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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado jose m.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA national Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

ABAting the Response:A novel ABA Signal Terminator that Disrupts the Hormone Co-receptor Complex

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molecular Plant 2020年第9期13卷 1241-1243页

作者： Akhtar Ali jose m.Pardo Dae-jin yun Institute of Glocal Disease Control Konkuk UniversitySeoul 05029Republic of Korea Department of Biomedical Science&Engineering Konkuk UniversitySeoul 05029South Korea Instituto de Bioquimica Vegetal y Fotosintesis cicCartujaCSIC-Universidad de SevillaAmericoVespucio 49Sevilla 41092Spain

The phytohormone abscisic acid(ABA)regulates multiple physiological processes such as embryo morphogenesis,seed maturation and germination,leaf senescence,fruit ripening,and stress adaptation(Gupta et al.,2020).ABA levels quickly rise in response to conditions leading to water deficit,including the developmental processes of seed drying and dormancy,as well as early post-germinative growth(Chen et al.,2020).Several proteins,commonly regarded as the ABA signaling core components,have been identified.

关键词： Gupta Signal Complex

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin yuxin.jin.yiming Qin Feifei yuan Hongbin Lu Jianzhong Hu yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina national Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. n6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RnA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(mETTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RnA immunoprecipitation-quantitative polymerase chain reaction, we found that mETTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of mETTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing mETTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(mETTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

Direct-fed microbes: A tool for improving the utilization of low quality roughages in ruminants

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Journal of Integrative Agriculture 2015年第3期14卷 526-533页

作者： mona m y Elghandour Abdelfattah Z m Salem.jose S martínez Castaeda Luis m Camacho Ahmed E Kholif Juan C Vázquez Chagoyán Faculty of Veterinary medicine and Animal Science Autonomous University of the State of Mexico Faculty of Veterinary medicine and Animal Science Autonomous University of Guerrero Dairy Science Department National Research Centre

For many years, ruminant nutritionists and microbiologists have been interested in manipulating the microbial ecosystem of the rumen to improve production efficiency of different ruminant species. Removal and restriction of antibiotics subtherapeutic uses from ruminant diets has amplified interest in improving nutrient utilization and animal performance and search for more safe alternatives. Some bacterial and fungal microorganisms as a direct-fed microbial（DFm） can be the most suitable solutions. microorganisms that are commonly used in DFm for ruminants may be classified mainly as lactic acid producing bacteria（LAB）, lactic acid utilizing bacteria（LUB）, or other microorganism＇s species like Lactobacillus, Bifidobacterium, Enterococcus, Streptococcus, Bacillus, Propionibacterium, megasphaera elsdenii and Prevotellabryantii, in addition to some fungal species of yeast such as Saccharomyces and Aspergillus. A definitive mode of action for bacterial or fungal DFm has not been established; although a variety of mechanisms have been suggested. Bacterial DFm potentially moderate rumen conditions, and improve weight gain and feed efficiency. Fungal DFm may reduce harmful oxygen from the rumen, prevent excess lactate production, increase feed digestibility, and alter rumen fermentation patterns. DFm may also compete with and inhibit the growth of pathogens, immune system modulation, and modulate microbial balance in the gastrointestinal tract. Improved dry matter intake, milk yield, fat corrected milk yield and milk fat content were obtained with DFm administration. However, the response to DFm is not constant; depending on dosages, feeding times and frequencies, and strains of DFm. nonetheless, recent studies have supported the positive effects of DFm on ruminant performance.

关键词： direct-fed microbial(DFm) mode of action ruminants

Random Batch Particle methods for the Homogeneous Landau Equation

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Communications in Computational Physics 2022年第4期31卷 997-1019页

作者： jose Antonio Carrillo Shi jin yijia Tang mathematical Institute University of OxfordOxfordOX26GGUK School of mathematical Sciences Institute of Natural SciencesMOE-LSCShanghai Jiao Tong UniversityShanghai200240P.R.China School of mathematical Sciences Shanghai Jiao Tong UniversityShanghai200240P.R.China.

We consider in this paper randombatch particlemethods for efficiently solving the homogeneous Landau equation in plasma *** methods are stochastic variations of the particle methods proposed by Carrillo et al.[***.:X 7:100066,2020]using the random batch *** collisions only take place inside the small but randomly selected batches so that the computational cost is reduced to O(n)per time ***,our methods can preserve the conservation of mass,momentum,energy and the decay of *** numerical examples are performed to validate our methods.

关键词： Homogeneous Landau equation random batch particle method Coulomb collision

Visual grading criteria for Japanese larch ( Larix kaempferi ) structural timber from Spain

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Journal of Forestry Research 2020年第6期31卷 2605-2614页

作者： mari-jose Barriola José-Ramón Aira Edgar Lafuente Tknika LHri Aplikatutako Ikerketa eta Berrikuntzako EAEko zentroaZamalbide Auzoa z/g20100 ErrenteriaGipuzkoaSpain Escuela de Ingeniería de la Industria Forestal Agronómica y de la BioenergíaUniversidad de ValladolidUVa-Campus Duques de Sorias/n42005 SoriaSpain Cesefor Centro de Servicios y Promoción Forestal y de su Industria de Castilla y LeónCalle C42005 SoriaSpain

Larch wood is structurally classifi ed in many countries as one of conifers with the highest load-bearing capacity(strength class of C30).The Spanish visual classifi cation regulation only assigns a strength class to 4 pine woods:Laricio pine(Pinus nigra ***),Silvestre pine(Pinus sylvestris L.),Radiata pine(Pinus radiata ***),and Pinaster pine(Pinus pinaster Ait.).This work adds to the number of structurally characterised species by creating a visual classifi cation table for Japanese larch wood(Larix kaempferi(Lamb.)Carr.)which diff erentiates between 2 visual classes,mEG-1 and *** strength values were calculated for each class(fk,mEG-1=31.80 mPa,f k,mEG-2=24.55 mPa),mean module of elasticity(E 0,mean,mEG-1=13,082 mPA,E 0,mean,mEG-2=12,320 mPA)and density(ρk,mEG-1=456.6 kg m−3,ρk,mEG-2=469.1 kg m−3),before fi nally assigning a strength class of C30 to visual class mEG-1,and a strength class of C24 to visual class mEG-2.

关键词： Japanese larch wood Visual grading Strength class mechanical properties Density

Cassini's motions of the moon and mercury and possible excitations of free librations

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Geodesy and Geodynamics 2018年第6期9卷 474-484页

作者： yu.V.Barkin jose Ferrandiz Shuanggen jin m.yu.Barkine Sternberg Astronomical Institute Moscow State University Moscow 119992 Russia University of Alicante Alicante Spain Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Department of Geomatics Engineering Bulent Ecevit University Zonguldak 67100 Turkey Bauman moscow State Technical University Moscow 119992 Russia

On the basis of conditionally-periodic solutions of Hamiltonian systems at resonance of main frequencies Cassini’s motions, their stability, Cassini’s angle and periods of free librations of the moon and mercury have been recently studied and determined. The generalized formulations of Cassini’s laws for the motion of the moon and mercury, that are considered as absolutely rigid non-spherical bodies, have been determined. The study of the second approximation equations of the desired quasi-periodic solutions in the case of the moon allows us to determine the constant components of the first order for six Andoyer variables and the constant component of the second order for the angular velocity of the moon. These effects are caused by the influence of the third harmonic of selenopotential. In this paper, these effects are described by analytical formulas, the dynamic and geometric interpretations are given, and a new interpretation of mercury’s motion under the generalized Cassini’s laws has been proposed. Predictions of the existence of free librations of significant amplitude in the mercury longitude, that are confirmed by the radar measurements data of the mercury angular velocity, and in its pole motion in the body and in space have been made. The mechanism describing free librations of celestial bodies and their pole oscillations has been proposed due to the forced relative oscillations and wobble of the core-mantle system of celestial bodies（moon, mercury, Earth and other bodies in the solar system） under gravitational action of the external celestial bodies. The paper shows that the ascending node of equator of mercury（and the intermediate plane orthogonal to the angular momentum） of epoch 2000.0 on the ecliptic does not coincide with the ascending node of orbital plane of mercury on the same plane, and is ahead of it at an angle 23°4’. Angular momentum vector of the rotational motion of mercury forms a constant angle p;=4’1±1’1 with normal to the moveable plan

关键词： Cassini's motions moon mercury

Effects of small-scale disturbances and elevation on the morphology,phenology and reproduction of a successful geophyte

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Journal of Plant Ecology 2009年第1期2卷 13-20页

作者： Daniel Gomez-Garcıa jose´Azorın AJavier Aguirre Instituto Pirenaico de Ecologı´a-CSIC Apartado.64E-22700 JacaHuescaSpain A´rea de Ingenierı´a Agroforestal.EPSH Universidad de Zaragoza.Ctra Cuarte s/n.E-22071 HuescaSpain

Aims We aimed to find out how a geophyte,merendera montana,occupies a wide ecological,elevational and climatic *** occurrence in that environmental array is outstanding not only among geophytes but also in the whole flora of the Iberian Peninsula,where only a very few plants show such an apparent ***,we compared morphological and reproductive traits,and frequency of different types of reproduction in disturbed and undisturbed ***,we have analyzed the phenology of this plant by trying to understand how it manages to spread in an exceptional elevational gradient of 2000 m,with contrasting climatic regimes between the mediterranean and the alpine *** We measured the plant density of *** populations in different types of Pyrenean grasslands either with or without small-scale disturbances at seven sites from the basal to the alpine belt(400–2300 m a.s.l.).In each one of these populations,100 individuals—1200 in total—were uprooted to measure their morphological features as well as type and occurrence of ***(flowering and fruiting dates and leaf lifespan)was estimated using 5 years of records in the studied areas and>200 herbarium sheets from the whole altitudinal rank and collected in the last 30 *** in plant densities were analyzed with non-parametric mann–Whitney U-test;differences in morphological traits,fruit and seed production associated with disturbance,with one-way analysis of covariance test(general linear model).Finally,linear regression analyses were used to determine the relationships between clonal reproduction and elevation and those between flowering,fruiting and senescence and date and *** Findings In all cases,plant density in disturbed grasslands was significantly higher than in undisturbed *** height and weight,bulb depth,leaf width and bulb and root weight were higher in disturbed *** and undisturbed plots were similar

关键词： Spanish Pyrenees merendera montana functional traits disturbed grasslands

Gabor Analysis on Finite Product of Cyclic Groups

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Journal of mathematical Research with Applications 2024年第4期44卷 521-532页

作者： jineesh THOmAS n.m.madhavan nAmBOOTHIRI Ajo jose Research Scholar of mathematics St.Thomas College Palai Professor and Principal Government Arts & Science College Idukki

We present a complete characterization of Gabor frame operators on finite dimensional Hilbert space L2（Γ）,where■and m1,m2,...,mpare positive *** notion of generalized B-modulation and generalized B-translation is ... 详细信息

关键词： Gabor frame Gabor frame operator modulation translation