of IN718 components.Excessive heat can be mitigated via air or water cooling.In this study,the material was deposited under four different heat-input conditions with air or water cooling.In air cooling,the layer is deposited in a normal atmospheric air environment,whereas with water cooling,the material is deposited inside a water tank by varying the water level.To validate the air and water cooling thermal management techniques,IN718 single-pass and multilayer linear walls were deposited using the bidirectional gas metal arc welding based WAAM setup under four different heat input conditions.During the deposition of single layers,the temperature profiles were recorded,and the geometric and microstructural features were explored.For multilayer wall structures,the mechanical properties(hardness,tensile strength,and elongation)were determined and assessed using the corresponding microstructural features explored through scanning electron microscopy(SEM),energy dispersive spectroscopy(EDS),and electron backscatter diffraction(EBSD)analyses.The microstructure observed through SEM analysis in the building direction was found to be nonhomogenous compared with that in the deposition direction.Moreover,water cooling was found to govern bead characteristics,such as wall width and height.The grain size and anisotropy of the mechanical properties also decreased in the water-cooled case.Hence,water cooling is an economical and efficient method to mitigate excessive heat accumulation in WAAM-deposited IN718.

关键词： Air cooling Water cooling IN718 Bead characteristics Microstructure Electron backscatter diffraction(EBSD)

Thermodynamic properties and phase diagram of quark matter within non-extensive Polyakov chiral SU(3)quark mean field model

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第5期48卷 60-71页

作者： Dhananjay singh Arvind kumar Department of Physics Dr.B R Ambedkar National Institute of Technology JalandharJalandhar–144008PunjabIndia

In the present study,we applied Tsallis non-extensive statistics to investigate the thermodynamic properties and phase diagram of quark matter in the Polyakov chiral SU(3)quark mean field model.Within this model,the properties of the quark matter were modified through the scalar fieldsσ,ζ,δ,χ,vector fieldsω,ρ,ϕ,and Polyakov fieldsΦandΦ¯at finite temperature and chemical potential.Non-extensive effects were introduced through a dimensionless parameter q,and the results were compared to those of the extensive case(q→1).In the non-extensive case,the exponential in the Fermi-Dirac(FD)function was modified to a q-exponential form.The influence of the q parameter on the thermodynamic properties,pressure,energy,and entropy density,as well as trace anomaly,was investigated.The speed of sound and specific heat with non-extensive effects were also studied.Furthermore,the effect of non-extensivity on the deconfinement phase transition as well as the chiral phase transition of u,d,and s quarks was explored.We found that the critical end point(CEP),which defines the point in the(T−μ)phase diagram where the order of the phase transition changes,shifts to a lower value of temperature,TCEP,and a higher value of chemical potential,μCEP,as the non-extensivity is increased,that is,q>1.

关键词： quark matter quark mean field model QCD phase diagram non-extensive statistics

Application of Response Surface Methodology for Analysing and Optimizing the Finned Solar Air Heater

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第3期33卷 985-1009页

作者： Vineet singh Vinod singh YADAV Vaibhav TRIVEDI Manoj kumar Niraj kumar Department of Mechanical Engineering School of Engineering&TechnologyIFTM UniversityMoradabadUttar PradeshIndia Department of Mechanical Engineering NITUttarakhandPauriUttarakhandIndia Department of Electronics and Communication Engineering Jaypee Institute of Information TechnologyNoidaUttar Pradesh201309India

In this research paper,a solar air heater with triangular fins has been experimentally analysed and optimized.Initially,an experimental set-up of a solar air heater having triangular fins has been developed at the location of 28.10°N,78.23°E.The heat transfer rate through fins and fins efficiency has been determined by the Finite Difference Method model equations.The experimental data and modeled data of response parameters have been optimized in MINITAB-17 software by the Response Surface Methodology tool.For creating the response surface design,three input parameters have been selected namely solar intensity,Reynolds number,and fin base-to-height ratio.The range of solar intensity,Reynolds number,and fin base-to-height ratio is 600 to 1000W/m^(2),4000 to 6000,and 0.4 to 0.8 respectively.The response surface design has been analyzed by calculating the outlet temperature,friction factor,Nusselt number,fin efficiency,thermal performance factor,and exergy efficiency.The optimum settings of input parameters:solar intensity is 1000 W/m^(2);Reynolds number is 4969.7,and the fin base to height ratio is 0.6060,on which these response:namely outlet temperature of 92.531℃,friction factor of 0.2350,Nusselt number of 127.761,thermal efficiency of 50.836%,thermal performance factor of 1.4947,and exergy efficiency of 8.762%.

关键词： solar air heater optimization fins exergy response surface methodology air

Nrf2 as a potential target for the treatment of epilepsy

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第9期19卷 1865-1866页

作者： Prince kumar singh Tawfeeq Shekh-Ahmad Institute for Drug Research School of PharmacyFaculty of MedicineThe Hebrew University of JerusalemJerusalemIsrael

Epilepsy is a prevalent chronic brain disorder that is characterized by a persistent predisposition to recurrently generate epileptic seizures and is often associated with cognitive and psychological consequences.Epilepsy affects approximately 65 million individuals,including both males and females of all ages worldwide,and poses a significant burden on patients,their families,and the health system(Vezzani et al.,2019).

关键词： epilepsy Nrf2

Constructing a biofunctionalized 3D-printed gelatin/sodium alginate/chitosan tri-polymer complex scaffold with improvised biological andmechanical properties for bone-tissue engineering

在线全文

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2024年第1期7卷 57-73页

作者： Amit kumar singh Krishna Pramanik Amit Biswas Centre of Excellence in Tissue Engineering Department of Biotechnology and Medical EngineeringNational Institute of TechnologyRourkela 769008India

Sodium alginate(SA)/chitosan(CH)polyelectrolyte scaffold is a suitable substrate for tissue-engineering application.The present study deals with further improvement in the tensile strength and biological properties of this type of scaffold to make it a potential template for bone-tissue regeneration.We experimented with adding 0%–15%(volume fraction)gelatin(GE),a protein-based biopolymer known to promote cell adhesion,proliferation,and differentiation.The resulting tri-polymer complex was used as bioink to fabricate SA/CH/GEmatrices by three-dimensional(3D)printing.Morphological studies using scanning electron microscopy revealed the microfibrous porous architecture of all the structures,which had a pore size range of 383–419μm.X-ray diffraction and Fourier-transform infrared spectroscopy analyses revealed the amorphous nature of the scaffold and the strong electrostatic interactions among the functional groups of the polymers,thereby forming polyelectrolyte complexes which were found to improve mechanical properties and structural stability.The scaffolds exhibited a desirable degradation rate,controlled swelling,and hydrophilic characteristics which are favorable for bone-tissue engineering.The tensile strength improved from(386±15)to(693±15)kPa due to the increased stiffness of SA/CH scaffolds upon addition of gelatin.The enhanced protein adsorption and in vitro bioactivity(forming an apatite layer)confirmed the ability of the SA/CH/GE scaffold to offer higher cellular adhesion and a bone-like environment to cells during the process of tissue regeneration.In vitro biological evaluation including the MTT assay,confocal microscopy analysis,and alizarin red S assay showed a significant increase in cell attachment,cell viability,and cell proliferation,which further improved biomineralization over the scaffold surface.In addition,SA/CH containing 15%gelatin designated as SA/CH/GE15 showed superior performance to the other fabricated 3D structures,demonstrating its potential for use in bone-tissue engineering.

关键词： Scaffold Biomaterial Sodium alginate Chitosan Gelatin 3D printing Tissue engineering