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Evolutionary and Pronostic Aspects of Cirrhosis at the University Hospital of Brazzaville (Congo)

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Open Journal of Gastroenterology 2020年第1期10卷 23-29页

作者： Jile Florient Mimiesse Ngalessami Mouakosso Marlyse Ahoui Apendi Clausina Mongo Onkouo Arnaud atipo-ibara ollandzobo lucie Firmin Bossali Akoa Ngala Itoua-Ngaporo Rody Stéphane Ngami Mahoungou Gael Honal Deby Gassaye atipo ibara Blaise Irénée ibara Jean-Rosaire Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Gastroenterology Service University Hospital of Brazzaville Brazzaville Congo

Introduction: cirrhosis is a serious pathology that leads to complications whose management remains difficult in our country. This study aimed to evaluate the evolutionary aspects of cirrhosis at the Brazzaville University Hospital. Patients and methods: this was a retrospective study over a period of 18 months (from January 2015 to July 2016), performed in the Gastroenterology Department of the Brazzaville University Hospital. All patients regularly followed for decompensated cirrhosis were included. The studied variables were the epidemiological, clinical and paraclinical characteristics, the occurrence of complications, the survival, and the causes of death. Univariate analysis was used to determine prognostic factors based on the Child Pugh score. Results: There were 43 patients, including 32 men and 11 women, with a mean age of 52 ± 9.5 years. Viral hepatitis B was the most common etiology (39.5%). Child Pugh stage C was found in 60.5%. Oesophageal varices were present in 93% of cases. Survival at 18 months was 72%. In univariate analysis, two variables were significantly associated with decreased survival, including Child Pugh stage C and esophageal varices (grade II and III). Conclusion: cirrhosis remains a worrying pathology because the diagnosis is often made at the stage of often serious complications putting at risk of vital prognosis.

关键词： Cirrhosis Evolution Brazzaville

Prevalence of Children Vaccinated against Viral Hepatitis B in Brazzaville

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Open Journal of Pediatrics 2024年第2期14卷 426-434页

作者： lucie Charlotte ollandzobo Ikobo Farrèche Colombe Missidi Hostaud Bienvenu atipo-ibara Arnaud Mongo Onkouo Clausina Philestine Ahoui Apendi Jile Florent Mimiesse Blaise Irénée atipo ibara Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo Infant Paediatrics Department Brazzaville University Hospital Brazzaville Republic of the Congo Gastroenterology and Internal Medicine Department Brazzaville University Hospital Brazzaville Republic of the Congo

Introduction: Viral hepatitis B (VHL) is a public health problem, particularly in sub-Sahara Africa. The aim of this study was to assess vaccination coverage against HBV in children in Brazzaville. Patients and Methods: This was a cross-sectional analytical study conducted in Brazzaville health centres from January to September 2019. It involved children aged between six months and six years who received a vaccination against HBV. Sampling was exhaustive and based on stratified sampling. Results: The overall prevalence of children vaccinated against HBV in Brazzaville was 96.2%. It was insufficient in the Talangai health district (79%). The pentavalent vaccine was administered to 97.7% of children, 85% of whom had received all three doses. The reasons for incomplete vaccination were parents’ ignorance of HVB (85.6%) and of vaccination (14.3%). Conclusion: Although the prevalence of vaccinated children is high in Brazzaville, it is still insufficient in some health districts, particularly Talangai, because parents are unaware of the disease and of vaccination. Pentavalent is the only vaccine available in the national vaccination programme, which is why an effective national vaccination policy needs to be put in place. .

关键词： Prevalence Vaccination Viral Hepatitis B Child Brazzaville

Microsphere-assisted quantitative phase microscopy:a review

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Light(Advanced Manufacturing) 2024年第1期5卷 131-150页

作者： Vahid Abbasian Tobias Pahl lucie Hüser Sylvain Lecler Paul Montgomery Peter Lehmann Arash Darafsheh Department of Radiation Oncology Washington University School of Medicine in St.LouisSt.LouisMO 63110USA Imaging Science Program McKelvey School of EngineeringWashington University in St.LouisSt.LouisMO 63130USA Measurement Technology Group Faculty of Electrical Engineering and Computer ScienceUniversity of KasselWilhelmshöher Allee 7134121 KasselGermany ICube Research Institute INSA StrasbourgUniversitéde StrasbourgCNRS67000 StrasbourgFrance

Light microscopes are the most widely used devices in life and material sciences that allow the study of the interaction of light with matter at a resolution better than that of the naked *** microscopes translate the spatial differences in the intensity of the reflected or transmitted light from an object to pixel brightness differences in the digital ***,a phase microscope converts the spatial differences in the phase of the light from or through an object to differences in pixel *** microscopy,a phase-based approach,has found application in various *** interferometry has brought nanometric axial resolution,the lateral resolution in quantitative phase microscopy(QPM)has still remained limited by diffraction,similar to other traditional microscopy *** the resolution has been the subject of intense investigation since the invention of the microscope in the 17th *** the past decade,microsphere-assisted microscopy(MAM)has emerged as a simple and effective approach to enhance the resolution in light *** can be integrated with QPM for 3D label-free imaging with enhanced ***,we review the integration of microspheres with coherence scanning interference and digital holographic microscopies,discussing the associated open questions,challenges,and opportunities.

关键词： Phase microscopy Digital holographic microscopy Microsphere Resolution

Distribution of atrial cardiomyopathy markers and association with atrial fibrillation detected after ischaemic stroke in the SAFAS study

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Stroke & Vascular Neurology 2024年第2期9卷 165-173,I0426,I0427页

作者： Romain Didier lucie Garnier Gauthier Duloquin Alexandre Meloux Audrey Sagnard Mathilde Graber Geoffrey Dogon Karim Benali Thibaut Pommier Gabriel Laurent Catherine Vergely Yannick Bejot Charles Guenancia Cardiology CHU Dijon BourgogneDijonFrance Dijon Stroke Registry Department of NeurologyUniversity Hospital Centre DijonDijonFrance PEC 2 Universitéde BourgogneDijonFrance Cardiology CHU Saint EtienneSaint EtienneFrance

Background Atrial cardiomyopathy(AC)is an emerging concept explaining the pathophysiology of cardioembolic strokes in absence of atrial fibrillation(AF).A definition based on the presence of electrical abnormality(P-wave terminal force in lead V1(PTFV1)>5000µV×ms),N-Terminal pro-B-type natriuretic peptide(NT pro BNP)>250pg/mL and/or indexed left atrial diameter(LADI)>3cm/m^(2)is currently tested in the ARCADIA(AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke)*** set out to estimate the prevalence of AC as defined in the ARCADIA trial,its determinants and its association with AF detected after stroke(AFDAS).Methods Stepwise screening for silent Atrial Fibrillation After Stroke(SAFAS)study prospectively included 240 ischaemic stroke *** markers were complete for 192 of them and 9 were not included in this analysis because AF had been diagnosed on *** A total of 183 patients were analysed,of whom 57%(104 patients)met the AC criteria(79 NT-proBNP,47 PTFV1,4 LADI).In the multivariate logistic regression,C reactive protein>3mg/L(OR(95%CI)2.60(1.30 to 5.21),p=0.007)and age(OR(95%CI)1.07(1.04 to 1.10),p34mL/m^(2),OR 2.35(CI 1.09 to 5.06)p=0029).Conclusion AC as defined in ARCADIA is mostly based on NT pro BNP elevation(76%of patients)and is associated with age and ***,AC was not independently associated with AFDAS at *** ARCADIA trial,which compares aspirin to apixaban in patients with embolic strokes of undetermined source with AC markers and must,therefore be analysed in the light of these limitations.

关键词： atrial cardiomyopathy prevention

Helicobacter Pylori Infection: Epidemiological, Clinical and Endoscopic Aspects in Brazzaville

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Open Journal of Gastroenterology 2023年第4期13卷 131-139页

作者： Bienvenu H. atipo-ibara Anicet Boumba lucie C. atipo ibara ollandzobo Ikobo Arnaud Mongo-Onkouo Jile F. Mimiesse Monamou Ngala A. Itoua-Ngaporo Donatien Moukassa Blaise I. atipo ibara Jean-Rosaire ibara Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo Hugues Dieudonné Loemba Molecular Biology Laboratory Pointe-Noire Republic of the Congo Pointe-Noire Research Zone National Institute for Research in Health Sciences (IRSSA) Pointe-Noire Republic of the Congo Department of Gastroenterology and Internal Medicine CHU Brazzaville Brazzaville Republic of the Congo Department of Anatomical Pathology Edith Lucie Bongo Odimba General Hospital Oyo Republic of the Congo

Introduction: Helicobacter pylori infection is a real health problem worldwide. It is the most common chronic bacterial infection in the world, and is particularly prevalent in developing countries. Objective: To determine the frequency of Helicobacter pylori infection and to study the epidemiological, clinical and endoscopic characteristics associated with this infection in Brazzaville. Patients and Methods: This was a descriptive cross-sectional study conducted from January to November 2020, i.e. 11 months. This work focused on 100 symptomatic patients over 18 years old referred for upper GI endoscopy. Gastric biopsies for biological study by urease test and molecular study by real time PCR technique were taken. Results: With a mean age of 46.32 ± 15.20 years, the frequency of Hp infection was 91%, with a female predominance of 53%. The sex ratio was 0.92. The average age was 46.32 ± 15.20 years. Carriage of the infection was more important in households with more than 3 persons, in patients consuming public tap water and in those using both types of sanitary facilities. Endoscopy was indicated for epigastralgia in 93.1% of cases. About 56.14% of the infected patients had normal mucosa versus 12.28% with ulcerated lesions and 22.81% with gastritis. Conclusion: The prevalence of Helicobacter pylori infection is significant in Congo, justifying early detection in order to improve management.

关键词： Helicobacter pylori Carriage Chronic Gastritis Gastric Ulcer Brazzaville

Ingestion of Caustics by Children in Brazzaville (CONGO)

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Open Journal of Pediatrics 2018年第3期8卷 283-291页

作者： lucie Charlotte atipo-ibara Ikobo ollandzobo Clausina Ahoui-Apendi Jile Florient Mimiesse-Monamou Jean Robert Mabiala Babela Deby-Gassaye Blaise Irénée atipo ibara Jean-Rosaire ibara Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Infant Pediatric Service University Hospital of Brazzaville Brazzaville Congo Gastroenterology and Internal Medicine Service University Hospital of Brazzaville Brazzaville Congo

Ingestion of caustics by children is serious because of the increase in their frequency and the difficulties due to their management. Objective: To improve the management of caustic lesions in Pediatric Department at the University Hospital of Brazzaville. Patients and Methods: Prospective study was conducted from January 2014 to December 2015 in the Pediatric Departments of the UHB and centers of digestive endoscopy in Brazzaville. All children who ingested a caustic product and hospitalized were included after obtaining parental’s consent. The studied parameters were: Age, sex, nature and quantity of the caustic, the family’s attitude, clinical signs, endoscopic results according to Zagar’s classification, therapeutic modalities and evolution. Results: 8292 children were hospitalized and 68 because of the ingestion of caustic, a frequency of 0.8%. The average age was 23.6 months [2 months - 16 years]. The male sex was predominant (57.4%). Ingestion was accidental in 88.2% and voluntary in 11.8%. Factors favoring ingestion were storage methods (81.5%) and parental’s inattention or negligence (10.8%). Bleach was the most incriminated caustic (54.4%) followed by caustic soda (29.4%). The estimated quantity ingested was assumed to be minimal in 61.7%. Unsuitable acts were practiced by the family before the medical consultation in 66.1%. The dominant symptoms were digestive (47%) and neurological (25%). The average time to perform endoscopy was 48 hours in 88.2%. Endoscopy revealed lesions in 51.7%, the different stages were I (12 cases), II (16 cases) and III (3 cases). The mains factors of gravity were inappropriate gestures (85%) and the non-respect of the fasting (9%). Proton pump inhibitors were used in 50%. The evolution was favorable for in 73.5%. Conclusion: Ingestion of caustics by children is most often accidental favored by the inadequate packaging and storage. Prevention is about educating people in order to reduce their frequency.

关键词： Caustic Lesions Child Brazzaville

Sustaining forest biodiversity:Exploring the effect of long-term natural disturbance dynamics on contemporary lichen communities in primary forest ecosystems

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Forest Ecosystems 2024年第4期11卷 556-567页

作者： Rhiannon Gloor Marek Svitok Martin Mikolas Jenyk Hofmeister Josef Halda Pavel Janda Francesco Maria Sabatini lucie Zemanova Arne Buechling Daniel Kozak Matej Ferencik Michal Frankovic Martin Dusatko Miroslav Svoboda Department of Forest Ecology Faculty of Forestry and Wood SciencesCzech University of Life Sciences PragueKamycka 129Praha 6–Suchdol16500Czech Republic Faculty of Ecology and Environmental Sciences Technical University in ZvolenT.G.Masaryka 2496001ZvolenSlovakia Institute of Botany Plant Science and Biodiversity CenterSlovak Academy of SciencesDúbravska cesta 984523BratislavaSlovakia PRALES Odtrnovie 56301322RosinaSlovakia Faculty of Science University of Hradec KraloveHradecka 1285Hradec KraloveⅢ50003Czech Republic BIOME–Biogeography and Macroecology Department of BiologicalGeological and Environmental Sciences(BIGEA)Alma Mater Studiorum-University of Bolognavia Irnerio 42BolognaItaly

In this era of biodiversity loss and climate change,quantifying the impacts of natural disturbance on forest communities is imperative to improve biodiversity conservation *** and epixylic lichens are effective forest quality bioindicators,as they are generally long-lived organisms supported by continuity of specific forest structures and their associated microclimatic ***,how lichen communities respond to the effects of fluctuating historical disturbances remains *** a dendrochronological approach,this study investigates how natural disturbance dynamics indirectly influence various lichen community metrics in some of Europe's best-preserved primary mixed-beech *** modelling revealed that natural historical disturbance processes have decades-long effects on forest structural attributes,which had both congruent and divergent impacts on lichen community richness and *** species richness indirectly benefited from both historical and recent higher-severity disturbances via increased standing dead tree basal area and canopy openness respectively-likely through the presence of both pioneer and late-successional species associated with these ***-listed species richness showed a dependence on habitat continuity(old trees),and increased with disturbance-related structures(standing dead trees)whilst simultaneously benefiting from periods without severe disturbance events(old trees and reduced deadwood volume).However,if the disturbance occurred over a century in the past,no substantial effect on forest structure was ***,while disturbance-mediated forest structures can promote overall richness,threatened species appear vulnerable to more severe disturbance events-a concern,as disturbances are predicted to intensify with climate ***,the high number of threatened species found reinforce the critical role of primary forest structural attributes for biodiversity ***

关键词： Mixed-beech forests Species richness Old-growth forests Carpathian mountains Biodiversity conservation Dendroecology Fagus sylvatica

Theoretical Study of Benzothiazole and Its Derivatives: Molecular Structure, Spectroscopic Properties, NBO, MEP and TD-DFT Analyses

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Journal of Materials Science and Chemical Engineering 2024年第3期12卷 31-50页

作者： Konaté Abdoulaye Bédé Affoué lucie Ouattara Lamoussa Koné Soleymane Bamba Kafoumba Laboratory of Constitution and Reaction of Matter University Félix Houphou&#235t-Boigny Abidjan Ivory Coast Department of Marine Sciences University of San-Pedro San-Pedro Ivory Coast Laboratory of Thermodynamics and Physico-Chemistry of Environment University Nangui Abrogoua Abidjan Ivory Coast

Benzothiazole (BTH) and its derivatives are organic molecules with biologic actions. Because of their many applications, they are produced on a massive scale and used in a number of environmental compartments. Their discharge into water produces environmental problems, exposing our environment to public health problems. A solution that can contribute to their deterioration is becoming a necessity. For this reason, a conceptual analysis of the reactivity of benzothiazole and four of its compounds was undertaken in order to investigate certain aspects of their biodegradability. A theoretical investigations of the compounds studied were conducted in the gas and water phases with the most widely used density functional theory method, Becke-3-Parameter-Lee-Yang-Parr (B3LYP) with 6-31G+ (d, p) basis. Reactivity study calculated global indices of reactivity revealed that 2-SCH3_BTH is the most reactive. Dipole moment values analysis reveals that 2-NH2_BTH is the most soluble in water, while the lipophilicity shows that 2-NH2_BTH is the most hydrophilic compound. Thermodynamic parameters values reflect that reactions are respectively exothermic and spontaneous. By analyzing an Electrostatic Molecular Potential (EMP) map, researchers can pinpoint reactive sites on a molecule and anticipate its reactivity. This assessment is further enhanced by incorporating global and local reactivity descriptors. Additionally, an exploration of frontier molecular orbitals offers valuable insights into the molecule’s charge transfer characteristics. Moreover, a combined examination of internal and external molecular interactions unveils hyperconjugative interactions arising from charge delocalization, as elucidated through natural bond orbital (NBO) analysis.

关键词： Benzothiazole Reactivity DFT/B3LYP Stability TD-DFT

Prevalence of Enteric Pathogens Associated with Infections among Table Egg Consumers in Some Primary Health Establishments in the Center Region of Cameroon

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Advances in Infectious Diseases 2024年第3期14卷 606-619页

作者： Mariane lucie Ngueguim Bernard Viban Tangwa Victor Ngu Ngwa Albert Ngakou Abdoulmoumini Mamoudou School of Veterinary Medicine and Sciences University of Ngaoundere Ngaoundere Cameroon Department of Veterinary Medicine University of Buea Buea Cameroon Faculty of Sciences University of Ngaoundere Ngaoundere Cameroon

Method: In Cameroon limited data are available regarding the prevalence of enteric bacteria associated with table egg consuming infections. As such, a situational-based study was performed in patients with complains of stomach disorders after egg consumption. Data related to sociodemographic characteristics and other factors were collected using a structured based questionnaire. Stool culture of utmost importance in stomach disorders patients and serum were collected for typhoid serological test. Results: A total of 207 participants took part in the survey, Results indicated nontyphoidal Salmonella infections were highest in the 3 areas of study with Mfoundi (73.44%) having the highest level of infection compared to other bacterial infection. other enteric bacteria associated to this infection were E. coli serotype 157, Aeromonas, Citrobacter freundii, Enterobacter cloaca and typhi salmonella. Meanwhile salmonelosis caused by typhic salmonella had highest prevalence in the Lekie Division (13.11%) as a result of poor hygienic practices associated with the conservation and preparation of eggs, Stool culture was observed to detect more positive cases in the diagnosis of typhoid fever than Widal test, but with no statistically significant (p > 0.05) difference between the stool culture and Widal test in the 3 areas of study. Conclusion: this study revealed that egg consumers are pruned to enteric bacterial and salmonella infections depending on how and where egg is consumed.

关键词： Enteric Pathogens Table Eggs Consumption Center Region Cameroon