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New role of α phase in the fracture behavior and fracture toughness of a β-type bio-titanium alloy

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International Journal of Minerals,Metallurgy and Materials 2023年第9期30卷 1756-1763页

作者： Ran Wang Xiu Song Lei Wang Yang Liu mitsuo Niinomi Deliang Zhang Jun Cheng Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education)School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Institute for Materials Research Tohoku University2-1-1 KatahiraAoba-kuSendai 980-8577Japan Meijo University 1-501 ShiogamaguchiTempaku-kuNagoya 468-8502Japan Nagoya University Furo-choChikusa-kuNagoya 464-8601Japan Shaanxi Key Laboratory of Biomedical Metal Materials Northwest Institute for Nonferrous Metal ResearchXi’an 710016China

The role of α precipitates formed during aging in the fracture toughness and fracture behavior of β-type bio-titanium alloy Ti–29Nb–13Ta–4.6Zr(TNTZ) was studied. Results showed that the fracture toughness of the TNTZ alloy aged at 723 K decreases to the minimum of 72.07–73.19 kJ·m^(-2)when the aging time is extended to 4–8 h and then gradually increases and reaches 144.89 kJ·m^(-2)after 72 h. The decrease in fracture toughness within the aging time of 4–8 h is caused by the large stress concentration at the tip of acicular α precipitates with a high aspect ratio and the preferential crack propagation along the inhomogeneous acicular α precipitates distributed in “V-shape” and “nearly perpendicular shape”. When the aging time is extended to 8–72 h, the precrack tip is uniformly blunted, and the crack is effectively deflected by α precipitates with multi long axis directions, more high homogeneity, low aspect ratio, and large number density. Analysis of the effect of αprecipitates on the fracture behavior suggested that the number of long axis directions of α precipitates is the key controlling factor for the fracture behavior and fracture toughness of the TNTZ alloy aged for different times.

关键词： fracture toughness Ti-29Nb-13Ta-4.6Zr alloy agedαphase crack tip blunting

Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer

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World Journal of Gastroenterology 2022年第32期28卷 4649-4667页

作者： Tomoyuki Fukami atsushi Shiozaki Toshiyuki Kosuga Michihiro Kudou Hiroki Shimizu Takuma Ohashi Tomohiro Arita Hirotaka Konishi Shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto mitsuo Kishimoto Yukiko Morinaga Eiichi Konishi Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Pathology Kyoto City HospitalKyoto 604-8845Japan Department of Pathology Kyoto Prefectural University of MedicineKyoto 602-8566Japan

BACKGROUND Anoctamin 5(ANO5)/transmembrane protein 16E belongs to the ANO/transmembrane protein 16 anion channel *** comprise a family of plasma membrane proteins that mediate ion transport and phospholipid scrambling and regulate other membrane proteins in numerous cell *** studies have elucidated the roles and mechanisms of ANO5 activation in various cancer ***,it remains unclear whether ANO5 acts as a plasma membrane chloride channel,and its expression and functions in gastric cancer(GC)have not been *** To examine the role of ANO5 in the regulation of tumor progression and clinicopathological significance of its expression in *** Knockdown experiments using ANO5 small interfering RNA were conducted in human GC cell lines,and changes in cell proliferation,cell cycle progression,apoptosis,and cellular movement were *** gene expression profiles of GC cells were investigated following ANO5 silencing by microarray *** staining of ANO5 was performed on 195 primary tumor samples obtained from patients with GC who underwent curative gastrectomy between 2011 and 2013 at our *** Reverse transcription-quantitative polymerase chain reaction(PCR)and western blotting demonstrated high ANO5 mRNA and protein expression,respectively,in NUGC4 and MKN45 *** these cells,ANO5 silencing inhibited cell proliferation and induced *** addition,the knockdown of ANO5 inhibited G1-S phase progression,invasion,and *** results of the microarray analysis revealed changes in the expression levels of several cyclin-associated genes,such as CDKN1A,CDK2/4/6,CCNE2,and E2F1,in ANO5-depleted NUGC4 *** expression of these genes was verified using reverse transcription-quantitative *** staining revealed that high ANO5 expression levels were associated with a poor *** analysis identified high ANO5 expression as an independent prognostic fa

关键词： Anoctamin 5 Gastric cancer Cell cycle G1/S checkpoint Cell proliferation

THREE-BODY SCATTERING CROSS SECTION AND SINGULARITIES OF THE T-MATRIX

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原子与分子物理学报 1990年第4期7卷 1614-1617页

作者： atsushi Ichimura Institute of Space and Astronautical Science Yoshinodai 3-l-1 Sagamihara-shiKanagawa229 Japan

Cross section is a fundamental concept in collision theory. This concept hasbeen formulated for binary collisions,i.e.,collisions between two *** far as binary collisions are concerned,one can describe withdifferential and integrated cross sections any elementary processes includingdissociation and rearrangement as well as elastic and inelastic *** isbelieved,however that besides binary collisions there are three-body colli-sions,i.e.,collisions among three incident *** it is of

关键词：三体碰撞碰撞截面下矩阵奇异性

Photonic MPLS Network Technologies to Create Bandwidth-Abundant IP Networks

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光学学报 2003年第S1期23卷 665-666页

作者： atsushi Watanabe NTT Network Innovation Laboratories NTT Corporation 1-1 Hikari-no-oka Yokosuka Kanagawa Japan.

This paper describes the prototypes of the Photonic MPLS router that can create bandwidth-abundant IP networks in a cost-effective manner. The characteristics of and recent advances in these prototypes are also descri... 详细信息

关键词： MPLS on et in OLSP Photonic MPLS Network Technologies to Create Bandwidth-Abundant IP Networks IP

Roles of galectins in inflammatory bowel disease

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World Journal of Gastroenterology 2008年第33期14卷 5133-5137页

作者： Akira Hokama Emiko Mizoguchi atsushi Mizoguchi Department of Medicine and Therapeutics (First Department of Internal Medicine) Control and Prevention of Infectious Disease Faculty of Medicine University of the RyukyusOkinawa 903-0215 Japan Gastrointestinal Unit Department of Medicine Massachusetts General Hospital Harvard Medical SchoolBoston MA 02114 United States Center for the Study of Inflammatory Bowel Disease Massachusetts General Hospital Harvard Medical School Boston MA 02114 United States Experimental Pathology Unit Department of Pathology Massachusetts General Hospital Harvard Medical SchoolBoston MA 02114 United States

Protein/carbohydrate interactions through specific protein families termed lectin control essential biological processes. Galectins, a family of animal lectins defined by shared amino acid sequence with affinity for β-galactosides, appear to be functionally polyvalent in a wide range of biological activity. Recent studies have identified immunoregulatory roles of galectins in intestinal inflammatory disorders. Galectin-1 and galectin -2 contribute to the suppression of intestinal inflammation by the induction of apoptosis of activated T cells, whereas galectin-4 is involved in the exacerbation of this inflammation by specifically stimulating intestinal CD4+ T cells to produce IL-6. We review how different members of the galectins provide inhibitory or stimulatory signals to control intestinal immune response under intestinal inflammation.

关键词： Galectin Inflammatory bowel disease Crohn's disease Ulcerative colitis Pathogenesis Apoptosis Glycosylation

Holographic 3D imaging through random media: methodologies and challenges

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Light(Advanced Manufacturing) 2022年第2期3卷 123-135页

作者： mitsuo Takeda Wolfgang Osten Eriko Watanabe Center for Optical Research and Education Utsunomiya University7-1-2YotoUtsunomiyaTochigi321-8585Japan Institut für Technische Optik Universität StuttgartPfaffenwaldring 970569 StuttgartGermany The University of Electro-Communications 1-5-1ChofugaokaChofuTokyo 182-8585Japan

Imaging through random media continues to be a challenging problem of crucial importance in a wide range of fields of science and technology,ranging from telescopic imaging through atmospheric turbulence in astronomy to microscopic imaging through scattering tissues in *** meet the scope of this anniversary issue in holography,this review places a special focus on holographic techniques and their unique functionality,which play a pivotal role in imaging through random *** review comprises two *** first part is intended to be a mini tutorial in which we first identify the true nature of the problems encountered in imaging through random *** then explain through a methodological analysis how unique functions of holography can be exploited to provide practical solutions to *** second part introduces specific examples of experimental implementations for different principles of holographic techniques,along with their performance results,which were taken from some of our recent work.

关键词： Holography Imaging Scattering Random Media Statistical Optics Coherence Speckles Correlation Digital Holography

Methane dehydroaromatization over Mo-modified H-MFI for gas to liquid catalysts

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Journal of Environmental Sciences 2009年第6期21卷 736-740页

作者： Hirofumi Aritani Hiromi Shibasaki Hitoshi Orihara atsushi Nakahira Department of Applied Chemistry Saitama Institute of Technology Graduate School of Engineering Osaka Prefecture University

For direct gas to liquid（GTL）,a novel process producing energy sources for methane dehydroaromatization is *** MoO3 on H-MFI zeolite shows the high catalytic capacity and a selective activity for dehydroaromatization of methane to benzene at 973 K in a fixed bed *** the other hand,deactivation by coke on the active sites in all the catalysts is formed during the reaction.H2 co-feed suppressed the deactivation,which is probably due to the decrease in coking *** K-edge X-ray absorption fine structure（XAFS） results showed the formation of dispersed Mo2C species with low crystallinity after *** LIII-edge XANES（X-ray absorption near-edge structure） indicated the formation of active Mo species including Mo2C and Mo-oxycarbide（MoOxCy）,where the redox state should be independent in the absence/presence of *** is concluded that Mo-oxycarbide species act as highly active species,and their stability affected the durable activity in the presence of H2.

关键词： direct gas to liquid methane dehydroaromatization Mo/H-MFI L-XANES K-XAFS

Selective synthesis of carbon monoxide via formates in reverse water–gas shift reaction over alumina-supported gold catalyst

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Journal of Energy Chemistry 2016年第2期25卷 304-308页

作者： Nobuhiro Ishito Kenji Hara Kiyotaka Nakajima atsushi Fukuoka Institute for Catalysis Hokkaido University Graduate School of Chemical Sciences and Engineering Hokkaido University School of Engineering Tokyo University of Technology

Thermal decomposition of formic acid on SiO2, CeO2 and γ-Al2O3 was studied as an elementary step of reverse water–gas shit reaction（RWGS） over supported Au catalysts. γ-Al2O3 showed the highest CO selectivity among the tested oxides in the decomposition of formic acid. Infrared spectroscopy showed the formation of four formate species on γ-Al2O3： three η~1-type and one μ~2-type species, and these formates decomposed to CO at 473 K or higher. Au-loaded γ-Al2O3 samples were prepared by a depositionprecipitation method and used as catalysts for RWGS. The supported Au catalyst gave CO with high selectivity over 99% from CO2 and H2, which is attributed to the formation of formates on Au and subsequent decomposition to CO on γ-Al2O3.

关键词： Reverse water–gas shift reaction Carbon dioxide Hydrogen Formate Carbon monoxide Alumina Gold

Profile and removal of endocrine disrupting chemicals by using an ER/AR competitive ligand binding assay and chemical analyses

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Journal of Environmental Sciences 2009年第7期21卷 900-906页

作者： Ze-hua Liu Mamoru Ito Yoshinori Kanjo atsushi Yamamoto Department of Urban Engineering Graduate School of Engineering Osaka City University 3-3-138 Sugimoto Sumiyoshi-ku Osaka 558-8585 Japan Osaka City Institute of Public Health and Environmental Sciences 8-34 Tojo-cho Tennoji-ku Osaka 543-0026 Japan

An estrogen receptor （ER）/androgen receptor （AR） ligand competitive binding assay （ER/AR-binding assay） and chemical analyses were used to evaluate the endocrine disrupting chemicals （EDCs） behavior of two municipal wastewater treatment plants （WWTPs）（K and S）. In the influents, estrone （E 1）, androsterone （A）, androstenedione （AD）, BPA （bisphenol A）, NP （nonylphenol） and daidzein （DZ） were detected in high amounts with subsequent 24 h-average concentrations of 350, 1000, 29, 1300, 3900, and 5700 ng/L in K-WWTP and of 310, 620, 59, 1600, 2600, and 8400 ng/L in S-WWTP. The estrogenic （androgenic） activity as 17β-estradiol （E2） equivalents （EEQ） or testosterone （Te） equivalents （TEQ） was consequently 620 ng E2/L （570 ng Te/L） and 580 ng E2/L （800 ng Te/L） for the two WWTPs. The removal efficiencies of the above mentioned sole target chemicals were 51%-100% for K-WWTP and 55.6%-100% for S-WWTP. The removal efficiencies of EEQ were about 73% for both WWTPs, while the removal efficiencies of TEQ were 62.1% for K-WWTP and 98.4% for S-WWTP. In addition, chemical-derived EEQ were about 1.2%-52.4% of those by ER-binding assay for K-WWTP and the corresponding ratios were 1.3%-83.3% for S-WWTP, while chemical derived TEQ were less than 3% of values measured by the AR-binding assay for both WWTPs.

关键词： bioassays ER-binding AR-binding 17β-estradiol equivalents testosterone equivalents