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Significance of timing of therapeutic line on effectiveness of nivolumab for metastatic renal cell carcinoma

Current Urology 2023年第1期17卷 52-57页

作者： Jun Teishima Daiki Murata Kazuma Yukihiro Yohei Sekino Shogo Inoue Tetsutaro Hayashi Koji Mita Yasuhisa Hasegawa Masao Kato Mitsuru Kajiwara Masanobu Shigeta Satoshi Maruyama Hiroyuki Moriyama Seiji Fujiwara Akio matsubara Department of Urology Graduate School of Biomedical and Health SciencesHiroshima UniversityHiroshimaJapan Department of Urology Hiroshima-City Asa Citizens HospitalHiroshimaJapan Department of Urology Fukuyama Medical CenterFukuyamaJapan Department of Urology Hiroshima General HospitalHatsukaichiJapan Department of Urology Hiroshima Prefectural HospitalHiroshimaJapan Department of Urology Kure Medical Center and Chugoku Cancer CenterKureJapan Department of Urology Miyoshi Central HospitalMiyoshiJapan Department of Urology Onomichi General HospitalOnomichiJapan Department of Urology Higashi-Hiroshima Medical Center Higashi-HiroshimaJapan

Objectives:This study aimed to clarify the significance of therapeutic timing on the effectiveness of nivolumab for treating metastatic renal cell *** and methods:Fifty-eight patients with metastatic renal cell carcinoma treated with nivolumab monotherapy were retrospectively *** who were treated with nivolumab as second-line therapy were included in the second-line group,while the others were included in the later-line *** clinicopathological characteristics,effects of nivolumab,and prognoses of these groups were ***:Twenty and thirty-eight patients were included in the second-line and later-line groups,*** were no significant differences in the distribution of International Metastatic Renal Cell Carcinoma Database Consotium risk and other clinicopathological characteristics between the 2 *** proportion of patients whose objective best response was progressive disease in the second-line group was significantly lower than that in the later-line group(15%vs.50%,p=0.0090).The 50%progression-free survival with nivolumab in the second-line group was significantly better than that in the later-line group(not reached and 5 months,p=0.0018).Multivariate analysis showed that the second-line setting was an independent predictive factor for better progression-free survival(p=0.0028,hazard ratio=0.108).The 50%overall survival after starting nivolumab in the second-line and later-line groups was not reached and 27.8 months,respectively(p=0.2652).Conclusions:The therapeutic efficacy of nivolumab as second-line therapy is expected to be better than that of later therapy.

关键词： Immune checkpoint inhibitor Metastatic renal cell carcinoma Nivolumab Prognostic factor Second-line treatment

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Maintenance treatment with infliximab for ulcerative ileitis after intestinal transplantation: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5270-5279页

作者： Takumi Fujimura Yohei Yamada Tomoshige Umeyama Yumi Kudo Hiroki Kanamori Teizaburo Mori Takahiro Shimizu Mototoshi Kato Miho Kawaida Naoki Hosoe Yasushi Hasegawa Kentaro matsubara Naoki Shimojima Masahiro Shinoda Hideaki Obara Makoto Naganuma Yuko Kitagawa Ken Hoshino Tatsuo Kuroda Department of Pediatric Surgery National Saitama HospitalWako ShiSaitama 351-0102Japan Department of Pediatric Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Pathology Keio University School of MedicineTokyo 160-8582Japan Center for Diagnostic and Therapeutic Endoscopy Keio University School ofMedicineTokyo 160-8582Japan Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Digestive Diseases Center International University of Health and WelfareMita HospitalTokyo 108-8329Japan Department of Gastroenterology and Hepatology Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND Evidence has been published on the successful applications of the anti-tumor necrosis factor alpha antibody infliximab,such as induction therapy,salvage treatment for acute cellular rejection,and treatment for chronic ulcerative inflammation,in intestinal transplant ***,the optimal protocol for the effective use of infliximab remains largely undetermined due to scarcity of available clinical *** report a continuative application of infliximab as maintenance therapy for recurrent chronic ulcerative ileitis in a recipient of isolated intestinal transplantation(ITx).CASE SUMMARY The patient was a 11-year-old boy with intestinal motility disorder classified as a hypogenic type of intestinal *** patient underwent living-donor related intestinal *** immunosuppression regimen consisted of daclizumab,tacrolimus,and *** he did not show rejection while on tacrolimus monotherapy,routine screening endoscopy showed several ulcerative lesions in the distal end of the graft 2 years after the intestinal *** work up to evaluate the progression of anemia revealed stenosis with ulcerative inflammatory changes and multiple longitudinal ulcers in the *** the endoscopic findings suggested ulcerative lesions in Crohn’s disease,infliximab treatment was *** with infliximab and a small dose of oral prednisolone afforded successful withdrawal of total parenteral nutrition and maintenance of a well-functioning graft without infectious complications for 5 years since the administration of the first dose of *** Infliximab is effective as maintenance therapy for recurrent chronic ulcerative ileitis in an isolated ITx patient.

关键词： Intestinal transplantation Chronic ulcer Infliximab Crohn’s disease Tumor necrosis factor alpha Case report

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肿瘤患者脑局部葡萄糖代谢变化的SPM分析

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中国医学影像技术 2004年第3期20卷 455-457页

作者：袁志斌 matsubara K Higuchi T Oriuchi N Endo K 上海交通大学上海市第六人民医院核医学科上海200233 日本群马大学医学部核医学科

目的　用1 8F 脱氧葡萄糖 (1 8F FDG)PET显像和SPM软件研究分析肿瘤患者脑局部葡萄糖代谢的变化。方法　研究对象为 2 0例确诊为无脑疾患的恶性肿瘤患者和 2 0例健康志愿者。1 8F FDG PET显像后 ,用统计参数显像 (SPM)法比较分析肿瘤患... 详细信息

目的　用1 8F 脱氧葡萄糖 (1 8F FDG)PET显像和SPM软件研究分析肿瘤患者脑局部葡萄糖代谢的变化。方法　研究对象为 2 0例确诊为无脑疾患的恶性肿瘤患者和 2 0例健康志愿者。1 8F FDG PET显像后 ,用统计参数显像 (SPM)法比较分析肿瘤患者和健康志愿者脑葡萄糖代谢的差别。结果　SPM分析显示肿瘤患者的的脑岛、松果体、顶叶皮质、小脑蚓部、颞叶和前额叶都表现为不同程度的葡萄糖代谢低下。结论　肿瘤病人的抑郁表现与脑葡萄糖代谢降低相关 ,SPM方法是一种客观和直观的分析脑功能性变化的工具。

关键词：肿瘤 ^18F-脱氧葡萄糖抑郁症正电子发射断层统计参数图

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Monitoring salivary amylase activity is useful for providing timely analgesia under sedation

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World Journal of Gastrointestinal Endoscopy 2014年第6期6卷 240-247页

作者： Masaya Uesato Yoshihiro Nabeya Takashi Akai Masahito Inoue Yoshiyuki Watanabe Daisuke Horibe Hiroshi Kawahira Hideki Hayashi Hisahiro matsubara Department of Frontier Surgery Chiba University Graduate School of Medicine Division of Gastroenterological Surgery Chiba Cancer Center Department of Endoscopic Diagnostics and Therapeutics Chiba University Hospital Research Center for Frontier Medical Engineering Chiba University

AIM:To detect the criteria and cause of elevated salivary amylase activity(sAMY)in patients undergoing endoscopic submucosal dissection(ESD)under ***:A total of 41 patients with early gastric cancer removed via ESD under deep sedation(DS)were *** perioperative sAMY,which was shown as sympathetic excitements(SE),was *** time at which a patient exhibited a relatively increased rate of sAMY compared with the preoperative baseline level(IR,%)≥100%(twice the actual value)was assumed as the moment when the patient received *** the 41 patients,we focused on 14 patients who exhibited an IR≥100% at any time that was associated with sAMY elevation during ESD(H-group)and examined whether any particular endoscopic procedures can cause SE by simultaneously monitoring the sAMY *** a patient demonstrated an elevated sAMY level above twice the baseline level,the endoscopic procedure was immediately *** the impossible case of discontinuance,analgesic medicines were *** study was performed ***:A total of 26 episodes of sAMY eruption were considered moments of SE in the *** baseline level of sAMY significantly increased in association with an IR of>100% at 5 min,with a significant difference(IR immediately before elevation/IR at elevation of sAMY=8.72±173/958±1391%,P<0.001).However,effective intervention decreased the elevated sAMY level immediately within only 5 min,with a significant difference(IR at sAMY elevation/immediately after intervention=958±1391/476±1031,P<0.001).The bispectral indices,systolic blood pressure and pulse rates,which were measured at the same time,remained stable throughout the *** endoscopic insertion or over insufflation was performed during 22 of the 26 *** of the gastric wall tension and/or the administration of analgesic medication resulted in the immediate recovery of the elevated sAMY level,independent of body ***:By detecting tw

关键词： Salivary amylase activity Endoscopic submucosal dissection Analgesia Anesthesia Sedation Sympathetic excitement Gastric wall tension

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ACADEX小学(第一、第二栋教室),金沙萨,刚果民主共和国

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世界建筑 2011年第1期 96-101页

作者： Keio University SFC Hironori matsubara Laboratory 庆应义塾大学SFC松原弘典研究室

在刚果自建学校此契机缘于大学的一个小型交流,一位刚果教师不久将回国,他想回老家建造并经营一所学校。刚果民主共和国长期连续内战,但西部金沙萨相对安定。因基础设施不完善,初等教育大体上依靠民间。ACADEX小学也是私立学校之一。

关键词：刚果民主共和国小学金沙教室私立学校基础设施初等教育

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Investigation of <i>β</i>-Cryptoxanthin Fatty Acid Ester Compositions in Citrus Fruits Cultivated in Japan

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Food and Nutrition Sciences 2013年第9期4卷 98-104页

作者： Yusuke Wada Atsuki matsubara Takato Uchikata Yugo Iwasaki Satoshi Morimoto Katsuta Kan Tetsuya Ookura Eiichiro Fukusaki Takeshi Bamba Department of Biotechnology Graduate School of Engineering Osaka University Osaka Japan Food Function Division National Food Research Institute National Agricultural and Food Research Organization Tsukuba Japan. Food Research Center Ehime Institute of Industrial Technology Matsuyama Japan Graduate School of Bioagricultural Sciences Nagoya University Nagoya Japan Omishima Fruits Processing Co. Ltd. Imabari Japan

In this study, a catalog of β-cryptoxanthin (βCX) and its fatty acid esters (βCXFAs) in citrus fruits were constructed. The peel and pulp of citrus fruits from nine Japanese cultivars and one foreign cultivar were surveyed by supercritical fluid chromatography/triple quadrupole mass spectrometry (SFC/QqQMS). In each citrus sample, the major components were βCX and its laurate ester, myristate ester, palmitate ester, and oleate ester. However, the composition ratio of βCXFA varied with the citrus breed and between the pulp and the peel of the fruit in most cultivars. The SFC/QqQMS system could be used to obtain new information about βCXs and carry out further discussion on the feature and tendency of each citrus variety.

关键词： β-Cryptoxanthin Fatty Acid Ester Supercritical Fluid Chromatography

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Visualization of Bio-Structures Using Coherent X-Ray Diffraction

Visualization of Bio-Structures Using Coherent X-Ray Diffrac...

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亚洲晶体学联合大会

作者： Yoshinori Nishino Kazuhiro Maeshima Naoko Imamoto Ryuta Hirohata Eiichiro matsubara Yukio Takahashi Tetsuya Ishikawa RIKEN SPring-8 Center 1-1-1 KoutoSayo-choSayo-gunHyogo 679-5148Japan Structural Biology Center National Institute of GeneticsShizuoka 411-8540Japan Cellular Dynamics Laboratory RIKENSaitama 351-0198Japan Graduate School of Engineering Osaka UniversityOsaka 565-0871Japan

＜正＞We report our studies on X-ray diffraction microscopy （XDM） for biological samples. XDM requires no lenses, and a sample image is directly reconstructed from the coherent diffraction data. It is ideal X-ray ph...

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Endoscopic ultrasound-guided fine needle aspiration in the differentiation of type 1 and type 2 autoimmune pancreatitis

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World Journal of Gastroenterology 2012年第29期18卷 3883-3888页

作者： Takuya Ishikawa Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Hirosh matsubara Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Masanao Nakamura Ryoji Miyahara Naoki Ohmiya Hidemi Goto Yoshiki Hirooka Department of Gastroenterology Nagoya University Graduate School of Medicine65 Tsuruma-choShowa-kuNagoya 466-8550Japan Department of Endoscopy Nagoya University Hospital65 Tsuruma-choShowa-kuNagoya 466-8550Japan

AIM:To investigate the usefulness of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) in the differentiation of autoimmune pancreatitis(AIP).METHODS:We retrospectively reviewed 47 of 56 AIP patients who underwent EUS-FNA and met the Asian diagnostic *** 47 EUS-FNA specimens,we evaluated the presence of adequate material and characteristic features of lymphoplasmacytic sclerosing pancreatitis(LPSP) and idiopathic duct-centric pancreatitis(IDCP) mentioned in the International Consensus Diagnostic Criteria and examined if these findings make a contribution to the differential diagnosis of type 1 and type 2 AIP.A disposable 22-gauge needle was used for ***:Adequate specimens including pancreatic tissue for differentiating AIP from cancer were obtained from 43 of 47 patients who underwent ***-FNA was performed from the pancreatic head in 21 cases,which is known to be technically difficult when performed by core biopsy;there was no significant difference in the results compared with pancreatic *** of 47 patients met level 1 findings of LPSP and 5 patients met level 2 findings of *** one met level 1 findings of IDCP,but 3 patients met level 2 findings of *** 10 seronegative cases,2 cases were diagnosed with "definitive type 1 AIP",and 3 cases were diagnosed with "probable type 2 AIP" when considering both the level 2 histological findings and response to ***:EUS-FNA is useful in the differentiation of type 1 and type 2 AIP,particularly in seronegative cases.

关键词： Autoimmune pancreatitis Endoscopic ultrasound-guided fine needle aspiration Idiopathic duct centric pancreatitis Lymphoplasmacytic sclerosing pancreatitis Pancreatic cancer

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Polysomnographic assessment of respiratory disturbance during deep propofol sedation for endoscopic submucosal dissection of gastric tumors

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World Journal of Gastrointestinal Endoscopy 2018年第11期10卷 340-347页

作者： Ryuma Urahama Masaya Uesato Mizuho Aikawa Yukiko Yamaguchi Koichi Hayano Tomoaki Matsumura Makoto Arai Reiko Kunii Shiroh Isono Hisahiro matsubara Department of Frontier Surgery Chiba University Graduate School of Medicine Department of Gastroenterology Chiba University Graduate School of Medicine Department of Medical Oncology Chiba University Graduate School of Medicine Staff of Clinical Laboratory Chiba University Hospital Department of Anesthesiology Chiba University Graduate School of Medicine

AIM To investigate that polysomnographic monitoring can accurately evaluate respiratory disturbance incidence during sedation for gastrointestinal endoscopy compare to pulse oximetry *** This prospective observational study included 10 elderly patients with early gastric cancer undergoing endoscopic submucosal dissection(ESD) under propofol sedation. Apart from routine cardiorespiratory monitoring, polysomnography measurements were acquired. The primary hypothesis was tested by comparing the apnea hypopnea index(AHI), defined as the number of apnea and hypopnea instances per hour during sedation, with and without hypoxemia; hypoxemia was defined as the reduction in oxygen saturation by ≥ 3% from *** Polysomnography(PSG) detected 207 respiratory disturbances in the 10 patients. PSG yielded a significantly greater AHI(10.44 ± 5.68/h) compared with pulse oximetry(1.54 ± 1.81/h, P < 0.001), thus supporting our hypothesis. Obstructive AHI(9.26 ± 5.44/h) was significantly greater than central AHI(1.19 ± 0.90/h, P < 0.001). Compared with pulse oximetry, PSG detected the 25 instances of respiratory disturbances with hypoxemia 107.4 s earlier on *** Compared with pulse oximetry, PSG can better detect respiratory irregularities and thus provide superior AHI values, leading to avoidance of fatal respiratory complications during ESD under propofol-induced sedation.

关键词： Polysomnography Hypoxemia Propofol Endoscopic submucosal dissection Pulse oximetry Sedation

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Colon perforation due to antigenemia-negative cytomegalovirus gastroenteritis after liver transplantation: A case report and review of literature

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World Journal of Gastroenterology 2019年第15期25卷 1899-1906页

作者： Takahiro Yokose Hideaki Obara Masahiro Shinoda Yutaka Nakano Minoru Kitago Hiroshi Yagi Yuta Abe Yohei Yamada Kentaro matsubara Go Oshima Shutaro Hori Sho Ibuki Hisanobu Higashi Yuki Masuda Masanori Hayashi Miho Kawaida Takehiko Mori Takumi Fujimura Ken Hoshino Kaori Kameyama Tatsuo Kuroda Yuko Kitagawa Department of Surgery Keio University School of Medicine Department of Pathology Keio University School of Medicine Division of Hematology Department of Medicine Keio University School of Medicine

BACKGROUND Cytomegalovirus(CMV) remains a critical complication after solid-organ transplantation. The CMV antigenemia(AG) test is useful for monitoring CMV infection. Although the AG-positivity rate in CMV gastroenteritis is known to be low at onset, almost all cases become positive during the disease course. We treated a patient with transverse colon perforation due to AG-negative CMV gastroenteritis, following a living donor liver transplantation(LDLT).CASE SUMMARY The patient was a 52-year-old woman with decompensated liver cirrhosis as a result of autoimmune hepatitis who underwent a blood-type compatible LDLT with her second son as the donor. On day 20 after surgery, upper and lower gastrointestinal endoscopy(GE) revealed multiple gastric ulcers and transverse colon ulcers. The biopsy tissue immunostaining confirmed a diagnosis of CMV gastroenteritis. On day 28 after surgery, an abdominal computed tomography revealed transverse colon perforation, and simple lavage and drainage were performed along with an urgent ileostomy. Although the repeated remission and aggravation of CMV gastroenteritis and acute cellular rejection made the control of immunosuppression difficult, the upper GE eventually revealed an improvement in the gastric ulcers, and the biopsy samples were negative for CMV. The CMV-AG test remained negative, therefore, we had to evaluate the status of the CMV infection on the basis of the clinical symptoms and *** This case report suggests a monitoring method that could be useful for AGnegative CMV gastroenteritis after a solid-organ transplantation.

关键词： Cytomegalovirus gastrointestinal disease Colon perforation Antigenemia negative Liver transplantation Case report

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