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设计新潮 2009年第1期 66-71页

作者：松原弘典 matsubara Hiranari（摄影）李俊（翻译）刘迪北京松原弘典建筑设计咨询有限公司执行董事庆应义墪大学SFC副教授

在地震发生后仅仅4个月里就实现了这座建筑的全面完工。用纸管、木板等可再生材料就地取材，中日志愿者全程同心协作，这些都令这次救援活动意义深远……

关键词：小学成都设计可再生材料就地取材救援活动志愿者

Postoperative recurrence of an IPMN of the pancreas with a fistula to the stomach

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World Journal of Gastrointestinal Endoscopy 2010年第10期2卷 349-351页

作者： Masaya Uesato Yoshihiro Nabeya Shinichi Miyazaki Taito Aoki Takashi Akai Kiyohiko Shuto Tohru Tanizawa Masaru Miyazaki Hisahiro matsubara Department of Frontier Surgery Chiba University Graduate School of MedicineChiba 260-8677Japan Makuhari Gastrointestinal Clinic Chiba 262-0033Japan Department of Pathology Chiba University HospitalChiba 260-8677Japan Department of General Surgery Chiba University Graduate School of MedicineChiba 260-8677Japan

We report on a case of a 74 year old man who was diagnosed with a recurrence of non-invasive carcinoma of intraductal papillary mucinous neoplasm (non-invasive IPMN) by postoperative gastroscopy (GS). A pylorus preserving pancreatico duodenectomy for IPMN in the pancreatic head was performed. A histopathological study revealed non-invasive adenocarcinoma. At first,the local recurrence of the tumor around the superior mesenteric artery circumference was diagnosed and disappeared with gemcitabine. Later,the GS showed the elevated lesion with mucin hypersecretion in the remnant stomach. The lesion had a central dip and a fistula common to the pancreas was confirmed on fisterography. We diagnosed a recurrence of IPMN and administered chemotherapy again. However,he died of his original illness. There are no reports of postoperative recurrence of IPMN checked by GS. It should be remembered that the elevated lesion of the remnant stomach is considered as one of the recurrent patterns of IPMN.

关键词： Intraductal papillary mucinous neoplasm Recurrence Fistula Stomach Endoscopy

Prognostic Value of SUVmax of <sup>18</sup>F-FDG PET/CT in Early Stage Breast Cancer with No LN Metastasis

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Open Journal of Medical Imaging 2017年第3期7卷 112-123页

作者： Ryusuke Murakami Yoshimitsu Fukushima Hitomi Tani Kotomi Iwata Shinichiro Kumita Maki Nakai Tomoko Kurita Keiko Yanagihara Hiroyuki Takei Miyuki matsubara Department of Radiology Nippon Medical School Hospital Tokyo Japan Department of Breast Surgery Nippon Medical School Hospital Tokyo Japan Division of Diagnostic Pathology Nippon Medical School Hospital Tokyo Japan

Purpose: To investigate the correlation between SUVmax of FDG-PET/CT and pathological findings including prognostic factors in early-stage T1-T2 breast cancer patients with no LN metastasis. Materials and Methods: This retrospective study investigated 75 patients (mean age 58.9 years;age range 30 - 82 years) with invasive breast cancer who underwent FDG-PET/CT for preoperative staging. All patients underwent subsequent surgery without prior neoadjuvant chemotherapy or endocrine therapy, and those who were confirmed to have T1- or T2-stage by histopathology with no LN metastasis were included. Two patients who had no perceptible FDG accumulation on PET/CT scans were excluded. The correlations between the SUVmax of the tumor and the pathological and immunohistochemical data were evaluated. Results: The mean SUVmax for the total 73 tumors was 5.46 ± 4.05. The mean SUVmax was 3.95 ± 3.28 for the T1 stage group (n = 36) and 7.23 ± 4.10 (p p p p = 0.008), and high Ki-67 status (p < 0.001), respectively. Conclusion: In T1-T2 breast cancer with no LN metastasis, the SUVmax of FDG-PET/CT had significant positive relationships with several prognostic parameters of pathological status. Even in early-stage breast cancer patients, pretreatment FDG-PET/CT is useful for predicting malignant behavior and prognosis).

关键词： Breast Cancer Molecular Subtype Prognosis PET/CT SUVmax

Amebic liver abscess by Entamoeba histolytica

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World Journal of Clinical Cases 2022年第36期10卷 13157-13166页

作者： Daisuke Usuda Shiho Tsuge Riki Sakurai Kenji Kawai Shun matsubara Risa Tanaka Makoto Suzuki Hayabusa Takano Shintaro Shimozawa Yuta Hotchi Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Amebic liver abscesses(ALAs)are the most commonly encountered extraintestinal manifestation of human invasive amebiasis,which results from Entamoeba histolytica(***)spreading *** can be complicated by liver abscess in 9%of cases,and ALAs led to almost 50000 fatalities worldwide in *** there have been fewer and fewer cases in the past several years,ALAs remain an important public health problem in endemic *** causes both amebic colitis and liver abscess by breaching the host’s innate defenses and invading the intestinal *** often enter the circulatory system,where they are filtered in the liver and produce abscesses,and develop into severe invasive diseases such as *** clinical presentation can appear to be colitis,including upper-right abdominal pain accompanied by a fever in ALA *** diagnosis requires nonspecific liver imaging as well as detecting *** antibodies;however,these antibodies cannot be used to distinguish between a previous infection and an acute ***,diagnostics primarily aim to use PCR or enzyme-linked immunosorbent assay to detect *** can be treated medically,and percutaneous catheter drainage is only necessary in approximately 15%of *** indicated treatment is to administer an amebicidal drug(such as tinidazole or metronidazole)and paromomycin or other luminal cysticidal agent for clinical *** is good with almost universal *** which diagnostic methods are most efficacious will necessitate further analysis of similar clinical cases.

关键词： Amebic liver abscess Entamoeba histolytica Polymerase chain reaction Enzyme-linked immunosorbent assay Percutaneous catheter drainage Amebicidal drug

Hemorrhagic shock due to submucosal esophageal hematoma along with mallory-weiss syndrome:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9911-9920页

作者： Jiro Oba Daisuke Usuda Shiho Tsuge Riki Sakurai Kenji Kawai Shun matsubara Risa Tanaka Makoto Suzuki Hayabusa Takano Shintaro Shimozawa Yuta Hotchi Kenki Usami Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima-ku 177-8521TokyoJapan Faculty of Medicine Juntendo UniversityBunkyo-ku 113-8421TokyoJapan

BACKGROUND Esophageal submucosal hematoma is a rare *** the exact etiology remains uncertain,vessel fragility with external factors is believed to have led to submucosal bleeding and hematoma formation;the vessel was ruptured by a sudden increase in pressure due to nausea,and the hematoma was enlarged by antiplatelet or anticoagulant *** conditions are rare,with a better *** present the first known case of submucosal esophageal hematoma-subsequent hemorrhagic shock due to Mallory-Weiss *** SUMMARY A 73-year-old female underwent endovascular treatment for an unruptured cerebral *** patient received aspirin and clopidogrel before surgery and heparin during surgery,and was well during the *** hours after returning to the ICU,she complained of chest discomfort,vomited 500 m L of fresh blood,and entered hemorrhagic *** submucosal hematoma with Mallory-Weiss syndrome was diagnosed through an endoscopic examination and computed *** addition to a massive fluid and erythrocyte transfusion,we performed a temporary compression for hemostasis with a Sengstaken-Blakemore(S-B)***,she became hemodynamically *** postoperative day 1,we performed an upper gastrointestinal endoscopy and confirmed no expansion of the hematoma nor any recurring bleeding;therefore,we removed the S-B tube and clipped the gastric mucosal laceration at the esophagogastric *** started oral intake on postoperative day *** patient made steady progress,and was discharged on postoperative day *** We present the first known case of submucosal esophageal hematoma subsequent hemorrhagic shock due to Mallory-Weiss syndrome.

关键词： Esophageal submucosal hematoma Hemorrhagic shock Mallory-Weiss syndrome Antithrombotic therapy Anticoagulant therapy Case report

Evaluation of Effective Dose Using the k-Factor of Optimal Scan Range for CT Examination

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Open Journal of Radiology 2015年第3期5卷 172-148页

作者： Masanao Kobayashi Yasuki Asada Kosuke matsubara Tomonobu Haba Yuta Matsunaga Ai Kawaguchi Kazuhiro Katada Hiroshi Toyama Kichiro Koshida Ryoichi Kato Shouichi Suzuki Graduate School of Health Sciences Fujita Health University Toyoake Japan Division of Medical Sciences Graduate School of Medical Sciences Kanazawa University Kanazawa Japan Department of Radiology Fujita Health University Hospital Toyoake Japan Department of Imaging Nagoya Kyoritsu Hospital Nagoya Japan Department of Radiology Toyota Memorial Hospital Toyota Japan Department of Radiology Fujita Health University School of Medicine Toyoake Japan

The American College of Radiology opened the computed tomography (CT) dose index registry (DIR) for general participation by all facilities in 2011. For each CT examination, data on volume CT dose index (CTDIvol), dose-length product (DLP), and, for body examinations, size-specific dose estimate (SSDE) were collected. However, effective dose is not estimated in DIR. The primary objective of this study was to estimate k-factor profile in detail at various scan positions with modified the ImPACT CT patient dosimetry. A tool that easily estimates the k-factor of suitable scan areas is essential for practical dose estimation in the DIR. We evaluated k-factor (effective dose/ DLP) profiles between a medical international radiation dose-five (MIRD-5) phantom positions using aImPACT software. As a result of this study, practicality of the k-factor profile method in clinical use was clarified. We speculate that a flexible k-factor improves the appropriateness of the E in hospital settings.

关键词： Radiation Protection CT ImPACT Dose Index Registry

High doses of dextromethorphan induced shock and convulsions in a 19-year-old female:A case report

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World Journal of Clinical Cases 2023年第16期11卷 3870-3876页

作者： Shintaro Shimozawa Daisuke Usuda Toru Sasaki Shiho Tsuge Riki Sakurai Kenji Kawai Shun matsubara Risa Tanaka Makoto Suzuki Yuta Hotchi Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Suguru Asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima-city 177-8521TokyoJapan Clinical Training Center Juntendo University Nerima HospitalNerima-city 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo-city 113-8421TokyoJapan

BACKGROUND Dextromethorphan is a prevalent antitussive agent that can be easily obtained as an over-the-counter *** has been a growing number of reported cases of toxicity in recent ***,there are numerous instances of mild symptoms,with only a limited number of reports of severe cases necessitating intensive *** presented the case of a female who ingested 111 tablets of dextromethorphan,leading to shock and convulsions and requiring intensive care that ultimately saved her *** SUMMARY A 19-year-old female was admitted to our hospital via ambulance,having overdosed on 111 tablets of dextromethorphan(15 mg)obtained through an online importer in a suicide *** patient had a history of drug abuse and multiple self-inflicted *** the time of admission,she exhibited symptoms of shock and altered ***,upon arrival at the hospital,the patient experienced recurrent generalized clonic convulsions and status epilepticus,necessitating tracheal *** convulsions were determined to have been caused by decreased cerebral perfusion pressure secondary to shock,and noradrenaline was administered as a *** lavage and activated charcoal were also administered after *** systemic management in the intensive care unit,the patient’s condition stabilized,and the need for vasopressors *** patient regained consciousness and was *** patient was subsequently transferred to a psychiatric facility,as suicidal ideation *** We report the first case of shock caused by an overdose of dextromethorphan.

关键词： Dextromethorphan Drug overdose Shock Symptom Treatment Case report

Stabilization of a high-order harmonic generation seeded extreme ultraviolet free electron laser by time-synchronization control with electro-optic sampling

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High Power Laser Science and Engineering 2015年第2期3卷 1-10页

作者： H.Tomizawa T.Sato K.Ogawa K.Togawa T.Tanaka T.Hara M.Yabashi H.Tanaka T.Ishikawa T.Togashi S.matsubara Y.Okayasu T.Watanabe E.J.Takahashi K.Midorikawa M.Aoyama K.Yamakawa S.Owada A.Iwasaki K.Yamanouchi RIKEN SPring-8 Center Japan Synchrotron Radiation Research Institute RIKEN Center for Advanced Photonics Japan Atomic Energy Agency The University of Tokyo

A fully coherent free electron laser(FEL) seeded with a higher-order harmonic(HH) pulse from high-order harmonic generation(HHG) is successfully operated for a sufficiently prolonged time in pilot user experiments by using a timing drift feedback. For HHG-seeded FELs, the seeding laser pulses have to be synchronized with electron bunches. Despite seeded FELs being non-chaotic light sources in principle, external laser-seeded FELs are often unstable in practice because of a timing jitter and a drift between the seeding laser pulses and the accelerated electron bunches. Accordingly,we constructed a relative arrival-timing monitor based on non-invasive electro-optic sampling(EOS). The EOS monitor made uninterrupted shot-to-shot monitoring possible even during the seeded FEL operation. The EOS system was then used for arrival-timing feedback with an adjustability of 100 fs for continual operation of the HHG-seeded FEL. Using the EOS-based beam drift controlling system, the HHG-seeded FEL was operated over half a day with an effective hit rate of 20%–30%. The output pulse energy was 20 μJ at the 61.2 nm wavelength. Towards seeded FELs in the water window region, we investigated our upgrade plan to seed high-power FELs with HH photon energy of 30–100 e V and lase at shorter wavelengths of up to 2 nm through high-gain harmonic generation(HGHG) at the energy-upgraded SPring-8Compact SASE Source(SCSS) accelerator. We studied a benefit as well as the feasibility of the next HHG-seeded FEL machine with single-stage HGHG with tunability of a lasing wavelength.

关键词： arrival-timing monitor electro-optic sampling(EOS)

Why is endosonography insufficient for residual diagnosis after neoadjuvant therapy for esophageal cancer?Solutions using muscle layer evaluation

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World Journal of Gastrointestinal Endoscopy 2022年第5期14卷 320-334页

作者： Shohei Yonemoto Masaya Uesato Akira Nakano Kentaro Murakami Takeshi Toyozumi Tetsuro Maruyama Hiroshi Suito Tomohide Tamachi Manami Kato Shunsuke Kainuma Keisuke Matsusaka Hisahiro matsubara Frontier Surgery Graduate School of MedicineChiba UniversityChiba 260-8670Japan

BACKGROUND The diagnosis of residual tumors using endoscopic ultrasound(EUS)after neoadjuvant therapy for esophageal cancer is considered ***,the reasons for this difficulty are not well *** To investigate the ultrasound imaging features of residual tumors and identify the limitations and potential of *** This exploratory prospective observational study enrolled 23 esophageal squamous cell carcinoma patients receiving esophagectomy after neoadjuvant therapy[15 patients after neoadjuvant chemotherapy(NAC)and 8 patients after chemoradiotherapy(CRT)]at the Department of Surgery,Chiba University Hospital,between May 2020 and October *** diagnosed the T stage for specimens using ultrasound just after surgery and compared ultrasound images with the cut surface of the fixed specimens of the same level of residual *** ratio of esophageal muscle layer defect measured by ultrasound was compared with clinicopathological ***,the rate of reduction for the muscle layer defect was evaluated using EUS images obtained before and after neoadjuvant *** The accuracy of T stage rate was 61%(n=14/23),which worsened after CRT(38%,n=3/8)than after NAC(73%,n=11/15)because of ***,pT0 could not be diagnosed in all *** detection rate of residual tumor for specimens using ultrasound retrospectively was 75%(n=15/20).There was no correlation between after-NAC(79%,n=11/14)and after-CRT(67%,n=4/6)detection *** detection of superficial and submucosal types was *** pathologic tumor size and pathological response were *** borders were irregular and echogenicity was mixed type after *** was a correlation between the pT stage(pT0/1 vs pT2/3)and the length of muscle layer circumference(P=0.025),the length of muscle layer defect(P<0.001),and the ratio of muscle layer defect(P<0.001).There was also a correlation between the pT stage and the rate of muscle layer defect reduction measu

关键词： Esophageal cancer Esophageal squamous cell carcinoma Neoadjuvant therapy Endoscopic ultrasound Residual tumor Endosonography

Current perspectives of viral hepatitis

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World Journal of Gastroenterology 2024年第18期30卷 2402-2417页

作者： Daisuke Usuda Yuki Kaneoka Rikuo Ono Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami Eri Nakajima Shiho Tsuge Riki Sakurai Kenji Kawai Shun matsubara Risa Tanaka Makoto Suzuki Shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Viral hepatitis represents a major danger to public health,and is a globally leading cause of *** five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk of liver complications,and response to antiviral *** remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver ***,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’*** 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral ***,treatment is sufficiently able to prevent the disease from reaching advanced ***,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral *** review aims to summarize the current state of knowledge on each type of viral hepatitis,together with major innovations.

关键词： Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus Current perspectives